-
1
-
-
0035856920
-
Global and societal implications of the diabetes epidemic
-
Zimmel P., Alberti K.M., and Shaw J. Global and societal implications of the diabetes epidemic. Nature 414 (2001) 782-787
-
(2001)
Nature
, vol.414
, pp. 782-787
-
-
Zimmel, P.1
Alberti, K.M.2
Shaw, J.3
-
2
-
-
0842324779
-
Obesity wars: Molecular progress confronts an expanding epidemic
-
Flier J.S. Obesity wars: Molecular progress confronts an expanding epidemic. Cell 116 (2004) 337-350
-
(2004)
Cell
, vol.116
, pp. 337-350
-
-
Flier, J.S.1
-
3
-
-
0034614490
-
Signaling: 2000 and beyond
-
Hunter T. Signaling: 2000 and beyond. Cell 100 (2000) 113-127
-
(2000)
Cell
, vol.100
, pp. 113-127
-
-
Hunter, T.1
-
4
-
-
0034507958
-
Molecular basis for the dephosphorylation of the activation segment of the insulin receptor by protein tyrosine phosphatase 1b
-
Salmeen A., Andersen J.N., Myers M.P., Tonks N.K., and Barford D. Molecular basis for the dephosphorylation of the activation segment of the insulin receptor by protein tyrosine phosphatase 1b. Mol. Cell 6 (2000) 1401-1412
-
(2000)
Mol. Cell
, vol.6
, pp. 1401-1412
-
-
Salmeen, A.1
Andersen, J.N.2
Myers, M.P.3
Tonks, N.K.4
Barford, D.5
-
5
-
-
0023834406
-
A cascade of tyrosine autophosphorylation in the β-subunit activates the phosphotransferase of the insulin receptor
-
White M.F., Shoelson S.E., Keutmann H., and Kahn C.R. A cascade of tyrosine autophosphorylation in the β-subunit activates the phosphotransferase of the insulin receptor. J. Biol. Chem. 263 (1988) 2969-2980
-
(1988)
J. Biol. Chem.
, vol.263
, pp. 2969-2980
-
-
White, M.F.1
Shoelson, S.E.2
Keutmann, H.3
Kahn, C.R.4
-
6
-
-
0035856949
-
Insulin signaling and the regulation of glucose and lipid metabolism
-
Saltiel A.R., and Kahn C.R. Insulin signaling and the regulation of glucose and lipid metabolism. Nature 414 (2001) 799-806
-
(2001)
Nature
, vol.414
, pp. 799-806
-
-
Saltiel, A.R.1
Kahn, C.R.2
-
7
-
-
0033778926
-
Protein tyrosine phosphatases (PTPs) as drug targets: Inhibitors of PTP-1b for the treatment of diabetes
-
Moller N.P.H., Iversen L.F., Andersen H.S., and McCormack J.G. Protein tyrosine phosphatases (PTPs) as drug targets: Inhibitors of PTP-1b for the treatment of diabetes. Curr. Opin. Drug Discov. Dev. 3 (2000) 527-540
-
(2000)
Curr. Opin. Drug Discov. Dev.
, vol.3
, pp. 527-540
-
-
Moller, N.P.H.1
Iversen, L.F.2
Andersen, H.S.3
McCormack, J.G.4
-
9
-
-
0036654436
-
Recent advances in the development of small molecule inhibitors of PTP1B for the treatment of insulin resistance and type 2 diabetes
-
Tobin J.F., and Tam S. Recent advances in the development of small molecule inhibitors of PTP1B for the treatment of insulin resistance and type 2 diabetes. Curr. Opin. Drug Discov. Dev. 5 (2002) 500-512
-
(2002)
Curr. Opin. Drug Discov. Dev.
