KC1 evokes contraction of airway smooth muscle via activation of RhoA and Rho-kinase

American Journal of Physiology - Lung Cellular and Molecular Physiology

Volumn 287, Issue 4 31-4, 2004, Pages

  Janssen, Luke J ^a   Tazzeo, Tracy ^a   Zuo, Jianmin ^a   Pertens, Evi ^a   Keshavjee, Shaf ^b  

^a ST JOSEPH S HOSPITAL   (Canada)

^b UNIVERSITY OF TORONTO   (Canada)

Author keywords

Myosin light chain phosphatase; Rho; Rho associated kinase; Voltage dependent calcium channels

Indexed keywords

4 (1 AMINOETHYL) N (4 PYRIDYL)CYCLOHEXANECARBOXAMIDE; CALCIUM; CALCIUM CHANNEL BLOCKING AGENT; FASUDIL; NICKEL CHLORIDE; NIFEDIPINE; POTASSIUM CHLORIDE; RHO KINASE; VOLTAGE GATED CALCIUM CHANNEL; AMIDE; ENZYME INHIBITOR; PROTEIN SERINE THREONINE KINASE; PYRIDINE DERIVATIVE; RHO-ASSOCIATED KINASE; RHOA GUANINE NUCLEOTIDE BINDING PROTEIN; SIGNAL PEPTIDE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BREATHING MUSCLE; BRONCHUS MUSCLE; CALCIUM TRANSPORT; CONTROLLED STUDY; COW; ENZYME ASSAY; FLUOROMETRY; HUMAN; MUSCLE CELL; MUSCLE CONTRACTILITY; MUSCLE CONTRACTION; NONHUMAN; PRIORITY JOURNAL; SENSITIVITY ANALYSIS; SMOOTH MUSCLE; SWINE; TRACHEA MUSCLE; WESTERN BLOTTING; BRONCHUS; DRUG EFFECT; IN VITRO STUDY; METABOLISM; PHYSIOLOGY; RESPIRATORY TRACT MUCOSA;

AMIDES; BRONCHI; CALCIUM; ENZYME INHIBITORS; HUMANS; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; MUSCLE, SMOOTH; POTASSIUM CHLORIDE; PROTEIN-SERINE-THREONINE KINASES; PYRIDINES; RESPIRATORY MUCOSA; RHOA GTP-BINDING PROTEIN;

EID: 4544323366     PISSN: 10400605     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajplung.00130.2004     Document Type: Article

References (27)

1. Carlin SM, Roth M, and Black JL. Urokinase potentiates PDGF-induced chemotaxis of human airway smooth muscle cells. Am J Physiol Lung Cell Mol Physiol 284: L1020-L1026, 2003.
2. Davies SP, Reddy H, Caivano M, and Cohen P. Specificity and mechanism of action of some commonly used protein kinase inhibitors. Biochem J 351: 95-105, 2000.
3. 2+-channels in bovine isolated trachealis cells. Pulm Pharmacol 6: 49-62, 1993.
4. Hashimoto K, Peebles RS Jr, Sheller JR, Jarzecka K, Furlong J, Mitchell DB, Hartert TV, and Graham BS. Suppression of airway hyperresponsiveness induced by ovalbumin sensitisation and RSV infection with Y-27632, a Rho kinase inhibitor. Thorax 57: 524-527, 2002.
5. Hashimoto T, Nakano Y, Yamashita M, Fang YI, Ohata H, and Momose K. Role of Rho-associated protein kinase and histamine in lysophosphatidic acid-induced airway hyperresponsiveness in guinea pigs. Jpn J Pharmacol 88: 256-261, 2002.
6. 2+ sensitization through inhibition of myosin phosphatase in rabbit trachea. Br J Pharmacol 128: 925-933, 1999.
7. 2+ currents in canine bronchial smooth muscle: characterization and physiological roles. Am J Physiol Cell Physiol 272: C1757-C1765, 1997.
8. 2+ regulation in airway smooth muscle contraction: do the data contradict dogma? Am J Physiol Lung Cell Mol Physiol 282: L1161-L1178, 2002.
9. 2+ in canine airway smooth muscle. Am J Physiol Lung Cell Mol Physiol 276: L744-L753, 1999.
10. Janssen LJ, Premji M, Netherton S, Catalli A, Cox G, Keshavjee S, and Crankshaw DJ. Excitatory and inhibitory actions of isoprostanes in human and canine airway smooth muscle. J Pharmacol Exp Ther 295: 506-511, 2000.
11. 2+-uptake mediate adrenergic relaxation of airway smooth muscle. Am J Respir Cell Mol Biol 30: 548-554, 2004.
12. 2+ exchange mechanisms. Am J Physiol Lung Cell Mol Physiol 273: L322-L330, 1997.
13. Janssen LJ, Wattie J, Lu-Chao H, and Tazzeo T. Muscarinic excitation-contraction coupling mechanisms in tracheal and bronchial smooth muscles. J Appl Physiol 91: 1142-1151, 2001.
14. 2+ sensitization of smooth muscle contraction through myosin light chain phosphorylation. J Biol Chem 266: 1708-1715, 1991.
15. McDonald TF, Pelzer S, Trautwein W, and Pelzer DJ, Regulation and modulation of calcium channels in cardiac, skeletal, and smooth muscle cells. Physiol Rev 74: 365-507, 1994.
16. Mita M, Yanagihara H, Hishinuma S, Saito M, and Walsh MP. Membrane depolarization-induced contraction of rat caudal arterial smooth muscle involves Rho-associated kinase. Biochem J 364: 431-440. 2002.
17. 2+. Circ Res 88: 1283-1290, 2001.
18. Parameswaran K, Cox G, Radford K, Janssen LJ, Sehmi R, and O'Byrne PM. Cysteinyl leukotrienes promote human airway smooth muscle migration. Am J Respir Crit Care Med 166: 738-742, 2002.
19. Rosenfeldt HM, Amrani Y, Watterson KR, Murthy KS, Panettieri RA Jr, and Spiegel S. Sphingosine-1-phosphate stimulates contraction of human airway smooth muscle cells. FASEB J 17: 1789-1799, 2003.
20. 2+-dependent activation of Rho and Rho kinase in membrane depolarization-induced and receptor stimulation-induced vascular smooth muscle contraction. Circ Res 93: 548-556, 2003.
21. 4 enhances the contraction of porcine tracheal smooth muscle through the activation of Y-27632, a rho kinase inhibitor, sensitive pathway. Br J Pharmacol 132: 111-118, 2001.
22. Smith PG, Roy C, Zhang YN, and Chauduri S. Mechanical stress increases RhoA activation in airway smooth muscle cells. Am J Respir Cell Mol Biol 28: 436-442, 2003.
23. Somlyo AP and Somlyo AV. Signal transduction by G-proteins, rho-kinase and protein phosphatase to smooth muscle and non-muscle myosin II. J Physiol 522: 177-185, 2000.
24. 2+ sensitivity of smooth muscle and nonmuscle myosin II: modulated by G proteins, kinases, and myosin phosphatase. Physiol Rev 83: 1325-1358, 2003.
25. Somlyo AP, Wu X, Walker LA, and Somlyo AV. Pharmacomechanical coupling: the role of calcium, G-proteins, kinases and phosphatases. Rev Physiol Biochem Pharmacol 134: 201-234, 1999.
26. Vetter SW and Leclerc E. Novel aspects of calmodulin target recognition and activation. Eur J Biochem 270: 404-414, 2003.
27. 2+ channels in porcine tracheal and bronchial smooth muscles. Anesthesiology 94: 683-693, 2001.