Interpretation of V/K isotope effects for enzymatic reactions exhibiting multiple isotopically sensitive steps

Journal of Theoretical Biology

Volumn 243, Issue 3, 2006, Pages 328-342

  Ruszczycky, Mark W ^a   Anderson, Vernon E ^a  

^a CASE WESTERN RESERVE UNIVERSITY   (United States)

Author keywords

Binding isotope effect; Catalytic commitment; Enzyme kinetics; Multiple kinetic isotope effects; Virtual transition state

Indexed keywords

CATALYSIS; DEUTERIUM; ENZYME ACTIVITY; EQUILIBRIUM; REACTION KINETICS;

ARTICLE; CATALYSIS; ENZYME KINETICS; EQUILIBRIUM CONSTANT; MICHAELIS MENTEN KINETICS; PRIORITY JOURNAL;

ANIMALS; CATALYSIS; ENZYMES; ISOTOPES; MODELS, CHEMICAL; SUBSTRATE SPECIFICITY;

EID: 33750444252     PISSN: 00225193     EISSN: 10958541     Source Type: Journal    
DOI: 10.1016/j.jtbi.2006.06.022     Document Type: Article

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