, vol.5
, pp. 500-512
-
-
Tobin, J.F.1
Tam, S.2
-
10
-
-
0033942614
-
Increased energy expenditure, decreased adiposity, and tissue-specific insulin sensitivity in protein-tyrosine phosphatase 1b-deficient mice
-
Klaman L.D., Boss O., Peroni O.D., Kim J.K., Martino J.L., Zabolotny J.M., Moghal N., Lubkin M., Kim Y.B., Sharpe A.H., Stricker-Krongrad A., Shulman G.I., Neel B.G., and Kahn B.B. Increased energy expenditure, decreased adiposity, and tissue-specific insulin sensitivity in protein-tyrosine phosphatase 1b-deficient mice. Mol. Cell. Biol. 20 (2000) 5479-5489
-
(2000)
Mol. Cell. Biol.
, vol.20
, pp. 5479-5489
-
-
Klaman, L.D.1
Boss, O.2
Peroni, O.D.3
Kim, J.K.4
Martino, J.L.5
Zabolotny, J.M.6
Moghal, N.7
Lubkin, M.8
Kim, Y.B.9
Sharpe, A.H.10
Stricker-Krongrad, A.11
Shulman, G.I.12
Neel, B.G.13
Kahn, B.B.14
-
11
-
-
0033525870
-
Increased insulin sensitivity and obesity resistance in mice lacking the protein tyrosine phosphatase-1b gene
-
Elchebly M., Payette P., Michaliszyn E., Cromlish W., Collins S., Loy A.L., Normandin D., Cheng A., Himms-Hagen J., Chan C.C., Ramachandran C., Gresser M.J., Tremblay M.L., and Kennedy B.P. Increased insulin sensitivity and obesity resistance in mice lacking the protein tyrosine phosphatase-1b gene. Science 283 (1999) 1544-1548
-
(1999)
Science
, vol.283
, pp. 1544-1548
-
-
Elchebly, M.1
Payette, P.2
Michaliszyn, E.3
Cromlish, W.4
Collins, S.5
Loy, A.L.6
Normandin, D.7
Cheng, A.8
Himms-Hagen, J.9
Chan, C.C.10
Ramachandran, C.11
Gresser, M.J.12
Tremblay, M.L.13
Kennedy, B.P.14
-
12
-
-
18344379861
-
PTP1B regulates leptin signal transduction in vivo
-
Zabolotny J.M., Bence-Hanulec K.K., Stricker-Krongrad A., Haj F., Wang Y., Minokoshi Y., Kim Y.B., Elmquist J.K., Tartaglia L.A., Kahn B.B., and Neel B.G. PTP1B regulates leptin signal transduction in vivo. Dev. Cell 2 (2002) 489-495
-
(2002)
Dev. Cell
, vol.2
, pp. 489-495
-
-
Zabolotny, J.M.1
Bence-Hanulec, K.K.2
Stricker-Krongrad, A.3
Haj, F.4
Wang, Y.5
Minokoshi, Y.6
Kim, Y.B.7
Elmquist, J.K.8
Tartaglia, L.A.9
Kahn, B.B.10
Neel, B.G.11
-
13
-
-
0036228770
-
Attenuation of leptin action and regulation of obesity by protein tyrosine phosphatase 1B
-
Cheng A., Uetani N., Simoncic P.D., Chaubey V.P., Lee-Loy A., McGlade C.J., Kennedy B.P., and Tremblay M.L. Attenuation of leptin action and regulation of obesity by protein tyrosine phosphatase 1B. Dev. Cell 2 (2002) 385-387
-
(2002)
Dev. Cell
, vol.2
, pp. 385-387
-
-
Cheng, A.1
Uetani, N.2
Simoncic, P.D.3
Chaubey, V.P.4
Lee-Loy, A.5
McGlade, C.J.6
Kennedy, B.P.7
Tremblay, M.L.8
-
14
-
-
0037143754
-
PTP1B antisense oligonucleotide lowers PTP1B protein, normalizes blood glucose, and improves insulin sensitivity in diabetic mice
-
Zinker B.A., Rondinone C.M., Trevillyan J.M., Gum R.J., Clampit J.E., Waring J.F., Xie N., Wilcox D., Jacobson P., Frost L., Kroeger P.E., Reilly R.M., Koterski S., Opgenorth T.J., Ulrich R.G., Crosby S., Butler M., Murray S.F., McKay R.A., Bhanot S., Monia B.P., and Jirousek M.R. PTP1B antisense oligonucleotide lowers PTP1B protein, normalizes blood glucose, and improves insulin sensitivity in diabetic mice. Proc. Natl. Acad. Sci. USA 99 (2002) 11357-11362
-
(2002)
Proc. Natl. Acad. Sci. USA
, vol.99
, pp. 11357-11362
-
-
Zinker, B.A.1
Rondinone, C.M.2
Trevillyan, J.M.3
Gum, R.J.4
Clampit, J.E.5
Waring, J.F.6
Xie, N.7
Wilcox, D.8
Jacobson, P.9
Frost, L.10
Kroeger, P.E.11
Reilly, R.M.12
Koterski, S.13
Opgenorth, T.J.14
Ulrich, R.G.15
Crosby, S.16
Butler, M.17
Murray, S.F.18
McKay, R.A.19
Bhanot, S.20
Monia, B.P.21
Jirousek, M.R.22
more..
