Dipyridamole inhibits in vitro renal fibroblast proliferation and collagen synthesis

Journal of Laboratory and Clinical Medicine

Volumn 140, Issue 3, 2002, Pages 199-208

  Hewitson, Tim D ^a,b   Tait, Melanie G ^a,b   Kelynack, Kristen J ^a,b   Martic, Marina ^a,b   Becker, Gavin J ^a,b  

^a ROYAL MELBOURNE HOSPITAL   (Australia)

^b UNIVERSITY OF MELBOURNE   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 0036740957     PISSN: 00222143     EISSN: None     Source Type: Journal    
DOI: 10.1067/mlc.2002.126828     Document Type: Article

References (30)

1. 1(III) collagen expression in experimental tubulointerstitial nephritis. Kidney Int 1997;51:926-31.
2. Hewitson TD, Darby IA, Bisucci T, Jones CL, Becker GJ. Evolution of tubulointerstitial fibrosis in experimental renal infection and scarring. J Am Soc Nephrol 1998;9:632-42.
3. Hewitson T, Wu H, Becker G. Interstitial myofibroblasts in experimental renal infection and scarring. Am J Nephrol 1995; I5:411-7.
4. Wardle EN. Can pentoxifylline prevent renal disease? Renal Failure 1998;30:437-40.
5. van Bockxmeer FM, Martin CE, Constable IJ. Effect of cyclic AMP on cellular contractility and DNA synthesis in chorioretinal fibroblasts maintained in collagen matrices. Exp Cell Res 1984; 155:413-21.
6. Hewitson TD, Martic M, Kelynack KJ, Pedagogos E, Becker GJ. Pentoxifylline reduces in vitro renal myofibroblast proliferation and collagen secretion. Am J Nephrol 2000;20:82-8.
7. Strutz F, Heeg M, Kochsiek T, Siemers G, Zeisberg M, Müller GA. Effects of pentoxifylline, pentifylline and gamma-interferon on proliferation, differentiation, and matrix synthesis of human renal fibroblasts. Nephrol Dial Transplant 2000;15:1535-46.
8. Camara S, de la Cruz JP, Frutos MA, Sanchez P, Lopez de Novales E, Sanchez E, et al. Effects of dipyridamole on the short-term evolution of glomerulonephritis. Nephron 1991;58: 13-6.
9. Hung KY, Chen CT, Yen CJ, Lee PH, Tsai TJ, Hsieh BS. Dipyridamole inhibits PDGF-stimulated human peritoneal mesothelial cell proliferation. Kidney Int 2001;60:872-81.
10. Tsai TJ, Lin RH, Chang CC, Chen YM, Chen CF, Ko FN, et al. Vasodilator agents modulate rat glomerular mesangial cell growth and collagen synthesis. Nephron 1995;70:91-9.
11. Himmelfarb J, Couper L. Dipyridamole inhibits PDGF- and bFGF-induced vascular smooth muscle cell proliferation. Kidney Int 1997;52:1671-7.
12. Hung KY, Chen CT, Huang JW, Lee PH, Tsai TJ, Hsieh BS. Dipyridamole inhibits TGFbeta-induced collagen gene expression in human peritoneal mesothelial cells. Kidney Int 2001;60: 1249-57.
13. Rajah SM, Crow MJ, Penny AF, Ahmad R, Watson DA. The effect of dipyridamole on platelet function: correlation with blood levels in man. J Clin Pharmacol 1977;4:129-33.
14. Rodemann HP, Müller GA. Abnormal growth and clonal proliferation of fibroblasts derived from kidneys with interstitial fibrosis. Proc Soc Exp Biol Med 1990;195:57-63.
15. Sharma AK, Mauer SM, Kim Y, Michael AF. Interstitial fibrosis in obstructive nephropathy. Kidney Int 1993;44:774-88.
16. Nakatsukasa H, Nagy P, Evarts RP, Hsia CC, Marsden E, Thorgeirsson SS. Cellular distribution of transforming growth factor β1 and procollagen types I, III, and IV transcripts in carbon tetrachloride-induced rat liver fibrosis. J Clin Invest 1990;85:1833-43.
17. Kelynack KJ, Hewitson TD, Nicholls KM, Darby IA, Becker GJ. Human renal fibroblast contraction of collagen I lattices is an integrin mediated process. Nephrol Dial Transplant 2000;15: 1766-72.
18. Nakatsukasa H, Evarts RP, Hsia CC, Thorgeirsson SS. Transforming growth factor-beta 1 and type I procollagen transcripts during regeneration and early fibrosis of rat liver. Lab Invest 2000;63:171-80.
19. Fullerton MJ, Funder JW. Aldosterone and cardiac fibrosis: in vitro studies. Cardiovasc Res 1994;28:1863-7.
20. Haralambous-Gasser A, Chan D, Walker RG, Powell HR, Becker GJ, Jones CL. Collagen studies in newborn rat kidneys with incomplete ureteric obstruction. Kidney Int 1993;44:593-605.
21. Pursiheimo JP, Jalkanen M, Tasken K, Jaakkola P. Involvment of protein kinase A in fibroblast growth facto-2-activated transcription. Proc Natl Acad Sci U S A 2000;97:168-73.
22. Glass DB, Cheng HC, Kemp BE, Walsh DA. Differential and common recognition of the catalytic sites of the cGMP-dependent and cAMP-dependent protein kinases by inhibitory peptides derived from the heat-stable inhibitor protein. J Biol Chem 1986;261:12166-71.
23. Hah HJ, Choi HJ, Park SH. High glucose inhibits glucose uptake in renal proximal tubule cells by oxidative stress and protein kinase C. Kidney Int 2000;57:918-26.
24. Yamaguchi T, Pelling JC, Ramaswamy NT, Eppler JW, Wallace DP, Nagao S, et al. cAMP stimulates the in vitro proliferation of renal cyst epithelial cells by activating the extracellular signal-regulated kinase pathway. Kidney Int 2000;57:1460-71.
25. Kreisberg JI, Karnovsky MJ. Glomerular cells in culture. Kidney Int 1983;23:439-47.
26. Lewis MP, Fine LG, Norman JT. Pexicrine effects of basement membrane components on paracrine signaling by renal tubular cells. Kidney Int 1996;49:48-58.
27. Graves L, Lawrence JC. Insulin, growth factors and cAMP: antagonism in the signal transduction pathways. Trends Endocrinol Metab 1996;7:43-50.
28. Dousa TP. Cyclic-3′,5′-nucleotide phosphodiesterase isoenzymes in cell biology and pathophysiology of the kidney. Kidney Int 1999;55:29-62.
29. Miyazaki M, Wahid S. Bai L, Namba M. Effects of intracellular cyclic AMP and cyclic GMP levels on DNA synthesis of young-adult rat hepatocytes in primary culture. Exp Cell Res 1992;200:404-9.
30. Iimura O, Kusano E, Amemiya M, Muto S, Ikeda U, Shimada K, et al. Dipyridamole enhances interleukin-1β stimulated nitric oxide production by cultured rat vascular smooth muscle cells. Eur J Clin Pharmacol 1996;296:319-26.