Conversion of mammalian 3α-hydroxysteroid dehydrogenase to 20α-hydroxysteroid dehydrogenase using loop chimeras: Changing specificity from androgens to progestins

Proceedings of the National Academy of Sciences of the United States of America

Volumn 96, Issue 20, 1999, Pages 11161-11166

  Ma, Haiching ^b   Penning, Trevor M ^a,b  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

^b UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

20ALPHA HYDROXYSTEROID DEHYDROGENASE; 3 ALPHA HYDROXYSTEROID DEHYDROGENASE (B SPECIFIC); 3(OR 17)BETA HYDROXYSTEROID DEHYDROGENASE; 3ALPHA HYDROXYSTEROID DEHYDROGENASE; 3ALPHA(OR 20BETA) HYDROXYSTEROID DEHYDROGENASE; ANDROGEN; GESTAGEN; HYBRID PROTEIN; 20ALPHA DIHYDROPROGESTERONE; ANDROSTANEDIOL; ANDROSTANOLONE; STEROID RECEPTOR;

ANIMAL; ARTICLE; CHEMICAL STRUCTURE; CHEMISTRY; ENZYME SPECIFICITY; HUMAN; METABOLISM; POINT MUTATION; PROTEIN ENGINEERING; RABBIT; RAT; STRUCTURE ACTIVITY RELATION; AMINO ACID SEQUENCE; CHEMICAL MODIFICATION; CHIMERA; NONHUMAN; PRIORITY JOURNAL; PROSTATE DISEASE; RECEPTOR OCCUPANCY; SEQUENCE HOMOLOGY; STEREOCHEMISTRY;

20-ALPHA-HYDROXYSTEROID DEHYDROGENASE; 20-HYDROXYSTEROID DEHYDROGENASES; 3-ALPHA-HYDROXYSTEROID DEHYDROGENASE (B-SPECIFIC); 3-HYDROXYSTEROID DEHYDROGENASES; ANDROGENS; ANIMALS; HUMANS; MODELS, MOLECULAR; POINT MUTATION; PROGESTINS; PROTEIN ENGINEERING; RABBITS; RATS; RECOMBINANT FUSION PROTEINS; STRUCTURE-ACTIVITY RELATIONSHIP; SUBSTRATE SPECIFICITY;

EID: 0033612962     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.96.20.11161     Document Type: Article

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