Regulatory network of inflammation downstream of proteinase-activated receptors

BMC Physiology

Volumn 7, Issue , 2007, Pages

  Saban, Ricardo ^a   D'Andrea, Michael R ^b   Andrade Gordon, Patricia ^b   Derian, Claudia K ^b   Dozmorov, Igor ^c   Ihnat, Michael A ^a   Hurst, Robert E ^a   Simpson, Cindy ^a   Saban, Marcia R ^a  

^a UNIVERSITY OF OKLAHOMA COLLEGE OF MEDICINE   (United States)

^b J/J Pharmaceut Res/Development   (United States)

^c OKLAHOMA MEDICAL RESEARCH FOUNDATION   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

MITOGEN ACTIVATED PROTEIN KINASE P38; PROTEINASE ACTIVATED RECEPTOR; ANTIGEN; CALCIUM; LIPOPOLYSACCHARIDE; PHOSPHOLIPASE A; PROTEINASE ACTIVATED RECEPTOR 1; SUBSTANCE P;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL ACTIVATION; COMPARATIVE STUDY; COMPUTER MODEL; CONTROLLED STUDY; CYTOKINE PRODUCTION; DNA MICROARRAY; GENE EXPRESSION; INFLAMMATION; MOLECULAR MECHANICS; MOUSE; NONHUMAN; QUANTITATIVE ANALYSIS; WILD TYPE; ANIMAL; BLADDER; C57BL MOUSE; CELL FRACTIONATION; CHEMICALLY INDUCED DISORDER; CHROMATIN; CYSTITIS; FEMALE; GENE EXPRESSION REGULATION; GENETICS; GENOME; IMMUNOLOGY; IMMUNOPRECIPITATION; METABOLISM; METHODOLOGY; MOUSE MUTANT; POLYMERASE CHAIN REACTION;

ANIMALS; ANTIGENS; CALCIUM; CHROMATIN; CYSTITIS; FEMALE; GENE EXPRESSION; GENE EXPRESSION REGULATION; GENOME; IMMUNOPRECIPITATION; LIPOPOLYSACCHARIDES; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; PHOSPHOLIPASES A; POLYMERASE CHAIN REACTION; RECEPTOR, PAR-1; SUBCELLULAR FRACTIONS; SUBSTANCE P; URINARY BLADDER;

EID: 34247323803     PISSN: None     EISSN: 14726793     Source Type: Journal    
DOI: 10.1186/1472-6793-7-3     Document Type: Article

References (98)

1. The relationship between the systemic inflammatory response, tumour proliferative activity, T-lymphocytic infiltration and COX-2 expression and survival in patients with transitional cell carcinoma of the urinary bladder. M Hilmy R Campbell JM Bartlett AM McNicol MA Underwood DC McMillan, Br J Cancer 2006 95 9 1234 1238 10.1038/sj.bjc.6603415 17024120
2. Prognostic role of the tumor-associated tissue inflammatory reaction in transitional bladder cell carcinoma. T Cai G Nesi V Boddi S Mazzoli M Dal Canto R Bartoletti, Oncol Rep 2006 16 2 329 334 16820911
3. The pharmacogenetic impact of inflammatory genes on bladder cancer recurrence. J Gu HB Grossman CP Dinney X Wu, Pharmacogenomics 2005 6 6 575 584 10.2217/14622416.6.6.575 16142998
4. Intense inflammation in bladder carcinoma is associated with angiogenesis and indicates good prognosis. BV Offersen MM Knap N Marcussen MR Horsman S Hamilton-Dutoit J Overgaard, Br J Cancer 2002 87 12 1422 1430 10.1038/sj.bjc.6600615 12454772
