Homeobox gene mutations and brain-stem developmental disorders: Learning from knockout mice

Current Opinion in Neurology

Volumn 14, Issue 2, 2001, Pages 177-184

  Pasqualetti, Massimo ^a   Rijli, Filippo M ^a  

^a INSTITUT DE GÉNÉTIQUE ET DE BIOLOGIE MOLÉCULAIRE ET CELLULAIRE   (France)

Author keywords

[No Author keywords available]

Indexed keywords

HOMEODOMAIN PROTEIN;

ANIMAL MODEL; BRAIN DEVELOPMENT; BRAIN FUNCTION; DEVELOPMENTAL DISORDER; EMBRYO PATTERN FORMATION; GENE INACTIVATION; GENE MUTATION; HOMEOBOX; KNOCKOUT MOUSE; MOUSE; NEUROTRANSMISSION; NONHUMAN; REVIEW;

ANIMALS; BODY PATTERNING; BRAIN STEM; CELL DIFFERENTIATION; GENES, HOMEOBOX; HUMANS; MICE; MICE, KNOCKOUT; NERVOUS SYSTEM MALFORMATIONS;

EID: 0035074209     PISSN: 13507540     EISSN: None     Source Type: Journal    
DOI: 10.1097/00019052-200104000-00007     Document Type: Review

References (84)

