Thrombin receptor expression is upregulated in prostate cancer

Prostate

Volumn 66, Issue 3, 2006, Pages 273-282

  Kaushal, Varsha ^a   Kohli, Manish ^a,b   Dennis, Richard A ^c   Siegel, Eric R ^a   Chiles, Walter W ^a   Mukunyadzi, Perkins ^a,d  

^a UNIVERSITY OF ARKANSAS FOR MEDICAL SCIENCES   (United States)

^b CENTRAL ARKANSAS VETERANS HEALTHCARE SYSTEM   (United States)

^c UNIVERSITY OF ARKANSAS FOR MEDICAL SCIENCES   (United States)

^d Parkview Medical Office Building   (United States)

Author keywords

Angiogenesis; PAR1; Prostate cancer

Indexed keywords

GROWTH FACTOR; GROWTH FACTOR RECEPTOR; PROTEINASE ACTIVATED RECEPTOR; RNA; THROMBIN RECEPTOR; VASCULOTROPIN;

ADVANCED CANCER; ANGIOGENESIS; ARTICLE; CANCER INHIBITION; CANCER STAGING; COMPARATIVE STUDY; CONTROLLED STUDY; EARLY CANCER; ENDOTHELIUM CELL; GENE EXPRESSION REGULATION; GENE LOCATION; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; IMMUNOBLOTTING; IMMUNOHISTOCHEMISTRY; MALE; METASTASIS; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROSTATE CANCER; PROSTATE HYPERTROPHY; PROTEIN EXPRESSION; REAL TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TUMOR GROWTH; VASCULAR ENDOTHELIUM;

ADULT; AGED; AGED, 80 AND OVER; BLOTTING, WESTERN; HUMANS; IMMUNOHISTOCHEMISTRY; MALE; MIDDLE AGED; NEOPLASM STAGING; NEOVASCULARIZATION, PATHOLOGIC; PROSTATIC HYPERPLASIA; PROSTATIC NEOPLASMS; RECEPTOR, PAR-1; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; STATISTICS, NONPARAMETRIC; UP-REGULATION;

EID: 31944448553     PISSN: 02704137     EISSN: None     Source Type: Journal    
DOI: 10.1002/pros.20326     Document Type: Article

References (49)