5. Lack of neurokinin-1 receptor expression affects tissue mast cell numbers but not their spatial relationship with nerves. MR D'Andrea MR Saban NP Gerard BK Wershil R Saban, Am J Physiol Regul Integr Comp Physiol 2005 288 2 R491 500 15458971
6. Mast cells mediate substance P-induced bladder inflammation through an NK(1) receptor-independent mechanism. R Saban NP Gerard MR Saban NB Nguyen DJ DeBoer BK Wershil, Am J Physiol Renal Physiol 2002 283 4 F616 629 12217852
7. Mast cell regulation of inflammation and gene expression during antigen-induced bladder inflammation in mice. R Saban MR Saban NB Nguyen TG Hammond BK Wershil, Physiol Genomics 2001 7 1 35 43 11595790
8. Elevated tryptase, nerve growth factor, neurotrophin-3 and glial cell line-derived neurotrophic factor levels in the urine of interstitial cystitis and bladder cancer patients. AJ Okragly AL Niles R Saban D Schmidt RL Hoffman TF Warner TD Moon DT Uehling M Haak-Frendscho, J Urol 1999 161 2 438 441 discussion 441-432. 10.1016/S0022-5347(01)61915-3 9915421
9. A role for proteinase-activated receptor-1 in inflammatory bowel diseases. N Vergnolle L Cellars A Mencarelli G Rizzo S Swaminathan P Beck M Steinhoff P Andrade-Gordon NW Bunnett MD Hollenberg, Journal of Clinical Investigation 2004 114 10 1444 15545995 10.1172/JCI200421689
10. Proteinase-activated receptor-2-induced colonic inflammation in mice: possible involvement of afferent neurons, nitric oxide, and paracellular permeability. N Cenac R Garcia-Villar L Ferrier M Larauche N Vergnolle NW Bunnett AM Coelho J Fioramonti L Bueno, J Immunol 2003 170 8 4296 4300 12682265
11. Protease-activated receptor 2 mediates eosinophil infiltration and hyperreactivity in allergic inflammation of the airway. F Schmidlin S Amadesi K Dabbagh DE Lewis P Knott NW Bunnett PR Gater P Geppetti C Bertrand ME Stevens, J Immunol 2002 169 9 5315 5321 12391252
12. Agonists of proteinase-activated receptor 2 induce inflammation by a neurogenic mechanism. M Steinhoff N Vergnolle SH Young M Tognetto S Amadesi HS Ennes M Trevisani MD Hollenberg JL Wallace GH Caughey, Nat Med 2000 6 2 151 158 10.1038/72247 10655102
13. Protease-activated receptors: contribution to physiology and disease. VS Ossovskaya NW Bunnett, Physiol Rev 2004 84 2 579 621 10.1152/physrev.00028.2003 15044683
14. Protease-activated receptor 2 sensitizes the capsaicin receptor transient receptor potential vanilloid receptor 1 to induce hyperalgesia. S Amadesi J Nie N Vergnolle GS Cottrell EF Grady M Trevisani C Manni P Geppetti JA McRoberts H Ennes, J Neurosci 2004 24 18 4300 4312 10.1523/JNEUROSCI.5679-03.2004 15128844
15. Mast cell tryptase and proteinase-activated receptor 2 induce hyperexcitability of guinea pig submucosal neurons. DE Reed C Barajas-Lopez G Cottrell S Velazquez-Rocha O Dery EF Grady NW Bunnett S Vanner, J Physiol 2003 10.1113/jphysiol.2002.032011.