-
15
-
-
0036329620
-
PTP1B reduction regulates adiposity and expression of genes involved in lipogenesis
-
Rondinone C.M., Trevillyan J.M., Clampit J., Gum R.J., Berg C., Kroeger P., Frost L., Zinker B.A., Reilly R., Ulrich R., Butler M., Monia B.P., Jirousek M.R., and Waring J.F. PTP1B reduction regulates adiposity and expression of genes involved in lipogenesis. Diabetes 51 (2002) 2405-2411
-
(2002)
Diabetes
, vol.51
, pp. 2405-2411
-
-
Rondinone, C.M.1
Trevillyan, J.M.2
Clampit, J.3
Gum, R.J.4
Berg, C.5
Kroeger, P.6
Frost, L.7
Zinker, B.A.8
Reilly, R.9
Ulrich, R.10
Butler, M.11
Monia, B.P.12
Jirousek, M.R.13
Waring, J.F.14
-
16
-
-
0037221179
-
Reduction of protein tyrosine phosphatase 1B increases insulin-dependent signaling in ob/ob mice
-
Gum R.J., Gaede L.L., Koterski S.L., Heindel M., Clampit J.E., Zinker B.A., Trevillyan J.M., Ulrich R.G., Jirousek M.R., and Rondinone C.M. Reduction of protein tyrosine phosphatase 1B increases insulin-dependent signaling in ob/ob mice. Diabetes 52 (2003) 21-28
-
(2003)
Diabetes
, vol.52
, pp. 21-28
-
-
Gum, R.J.1
Gaede, L.L.2
Koterski, S.L.3
Heindel, M.4
Clampit, J.E.5
Zinker, B.A.6
Trevillyan, J.M.7
Ulrich, R.G.8
Jirousek, M.R.9
Rondinone, C.M.10
-
17
-
-
3843121119
-
Prospects for inhibitors of protein tyrosine phosphatase 1B as antidiabetic drugs
-
Hooft van Huijsduijnen R., Sauer W.H.B., Bombrun A., and Swinnen D. Prospects for inhibitors of protein tyrosine phosphatase 1B as antidiabetic drugs. J. Med. Chem. 47 (2004) 4142-4146
-
(2004)
J. Med. Chem.
, vol.47
, pp. 4142-4146
-
-
Hooft van Huijsduijnen, R.1
Sauer, W.H.B.2
Bombrun, A.3
Swinnen, D.4
-
18
-
-
0037061628
-
A common mechanism underlying promiscuous inhibitors from virtual and high-throughput screening
-
McGovern S.L., Caselli E., Grigorieff N.N., and Shoichet B.K. A common mechanism underlying promiscuous inhibitors from virtual and high-throughput screening. J. Med. Chem. 45 (2002) 1712-1722
-
(2002)
