Inhibition of tyrosine-kinase-mediated cellular signaling by tyrphostins AG 126 and AG556 modulates murine experimental acute pancreatitis

Surgery

Volumn 138, Issue 5, 2005, Pages 913-923

  Balachandra, Srinivasan ^a   Genovese, Tiziana ^b   Mazzon, Emanuela ^c   Di Paola, Rosanna ^b   Thiemerman, Christoph ^d   Siriwardena, Ajith K ^a   Cuzzocrea, Salvatore ^b,c  

^a MANCHESTER ROYAL INFIRMARY   (United Kingdom)

^b UNIVERSITY OF MESSINA   (Italy)

^c UNIVERSITY OF MESSINA   (Italy)

^d QUEEN MARY UNIVERSITY OF LONDON   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

3 NITROTYROSINE; CERULETIDE; MALONALDEHYDE; MYELOPEROXIDASE; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; PROTEIN TYROSINE KINASE; PROTEIN TYROSINE KINASE INHIBITOR; TUMOR NECROSIS FACTOR ALPHA; TYRPHOSTIN;

ACUTE PANCREATITIS; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; ENZYME ACTIVITY; IMMUNOHISTOCHEMISTRY; IMMUNOREACTIVITY; LIPID PEROXIDATION; MALE; MOUSE; NEUTROPHIL CHEMOTAXIS; NONHUMAN; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; TISSUE INJURY;

ACUTE DISEASE; AMYLASES; ANIMALS; ENZYME INHIBITORS; LIPASE; LIPID PEROXIDATION; MALE; MICE; MICE, INBRED STRAINS; NEUTROPHILS; NITRIC OXIDE; PANCREAS; PANCREATITIS; PEROXYNITROUS ACID; POLY(ADP-RIBOSE) POLYMERASES; PROTEIN-TYROSINE KINASES; SIGNAL TRANSDUCTION; TUMOR NECROSIS FACTOR-ALPHA; TYROSINE; TYRPHOSTINS;

EID: 27744541107     PISSN: 00396060     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.surg.2005.05.021     Document Type: Article

References (29)

