Leptin receptors in human skeletal muscle

Journal of Applied Physiology

Volumn 102, Issue 5, 2007, Pages 1786-1792

  Guerra, Borja ^a   Santana, Alfredo ^b   Fuentes, Teresa ^a   Delgado Guerra, Safira ^a   Cabrera Socorro, Alfredo ^c   Dorado, Cecilia ^a   Calbet, Jose A L ^a  

^a UNIVERSITY OF LAS PALMAS DE GRAN CANARIA   (Spain)

^b HOSPITAL UNIVERSITARIO MATERNO INFANTIL DE CANARIAS   (Spain)

^c UNIVERSIDAD DE LA LAGUNA   (Spain)

Author keywords

Adipose tissue; Hypothalamus; Obesity; Perilipin

Indexed keywords

LEPTIN RECEPTOR; LEPTIN RECEPTOR ANTIBODY; MESSENGER RNA; PERILIPIN A ANTIBODY; PROTEIN ANTIBODY; UNCLASSIFIED DRUG;

ADULT; ARTICLE; CONTROLLED STUDY; HUMAN; HUMAN TISSUE; HYPOTHALAMUS; MALE; PRIORITY JOURNAL; PROTEIN EXPRESSION; SKELETAL MUSCLE; SUBCUTANEOUS FAT; WESTERN BLOTTING;

ADULT; ANTIBODIES; ANTIBODY SPECIFICITY; BLOTTING, WESTERN; HUMANS; HYPOTHALAMUS; LEPTIN; MALE; MOLECULAR WEIGHT; MUSCLE, SKELETAL; PHOSPHOPROTEINS; PROTEIN ISOFORMS; RECEPTORS, CELL SURFACE; SUBCUTANEOUS FAT;

EID: 34247877511     PISSN: 87507587     EISSN: 15221601     Source Type: Journal    
DOI: 10.1152/japplphysiol.01313.2006     Document Type: Article

References (66)

