Mouse 17α-Hydroxysteroid Dehydrogenase (AKR1C21) Binds Steroids Differently from other Aldo-keto Reductases: Identification and Characterization of Amino Acid Residues Critical for Substrate Binding

Journal of Molecular Biology

Volumn 369, Issue 2, 2007, Pages 525-540

  Faucher, Frédérick ^a   Cantin, Line ^a   Pereira de Jésus Tran, Karine ^a   Lemieux, Mélanie ^a   Luu The, Van ^a   Labrie, Fernand ^a   Breton, Rock ^a  

^a LAVAL UNIVERSITY   (Canada)

Author keywords

aldo keto reductase; androstenedione; epi testosterone; mouse 17 HSD; ternary complex crystal structure

Indexed keywords

17ALPHA HYDROXYSTEROID DEHYDROGENASE; 3ALPHA HYDROXYSTEROID DEHYDROGENASE; AMINO ACID; ANDROSTENEDIONE; CELL NUCLEUS RECEPTOR; HYDROXYSTEROID DEHYDROGENASE; KETONE; OXYGEN; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; STEROID; TERNARY COMPLEX FACTOR; UNCLASSIFIED DRUG; 3(17) HYDROXYSTEROID DEHYDROGENASE; 3(17)-HYDROXYSTEROID DEHYDROGENASE; NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; RECOMBINANT PROTEIN;

AFFINITY LABELING; ARTICLE; CATALYSIS; CONTROLLED STUDY; CRYSTAL STRUCTURE; ENZYME BINDING; HORMONE RELEASE; HUMAN; HYDROGEN BOND; KINETICS; MOUSE; MUTAGENESIS; NONHUMAN; PRIORITY JOURNAL; RESIDUE ANALYSIS; STEREOSPECIFICITY; STEROID BINDING; ANIMAL; BINDING SITE; CHEMICAL STRUCTURE; CHEMISTRY; COENZYME; GENETICS; METABOLISM; PROTEIN BINDING; PROTEIN TERTIARY STRUCTURE; SITE DIRECTED MUTAGENESIS; X RAY CRYSTALLOGRAPHY;

ANIMALS; BINDING SITES; COENZYMES; CRYSTALLOGRAPHY, X-RAY; HUMANS; HYDROXYSTEROID DEHYDROGENASES; MICE; MODELS, MOLECULAR; MOLECULAR STRUCTURE; MUTAGENESIS, SITE-DIRECTED; NADP; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY; RECOMBINANT PROTEINS; STEROIDS;

EID: 34247603437     PISSN: 00222836     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jmb.2007.03.058     Document Type: Article

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