1. C.J. McKay, S. Evans, M. Sinclair, C.R. Carter, and C.W. Imrie High early mortality rate from acute pancreatitis in Scotland, 1984-1995 Br J Surg 86 1999 1302 1305
2. L.I. Cosen-Binker, M.G. Binker, G. Negri, and O. Tiscornia Acute pancreatitis possible initial triggering mechanism and prophylaxis Pancreatology 3 2003 445 456
3. C.A. Dinarello Cytokines as mediators in the pathogenesis of septic shock Curr Top Microbiol Immunol 216 1996 133 165
4. C. Thiemermann Protein tyrosine kinase inhibitors as novel therapeutics for systemic inflammation, shock, and organ injury Crit Care Med 31 2003 652 653
5. S. Cuzzocrea, M.C. McDonald, E. Mazzon, D. Siriwardena, G. Calabro, and D. Britti The tyrosine kinase inhibitor tyrphostin AG126 reduces the development of acute and chronic inflammation Am J Pathol 157 2000 145 158
6. A. Novogrodsky, A. Vanichkin, M. Patya, A. Gazit, N. Osherov, and A. Levitzki Prevention of lipopolysaccharide-induced lethal toxicity by tyrosine kinase inhibitors Science 264 1994 1319 1322
7. H. Ruetten, and C. Thiemermann Effects of tyrphostins and genistein on the circulatory failure and organ dysfunction caused by endotoxin in the rat: a possible role for protein tyrosine kinase Br J Pharmacol 122 1997 59 70
8. A. Levitzki, and A. Gazit Tyrosine kinase inhibition: an approach to drug development Science 267 1995 1782 1788
9. A. Vanichkin, M. Patya, A. Gazit, A. Levitzki, and A. Novogrodsky Late administration of a lipophilic tyrosine kinase inhibitor prevents lipopolysaccharide and Escherichia coli-induced lethal toxicity J Infect Dis 173 1996 927 933
10. S. Cuzzocrea, M.C. McDonald, E. Mazzon, H. Mota-Filipe, V. Lepore, and A. Ciccolo The tyrosine kinase inhibitor tyrphostin AG 126 reduced the development of colitis in the rat Lab Invest 80 2000 1439 1453
11. T. Brenner, E. Poradosu, D. Soffer, C. Sicsic, A. Gazit, and A. Levitzki Suppression of experimental autoimmune encephalomyelitis by tyrphostin AG-556 Exp Neurol 154 1998 489 498
12. L. Dugo, P.K. Chatterjee, E. Mazzon, M.C. McDonald, R.D. Paola, and F. Fulia The tyrosine kinase inhibitor tyrphostin AG 126 reduces the multiple organ failure induced by zymosan in the rat Intensive Care Med 28 2002 775 788
13. M. McDonald, M. Abdelrahman, S. Cuzzocrea, and C. Thiemermann Tyrphostin reduces the organ injury in haemorrhagic shock: role of inducible nitric oxide synthase Resuscitation 58 2003 349 361
14. D. Jarrar, P. Wang, G.Y. Song, W.G. Cioffi, K.I. Bland, and I.H. Chaudry Inhibition of tyrosine kinase signaling after trauma-hemorrhage: a novel approach for improving organ function and decreasing susceptibility to subsequent sepsis Ann Surg 231 2000 399 407
15. P.K. Chatterjee, N.S. Patel, E.O. Kvale, P.A. Brown, K.N. Stewart, and D. Britti The tyrosine kinase inhibitor tyrphostin AG126 reduces renal ischemia/reperfusion injury in the rat Kidney Int 64 2003 1605 1619
16. S. Cuzzocrea, T.P. Misko, G. Costantino, E. Mazzon, A. Micali, and A.P. Caputi Beneficial effects of peroxynitrite decomposition catalyst in a rat model of splanchnic artery occlusion and reperfusion FASEB J 14 2000 1061 1072
17. T. Grady, A.K. Saluja, A. Kaiser, and M.L. Steer Edema and intrapancreatic trypsinogen activation precedes glutathione depletion during caerulein pancreatitis Am J Physiol 271 1996 G20 G26
18. K.M. Mullane, R. Kraemer, and B. Smith Myeloperoxidase activity as a quantitative assessment of neutrophil infiltration into ischemic myocardium J Pharmacol Methods 141 1985 157 167
19. S. Cuzzocrea, A.P. Caputi, and B. Zingarelli Peroxynitrite-mediated DNA strand breakage activates poly (ADP-ribose) synthetase and causes cellular energy depletion in carrageenan-induced pleurisy Immunology 93 1998 96 101
20. S. Cuzzocrea, D.P. Riley, A.P. Caputi, and D. Salvemini Antioxidant therapy: a new pharmacological approach in shock, inflammation, and ischemia/reperfusion injury Pharmacol Rev 53 2001 135 159
21. K. Angstwurm, U.K. Hanisch, T. Gassemi, M.B. Bille, M. Prinz, and U. Dirnagl Tyrosine kinase inhibition reduces inflammation in the acute stage of experimental pneumococcal meningitis Infect Immun 72 2004 3294 3298
22. J. George, I. Barshack, I. Goldberg, P. Keren, A. Gazit, and A. Levitzki The effect of early and late treatment with the tyrphostin AG-556 on the progression of experimental autoimmune myocarditis Exp Mol Pathol 76 2004 234 241
23. K. Hirasawa, H.S. Jun, H.S. Han, M.L. Zhang, M.D. Hollenberg, and J.W. Yoon Prevention of encephalomyocarditis virus-induced diabetes in mice by inhibition of the tyrosine kinase signalling pathway and subsequent suppression of nitric oxide production in macrophages J Virol 73 1999 8541 8548
24. N. Oruc, A.O. Ozutemiz, V. Yukselen, D. Nart, H.A. Celik, and G. Yuce Infliximab: a new therapeutic agent in acute pancreatitis? Pancreas 28 2004 e1 e8
25. I. Virlos, E. Mazzon, I. Serraino, T. Genovese, R. Di Paola, and C. Thiemerman Calpain I inhibitor ameliorates the indices of disease severity in a murine model of cerulein-induced acute pancreatitis Intensive Care Med 30 2004 1645 1651
26. S.H. Um, Y.D. Kwon, C.D. Kim, H.S. Lee, Y.T. Jeen, and H.J. Chun The role of nitric oxide in experimental cerulein induced pancreatitis J Korean Med Sci 18 2003 520 526
27. S. Cuzzocrea, E. Mazzon, L. Dugo, I. Serraino, T. Centorrino, and A. Ciccolo Inducible nitric oxide synthase-deficient mice exhibit resistance to the acute pancreatitis induced by cerulein Shock 17 2002 416 422
28. J.S. Beckman Oxidative damage and tyrosine nitration from peroxynitrite Chem Res Toxicol 9 1996 836 844
29. M. Endoh, K. Maiese, and J. Wagner Expression of the inducible form of nitric oxide synthase by reactive astrocytes after transient global ischemia Brain Res 651 1994 92 100