Inhibition of tyrosine kinase-mediated cellular signalling by Tyrphostins AG126 and AG556 modulates secondary damage in experimental spinal cord trauma

Neuropharmacology

Volumn 52, Issue 7, 2007, Pages 1454-1471

  Genovese, Tiziana ^a,b   Mazzon, Emanuela ^a,b   Esposito, Emanuela ^c   Muià, Carmelo ^a   Di Paola, Rosanna ^a,b   Crisafulli, Concetta ^a   Bramanti, Placido ^b   Cuzzocrea, Salvatore ^a,b  

^a UNIVERSITY OF MESSINA   (Italy)

^b IRCCS CENTRO NEUROLESI BONINO PULEJO   (Italy)

^c UNIVERSITY OF NAPLES FEDERICO II   (Italy)

Author keywords

COX 2; iNOS; Myeloperoxidase activity; NF B expression; Nitrotyrosine; Spinal cord injury; Tyrosine kinase

Indexed keywords

3 NITROTYROSINE; MYELOPEROXIDASE; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE INHIBITOR; PROTEIN BAX; PROTEIN BCL 2; PROTEIN TYROSINE KINASE; TYRPHOSTIN; TYRPHOSTIN AG126; TYRPHOSTIN AG556; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CLIP; CONTROLLED STUDY; DRUG INHIBITION; DURA MATER; EDEMA; EXPERIMENTAL STUDY; LAMINECTOMY; MALE; MOUSE; MYELITIS; NEUROMODULATION; NEUTROPHIL CHEMOTAXIS; NICK END LABELING; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; SPINAL CORD INJURY; TISSUE INJURY;

ANIMALS; APOPTOSIS; BCL-2-ASSOCIATED X PROTEIN; BRAIN EDEMA; DISEASE MODELS, ANIMAL; ENZYME INHIBITORS; IN SITU NICK-END LABELING; INFLAMMATION; LAMINECTOMY; MALE; MICE; MOTOR ACTIVITY; NEUTROPHIL INFILTRATION; PEROXIDASE; PROTEIN-TYROSINE KINASES; PROTO-ONCOGENE PROTEINS C-BCL-2; SIGNAL TRANSDUCTION; SPINAL CORD INJURIES; TYRPHOSTINS;

EID: 34247590173     PISSN: 00283908     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.neuropharm.2007.01.017     Document Type: Article

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