J. Med. Chem.
, vol.45
, pp. 1712-1722
-
-
McGovern, S.L.1
Caselli, E.2
Grigorieff, N.N.3
Shoichet, B.K.4
-
19
-
-
0037161605
-
Molecular docking and high-throughput screening for novel inhibitors of protein tyrosine phosphatase-1B
-
Doman T.N., McGovern S.L., Witherbee B.J., Kasten T.P., Kurumbail R., Stallings W.C., Connolly D.T., and Shoichet B.K. Molecular docking and high-throughput screening for novel inhibitors of protein tyrosine phosphatase-1B. J. Med. Chem. 45 (2002) 2213-2221
-
(2002)
J. Med. Chem.
, vol.45
, pp. 2213-2221
-
-
Doman, T.N.1
McGovern, S.L.2
Witherbee, B.J.3
Kasten, T.P.4
Kurumbail, R.5
Stallings, W.C.6
Connolly, D.T.7
Shoichet, B.K.8
-
21
-
-
0028273420
-
Characterization and kinetic analysis of the intracellular domain of human protein tyrosine phosphatase β (HPTPβ) using synthetic phosphopeptides
-
Harder K.W., Owen P., Wong L.K., Aebersold R., Clark-Lewis I., and Jirik F.R. Characterization and kinetic analysis of the intracellular domain of human protein tyrosine phosphatase β (HPTPβ) using synthetic phosphopeptides. Biochem. J. 298 (1994) 395-401
-
(1994)
Biochem. J.
, vol.298
, pp. 395-401
-
-
Harder, K.W.1
Owen, P.2
Wong, L.K.3
Aebersold, R.4
Clark-Lewis, I.5
Jirik, F.R.6
-
22
-
-
0033564888
-
Microtiter well assays for protein tyrosine phosphatase activities directed against phosphorylated insulin receptor or insulin receptor substrate-1
-
Krutzfeldt J., Grunweller A., Raasch W., Drenckhan M., and Klein H.H. Microtiter well assays for protein tyrosine phosphatase activities directed against phosphorylated insulin receptor or insulin receptor substrate-1. Anal. Biochem. 271 (1999) 97-99
-
(1999)
Anal. Biochem.
, vol.271
, pp. 97-99
-
-
Krutzfeldt, J.1
Grunweller, A.2
Raasch, W.3
Drenckhan, M.4
Klein, H.H.5
-
23
-
-
0026675146
-
Analysis of the order of auto-phosphorylation of human insulin receptor tyrosines 1158, 1162, and 1163
-
Dickens M., and Tavare J.M. Analysis of the order of auto-phosphorylation of human insulin receptor tyrosines 1158, 1162, and 1163. Biochem. Biophys. Res. Commun. 186 (1992) 244-250
-
(1992)
Biochem. Biophys. Res. Commun.
, vol.186
, pp. 244-250
-
-
Dickens, M.1
Tavare, J.M.2
-
24
-
-
0030766163
-
Crystal structure of the activated insulin receptor tyrosine kinase in complex with peptide substrate and ATP analog
-
Hubbard S.R. Crystal structure of the activated insulin receptor tyrosine kinase in complex with peptide substrate and ATP analog. EMBO J. 16 (1997) 5573-5581
-
(1997)
EMBO J.
, vol.16
, pp. 5573-5581
-
-
Hubbard, S.R.1
-
25
-
-
0036808565
-
Development of a time-resolved fluorescent assay for measuring tyrosine-phosphorylated proteins in cells
-
Waddleton D., Ramachandran C., and Wang Q. Development of a time-resolved fluorescent assay for measuring tyrosine-phosphorylated proteins in cells. Anal. Biochem. 309 (2002) 150-157
-
(2002)
Anal. Biochem.
, vol.309
, pp. 150-157
-
-
Waddleton, D.1
Ramachandran, C.2
Wang, Q.3
-
26
-
-
0031568284
-
A chemiluminescent microtiter plate assay for sensitive detection of protein kinase activity
-
Lehel C., Daniel-Issakani S., Brasseur M., and Strulovici B. A chemiluminescent microtiter plate assay for sensitive detection of protein kinase activity. Anal. Biochem. 244 (1997) 340-346
-
(1997)
Anal. Biochem.