16. Protease-activated receptors in inflammation, neuronal signaling and pain. N Vergnolle JL Wallace NW Bunnett MD Hollenberg, Trends Pharmacol Sci 2001 22 3 146 152 10.1016/S0165-6147(00)01634-5 11239578
17. Proteinase-activated receptor-2 and hyperalgesia: A novel pain pathway. N Vergnolle NW Bunnett KA Sharkey V Brussee SJ Compton EF Grady G Cirino N Gerard AI Basbaum P Andrade-Gordon, Nat Med 2001 7 7 821 826 10.1038/89945 11433347
18. International Union of Pharmacology. XXVIII. Proteinase-Activated Receptors. D Hollenberg S Compton, Pharmacol Reviews 2002 54 203 217 10.1124/pr.54.2.203
19. Review article: proteinase-activated receptors - novel signals for gastrointestinal pathophysiology. N Vergnolle, Aliment Pharmacol Ther 2000 14 3 257 266 10.1046/j.1365-2036.2000.00690.x 10735917
20. Gene expression profiling of mouse bladder inflammatory responses to LPS, substance P, and antigen-stimulation. MR Saban NB Nguyen TG Hammond R Saban, Am J Pathol 2002 160 6 2095 2110 12057914
21. Gene expression profiling of inflammatory bladder disorders. MR Saban NB Nguyen RE Hurst R Saban, Expert Rev Mol Diagn 2003 3 2 217 235 10.1586/14737159.3.2.217 12647997
22. LPS-sensory peptide communication in experimental cystitis. MR Saban R Saban TG Hammond M Haak-Frendscho H Steinberg MW Tengowski DE Bjorling, Am J Physiol Renal Physiol 2002 282 2 F202 210 11788433
23. Mandatory Role of Proteinase-Activated Receptor 1 in Experimental Bladder Inflammation. R Saban MR D'Andrea P Andrade-Gordon C Derian I Dozmorov MA Ihnat RE Hurst C Simpson MR Saban, BMC Physiol 2007 7 4
24. Expression of protease-activated receptor-1, -2, -3, and -4 in control and experimentally inflamed mouse bladder. MR D'Andrea MR Saban NB Nguyen P Andrade-Gordon R Saban, Am J Pathol 2003 162 3 907 923 12598324
25. Up-regulation of protease activated receptors in bladder after cyclophosphamide induced cystitis and colocalization with capsaicin receptor (VR1) in bladder nerve fibers. A Dattilio MA Vizzard, J Urol 2005 173 2 635 639 10.1097/01.ju.0000143191.55468.1d 15643279
26. Proteinase-Activated Receptors: Transducers of Proteinase-Mediated Signaling in Inflammation and Immune Response. M Steinhoff J Buddenkotte V Shpacovitch A Rattenholl C Moormann N Vergnolle TA Luger MD Hollenberg, Endocr Rev 2005 26 1 1 43 10.1210/er.2003-0025 15689571
27. http://www.ingenuity.com
28. A network-based analysis of systemic inflammation in humans. SE Calvano W Xiao DR Richards RM Felciano HV Baker RJ Cho RO Chen BH Brownstein JP Cobb SK Tschoeke, Nature 2005 437 7061 1032 1037 10.1038/nature03985 16136080
29. website. http://www.ingenuity.com/
30. Protease-activated receptor stimulation activates a Ca2+-independent phospholipase A2 in bladder microvascular endothelial cells. A Rickard C Portell PJ Kell SM Vinson J McHowat, Am J Physiol Renal Physiol 2005 288 4 F714 721 10.1152/ajprenal.00288.2004 15561975
31. Phospholipid metabolite production in human urothelial cells after protease-activated receptor cleavage. A Rickard J McHowat, Am J Physiol Renal Physiol 2002 283 5 F944 951 12372769
32. Stimulation of protease activated receptors on RT4 cells mediates arachidonic acid release via Ca2+ independent phospholipase A2. J McHowat MH Creer A Rickard, J Urol 2001 165 6 Pt 1 2063 2067 11371929