1. Ahima RS, Flier JS. Leptin. Annu Rev Physiol 62: 413-437, 2000.
2. Akerman F, Lei ZM, Rao CV. Human umbilical cord and fetal membranes co-express leptin and its receptor genes. Gynecol Endocrinol 16: 299-306, 2002.
3. Aparicio T, Kermorgant S, Darmoul D, Guilmeau S, Hormi K, Mahieu-Caputo D, Lehy T. Leptin and Ob-Rb receptor isoform in the human digestive tract during fetal development. J Clin Endocrinol Metab 90: 6177-6184, 2005.
4. Ara I, Pérez Gómez J, Vicente-Rodriguez G, Chavarren J, Dorado C, Calbet JA. Serum free testosterone, leptin and soluble leptin receptor changes in a 6-week strength-training programme. Br J Nutr 96: 1053-1059, 2006.
5. Ara I, Vicente-Rodriguez G, Jimenez-Ramirez J, Dorado C, Serrano-Sanchez JA, Calbet JA. Regular participation in sports is associated with enhanced physical fitness and lower fat mass in prepubertal boys. Int J Obes Relat Metab Disord 28: 1585-1593, 2004.
6. Ara I, Vicente-Rodriguez G, Perez-Gomez J, Jimenez-Ramirez J, Serrano-Sanchez JA, Dorado C, Calbet JA. Influence of extracurricular sport activities on body composition and physical fitness in boys: a 3-year longitudinal study. Int J Obes 30: 1062-1071, 2006.
7. Argiles JM, Lopez-Soriano J, Almendro V, Busquets S, Lopez-Soriano FJ. Cross-talk between skeletal muscle and adipose tissue: a link with obesity? Med Res Rev 25: 49-65, 2005.
8. Bates SH, Myers MG Jr. The role of leptin receptor signaling in feeding and neuroendocrine function. Trends Endocrinol Metab 14: 447-452, 2003.
9. Baumann H, Morella KK, White DW, Dembski M, Bailon PS, Kim H, Lai CF, Tartaglia LA. The full-length leptin receptor has signaling capabilities of interleukin 6-type cytokine receptors. Proc Natl Acad Sci USA 93: 8374-8378, 1996.
10. Bjorbaek C, Kahn BB. Leptin signaling in the central nervous system and the periphery. Recent Prog Horm Res 59: 305-331, 2004.
11. Bjorbaek C, Lavery HJ, Bates SH, Olson RK, Davis SM, Flier JS, Myers MG Jr. SOCS3 mediates feedback inhibition of the leptin receptor via Tyr985. J Biol Chem 275: 40649-40657, 2000.
12. Bjorbaek C, Uotani S, da Silva B, Flier JS. Divergent signaling capacities of the long and short isoforms of the leptin receptor. J Biol Chem 272: 32686-32695, 1997.
13. Bouloumie A, Drexler HC, Lafontan M, Busse R. Leptin, the product of Ob gene, promotes angiogenesis. Circ Res 83: 1059-1066, 1998.
14. Briscoe CP, Hanif S, Arch JR, Tadayyon M. Leptin receptor long-form signalling in a human liver cell line. Cytokine 14: 225-229, 2001.
15. Burguera B, Couce ME, Long J, Lamsam J, Laakso K, Jensen MD, Parisi JE, Lloyd RV. The long form of the leptin receptor (OB-Rb) is widely expressed in the human brain. Neuroendocrinology 71: 187-195, 2000.
16. Cabrera-Socorro A, Pueyo Morlans M, Suarez Sola ML, Gonzalez Delgado FJ, Castaneyra-Perdomo A, Marin MC, Meyer G. Multiple isoforms of the tumor protein p73 are expressed in the adult human telencephalon and choroid plexus and present in the cerebrospinal fluid. Eur J Neurosci 23: 2109-2118, 2006.
17. Ceddia RB, William WN Jr, Curi R. The response of skeletal muscle to leptin. Front Biosci 6: D90-D97, 2001.
18. Chua SC Jr, Koutras IK, Han L, Liu SM, Kay J, Young SJ, Chung WK, Leibel RL. Fine structure of the murine leptin receptor gene: splice site suppression is required to form two alternatively spliced transcripts. Genomics 45: 264-270, 1997.
19. Considine RV, Caro JF. Leptin and the regulation of body weight. Int J Biochem Cell Biol 29: 1255-1272, 1997.
20. Considine RV, Sinha MK, Heiman ML, Kriauciunas A, Stephens TW, Nyce MR, Ohannesian JP, Marco CC, McKee LJ, Bauer TL, Caro JF. Serum immunoreactive-leptin concentrations in normal-weight and obese humans. N Engl J Med 334: 292-295, 1996.
21. Cornish J, Callon KE, Bava U, Lin C, Naot D, Hill BL, Grey AB, Broom N, Myers DE, Nicholson GC, Reid IR. Leptin directly regulates bone cell function in vitro and reduces bone fragility in vivo. J Endocrinol 175: 405-415, 2002.
