Intraocular injection of dibutyryl cyclic AMP promotes axon regeneration in rat optic nerve

Experimental Neurology

Volumn 186, Issue 2, 2004, Pages 124-133

  Monsul, Nicholas T ^a   Geisendorfer, Abram R ^a   Han, Paul J ^a   Banik, Rudrani ^a   Pease, Mary Ellen ^a   Skolasky Jr , Richard L ^a   Hoffman, Paul N ^a,b  

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b JOHNS HOPKINS HOSPITAL   (United States)

Author keywords

Axon elongation; Axon regeneration; Axotomy; CNS regeneration; Dibutyryl cyclic AMP; Optic nerve injury; Rat optic nerve; Retinal ganglion cell

Indexed keywords

BUCLADESINE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CELL DEATH; CELL ELONGATION; CELL SURVIVAL; CONTROLLED STUDY; FEMALE; GENE EXPRESSION REGULATION; NERVE FIBER REGENERATION; NEUROTROPISM; NONHUMAN; OPTIC NERVE; OPTIC NERVE INJURY; PRIORITY JOURNAL; RAT; REMYELINIZATION; RETINA GANGLION CELL; VISION;

ANIMALS; AXONS; BUCLADESINE; CELL COUNT; CELL SURVIVAL; CHOLERA TOXIN; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; FLUORESCENT DYES; HORSERADISH PEROXIDASE; NERVE CRUSH; NERVE REGENERATION; OPTIC NERVE; ORBIT; RATS; RATS, SPRAGUE-DAWLEY; RETINAL GANGLION CELLS; STILBAMIDINES; TIME FACTORS;

EID: 1542408477     PISSN: 00144886     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0014-4886(03)00311-X     Document Type: Article

References (38)

