Enhanced daunomycin accumulation in human intestinal Caco-2 cells from non-ionic food emulsifiers unrelated to the P-glycoprotein inhibitory mechanism

Bioscience, Biotechnology and Biochemistry

Volumn 70, Issue 11, 2006, Pages 2703-2711

  Takaishi, Naoki ^a,b   Satsu, Hideo ^a   Shimizu, Makoto ^a  

^a UNIVERSITY OF TOKYO   (Japan)

^b UNITIKA LTD   (Japan)

Author keywords

Caco 2; Emulsifier; Intestinal cell; P glycoprotein; Surfactant

Indexed keywords

CELLS; EMULSIFICATION; ESTERS; FATTY ACIDS; FOOD PRODUCTS; PROTEINS; SUGAR (SUCROSE); SURFACE ACTIVE AGENTS;

EMULSIFIERS; INTESTINAL CELLS; P GLYCOPROTEIN; POLYGLYCEROL ESTERS (PGE);

ANTIBIOTICS;

DAUNORUBICIN; EMULSIFYING AGENT; ESTER; GLYCEROL; GLYCOPROTEIN P; ION; POLYGLYCEROL; POLYMER;

ARTICLE; CELL STRAIN CACO 2; CHEMICAL STRUCTURE; CHEMISTRY; DRUG ANTAGONISM; DRUG EFFECT; FOOD; HUMAN; INTESTINE; METABOLISM; TRANSPORT AT THE CELLULAR LEVEL;

BIOLOGICAL TRANSPORT; CACO-2 CELLS; DAUNORUBICIN; EMULSIFYING AGENTS; ESTERS; FOOD; GLYCEROL; HUMANS; INTESTINES; IONS; MOLECULAR STRUCTURE; P-GLYCOPROTEIN; POLYMERS;

EID: 33751421998     PISSN: 09168451     EISSN: 13476947     Source Type: Journal    
DOI: 10.1271/bbb.60306     Document Type: Article

References (25)

