Leptin and leptin receptor expression in skeletal muscle and adipose tissue in response to in vivo porcine somatotropin treatment

Journal of Animal Science

Volumn 83, Issue 11, 2005, Pages 2501-2508

  Ramsay, T G ^a,b   Richards, M P ^a  

^a AGRICULTURAL RESEARCH SERVICE   (United States)

^b BARC East   (United States)

Author keywords

Leptin; Leptin Receptor; Somatotropin; Swine

Indexed keywords

ANIMALIA; SUIDAE; SUS SCROFA;

EID: 33645997709     PISSN: 00218812     EISSN: None     Source Type: Journal    
DOI: 10.2527/2005.83112501x     Document Type: Article

References (52)

1. Ajuwon, K. M., J. L. Kuske, D. Ragland, O. Adeola, D. L. Hancock, D. B. Anderson, and M. E. Spurlock. 2003. The regulation of IGF-1 by leptin in the pig is tissue specific and independent of changes in growth hormone. J. Nutr. Biochem. 14:522-530.
2. Almeida, F. R., J. Mao, S. Novak, J. R. Cosgrove, and G. R. Foxcroft. 2001. Effects of different patterns of feed restriction and insulin treatment during the luteal phase on reproductive, metabolic, and endocrine parameters in cyclic gilts. J. Anim. Sci. 79:200-212.
3. Anderson, D. B., R. G. Kauffman, and L. L. Kastenschmidt. 1972. Lipogenic enzyme activities and cellularity of porcine adipose tissue from various anatomical locations. J. Lipid Res. 13:593-599.
4. ARC. 1981. The Nutrient Requirements of Pigs. Commonwealth Agricultural Bureaux, Slough, UK.
5. Ashwell, C. M., J. P. McMurtry, X. H. Wang, Y. Zhou, and R. Vasilatos-Younken. 1999. Effects of growth hormone and pair-feeding on leptin mRNA expression in liver and adipose tissue. Domest. Anim. Endocrinol. 17:77-84.
6. Barb, C. R., G. J. Hausman, and K. L. Houseknecht. 2001. Biology of leptin in the pig. Domest. Anim. Endocrinol. 21:297-317.
7. Berti, L., and S. Gammeltoft. 1999. Leptin stimulates glucose uptake in C2C12 muscle cells by activation of ERK2. Mol. Cell. Endocrinol. 157:121-130.
8. Bolanowski, M., A. Milewicz, B. Bidzinska, D. Jedrejuk, J. Daroszewski, and E. Mikulski. 2002. Serum leptin levels in acromegaly-A significant role for adipose tissue and fasting insulin/glucose ratio. Med. Sci. Monit. 8:CR685-689.
9. Boni-Schnetzler, M., C. Hauri, and J. Zapf. 1999. Leptin is suppressed during infusion of recombinant human insulin-like growth factor I (rhIGF I) in normal rats. Diabetologia 42:160-166.
10. Budd, T. J., J. L. Atkinson, P. J. Buttery, A. M. Salter, and J. Wiseman. 1994. Effect of insulin and isoproterenol on lipid metabolism in porcine adipose tissue from different depots. Comp. Biochem. Physiol. Pharmacol. Toxicol. Endocrinol. 108:137-143.
11. Cammisotto, P. G., Y. Gelinas, Y. Deshaies, and L. J. Bukowiecki. 2003. Regulation of leptin secretion from white adipocytes by free fatty acids. Am. J. Physiol. Endocrinol. Metab. 285:E521-E526.
12. Campbell, R. G., N. C. Steele, T. J. Caperna, J. P. McMurtry, M. B. Solomon, and A. D. Mitchell. 1988. Interrelationships between energy intake and endogenous porcine growth hormone administration on the performance, body composition and protein and energy metabolism of growing pigs weighing 25 to 55 kilograms live weight. J. Anim Sci. 66:1643-1650.
13. Caperna, T. J., N. C. Steele, D. R. Komarek, J. P. McMurtry, R. W. Rosebrough, M. B. Solomon, and A. D. Mitchell. 1990. Influence of dietary protein and recombinant porcine somatotropin administration in young pigs: Growth, body composition and hormone status. J. Anim. Sci. 68:4243-4252.
14. Ceddia, R. B., W. N. William, Jr., and R. Curi. 1998. Leptin increases glucose transport and utilization in skeletal muscle in vitro. Gen. Pharmacol. 31:799-801.
15. Czaja, K., M. Lakomy, W. Sienkiewicz, J. Kaleczyc, Z. Pidsudko, C. R. Barb, G. B. Rampacek, and R. R. Kraeling. 2002. Distribution of neurons containing leptin receptors in the hypothalamus of the pig. Biochem. Biophys. Res. Commun. 298:333-337.
16. Denis, R. G., C. Bing, E. K. Naderali, R. G. Vernon, and G. Williams. 2003. Lactation modulates diurnal expression profiles of specific leptin receptor isoforms in the rat hypothalamus. J. Endocrinol. 178:225-232.