1. Andersen P.L., Webber C.A., Kimura K.A., Schreyer D.J. Cyclic AMP prevents an increase in GAP-43 but promotes neurite growth in cultured adult rat dorsal root ganglion neurons. Exp. Neurol. 166:2000;153-165.
2. Berry M., Carlile J., Hunter A. Peripheral nerve explants grafted into the vitreous body of the eye promote the regeneration of retinal ganglion cell axons severed in the optic nerve. J. Neurocytol. 25:1996;147-170.
3. Berry M., Carlile J., Hunter A., Tsang W., Rosustrel P., Sievers J. Optic nerve regeneration after intravitreal peripheral nerve implants: trajectories of axons regrowing through the optic chiasm into the optic tracts. J. Neurocytol. 28:1999;721-741.
4. Bomze H.M., Bulsara K.R., Iskandar B.J., Caroni P., Skene J.H. Spinal axon regeneration evoked by replacing two growth cone proteins in adult neurons. Nat. Neurosci. 4:2001;38-43.
5. Cai D., Shen Y., De Bellard M., Tang S., Filbin M.T. Prior exposure to neurotrophins blocks inhibition of axonal regeneration by MAG and myelin via a cAMP-dependent mechanism. Neuron. 22:1999;89-101.
6. Cai D., Qui J., Cao Z., McAtee M., Bregman B.S., Filbin M.T. Neuronal cyclic AMP controls the developmental loss in ability of axons to regenerate. J. Neurosci. 21:2001;4731-4739.
7. Chen M.S., Huber A.B., Van Der Haar M.E., Frank M., Schnell L., Spillmann A.A., Christ F., Schwab M.E. Nogo-A is a myelin-associated neurite outgrowth inhibitor and an antigen for monoclonal antibody IN-1. Nature. 403:2000;434-439.
8. Finkbeiner S., Tavazoie S.F., Maloratsky A., Jacobs K.M., Harris K.M., Greenberg M.E. CREB: a major mediator of neuronal neurotrophin responses. Neuron. 19:1997;1031-1047.
9. Fischer D., Pavlidis M., Thanos S. Cataractogenic lens injury prevents traumatic ganglion cell death and promotes axonal regeneration both in vivo and in culture. Investig. Ophthalmol. Vis. Sci. 41:2000;3943-3954.
10. Fischer D., Heiduschka P., Thanos S. Lens-injury-stimulated axonal regeneration throughout the optic pathway of adult rats. Exp. Neurol. 172:2001;257-272.
11. Goldberg J.L., Espinosa J.S., Xu Y., Davidson N., Kovacs G.T., Barres B.A. Retinal ganglion cells do not extend axons by default. Promotion by neurotrophic signaling and electrical activity. Neuron. 33:2002;689-702.
12. Grewal S.S., Horgan A.M., York R.D., Withers G.S., Banker G.A., Stork P.J. Neuronal calcium activates a Rap1 and B-Raf signaling pathway via the cyclic adenosine monophosphate-dependent protein kinase. J. Biol. Chem. 275:2000;3722-3728.
13. Hoffman P.N. Expression of GAP-43, a rapidly transported growth-associated protein, and class II β-tubulin, a slowly transported cytoskeletal protein, are coordinated in regenerating neurons. J. Neurosci. 9:1989;893-897.
14. Hoffman P.N., Cleveland D.W. Neurofilament and tubulin expression recapitulates the developmental program during axonal regeneration: induction of a specific β-tubulin isotype. Proc. Natl. Acad. Sci. U. S. A. 85:1988;4530-4533.
15. Lang P., Gesbert F., Delespine-Carmagnat M., Stancou R., Pouchelet M., Bertoglio J. Protein kinase A phosphorylation of RhoA mediates the morphological and functional effects of cyclic AMP in cytotoxic lymphocytes. EMBO J. 15:1996;510-519.
16. Lehmann M., Fournier A., Selles-Navarro I., Dergham P., Sebok A., Leclerc N., Tigyi G., McKerracher L. Inactivation of Rho signaling pathway promotes CNS axon regeneration. J. Neurosci. 19:1999;7537-7547.
17. Leon S., Yin Y., Nguyen J., Irwin N., Benowitz L.I. Lens injury stimulates axon regeneration in the mature rat optic nerve. J. Neurosci. 20:2000;4615-4626.
18. Liuzzi F.J., Lasek R.J. Astrocytes block axonal regeneration in mammals by activating the physiological stop pathway. Science. 237:1987;642-645.
19. Lucius R., Gallinat S., Rosenstiel P., Herdegen T., Sievers J., Unger T. The angiotensin II type 2 (AT2) receptor promotes axonal regeneration in the optic nerve of adult rats. J. Exp. Med. 188:1998;661-670.
20. Mansour-Robaey S., Clarke D.B., Wang Y.C., Bray G.M., Aguayo A.J. Effects of ocular injury and administration of brain-derived neurotrophic factor on survival and regrowth of axotomized retinal ganglion cells. Proc. Natl. Acad. Sci. U. S. A. 91:1994;1632-1636.
21. McKerracher L., David S., Jackson D.L., Kottis V., Dunn R.J., Braun P.E. Identification of myelin-associated glycoprotein as a major myelin-derived inhibitor of neurite growth. Neuron. 13:1994;805-811.
22. McQuarrie I.G., Grafstein B. Effect of acetoxycycloheximide and dibutyryladenosine cyclic 3′: 5′-monophosphate on axonal regeneration in the goldfish optic nerve. Brain Res. 279:1983;377-381.
23. McQuarrie I.G., Grafstein B., Gershon M.D. Axonal regeneration in the rat sciatic nerve: effect of a conditioning lesion and of dbcAMP. Brain Res. 132:1977;443-453.
24. Meyer-Franke A., Kaplan M.R., Pfrieger F.W., Barres B.A. Characterization of the signaling interactions that promote the survival and growth of developing retinal ganglion cells in culture. Neuron. 15:1995;805-819.
25. Meyer-Franke A., Wilkinson G.A., Kruttgen A., Hu M., Munro E., Hanson M.G. Jr., Reichardt L.F., Barres B.A. Depolarization and cAMP elevation rapidly recruit TrkB to the plasma membrane of CNS neurons. Neuron. 21:1998;681-693.
26. Mukhopadhyay G., Doherty P., Walsh F.S., Crocker P.R., Filbin M.T. A novel role for myelin-associated glycoprotein as an inhibitor of axonal regeneration. Neuron. 13:1994;757-767.
27. Neumann S., Bradke F., Tessier-Lavigne M., Basbaum A.I. Regeneration of sensory axons within the injured spinal cord induced by intraganglionic cAMP elevation. Neuron. 34:2002;885-893.
28. Qiu J., Cai D., McAtee M., Hoffman P.N., Bregman B.S., Filbin M.T. Spinal axon regeneration induced by elevation of cyclic AMP. Neuron. 34:2002;895-903.
29. Ramon y Cajal S. Degeneration and Regeneration of the Nervous System. 1928;Oxford Univ. Press, London.
30. Richardson P.M., Issa V.M.K. Peripheral injury enhances central regeneration of primary sensory neurones. Nature. 309:1984;791-793.
31. Richardson P.M., Verge V.M.K. Axonal regeneration in dorsal spinal roots is accelerated by peripheral axon transection. Brain Res. 411:1987;406-408.
32. Rudge J.S., Silver J. Inhibition of neurite outgrowth on astroglial scars in vitro. J. Neurosci. 10:1990;3594-3603.
33. Selles-Navarro I., Ellezam B., Fajardo R., Latour M., McKerracher L. Retinal ganglion cell and nonneuronal cell responses to a microcrush lesion of adult rat optic nerve. Exp. Neurol. 167:2001;282-289.
34. Smith D.S., Skene J.H.P. A transcription-dependent switch controls competence of adult neurons for distinct modes of axon growth. J. Neurosci. 17:1997;646-658.
35. Song H., Ming G., He Z., Lehmann M., McKerracher L., Tessier-Lavigne M., Poo M. Conversion of neuronal growth cone responses from repulsion to attraction by cyclic nucleotides. Science. 281:1998;1515-1518.
36. Tsukahara Y., Maurice D.M. Local pressure effects on vitreous kinetics. Exp. Eye Res. 60:1995;563-573.
37. Wang K.C., Koprivica V., Kim J.A., Sivasankaran R., Guo Y., Neve R.L., He Z. Oligodendrocyte-myelin glycoprotein is a Nogo receptor ligand that inhibits neurite outgrowth. Nature. 417:2002;941-944.
38. West A.E., Chen W.G., Dalva M.B., Dolmetsch R.E., Kornhauser J.M., Shaywitz A.J., Takasu M.A., Tao X., Greenberg M.E. Calcium regulation of neuronal gene expression. Proc. Natl. Acad. Sci. U. S. A. 98:2001;11024-11031.