, vol.244
, pp. 340-346
-
-
Lehel, C.1
Daniel-Issakani, S.2
Brasseur, M.3
Strulovici, B.4
-
27
-
-
0028122282
-
Expression, purification, and crystallization of human phosphotyrosine phosphatase 1B
-
Hoppe E., Berne P.F., Stock D., Rasmussen J.S., Moeller N.P.H., Ullrich A., and Huber R. Expression, purification, and crystallization of human phosphotyrosine phosphatase 1B. Eur. J. Biochem. 223 (1994) 1069-1077
-
(1994)
Eur. J. Biochem.
, vol.223
, pp. 1069-1077
-
-
Hoppe, E.1
Berne, P.F.2
Stock, D.3
Rasmussen, J.S.4
Moeller, N.P.H.5
Ullrich, A.6
Huber, R.7
-
28
-
-
0027215589
-
A continuous and fluorimetric assay for protein tyrosine phosphatase using phosphotyrosine-containing peptides
-
Zhang Z.Y., Maclean D., Thieme Sefler A.M., Roeske R.W., and Dixon J.E. A continuous and fluorimetric assay for protein tyrosine phosphatase using phosphotyrosine-containing peptides. Anal. Biochem. 211 (1993) 7-15
-
(1993)
Anal. Biochem.
, vol.211
, pp. 7-15
-
-
Zhang, Z.Y.1
Maclean, D.2
Thieme Sefler, A.M.3
Roeske, R.W.4
Dixon, J.E.5
-
29
-
-
34247887726
-
-
D.P. Wilson, Z.-K. Wan, W.-X. Xu, S.J. Kirincich, B.C. Follows, D. Joseph-McCarthy, K. Foreman, A. Moretto, J.J. Wu, M. Zhu, E. Binnun, Y.-L. Zhang, M. Tam, D.V. Erbe, J. Tobin, X. Xu, L. Leung, A. Shilling, S.Y. Tam, T. Mansour, J. Lee. Structure-based optimization of protein tyrosine phosphatase 1b inhibitors: From the active site to the 2nd phosphotyrosine binding site. Submitted.
-
-
-
-
30
-
-
2442501720
-
Determining appropriate substrate conversion for enzymatic assays in high-throughput screening
-
Wu G., Yuan Y., and Hodge C.N. Determining appropriate substrate conversion for enzymatic assays in high-throughput screening. J. Biomol. Screen. 8 (2003) 694-700
-
(2003)
J. Biomol. Screen.
, vol.8
, pp. 694-700
-
-
Wu, G.1
Yuan, Y.2
Hodge, C.N.3
-
31
-
-
32944477948
-
Bicyclic and tricyclic thiophenes as protein tyrosine phosphatase 1b inhibitors
-
Moretto A.F., Kirincich S.J., Xu W.X., Smith M.J., Wan Z.K., Wilson D.P., Follows B.C., Binnun E., Joseph-McCarthy D., Foreman K., Erbe D.V., Zhang Y.L., Tam S.K., Tam S.Y., and Lee J. Bicyclic and tricyclic thiophenes as protein tyrosine phosphatase 1b inhibitors. Bioorg. Med. Chem. 14 (2006) 2162-2177
-
(2006)
Bioorg. Med. Chem.
, vol.14
, pp. 2162-2177
-
-
Moretto, A.F.1
Kirincich, S.J.2
Xu, W.X.3
Smith, M.J.4
Wan, Z.K.5
Wilson, D.P.6
Follows, B.C.7
Binnun, E.8
Joseph-McCarthy, D.9
Foreman, K.10
Erbe, D.V.11
Zhang, Y.L.12
Tam, S.K.13
Tam, S.Y.14
Lee, J.15
-
32
-
-
33746802788
-
Monocyclic thiophenes as protein tyrosine phosphatase 1b inhibitors: Capturing interactions with Asp48
-
Wan Z.K., Lee J., Xu W.X., Erbe D.V., Joseph-McCarthy D., Follows B.C., and Zhang Y.L. Monocyclic thiophenes as protein tyrosine phosphatase 1b inhibitors: Capturing interactions with Asp48. Bioorg. Med. Chem. Lett. 16 (2006) 4941-4945
-
(2006)
Bioorg. Med. Chem. Lett.