33. Possible involvement of Ca2+-independent phospholipase A2 in protease-activated receptor-2-mediated contraction of rat urinary bladder. Y Kubota T Nakahara A Mitani T Maruko M Saito K Sakamoto K Ishii, Naunyn Schmiedebergs Arch Pharmacol 2003 367 6 588 591 10.1007/s00210-003-0753-0 12750876
34. Protease-activated receptors: how proteases signal to cells to cause inflammation and pain. NW Bunnett, Semin Thromb Hemost 2006 32 Suppl 1 39 48 10.1055/s-2006-939553 16673265
35. Proteinase-activated receptors, targets for kallikrein signaling. K Oikonomopoulou KK Hansen M Saifeddine I Tea M Blaber SI Blaber I Scarisbrick P Andrade-Gordon GS Cottrell NW Bunnett, J Biol Chem 2006 281 43 32095 32112 10.1074/jbc.M513138200 16885167
36. Integrative control of the lower urinary tract: preclinical perspective. WC de Groat, Br J Pharmacol 2006 147 Suppl 2 S25 40 10.1038/sj.bjp.0706604 16465182
37. Proteinase-activated receptors: novel mechanisms of signaling by serine proteases. O Dery CU Corvera M Steinhoff NW Bunnett, Am J Physiol 1998 274 6 Pt 1 C1429 1452 9696685
38. The inflammatory and normal transcriptome of mouse bladder detrusor and mucosa. MR Saban HL Hellmich M Turner NB Nguyen R Vadigepalli DW Dyer RE Hurst M Centola R Saban, BMC Physiol 2006 6 1 1 16420690 10.1186/1472-6793-6-1
39. Connective molecular pathways of experimental bladder inflammation. I Dozmorov MR Saban N Knowlton M Centola R Saban, Physiol Genomics 2003 15 3 209 222 12966137
40. Neurokinin 1 receptors and neprilysin modulation of mouse bladder gene regulation. I Dozmorov MR Saban NP Gerard B Lu NB Nguyen M Centola R Saban, Physiol Genomics 2003 12 3 239 250 12499446
41. Time course of LPS-induced gene expression in a mouse model of genitourinary inflammation. MR Saban H Hellmich NB Nguyen J Winston TG Hammond R Saban, Physiol Genomics 2001 5 3 147 160 11285368
42. Multiple pathways of cell invasion are regulated by multiple families of serine proteases. M Del Rosso G Fibbi M Pucci S D'Alessio A Del Rosso L Magnelli V Chiarugi, Clin Exp Metastasis 2002 19 3 193 207 10.1023/A:1015531321445 12067200
43. von Hippel-Lindau tumor suppressor protein stimulation by thrombin involves RhoA activation. S Turcotte RR Desrosiers G Brand R Beliveau, Int J Cancer 2004 112 5 777 786 10.1002/ijc.20468 15386385
44. Protease-activated receptors (PAR1 and PAR2) contribute to tumor cell motility and metastasis. X Shi B Gangadharan LF Brass W Ruf BM Mueller, Mol Cancer Res 2004 2 7 395 402 15280447
45. Thrombin receptor expression is upregulated in prostate cancer. V Kaushal M Kohli RA Dennis ER Siegel WW Chiles P Mukunyadzi, Prostate 2006 66 3 273 282 10.1002/pros.20326 16245281
46. Protease-activated receptor 1: a role in prostate cancer metastasis. TC Yuan MF Lin, Clin Prostate Cancer 2004 3 3 189 191 15634362
47. Amplification of MMP-2 and MMP-9 production by prostate cancer cell lines via activation of protease-activated receptors. SR Wilson S Gallagher K Warpeha SJ Hawthorne, Prostate 2004 60 2 168 174 10.1002/pros.20047 15162383
48. An antiproliferative factor from interstitial cystitis patients is a frizzled 8 protein-related sialoglycopeptide. SK Keay Z Szekely TP Conrads TD Veenstra JJ Barchi Jr CO Zhang KR Koch CJ Michejda, Proc Natl Acad Sci USA 2004 101 32 11803 11808 15282374 10.1073/pnas.0404509101
