The neuroprotective effects of BNG-1: A new formulation of traditional Chinese medicines for stroke

American Journal of Chinese Medicine

Volumn 33, Issue 1, 2005, Pages 61-71

  Cheng, Fong Chi ^a   Chen, Wen Long ^a   Wei, Jiann Wu ^a   Huang, Ken Shung ^b   Yarbrough, George G ^c  

^a MDS Pharma Services   (Taiwan)

^b Braingenesis Biotechnology Ltd   (Taiwan)

^c TRH Therapeutics LLC   (United States)

Author keywords

Anti thrombic effect; Bambusae concretio silicea; BNG 1; Bupleuri radix; Ginseng radix; Neuroprotection; Phosphodiesterase inhibition

Indexed keywords

ACETYLSALICYLIC ACID; ADRENALIN; ARACHIDONIC ACID; BNG 1; CHINESE DRUG; DIZOCILPINE; DRUG VEHICLE; INDOMETACIN; ISOPRENALINE; PHOSPHODIESTERASE; PHOSPHODIESTERASE I; PHOSPHODIESTERASE III; PHOSPHODIESTERASE INHIBITOR; PHOSPHODIESTERASE IV; PHOSPHODIESTERASE V; PHOSPHODIESTERASE VI; SODIUM CHLORIDE; SPLEEN EXONUCLEASE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLEEDING TIME; CONTROLLED STUDY; DRUG FORMULATION; DRUG MECHANISM; DRUG SAFETY; MALE; MIDDLE CEREBRAL ARTERY OCCLUSION; NEUROPROTECTION; NONHUMAN; RAT; STROKE; THROMBOCYTE AGGREGATION; THROMBOSIS;

ANIMALS; CEREBROVASCULAR ACCIDENT; DRUGS, CHINESE HERBAL; FEMALE; GUINEA PIGS; MALE; MICE; MICE, INBRED ICR; NEUROPROTECTIVE AGENTS; PANAX; PHOSPHODIESTERASE INHIBITORS; PLATELET AGGREGATION INHIBITORS; RABBITS; RATS; RATS, SPRAGUE-DAWLEY;

EID: 16344376275     PISSN: 0192415X     EISSN: None     Source Type: Journal    
DOI: 10.1142/S0192415X05002667     Document Type: Article

References (18)

1. Baehr, W., M.J. Devlin and M.L. Applebury. Isolation and characterization of cGMP phosphodiesterase from bovine rod outer segments. J. Biol. Chem. 254: 11669-11677, 1979.
2. Bertele, V., A. Falanga, E. Dejana, C. Cerletti and G. De Gaetano. Platelet thromboxane synthetase inhibitors with low dose of aspirin: possible resolution of the "aspirin dilemma." Science 220: 517-519, 1983.
3. Butler, K.D., E.D. Maguire, J.R. Smith, A.A. Turnbull, R.B. Wallis and A.M. White. Prolongation of rat tail bleeding time caused by oral doses of a thromboxane synthetase inhibitor which have little effect upon platelet aggregation. Thromb. Hemost. 47: 46-49, 1982.
4. Cao, X. and J.W. Phillis. α-Phenyl-tert-butyl-nitrone reduced cortical infarct and edema in rats subjected to focal ischemia. Brain Res. 644: 267-272, 1994.
5. Cortijo, J., J. Bou, J. Beleta, I. Cardelús, J. Llenas, E. Morcillo and R.W. Gristwood. Investigation into the role of phosphodiesterase IV in brochorelaxation, including studies with human bronchus. Br. J. Pharmacol. 108: 562-568, 1993.
6. Erjavek, F. and S. Adamic. Cardiotonic and active transport-inhibiting action of some cardiotonic glycosides and ivorine. Arch. Int. Pharmacodyn. 155: 251-261, 1965.
7. Feldman, A.M. and D.M. McNamara. Re-evaluating the role of phosphodiesterase inhibitors in the treatment of cardiovascular disease. Clin. Cardiol. 25: 256-262, 2002.
8. Gillespie, P.G. and J.A. Beavo. Inhibition and stimulation of photoreceptor phosphodiesterases by dipyridamole and M&B 22, 948. Mol. Pharm. 36: 773-781, 1989.
9. Gong, X. and N.J. Sucher. Stroke therapy in traditional Chinese medicine (TCM): Prospects for drug discovery and development. Trends Pharmacol. Sci. 20: 191-198, 1999.
10. Gotoh, F., H. Tohgi and S. Hirai. Cilostazol Stroke Prevention Study: A placebo-controlled double-blind trial for secondary prevention of cerebral infarction. J. Stroke Cerebrovasc. Dis. 9: 147-157, 2000.
11. m phosphodiesterase. Biochem. Biophys. Acta. 429: 485-497, 1976.
12. Johnson, M.P., D.R. McCarty and P.A. Chmielewski. Temporal dependent neuroprotection with propentofylline (HWA285) in a temporary focal ischemia model. Eur. J. Pharmacol. 346: 151-157, 1998.
13. Kishi, Y., S. Ohta, N. Kasuya, S. Sakita, T. Ashikaga and M. Isobe. Ibudilast: A non-selective PDE inhibitor with multiple actions on blood cells and the vascular wall. Cardiovasc. Drug Rev. 19: 215-225, 2001.
14. Lundblad, L.K.A. and C.G.A. Persson. The epithelium and the pharmacology of guinea pig tracheal tone in vitro. Br. J. Pharmacol. 93: 909-917, 1988.
15. Nicholsen, C.D., R.A. Chaliss and M. Shalid. Differential modulation of tissue function and therapeutic potential of selective inhibitors of cyclic nucleotide phosphodiesterase isoenzymes. Trends Pharmacol. Sci. 12: 19-27, 1991.
16. Tamura, A., D.I. Graham, J. McCulloch and G.M. Teasdale. Focal cerebral ischaemia in the rat. Description of technique and early neuropathological consequences following middle cerebral artery occlusion. J. Cereb. Blood Flow Metab. 1: 53-60, 1981.
17. Vas, A., B. Gulyas, Z. Szabo, P. Bonoczk, L. Csiba, B. Kiss, E. Karpati, G. Panczel and Z. Nagy. Clinical and non-clinical investigations using positron emission tomography, near infrared spectroscopy and transcranial Doppler methods on the neuroprotective drug vinpocetin: A summary of evidences. J. Neurol. Sci. 203-204 (C): 259-262, 2002.
18. Zhang, R., Y. Wang, L. Zhang, Z. Zhang, W. Tsang, M. Lu, L. Zhang and M. Chopp. Sildenafil (Viagra) induces neurogenesis and promotes functional recovery stroke in rats. Stroke 33: 2675-2680, 2002.