, vol.16
, pp. 4941-4945
-
-
Wan, Z.K.1
Lee, J.2
Xu, W.X.3
Erbe, D.V.4
Joseph-McCarthy, D.5
Follows, B.C.6
Zhang, Y.L.7
-
33
-
-
0033003760
-
A simple statistical parameter for use in evaluation and validation of high throughput screening assays
-
Zhang J.H., Chung T.D.Y., and Oldenburg K.R. A simple statistical parameter for use in evaluation and validation of high throughput screening assays. J. Biomol. Screen 4 (1999) 67-73
-
(1999)
J. Biomol. Screen
, vol.4
, pp. 67-73
-
-
Zhang, J.H.1
Chung, T.D.Y.2
Oldenburg, K.R.3
-
34
-
-
0031022433
-
Mechanism of inhibition of protein-tyrosine phosphatases by vanadate and pervanadate
-
Huyer G., Liu S., Kelly J., Moffat J., Payette P., Kennedy B., Tsaprailis G., Gresser M.J., and Ramachandran C. Mechanism of inhibition of protein-tyrosine phosphatases by vanadate and pervanadate. J. Biol. Chem. 272 (1997) 843-851
-
(1997)
J. Biol. Chem.
, vol.272
, pp. 843-851
-
-
Huyer, G.1
Liu, S.2
Kelly, J.3
Moffat, J.4
Payette, P.5
Kennedy, B.6
Tsaprailis, G.7
Gresser, M.J.8
Ramachandran, C.9
-
35
-
-
0032751619
-
Bis(N,N-dimethylhydroxamido) hydroxooxovanadate inhibition of protein tyrosine phosphatase activity in intact cells: Comparison with vanadate
-
Cuncic C., Desmarais S., Detich N., Tracey A.S., Gresser M.J., and Ramachandran C. Bis(N,N-dimethylhydroxamido) hydroxooxovanadate inhibition of protein tyrosine phosphatase activity in intact cells: Comparison with vanadate. Biochem. Pharmacol. 58 (1999) 1859-1867
-
(1999)
Biochem. Pharmacol.
, vol.58
, pp. 1859-1867
-
-
Cuncic, C.1
Desmarais, S.2
Detich, N.3
Tracey, A.S.4
Gresser, M.J.5
Ramachandran, C.6
-
36
-
-
0034615991
-
Structure-based design of a low molecular weight, nonphosphorus, nonpeptide, and highly selective inhibitor of protein-tyrosine phosphatase 1B
-
Iversen L.F., Andersen H.S., Branner S., Mortensen S.B., Peters G.H., Norris K., Olsen O.H., Jeppesen C.B., Lundt B.F., Ripka W., Moller K.B., and Moller N.P.H. Structure-based design of a low molecular weight, nonphosphorus, nonpeptide, and highly selective inhibitor of protein-tyrosine phosphatase 1B. J. Biol. Chem. 275 (2000) 10300-10307
-
(2000)
J. Biol. Chem.
, vol.275
, pp. 10300-10307
-
-
Iversen, L.F.1
Andersen, H.S.2
Branner, S.3
Mortensen, S.B.4
Peters, G.H.5
Norris, K.6
Olsen, O.H.7
Jeppesen, C.B.8
Lundt, B.F.9
Ripka, W.10
Moller, K.B.11
Moller, N.P.H.12
-
37
-
-
0033596855
-
Potent and highly selective inhibitors of the protein tyrosine phosphatase 1B
-
Taing M., Keng Y.F., Shen K., Wu L., Lawrence D.S., and Zhang Z.Y. Potent and highly selective inhibitors of the protein tyrosine phosphatase 1B. Biochemistry 28 (1999) 3793-3803
-
(1999)
Biochemistry
, vol.28
, pp. 3793-3803
-
-
Taing, M.1
Keng, Y.F.2
Shen, K.3
Wu, L.4
Lawrence, D.S.5
Zhang, Z.Y.6
-
38
-
-
0041842685
-
Selective protein tyrosine phosphatase 1B inhibitors: Targeting the second phosphotyrosine binding site with non-carboxylic acid-containing ligands
-
Liu G., Xin Z., Liang H., Abad-Zapatero C., Hajduk P.J., Janowick D.A., Szczepankiewicz B.G., Pei Z., Hutchins C.W., Ballaron S.J., Stashko M.A., Lubben T.H., Berg C.E., Rondinone C.M., Trevillyan J.M., and Jirousek M.R. Selective protein tyrosine phosphatase 1B inhibitors: Targeting the second phosphotyrosine binding site with non-carboxylic acid-containing ligands. J. Med. Chem. 46 (2003) 3437-3440
-
(2003)