49. Changes in human bladder epithelial cell gene expression associated with interstitial cystitis or antiproliferative factor treatment. S Keay F Seillier-Moiseiwitsch CO Zhang TC Chai J Zhang, Physiol Genomics 2003 14 2 107 115 12847144
50. Is the CD200/CD200 receptor interaction more than just a myeloid cell inhibitory signal? K Minas J Liversidge, Crit Rev Immunol 2006 26 3 213 230 16928187
51. Signal transduction. Decoding NF-kappaB signaling. AY Ting D Endy, Science 2002 298 5596 1189 1190 10.1126/science.1079331 12424362
52. Oscillations in NF-kappaB signaling control the dynamics of gene expression. DE Nelson AE Ihekwaba M Elliott JR Johnson CA Gibney BE Foreman G Nelson V See CA Horton DG Spiller, Science 2004 306 5696 704 708 10.1126/science.1099962 15499023
53. Anti-CD63 antibodies suppress IgE-dependent allergic reactions in vitro and in vivo. S Kraft T Fleming JM Billingsley SY Lin MH Jouvin P Storz JP Kinet, J Exp Med 2005 201 3 385 396 10.1084/jem.20042085 15684326
54. Allograft inflammatory factor-1 (AIF-1) is crucial for the survival and pro-inflammatory activity of macrophages. ZF Yang DW Ho CK Lau CT Lam CT Lum RT Poon ST Fan, Int Immunol 2005 17 11 1391 1397 10.1093/intimm/dxh316 16157606
55. Structural basis fortetraspanin functions as revealed by the cryo-EM structure of uroplakin complexes at 6-A resolution. G Min H Wang TT Sun XP Kong, J Cell Biol 2006 173 6 975 983 10.1083/jcb.200602086 16785325
56. Origin of the tetraspanin uroplakins and their co-evolution with associated proteins: Implications for uroplakin structure and function. A Garcia-Espana PJ Chung X Zhao A Lee A Pellicer J Yu TT Sun R Desalle, Mol Phylogenet Evol 2006 16814572
57. Assembly of urothelial plaques: tetraspanin function in membrane protein trafficking. CC Hu FX Liang G Zhou L Tu CH Tang J Zhou G Kreibich TT Sun, Mol Biol Cell 2005 16 9 3937 3950 15958488 10.1091/mbc.E05-02-0136
58. What determines differentiation of urothelial umbrella cells? P Veranic R Romih K Jezernik, Eur J Cell Biol 2004 83 1 27 34 10.1078/0171-9335-00351 15085953
59. Bladder permeability barrier: recovery from selective injury of surface epithelial cells. J Lavelle S Meyers R Ramage S Bastacky D Doty G Apodaca ML Zeidel, Am J Physiol Renal Physiol 2002 283 2 F242 253 12110507
60. Altered phenotype of cultured urothelial and other stratified epithelial cells: implications for wound healing. TT Sun, Am J Physiol Renal Physiol 2006 291 1 F9 21 10.1152/ajprenal.00035.2006 16609152
61. Distinct glycan structures of uroplakins Ia and Ib: structural basis for the selective binding of FimH adhesin to uroplakin Ia. B Xie G Zhou SY Chan E Shapiro XP Kong XR Wu TT Sun CE Costello, J Biol Chem 2006 281 21 14644 14653 10.1074/jbc.M600877200 16567801
62. Disruption of guinea pig urinary bladder permeability barrier in noninfectious cystitis. JP Lavelle G Apodaca SA Meyers WG Ruiz ML Zeidel, Am J Physiol 1998 274 1 Pt 2 F205 214 9458841
63. Angiogenic and lymphangiogenic microvessel density in breast carcinoma: correlation with clinicopathologic parameters and VEGF-family gene expression. WW Choi MM Lewis D Lawson Q Yin-Goen GG Birdsong GA Cotsonis C Cohen AN Young, Mod Pathol 2004 15254555
64. Requirement of the enzymatic and signaling activities of plasmin for phorbol-ester-induced scattering of colon cancer cells. VM Diaz M Hurtado EJ Kort M Resnati F Blasi T Thomson R Paciucci, Exp Cell Res 2006 312 12 2203 2213 10.1016/j.yexcr.2006.03.017 16631161