17. Eden-Engstrom, B., P. Burman, C. Holdstock, and F. A. Karlsson. 2003. Effects of growth hormone (GH) on ghrelin, leptin, and adiponectin in GH-deficient patients. J. Clin. Endocrinol. Metab. 88:5193-5198.
18. Etherton, T. D. 2004. Somatotropic function: The somatomedin hypothesis revisited. J. Anim. Sci. 82(E-Suppl.) Online. Available: http://jas.fass.org/ cgi/reprint/82/13_suppl/E239.pdf. Accessed December 1, 2004.
19. Fernandez-Figares, I., A. E. Shannon, D. Wray-Cahen, and T. J. Caperna. 2004. The role of insulin, glucagon, dexaniethasone, and leptin in the regulation of ketogenesis and glycogen storage in primary cultures of porcine hepatocytes prepared from 60 kg pigs. Domest. Anim. Endocrinol. 27:125-140.
20. Fruhbek, G., J. Gomez-Ambrosi, and J. A. Martinez. 1999. Pre- and postprandial expression of the leptin receptor splice variants OB-Ra and OB-Rb in murine peripheral tissues. Physiol. Res. 48:189-195.
21. Guo, K. Y., P. Halo, R. L. Leibel, and Y. Zhang. 2004. Effects of obesity on the relationship of leptin mRNA expression and adipocyte size in anatomically distinct fat depots in mice. Am. J. Physiol. Regul. Integr. Comp. Physiol. 287:R112-R119.
22. Houseknecht, K. L., C. P. Portocarrero, S. Ji, R. Lemenager, and M. E. Spurlock. 2000. Growth hormone regulates leptin gene expression in bovine adipose tissue: Correlation with adipose IGF-1 expression. J. Endocrinol. 164:51-57.
23. Iglesias, P., J. J. Diez, M. J. Fernandez-Reyes, M. A. Bajo, A. Aguilera, J. Mendez, R. Codoceo, and R. Selgas. 2002. Effects of short-term recombinant human growth hormone therapy on plasma leptin concentrations in dialysis patients. Nephrol. Dial. Transplant 17:260-264.
24. Isozaki, O., T. Tsushima, M. Miyakawa, Y. Nozoe, H. Demura, and H. Seki. 1999. Growth hormone directly inhibits leptin gene expression in visceral fat tissue in fatty Zucker rats. J. Endocrinol. 161:511-516.
25. Leininger, M. T., C. P. Portocarrero, A. P. Schinckel, M. E. Spurlock, C. A. Bidwell, J. N. Nielsen, and K. L. Houseknecht. 2000. Physiological response to acute endotoxemia in swine: Effect of genotype on energy metabolites and leptin. Domest. Anim. Endocrinol. 18:71-82.
26. Lin, J., C. R. Barb, R. R. Kraeling, and G. B. Rampacek. 2003. Growth hormone releasing factor decreases long form leptin receptor expression in porcine anterior pituitary cells. Domest. Anim. Endocrinol. 24:95-101.
27. Lin, J., C. R. Barb, R. L. Matteri, R. R. Kraeling, X. Chen, R. J. Meinersmann, and G. B. Rampacek. 2000. Long form leptin receptor mRNA expression in the brain, pituitary, and other tissues in the pig. Domest. Anim. Endocrinol. 19:53-61.
28. Louveau, I., H. Quesnel, and A. Prunier. 2000. GH and IGF-I binding sites in adipose tissue, liver, skeletal muscle and ovaries of feed-restricted gilts. Reprod. Nutr. Dev. 40:571-578.
29. Malmlof, K., and T. Johansen. 2003. Growth hormone-mediated breakdown of body fat: Insulin and leptin responses to GH are modulated by diet composition and caloric intake in old rats. Horm. Metab. Res. 35:236-242.
30. Montague, C. T., J. B. Prins, L. Sanders, J. E. Digby, and S. O'Rahilly. 1997. Depot- and sex-specific differences in human leptin mRNA expression: Implications for the control of regional fat distribution. Diabetes 46:342-347.
31. Ono, Y., M. B. Solomon, C. M. Evock-Clover, N. C. Steele, and K. Maruyama. 1995. Effects of porcine somatotropin administration on porcine muscles located within different regions of the body. J. Anim. Sci. 73:2282-2288.
32. Otte, C., J. M. Otte, D. Strodthoff, S. R. Bornstein, U. R. Folsch, H. Monig, and S. Kloehn. 2004. Expression of leptin and leptin receptor during the development of liver fibrosis and cirrhosis. Exp. Clin. Endocrinol. Diabetes 112:10-17.
33. Potter, J. J., L. Womack, E. Mezey, and F. A. Anania. 1998. Transdifferentiation of rat hepatic stellate cells results in leptin expression. Biochem. Biophys. Res. Commun. 244:178-182.