J. Med. Chem.
, vol.46
, pp. 3437-3440
-
-
Liu, G.1
Xin, Z.2
Liang, H.3
Abad-Zapatero, C.4
Hajduk, P.J.5
Janowick, D.A.6
Szczepankiewicz, B.G.7
Pei, Z.8
Hutchins, C.W.9
Ballaron, S.J.10
Stashko, M.A.11
Lubben, T.H.12
Berg, C.E.13
Rondinone, C.M.14
Trevillyan, J.M.15
Jirousek, M.R.16
-
39
-
-
0141680857
-
Fragment screening and assembly: A highly efficient approach to a selective and cell active protein tyrosine phosphatase 1B inhibitor
-
Liu G., Xin Z., Pei Z., Hajduk P.J., Abad-Zapatero C., Hutchins C.W., Zhao H., Lubben T.H., Ballaron S.J., Haasch D.L., Kaszubska W., Rondinone C.M., Trevillyan J.M., and Jirousek M.R. Fragment screening and assembly: A highly efficient approach to a selective and cell active protein tyrosine phosphatase 1B inhibitor. J. Med. Chem. 46 (2003) 4232-4235
-
(2003)
J. Med. Chem.
, vol.46
, pp. 4232-4235
-
-
Liu, G.1
Xin, Z.2
Pei, Z.3
Hajduk, P.J.4
Abad-Zapatero, C.5
Hutchins, C.W.6
Zhao, H.7
Lubben, T.H.8
Ballaron, S.J.9
Haasch, D.L.10
Kaszubska, W.11
Rondinone, C.M.12
Trevillyan, J.M.13
Jirousek, M.R.14
-
40
-
-
0038199726
-
PTP1B: From the sidelines to the front lines!
-
Tonks N.K. PTP1B: From the sidelines to the front lines!. FEBS Lett. 546 (2003) 140-148
-
(2003)
FEBS Lett.
, vol.546
, pp. 140-148
-
-
Tonks, N.K.1
-
41
-
-
0028231388
-
Crystal structure of human protein tyrosine phosphatase 1B
-
Barford D., Flint A.J., and Tonks N.K. Crystal structure of human protein tyrosine phosphatase 1B. Science 263 (1994) 1397-1404
-
(1994)
Science
, vol.263
, pp. 1397-1404
-
-
Barford, D.1
Flint, A.J.2
Tonks, N.K.3
-
42
-
-
0029066496
-
Structure basis for phosphotyrosine peptide recognition by protein tyrosine phosphatase 1B
-
Jia Z., Barford D., Flint A.J., and Tonks N.K. Structure basis for phosphotyrosine peptide recognition by protein tyrosine phosphatase 1B. Science 268 (1995) 1754-1758
-
(1995)
Science
, vol.268
, pp. 1754-1758
-
-
Jia, Z.1
Barford, D.2
Flint, A.J.3
Tonks, N.K.4
-
43
-
-
0038662654
-
Crystal structure of PTP1B complexed with a potent and selective bidentate inhibitor
-
Sun J.P., Fedorov A.A., Lee S.Y., Guo X.L., Shen K., Lawrence D.S., Almo S.C., and Zhang Z.Y. Crystal structure of PTP1B complexed with a potent and selective bidentate inhibitor. J. Biol. Chem. 278 (2003) 12406-12414
-
(2003)