65. Urokinase-Receptor (u-PAR): An Essential Player in Multiple Games of Cancer: A Review on Its Role in Tumor Progression, Invasion, Metastasis, Proliferation/Dormancy, Clinical Outcome and Minimal Residual Disease. S Laufs J Schumacher H Allgayer, Cell Cycle 2006 5 16 16931909
66. Antiinflammatory effects of dexamethasone are partly dependent on induction of dual specificity phosphatase 1. SM Abraham T Lawrence A Kleiman P Warden M Medghalchi J Tuckermann J Saklatvala AR Clark, J Exp Med 2006 203 8 1883 1889 10.1084/jem.20060336 16880258
67. Positive regulation of immune cell function and inflammatory responses by phosphatase PAC-1. KL Jeffrey T Brummer MS Rolph SM Liu NA Callejas RJ Grumont C Gillieron F Mackay S Grey M Camps, Nat Immunol 2006 7 3 274 283 10.1038/ni1310 16474395
68. Dual specificity phosphatase 1 (DUSP1) regulates a subset of LPS-induced genes and protects mice from lethal endotoxin shock. M Hammer J Mages H Dietrich A Servatius N Howells AC Cato R Lang, J Exp Med 2006 203 1 15 20 10.1084/jem.20051753 16380512
69. Relative contribution of G-protein-coupled pathways to protease-activated receptor-mediated Akt phosphorylation in platelets. S Kim J Jin SP Kunapuli, Blood 2006 107 3 947 954 10.1182/blood-2005-07-3040 16223779
70. Characterization and functional activity of thrombin receptors in the human lens. C James DJ Collison G Duncan, Invest Ophthalmol Vis Sci 2005 46 3 925 932 10.1167/iovs.04-0523 15728549
71. Akt activation in platelets depends on Gi signaling pathways. S Kim J Jin SP Kunapuli, J Biol Chem 2004 279 6 4186 4195 10.1074/jbc.M306162200 14623889
72. Arf6-independent GPI-anchored protein-enriched early endosomal compartments fuse with sorting endosomes via a Rab5/phosphatidylinositol-3'- kinase-dependent machinery. M Kalia S Kumari R Chadda MM Hill RG Parton S Mayor, Mol Biol Cell 2006 17 8 3689 3704 16760436 10.1091/mbc.E05-10-0980
73. Protease-activated receptor 2: activation, signalling and function. GS Cottrell S Amadesi F Schmidlin N Bunnett, Biochem Soc Trans 2003 31 Pt 6 1191 1197 14641024
74. Intracellular trafficking of hormone receptors. Z Gaborik L Hunyady, Trends Endocrinol Metab 2004 15 6 286 293 10.1016/j.tem.2004.06.009 15358282
75. TNF-alpha increases ubiquitin-conjugating activity in skeletal muscle by up-regulating UbcH2/E220k. YP Li SH Lecker Y Chen ID Waddell AL Goldberg MB Reid, Faseb J 2003 17 9 1048 1057 10.1096/fj.02-0759com 12773487
76. Ubiquitin and endocytic protein sorting. S Urbe, Essays in biochemistry 2005 41 81 98 16250899
77. Rab5a and rab11a mediate agonist-induced trafficking of protease-activated receptor 2. D Roosterman F Schmidlin NW Bunnett, Am J Physiol Cell Physiol 2003 284 5 C1319 1329 12540381
78. A role for the Rab6A' GTPase in the inactivation of the Mad2-spindle checkpoint. S Miserey-Lenkei A Couedel-Courteille E Del Nery S Bardin M Piel V Racine JB Sibarita F Perez M Bornens B Goud, Embo J 2006 25 2 278 289 16395330 10.1038/sj.emboj.7600929
79. The Rab6 GTPase regulates recruitment of the dynactin complex to Golgi membranes. B Short C Preisinger J Schaletzky R Kopajtich FA Barr, Curr Biol 2002 12 20 1792 1795 10.1016/S0960-9822(02)01221-6 12401177