1. The specification of neuronal identity by graded Sonic Hedgehog signalling
2. Neuronal specification in the spinal cord: Inductive signals and transcriptionals codes
3. Targeted gene replacement
4. ETS gene Er81 controls the formation of functional connections between group la sensory afferents and motor neurons
5. Transcriptional control of neurotransmitter phenotype
6. Helix-loop-helix factors in growth and differentiation of the vertebrate nervous system
7. Neuronal diversification: Development of motor neuron subtypes
8. The cellular basis of segmentation in the developing hindbrain
9. Violation of cell lineage restriction compartments in the chick hindbrain
10. Differential progenitor dispersal and the spatial origin of early neurons can explain the predominance of single-phenotype clones in the chick hindbrain
11. Persistence of rhombomeric organisation in the postsegmental hindbrain
12. Morphological fate of rhombomeres in quail/chick chimeras: A segmental analysis of hindbrain nuclei
13. Segmental repetition of neuronal phenotype sets in the chick embryo hindbrain
14. The relationship between rhombomeres and vestibular neuron populations as assessed in quail-chicken chimeras
15. Retinoic acid alters hindbrain Hox code and induces transformation of rhombomeres 2/3 into a 4/5 identity
16. Altered segmental identity and abnormal migration of motor neurons in mice lacking Hoxb-1
17. Loss of Hox-A1 (Hox-1.6) function results in the reorganization of the murine hindbrain
18. Regional patterning of reticulospinal and vestibulospinal neurons in the hindbrain of mouse and rat embryos
19. Neuroepithelial 'compartments' and the specification of vestibular projections
20. Development of specific connectivity between premotor neurons and motoneurons in the brain stem and spinal cord
21. Segmental specification of GABAergic inhibition during development of hindbrain neural networks
22. Reorganization of pontine rhythmogenic neuronal networks in Krox-20 knockout mice
23. Genetic and developmental models for the neural control of breathing in vertebrates
24. Initiation of rhombomeric Hoxb4 expression requires induction by somites and a retinoid pathway
25. Hox gene induction in the neural tube depends on three parameters: Competence, signal supply and paralogue group
26. Reprogramming Hox expression in the vertebrate hindbrain: Influence of paraxial mesoderm and rhombomere transposition
27. Retinoid signalling and hindbrain patterning
28. Midbrain development induced by FGF8 in the chick embryo
29. Signalling by FGF8 from the isthmus patterns anterior hindbrain and establishes the anterior limit of Hox gene expression
30. Pax6 controls progenitor cell identity and neuronal fate in response to graded Shh signaling
31. Ventral neural patterning by Nkx homeobox genes: Nkx6.1 controls somatic motor neuron and ventral interneuron fates
32. A homeodomain protein code specifies progenitor cell identity and neuronal fate in the ventral neural tube
33. Achieving neuronal patterning by repression
34. Specification of ventral neuron types is mediated by an antagonistic interaction between shh and gli3
35. A sonic hedgehog-independent, retinoid-activated pathway of neurogenesis in the ventral spinal cord
36. The specification of dorsal cell fates in the vertebrate central nervous system
37. Genetic ablation reveals that the roof plate is essential for dorsal interneuron specification
38. The mouse Dreher gene Lmx1a controls formation of the roof plate in the vertebrate CNS
39. FGF and Shh signals control dopaminergic and serotonergic cell fate in the anterior neural plate
40. Rhombomere-specific origin of the contralateral vestibulo-acoustic efferent neurons and their migration across the embryonic midline
41. Hoxa2 and Hoxb2 control dorsoventral patterns of neuronal development in the rostral hindbrain
42. Patterning the vertebrate neuraxis
43. Gli genes in development and cancer
44. Gli proteins and Hedgehog signaling: Development and cancer
45. Neural patterning: The role of Nkx genes in the ventral spinal cord
46. Patterning motoneurons in the vertebrate nervous system
47. Segmentation and specification in the branchial region of the head: The role of the Hox selector genes
48. The murine Hox-2 genes display dynamic dorsoventral patterns of expression during central nervous system development
49. Hoxb1 controls effectors of sonic hedgehog and Mash1 signaling pathways
50. Increased apoptosis of motoneurons and altered somatotopic maps in the brachial spinal cord of Hoxc-8-deficient mice
51. Disruption of the Hox-1.6 homeobox gene results in defects in a region corresponding to its rostral domain of expression
52. Two rhombomeres are altered in Hoxa-1 mutant mice
53. Developmental defects of the ear, cranial nerves and hindbrain resulting from targeted disruption of the mouse homeobox gene Hox-1.6
54. Targeted disruption of the Hoxb-2 locus in mice interferes with expression of Hoxb-1 and Hoxb-4
55. Genetic interactions between Hoxa1 and Hoxb1 reveal new roles in regulation of early hindbrain patterning
56. Mice with targeted disruption of Hoxb-1 fail to form the motor nucleus of the VIIth nerve
57. Role of Hoxa-2 in axon pathfinding and rostral hindbrain patterning
58. In vivo functional analysis of the Hoxa-1 3′ retinoic acid response element (3′RARE)
59. Hoxa1 and Krox-20 synergize to control the development of rhombomere 3
60. Hoxa1 and Hoxb1 synergize in patterning the hindbrain, cranial nerves and second pharyngeal arch
61. Roles of Hoxa1 and Hoxa2 in patterning the early hindbrain of the mouse
62. Mice mutant for both Hoxa1 and Hoxb1 show extensive remodeling of the hindbrain and defects in craniofacial development
63. A new approach to the development of the cerebellum provided by the quail-chick marker system
64. The role of the rhombic lip in avian cerebellum development
65. Rhombomere-specific origin of branchial and visceral motoneurons of the facial nerve in the rat embryo
66. The transcription factor GATA3 is a downstream effector of Hoxb1 specification in rhombomere 4
67. Specification of distinct motor neuron identities by the singular activities of individual Hox genes
68. The development of vestibulocochlear efferents and cochlear afferents in mice
69. Deconstructing cell determination: Proneural genes and neuronal identity
70. Homeobox gene Nkx2.2 and specification of neuronal identity by graded Sonic hedgehog signalling
71. Nkx2-9 is a novel homeobox transcription factor which demarcates ventral domains in the developing mouse CNS
72. The mouse homeodomain protein Phox2 regulates Ncam promoter activity in concert with Cux/CDP and is a putative determinant of neurotransmitter phenotype
73. The expression pattern of the transcription factor Phox2 delineates synaptic pathways of the autonomic nervous system
74. Expression and interactions of the two closely related homeobox genes Phox2a and Phox2b during neurogenesis
75. Defects in sensory and autonomic ganglia and absence of locus coeruleus in mice deficient for the homeobox gene Phox2a
76. Development of noradrenergic neurons in the zebrafish hindbrain requires BMP, FGF8, and the homeodomain protein soulless/Phox2a
77. Specification of the central noradrenergic phenotype by the homeobox gene Phox2b
78. Control of hindbrain motor neuron differentiation by the homeobox gene Phox2b
79. The homeobox gene Phox2b is essential for the development of autonomic neural crest derivatives
80. The Phox2b transcription factor coordinately regulates neuronal cell cycle exit and identity
81. Region-specific differentiation of neural tube-derived neuronal restricted progenitor cells after heterotopic transplantation
82. Quantitative monitoring of gene expression patterns with a complementary DNA microarray
83. Skin abnormalities generated by temporally controlled RXRalpha mutations in mouse epidermis