1. Aungst, B. J., Intestinal permeation enhancers. J. Pharm. Sci., 89, 429-442 (2000).
2. Anderberg, E. K., Nystrom, C., and Artursson, P., Epithelial transport of drugs in cell culture. VII: effects of pharmaceutical surfactant excipients and bile acids on transepithelial permeability in monolayers of human intestinal epithelial (Caco-2) cells. J. Pharm. Sci., 81, 879-887 (1992).
3. Narai, A., Arai, S., and Shimizu, M., Rapid decrease in the transepithelial electrical resistance of human intestinal Caco-2 cell monolayers by cytotoxic membrane perturbents. Toxicol. in Vitro, 11, 347-354 (1997).
4. Mine, Y., and Zhang, J. W., Surfactants enhance the tight-junction permeability of food allergens in human intestinal epithelial Caco-2 cells. Int. Arch. Allergy Immunol., 130, 135-142 (2003).
5. Xia, W. J., and Onyuksel, H., Mechanistic studies on surfactant-induced membrane permeability enhancement. Pharm. Res., 17, 612-618 (2000).
6. Zordan-Nudo, T., Ling, V., Liu, Z., and Georges, E., Effects of nonionic detergents on P-glycoprotein drug binding and reversal of multidrug resistance. Cancer Res., 53, 5994-6000 (1993).
7. Buckingham, L. E., Balasubramanian, M., Safa, A. R., Shah, H., Komarov, P., Emanuele, R. M., and Coon, J. S., Reversal of multi-drug resistance in vitro by fatty acid-PEG-fatty acid diesters. Int. J. Cancer, 65, 74-79 (1996).
8. Lo, Y. L., Hsu, C. Y., and Huang, J. D., Comparison of effects of surfactants with other MDR reversing agents on intracellular uptake of epirubicin in Caco-2 cell line. Anticancer Res., 18, 3005-3009 (1998).
9. Cornaire, G., Woodley, J. F., Saivin, S., Legendre, J. Y., Decourt, S., Cloarec, A., and Houin, G., Effect of polyoxyl 35 castor oil and Polysorbate 80 on the intestinal absorption of digoxin in vitro. Arzneimittelforschung, 50, 76-79 (2000).
10. Zhang, H., Yao, M., Morrison, R. A., and Chong, S., Commonly used surfactant, Tween 80, improves absorption of P-glycoprotein substrate, digoxin, in rats. Arch. Pharm. Res., 26, 768-772 (2003).
11. Batrakova, E. V., Han, H. Y., Alakhov, V. Y., Miller, D. W., and Kabanov, A. V., Effects of pluronic block copolymers on drug absorption in Caco-2 cell monolayers. Pharm. Res., 15, 850-855 (1998).
12. Litman, T., Druley, T. E., Stein, W. D., and Bates, S. E., From MDR to MXR: new understanding of multidrug resistance systems, their properties and clinical significance. Cell. Mol. Life Sci., 58, 931-959 (2001).
13. Whitehurst, R. J., "Emulsifiers in Food Technology," Blackwell Pub., Oxford (2004).
14. Hidalgo, I. J., Raub, T. J., and Borchardt, R. T., Characterization of a human colon carcinoma cell line (Caco-2) as a model system for intestinal epithelial permeability. Gastroenterology, 96, 736-749 (1989).
15. Artursson, P., and Karlsson, J., Correlation between oral drug absorption in humans and apparent drug permeability coefficients in human intestinal epithelial (Caco-2) cells. Biochem. Biophys. Res. Commun., 175, 880-885 (1991).
16. Lo, Y. L., Relationships between the hydrophilic-lipophilic balance values of pharmaceutical excipients and their multidrug resistance modulating effect in Caco-2 cells and rat intestines. J. Control Release, 90, 37-48 (2003).
17. Jones, M. N., Surfactants in membrane solubilisation. Int. J. Pharm., 177, 137-159 (1999).
18. Doige, C. A., Yu, X., and Sharom, F. J., The effects of lipids and detergents on ATPase-active P-glycoprotein. Biochim. Biophys. Acta, 1146, 65-72 (1993).
19. Rege, B. D., Kao, J. P., and Polli, J. E., Effects of nonionic surfactants on membrane transporters in Caco-2 cell monolayers. Eur. J. Pharm. Sci., 16, 237-246 (2002).
20. Meredith, D., and Boyd, C. A. R., Oligopeptide transport by epithelial cells. J. Membrane Biol., 145, 1-12 (1995).
21. Tsuji, A., Takanaga, H., Tamai, I., and Terasaki, T., Transcellular transport of benzoic acid across Caco-2 cells by a pH-dependent and carrier-mediated transport mechanism. Pharm. Res., 11, 30-37 (1994).
22. Bogman, K., Erne-Brand, F., Alsenz, J., and Drewe, J., The role of surfactants in the reversal of active transport mediated by multidrug resistance proteins. J. Pharm. Sci., 92, 1250-1261 (2003).
23. Demina, T., Grozdova, I., Krylova, O., Zhirnov, A., Istratov, V., Frey, H., Kautz, H., and Melik-Nubarov, N., Relationship between the structure of amphiphilic copolymers and their ability to disturb lipid bilayers. Biochemistry, 44, 4042-4054 (2005).
24. Batrakova, E. V., Li, S., Li, Y., Alakhov, V. Y., and Kabanov, A. V., Effect of pluronic P85 on ATPase activity of drug efflux transporters. Pharm. Res., 21, 2226-2233 (2004).
25. Konishi, T., Satsu, H., Hatsugai, Y., Aizawa, K., Inakuma, T., Nagata, S., Sakuda, S. H., Nagasawa, H., and Shimizu, M., Inhibitory effect of a bitter melon extract on the P-glycoprotein activity in intestinal Caco-2 cells. Br. J. Pharmacol., 143, 379-387 (2004).