1. Weidner N, Carroll PR, Flax J, Blumenfeld W, Folkman J. Tumor angiogenesis correlates with metastasis in invasive prostate carcinoma. Am J Pathol 1993;143(2):401-409.
2. Zetter BR. Angiogenesis and tumor metastasis. Annu Rev Med 1998;49:407-424.
3. Falanga A. Thrombophilia in cancer. Semin Thromb Hemost 2005;31(1):104-110.
4. Camerer E, Qazi AA, Duong DN, Cornelissen I, Advincula R, Coughlin SR. Platelets, protease-activated receptors, and fibrinogen in hematogenous metastasis. Blood 2004;104(2):397-401.
5. Hirano K, Kanaide H. Role of protease-activated receptors in the vascular system. J Atheroscler Thromb 2003;10(4):211-225.
6. Kohli M, Kaushal V, Mehta P. Role of coagulation and fibrinolytic system in prostate cancer. Semin Thromb Hemost 2003;29(3):301-308.
7. Ruf W. Molecular regulation of blood clotting in tumor biology. Haemostasis 2001;31(Suppl 1):5-7.
8. Naldini A, Carney DH, Pucci A, Pasquali A, Carraro F. Thrombin regulates the expression of proangiogenic cytokines via proteolytic activation of protease-activated receptor-1. Gen Pharmacol 2000;35(5):255-259.
9. Riewald M, Ruf W. Mechanistic coupling of protease signaling and initiation of coagulation by tissue factor. Proc Natl Acad Sci USA 2001;98(14):7742-7747.
10. Siegbahn A. Cellular consequences upon factor VIIa binding to tissue factor. Haemostasis 2000;30(Suppl 2):41-47.
11. Sampson MT, Kakkar AK. Coagulation proteases and human cancer. Biochem Soc Trans 2002;30(2):201-207.
12. Kohli M, Fink L, Spencer HJ, Zent CS. Advanced prostate cancer activates coagulation: A controlled study comparing activation markers of coagulation in ambulatory patients with advanced prostate cancer to age and healthy male controls. Blood Coag Fib 2001;13(1):1-5.
13. Coughlin SR. Thrombin signalling and protease-activated receptors. Nature 2000;407(6801):258-264.
14. Molino M, Barnathan ES, Numerof R, Clark J, Dreyer M, Cumashi A, Hoxie JA, Schechter N, Woolkalis M, Brass LF. Interactions of mast cell tryptase with thrombin receptors and PAR-2. J Biol Chem 1997;272(7):4043-4049.
15. Camerer E, Huang W, Coughlin SR. Tissue factor- and factor X-dependent activation of protease-activated receptor 2 by factor Vila. Proc Natl Acad Sci USA 2000;97(10):5255-5260.
16. - channel that mediates hyperpolarization via the thrombin receptor pathway. Am J Physiol 1998;275(5 Pt 1):C1342-C1348.
17. Greenberg DL, Mize GJ, Takayama TK. Protease-activated receptor mediated RhoA signaling and cytoskeletal reorganization in LNCaP cells. Biochemistry 2003;42(3):702-709.
18. Carmeliet P. Biomedicine. Clotting factors build blood vessels. Science 2001;293(5535):1602-1604.
19. Griffin CT, Srinivasan Y, Zheng YW, Huang W, Coughlin SR. A role for thrombin receptor signaling in endothelial cells during embryonic development. Science 2001;293(5535):1666-1670.
20. Even-Ram S, Uziely B, Cohen P, Grisaru-Granovsky S, Maoz M, Ginzburg Y, Reich R, Vlodavsky I, Bar-Shavit R. Thrombin receptor overexpression in malignant and physiological invasion processes. Nat Med 1998;4(8):909-914.
21. D'Andrea MR, Derian CK, Santulli RJ, Andrade-Gordon P. Differential expression of protease-activated receptors-1 and -2 in stromal fibroblasts of normal, benign, and malignant human tissues. Am J Pathol 2001;158(6):2031-2041.
22. Darmoul D, Gratio V, Devaud H, Lehy T, Laburthe M. Aberrant expression and activation of the thrombin receptor protease-activated receptor-1 induces cell proliferation and motility in human colon cancer cells. Am J Pathol 2003;162(5):1503-1513.
23. Nierodzik ML, Chen K, Takeshita K, Li JJ, Huang YQ, Feng XS, D'Andrea MR, Andrade-Gordon P, Karpatkin S. Protease-activated receptor 1 (PAR-1) is required and rate-limiting for thrombin-enhanced experimental pulmonary metastasis. Blood 1998;92(10):3694-3700.
24. Bromberg ME, Bailly MA, Konigsberg WH. Role of protease-activated receptor 1 in tumor metastasis promoted by tissue factor. Thromb Haemost 2001;86(5):1210-1214.
25. Shi X, Gangadharan B, Brass LF, Ruf W, Mueller BM. Protease-activated receptors (PAR1 and PAR2) contribute to tumor cell motility and metastasis. Mol Cancer Res 2004;2(7):395-402.