22. Couce ME, Burguera B, Parisi JE, Jensen MD, Lloyd RV. Localization of leptin receptor in the human brain. Neuroendocrinology 66: 145-150, 1997.
23. Dulloo AG, Stock MJ, Solinas G, Boss O, Montani JP, Seydoux J. Leptin directly stimulates thermogenesis in skeletal muscle. FEBS Lett 515: 109-113, 2002.
24. Friedman JM, Halaas JL. Leptin and the regulation of body weight in mammals. Nature 395: 763-770, 1998.
25. Gallagher D, Kuznia P, Heshka S, Albu J, Heymsfield SB, Goodpaster B, Visser M, Harris TB. Adipose tissue in muscle: a novel depot similar in size to visceral adipose tissue. Am J Clin Nutr 81: 903-910, 2005.
26. Greenberg AS, Egan JJ, Wek SA, Garty NB, Blanchette-Mackie EJ, Londos C. Perilipin, a major hormonally regulated adipocyte-specific phosphoprotein associated with the periphery of lipid storage droplets. J Biol Chem 266: 11341-11346, 1991.
27. Hekerman P, Zeidler J, Bamberg-Lemper S, Knobelspies H, Lavens D, Tavernier J, Joost HG, Becker W. Pleiotropy of leptin receptor signalling is defined by distinct roles of the intracellular tyrosines. FEBS J 272: 109-119, 2005.
28. Houmard JA, Cox JH, MacLean PS, Barakat HA. Effect of short-term exercise training on leptin and insulin action. Metabolism 49: 858-861, 2000.
29. Kim J, Heshka S, Gallagher D, Kotler DP, Mayer L, Albu J, Shen W, Freda PU, Heymsfield SB. Intermuscular adipose tissue-free skeletal muscle mass: estimation by dual-energy X-ray absorptiometry in adults. J Appl Physiol 97: 655-660, 2004.
30. Krentz AJ. Insulin resistance. BMJ 313: 1385-1389, 1996.
31. Laemmli UK. Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature 227: 680-685, 1970.
32. Lee DW, Leinung MC, Rozhavskaya-Arena M, Grasso P. Leptin and the treatment of obesity: its current status. Eur J Pharmacol 440: 129-139, 2002.
33. Lee GH, Proenca R, Montez JM, Carroll KM, Darvishzadeh JG, Lee JI, Friedman JM. Abnormal splicing of the leptin receptor in diabetic mice. Nature 379: 632-635, 1996.
34. Liu YL, Emilsson V, Cawthorne MA. Leptin inhibits glycogen synthesis in the isolated soleus muscle of obese (ob/ob) mice. FEBS Lett 411: 351-355, 1997.
35. Lundby C, Sander M, van Hall G, Saltin B, Calbet JA. Maximal exercise and muscle oxygen extraction in acclimatizing lowlanders and high altitude natives. J Physiol 573: 535-547, 2006.
36. Margetic S, Gazzola C, Pegg GG, Hill RA. Leptin: a review of its peripheral actions and interactions. Int J Obes Relat Metab Disord 26: 1407-1433, 2002.
37. Maroni P, Bendinelli P, Piccoletti R. Early intracellular events induced by in vivo leptin treatment in mouse skeletal muscle. Mol Cell Endocrinol 201: 109-121, 2003.
38. Mars M, de Graaf C, de Groot CP, van Rossum CT, Kok FJ. Fasting leptin and appetite responses induced by a 4-day 65%-energy-restricted diet. Int J Obes 30: 122-128, 2006.
39. Merino B, Diez-Fernandez C, Ruiz-Gayo M, Somoza B. Choroid plexus epithelial cells co-express the long and short form of the leptin receptor. Neurosci Lett 393: 269-272, 2006.
40. Mingrone G, Bertuzzi A, Capristo E, Greco AV, Manco M, Pietrobelli A, Salinari S, Heymsfield SB. Unreliable use of standard muscle hydration value in obesity. Am J Physiol Endocrinol Metab 280: E365-E371, 2001.
41. Minokoshi Y, Kim YB, Peroni OD, Fryer LG, Muller C, Carling D, Kahn BB. Leptin stimulates fatty-acid oxidation by activating AMP-activated protein kinase. Nature 415: 339-343, 2002.
42. Muoio DM, Dohm GL, Fiedorek FT Jr, Tapscott EB, Coleman RA. Leptin directly alters lipid partitioning in skeletal muscle. Diabetes 46: 1360-1363, 1997.
43. Muoio DM, Lynis Dohm G. Peripheral metabolic actions of leptin. Best Pract Res Clin Endocrinol Metab 16: 653-666, 2002.
44. Olefsky JM, Kolterman OG, Scarlett JA. Insulin action and resistance in obesity and noninsulin-dependent type II diabetes mellitus. Am J Physiol Endocrinol Metab 243: E15-E30, 1982.
45. Pelleymounter MA, Cullen MJ, Baker MB, Hecht R, Winters D, Boone T, Collins F. Effects of the obese gene product on body weight regulation in ob/ob mice. Science 269: 540-543, 1995.