J. Biol. Chem.
, vol.278
, pp. 12406-12414
-
-
Sun, J.P.1
Fedorov, A.A.2
Lee, S.Y.3
Guo, X.L.4
Shen, K.5
Lawrence, D.S.6
Almo, S.C.7
Zhang, Z.Y.8
-
44
-
-
0032144872
-
Low-affinity binding determined by titration calorimetry using a high-affinity coupling ligand
-
Zhang Y.L., and Zhang Z.Y. Low-affinity binding determined by titration calorimetry using a high-affinity coupling ligand. Anal. Biochem. 261 (1998) 139-148
-
(1998)
Anal. Biochem.
, vol.261
, pp. 139-148
-
-
Zhang, Y.L.1
Zhang, Z.Y.2
-
45
-
-
0032480809
-
Conformational and dynamic changes of Yersinia protein tyrosine phosphatase induced by ligand binding and active site mutation and revealed by H/D exchange and electrospray ionization Fourier transform ion cyclotron resonance mass spectrometry
-
Wang F., Li W., Emmelt M.L., Hendrickson C.L., Marchall A.G., Zhang Y.L., Wu L., and Zhang Z.L. Conformational and dynamic changes of Yersinia protein tyrosine phosphatase induced by ligand binding and active site mutation and revealed by H/D exchange and electrospray ionization Fourier transform ion cyclotron resonance mass spectrometry. Biochemistry 37 (1998) 15289-15299
-
(1998)
Biochemistry
, vol.37
, pp. 15289-15299
-
-
Wang, F.1
Li, W.2
Emmelt, M.L.3
Hendrickson, C.L.4
Marchall, A.G.5
Zhang, Y.L.6
Wu, L.7
Zhang, Z.L.8
-
46
-
-
0034602144
-
Thermodynamic study of ligand binding to protein-tyrosine phosphatase 1B and its substrate-trapping mutants
-
Zhang Y.L., Yao Z.J., Sarmiento M., Wu L., Burke T.R., and Zhang Z.Y. Thermodynamic study of ligand binding to protein-tyrosine phosphatase 1B and its substrate-trapping mutants. J. Biol. Chem. 275 (2000) 34205-34212
-
(2000)
J. Biol. Chem.
, vol.275
, pp. 34205-34212
-
-
Zhang, Y.L.1
Yao, Z.J.2
Sarmiento, M.3
Wu, L.4
Burke, T.R.5
Zhang, Z.Y.6
-
47
-
-
0031457541
-
Identification of a second aryl phosphate-binding site in protein-tyrosine phosphatase 1B: A paradigm for inhibitor design
-
Puius Y.A., Zhao Y., Sullivan M., Lawrence D.S., Almo S.C., and Zhang Z.Y. Identification of a second aryl phosphate-binding site in protein-tyrosine phosphatase 1B: A paradigm for inhibitor design. Proc. Natl. Acad. Sci. USA 94 (1997) 13420-13425
-
(1997)
Proc. Natl. Acad. Sci. USA
, vol.94
, pp. 13420-13425
-
-
Puius, Y.A.1
Zhao, Y.2
Sullivan, M.3
Lawrence, D.S.4
Almo, S.C.5
Zhang, Z.Y.6
-
48
-
-
3543017313
-
Allosteric inhibition of protein tyrosine phosphatase 1B
-
Weismann C., Barr K.J., Kung J., Zhu J., Erlanson D.A., Shen W., Fahr B.J., Zhong M., Taylor L., Randal M., McDowell R.S., and Hansen S.K. Allosteric inhibition of protein tyrosine phosphatase 1B. Nat. Struct. Mol. Biol. 11 (2004) 730-737
-
(2004)
Nat. Struct. Mol. Biol.
, vol.11
, pp. 730-737
-
-
Weismann, C.1
Barr, K.J.2
Kung, J.3
Zhu, J.4
Erlanson, D.A.5
Shen, W.6
Fahr, B.J.7
Zhong, M.8
Taylor, L.9
Randal, M.10
McDowell, R.S.11
Hansen, S.K.12
|