80. ARF proteins: roles in membrane traffic and beyond. C D'Souza-Schorey P Chavrier, Nat Rev Mol Cell Biol 2006 7 5 347 358 10.1038/nrm1910 16633337
81. Localization and function of Arf family GTPases. JG Donaldson A Honda, Biochem Soc Trans 2005 33 Pt 4 639 642 16042562
82. Multiple activities for Arf1 at the Golgi complex. JG Donaldson A Honda R Weigert, Biochim Biophys Acta 2005 1744 3 364 373 10.1016/j.bbamcr.2005.03.001 15979507
83. Constitutive endocytosis of the metabotropic glutamate receptor mGluR7 is clathrin-independent. G Lavezzari KW Roche, Neuropharmacology 2006
84. Thrombin/thrombin receptor (PAR-1)-mediated induction of IL-8 and VEGF expression in prostate cancer cells. J Liu P Schuff-Werner M Steiner, Biochem Biophys Res Commun 2006 343 1 183 189 10.1016/j.bbrc.2006.02.136 16530725
85. Protease-activated receptor-2 regulates vascular endothelial growth factor expression in MDA-MB-231 cells via MAPK pathways. Y Liu BM Mueller, Biochem Biophys Res Commun 2006 344 4 1263 1270 10.1016/j.bbrc.2006.04.005 16650817
86. The agonist of the protease-activated receptor-1 (PAR) but not PAR3 mimics thrombin-induced vascular endothelial growth factor release in human smooth muscle cells. T Arisato KP Sarker K Kawahara M Nakata T Hashiguchi M Osame I Kitajima I Maruyama, Cell Mol Life Sci 2003 60 8 1716 1724 10.1007/s00018-003-3140-6 14513837
87. Cysteinyl leukotriene 2 receptor and protease-activated receptor 1 activate strongly correlated early genes in human endothelial cells. B Uzonyi K Lotzer S Jahn C Kramer M Hildner E Bretschneider D Radke M Beer R Vollandt JF Evans, Proceedings of the National Academy of Sciences of the United States of America 2006 103 16 6326 6331 16606835 10.1073/pnas.0601223103
88. Therapeutic promise of proteinase-activated receptor-2 antagonism in joint inflammation. EB Kelso JC Lockhart T Hembrough L Dunning R Plevin MD Hollenberg CP Sommerhoff JS McLean WR Ferrell, J Pharmacol Exp Ther 2006 316 3 1017 1024 10.1124/jpet.105.093807 16260582
89. Biological consequences of thrombin receptor deficiency in mice. AL Darrow WP Fung-Leung RD Ye RJ Santulli WM Cheung CK Derian CL Burns BP Damiano L Zhou CM Keenan, Thromb Haemost 1996 76 6 860 866 8972001
90. Minimum information about a microarray experiment (MIAME)-toward standards for microarray data. A Brazma P Hingamp J Quackenbush G Sherlock P Spellman C Stoeckert J Aach W Ansorge CA Ball HC Causton, Nat Genet 2001 29 4 365 371 10.1038/ng1201-365 11726920
91. http://www.ncbi.nlm.nih.gov/projects/geo/query/acc.cgi?acc=GPL151
92. http://www.ncbi.nlm.nih.gov/geo/
93. Gene expression profiling of the left ventricles in a rat model of intrinsic aerobic running capacity. SJ Lee JA Ways JC Barbato D Essig K Pettee SJ DeRaedt S Yang DA Weaver LG Koch GT Cicila, Physiol Genomics 2005 23 1 62 71 10.1152/physiolgenomics.00251.2004 16033863
94. Proteinase-activated receptors. SR Macfarlane MJ Seatter T Kanke GD Hunter R Plevin, Pharmacological reviews 2001 53 2 245 282 11356985
95. http://www.genpathway.com.
96. Identification of target genes in breast cancer cells directly regulated by the SRC-3/AIB1 coactivator. P Labhart S Karmakar EM Salicru BS Egan V Alexiadis BW O'Malley CL Smith, Proc Natl Acad Sci USA 2005 102 5 1339 1344 15677324 10.1073/pnas.0409578102
97. http://frodo.wi.mit.edu/cgi-bin/primer3/primer3_www.cgi
98. http://rsb.info.nih.gov/ij/