46. Perusse L, Collier G, Gagnon J, Leon AS, Rao DC, Skinner JS, Wilmore JH, Nadeau A, Zimmet PZ, Bouchard C. Acute and chronic effects of exercise on leptin levels in humans. J Appl Physiol 83: 5-10, 1997.
47. Phillips SA, Choe CC, Ciaraldi TP, Greenberg AS, Kong AP, Baxi SC, Christiansen L, Mudaliar SR, Henry RR. Adipocyte differentiation-related protein in human skeletal muscle: relationship to insulin sensitivity. Obes Res 13: 1321-1329, 2005.
48. Ramsay TG, Richards MP. Leptin and leptin receptor expression in skeletal muscle and adipose tissue in response to in vivo porcine somatotropin treatment. J Anim Sci 83: 2501-2508, 2005.
49. Sahu A. Leptin signaling in the hypothalamus: emphasis on energy homeostasis and leptin resistance. Front Neuroendocrinol 24: 225-253, 2003.
50. Segal KR, Landt M, Klein S. Relationship between insulin sensitivity and plasma leptin concentration in lean and obese men. Diabetes 45: 988-991, 1996.
51. Seron K, Corset L, Vasseur F, Boutin P, Gomez-Ambrosi J, Salvador J, Fruhbeck G, Froguel P. Distinct impaired regulation of SOCS3 and long and short isoforms of the leptin receptor in visceral and subcutaneous fat of lean and obese women. Biochem Biophys Res Commun 348: 1232-1238, 2006.
52. Shefer G, Wleklinski-Lee M, Yablonka-Reuveni Z. Skeletal muscle satellite cells can spontaneously enter an alternative mesenchymal pathway. J Cell Sci 117: 5393-5404, 2004.
53. Shih CD, Au LC, Chan JY. Differential role of leptin receptors at the hypothalamic paraventricular nucleus in tonic regulation of food intake and cardiovascular functions. J Biomed Sci 10: 367-378, 2003.
54. Smith PK, Krohn RI, Hermanson GT, Mallia AK, Gartner FH, Provenzano MD, Fujimoto EK, Goeke NM, Olson BJ, Klenk DC. Measurement of protein using bicinchoninic acid. Anal Biochem 150: 76-85, 1985.
55. Solberg R, Aas V, Thoresen GH, Kase ET, Drevon CA, Rustan AC, Reseland JE. Leptin expression in human primary skeletal muscle cells is reduced during differentiation. J Cell Biochem 96: 89-96, 2005.
56. Sorensen TI, Echwald S, Holm JC. Leptin in obesity. BMJ 313: 953-954, 1996.
57. Steinberg GR, Dyck DJ. Development of leptin resistance in rat soleus muscle in response to high-fat diets. Am J Physiol Endocrinol Metab 279: E1374-E1382, 2000.
58. Steinberg GR, Dyck DJ, Calles-Escandon J, Tandon NN, Luiken JJ, Glatz JF, Bonen A. Chronic leptin administration decreases fatty acid uptake and fatty acid transporters in rat skeletal muscle. J Biol Chem 277: 8854-8860, 2002.
59. Steinberg GR, McAinch AJ, Chen MB, O'Brien PE, Dixon JB, Cameron-Smith D, Kemp BE. The suppressor of cytokine signaling 3 inhibits leptin activation of AMP-kinase in cultured skeletal muscle of obese humans. J Clin Endocrinol Metab 91: 3592-3597, 2006.
60. Steinberg GR, Parolin ML, Heigenhauser GJ, Dyck DJ. Leptin increases FA oxidation in lean but not obese human skeletal muscle: evidence of peripheral leptin resistance. Am J Physiol Endocrinol Metab 283: E187-E192, 2002.
61. Tartaglia LA. The leptin receptor. J Biol Chem 272: 6093-6096, 1997.
62. Thong FS, Hudson R, Ross R, Janssen I, Graham TE. Plasma leptin in moderately obese men: independent effects of weight loss and aerobic exercise. Am J Physiol Endocrinol Metab 279: E307-E313, 2000.
63. Towbin H, Staehelin T, Gordon J. Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: procedure and some applications. Proc Natl Acad Sci USA 76: 4350-4354, 1979.
64. Wang Y, Sullivan S, Trujillo M, Lee MJ, Schneider SH, Brolin RE, Kang YH, Werber Y, Greenberg AS, Fried SK. Perilipin expression in human adipose tissues: effects of severe obesity, gender, and depot. Obes Res 11: 930-936, 2003.
65. White DW, Tartaglia LA. Leptin and OB-R: body weight regulation by a cytokine receptor. Cytokine Growth Factor Rev 7: 303-309, 1996.
66. Zhang F, Basinski MB, Beals JM, Briggs SL, Churgay LM, Clawson DK, DiMarchi RD, Furman TC, Hale JE, Hsiung HM, Schoner BE, Smith DP, Zhang XY, Wery JP, Schevitz RW. Crystal structure of the obese protein leptin-E100. Nature 387: 206-209, 1997.