34. Raman, P., S. S. Donkin, and M. E. Spurlock. 2004. Regulation of hepatic glucose metabolism by leptin in pig and rat primary hepatocyte cultures. Am. J. Physiol. Regul. Integr. Comp. Physiol. 286:R206-R216.
35. Ramsay, T. G. 2000. Porcine leptin alters insulin inhibition of lipolysis in porcine adipocytes in vitro. J. Anim. Sci. 79:653-657.
36. Ramsay, T. G. 2003a. Porcine leptin inhibits lipogenesis in porcine adipocytes. J. Anim. Sci. 81:3008-3017.
37. Ramsay, T. G. 2003b. Porcine leptin inhibits protein breakdown and stimulates fatty acid oxidation in C2C12 myotubes. J. Anim. Sci. 81:3046-3051.
38. Ramsay, T. G., C. Morrison, and X. Yan. 1998. The obesity gene in swine: Sequence and expression of porcine leptin. J. Anim. Sci. 76:484-490.
39. Ramsay, T. G., and M. P. Richards. 2004. Hormonal regulation of leptin and leptin receptor expression in porcine subcutaneous adipose tissue. J. Anim. Sci. 82:3486-3492.
40. Raver, N., E. E. Gussakovsky, D. H. Keisler, R. Krishna, J. Mistry, and A. Gertler. 2000. Preparation of recombinant bovine, porcine, and porcine W4R/R5K leptins and comparison of their activity and inimunoreactivity with ovine, chicken, and human leptins. Protein Expr. Purif. 19:30-40.
41. Rentsch, J., and M. Chiesi. 1996. Regulation of ob gene mRNA levels in cultured adipocytes. FEBS Lett. 379:55-59.
42. Richards, M. P., and S. M. Poch. 2002. Quantitative analysis of gene expression by reverse transcription polymerase chain reaction and capillary electrophoresis with laser-induced fluorescence detection. Mol. Biotecbnol. 21:19-37.
43. Rule, D. C., S. B. Smith, and H. J. Mersmann. 1989. Glycerolipid biosynthesis in porcine adipose tissue in vitro: Effect of adiposity and depot site. J. Anim. Sci. 67:364-373.
44. Salfen, B. E., J. A. Carroll, and D. H. Keisler. 2003. Endocrine responses 4 to short-term feed deprivation in weanling pigs. J. Endocrinol. 178:541-551.
45. Schulz, C., I. Wieczorek, K. Reschke, and H. Lehnert. 2002. Effects of intracerebroventricularly and intraperitoneally administered growth hormone on body weight and food intake in fa/fa Zucker rats. Neuropsychobiology 45:36-40.
46. Shintani, M., H. Nishimura, S. Yonemitsu, H. Masuzaki, Y. Ogawa, K. Hosoda, G. Inoue, Y. Yoshimasa, and K. Nakao. 2000. Down-regulation of leptin by free fatty acids in rat adipocytes: Effects of triacsin C, palmitate, and 2-bromopalmitate. Metabolism 49:326-330.
47. Spurlock, M. E., M. A. Ranalletta, S. G. Cornelius, G. R. Frank, G. M. Willis, S, Ji, A. L. Grant, and C. A. Bidwell. 1998. Leptin expression in porcine adipose tissue is not increased by endotoxin but is reduced by growth hormone. J. Interferon Cytokine Res. 18:1051-1058.
48. Steele, N. C., J. P. McMurtry, R. G. Campbell, T. J. Caperna, and R. W. Rosebrough. 1995. Effect of dietary energy intake and exogenous porcine growth hormone administration on circulating porcine growth hormone concentration and response to human growth hormone-releasing factor administration in growing swine. Domest. Anim. Endocrinol. 12:293-298.
49. Tena-Sempere, M., L. Pinilla, F. P. Zhang, L. C. Gonzalez, I. Huhtaniemi, F. F. Casanueva, C. Dieguez, and E. Aguilar. 2001. Developmental and hormonal regulation of leptin receptor (Ob-R) messenger ribonucleic acid expression in rat testis. Biol. Reprod. 64:634-643.
50. Wang, J., L. Kong, M. Hawkins, N. Barzilai, and L. Rossetti. 1998. A nutrient-sensing pathway regulates leptin gene expression in muscle and fat. Nature 393:684-688.
51. Whisnant, C. S., and R. J. Harrell. 2002. Effect of short-term feed restriction and refeeding on serum concentrations of leptin, luteinizing hormone and insulin in ovariectomized gilts. Domest. Anim. Endocrinol. 22:73-80.
52. Zhang, Y., K. Y. Guo, P. A. Diaz, M. Heo, and R. L. Leibel. 2002. Determinants of leptin gene expression in fat depots of lean mice. Am. J. Physiol. Regul. Integr. Comp. Physiol. 282:R226-R234.