Crystal Structures of Mouse 17α-Hydroxysteroid Dehydrogenase (Apoenzyme and Enzyme-NADP(H) Binary Complex): Identification of Molecular Determinants Responsible for the Unique 17α-reductive Activity of this Enzyme

Journal of Molecular Biology

Volumn 364, Issue 4, 2006, Pages 747-763

  Faucher, Frédérick ^a   Pereira de Jésus Tran, Karine ^a   Cantin, Line ^a   Luu The, Van ^a   Labrie, Fernand ^a   Breton, Rock ^a  

^a LAVAL UNIVERSITY   (Canada)

Author keywords

17 HSD apoenzyme crystal structure; 17 HSD:NADP(H) binary complex crystal structure; 17 17 stereospecificity; epitestosterone; mouse 17 hydroxysteroid dehydrogenase

Indexed keywords

17ALPHA HYDROXYSTEROID DEHYDROGENASE; APOENZYME; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE DEHYDROGENASE; UNCLASSIFIED DRUG;

AMINO ACID ANALYSIS; ARTICLE; COMPARATIVE STUDY; COMPLEX FORMATION; CRYSTAL STRUCTURE; CRYSTALLIZATION; ENZYME ACTIVITY; ENZYME ANALYSIS; ENZYME STRUCTURE; MOLECULAR INTERACTION; MUTAGENIC ACTIVITY; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; REDUCTION; SEQUENCE HOMOLOGY; STEREOSPECIFICITY; TESTOSTERONE SYNTHESIS;

ORYCTOLAGUS CUNICULUS;

EID: 33750948215     PISSN: 00222836     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jmb.2006.09.030     Document Type: Article

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