26. Liu J, Bastian M, Kohlschein P, Schuff-Werner P, Steiner M. Expression of functional protease-activated receptor 1 in human prostate cancer cell lines. Urol Res 2003;31(3):163-168.
27. Yoshida E, Verrusio EN, Mihara H, Oh D, Kwaan HC. Enhancement of the expression of urokinase-type plasminogen activator from PC-3 human prostate cancer cells by thrombin. Cancer Res 1994;54(12):3300-3304.
28. Chay CH, Cooper CR, Gendernalik JD, Dhanasekaran SM, Chinnaiyan AM, Rubin MA, Schmaier AH, Pienta KJ. A functional thrombin receptor (PAR1) is expressed on bone-derived prostate cancer cell lines. Urology 2002;60(5):760-765.
29. Cooper CR, Chay CH, Gendernalik JD, Lee HL, Bhatia J, Taichman RS, McCauley LK, Keller ET, Pienta KJ. Stromal factors involved in prostate carcinoma metastasis to bone. Cancer 2003;97(3 Suppl):739-747.
30. Yuan TC, Lin MF. Protease-activated receptor 1: A role in prostate cancer metastasis. Clin Prostate Cancer 2004;3(3):189-191.
31. Kaushal V, Mukunyadzi P, Dennis RA, Siegel ER, Johnson DE, Kohli M. Stage-specific characterization of the vascular endothelial growth factor axis in prostate cancer: Expression of lymphangiogenic markers is associated with advanced-stage disease. Clin Cancer Res 2005;11(2 Pt 1):584-593.
32. Carmeliet P. Angiogenesis in health and disease. Nat Med 2003;9(6):653-660.
33. Yin YJ, Salah Z, Maoz M, Ram SC, Ochayon S, Neufeld G, Katzav S, Bar-Shavit R. Oncogenic transformation induces tumor angiogenesis: A role for PAR1 activation. Faseb J 2003;17(2):163-174.
34. Fischer EG, Ruf W, Mueller BM. Tissue factor-initiated thrombin generation activates the signaling thrombin receptor on malignant melanoma cells. Cancer Res 1995;55(8):1629-1632.
35. Nierodzik ML, Kajumo F, Karpatkin S. Effect of thrombin treatment of tumor cells on adhesion of tumor cells to platelets in vitro and tumor metastasis in vivo. Cancer Res 1992;52(12):3267-3272.
36. Jin E, Fujiwara M, Pan X, Ghazizadeh M, Arai S, Ohaki Y, Kajiwara K, Takemura T, Kawanami O. Protease-activated receptor (PAR)-1 and PAR-2 participate in the cell growth of alveolar capillary endothelium in primary lung adenocarcinomas. Cancer 2003;97(3):703-713.
37. Rudroff C, Striegler S, Schilli M, Scheele J. Thrombin enhances adhesion in pancreatic cancer in vitro through the activation of the thrombin receptor PAR 1. Eur J Surg Oncol 2001;27(5):472-476.
38. Yin YJ, Salah Z, Grisaru-Granovsky S, Cohen I, Even-Ram SC, Maoz M, Uziely B, Peretz T, Bar-Shavit R. Human protease-activated receptor 1 expression in malignant epithelia: A role in invasiveness. Arterioscler Thromb Vasc Biol 2003;23(6):940-944.
39. Tellez C, Bar-Eli M. Role and regulation of the thrombin receptor (PAR-1) in human melanoma. Oncogene 2003;22(20):3130-3137.
40. Rudroff C, Seibold S, Kaufmann R, Zetina CC, Reise K, Schafer U, Schneider A, Brockmann M, Scheele J, Neugebauer EA. Expression of the thrombin receptor PAR-1 correlates with tumour cell differentiation of pancreatic adenocarcinoma in vitro. Clin Exp Metastasis 2002;19(2):181-189.
41. Grisaru-Granovsky S, Salah Z, Maoz M, Pruss D, Beller U, Bar-Shavit R. Differential expression of protease activated receptor 1 (Pari) and pY397FAK in benign and malignant human ovarian tissue samples. Int J Cancer 2005;113(3):372-378.
42. Wilson SR, Gallagher S, Warpeha K, Hawthorne SJ. Amplification of MMP-2 and MMP-9 production by prostate cancer cell lines via activation of protease-activated receptors. Prostate 2004;60(2):168-174.
43. Nguyen QD, Faivre S, Bruyneel E, Rivat C, Seto M, Endo T, Mareel M, Emami S, Gespach C. RhoA- and RhoD-dependent regulatory switch of Galpha subunit signaling by PAR-1 receptors in cellular invasion. Faseb J 2002;16(6):565-576.
44. Even-Ram SC, Maoz M, Pokroy E, Reich R, Katz BZ, Gutwein P, Altevogt P, Bar-Shavit R. Tumor cell invasion is promoted by activation of protease activated receptor-1 in cooperation with the alpha vbeta 5 integrin. J Biol Chem 2001;276(14);10952-10962.
45. Latil A, Bieche I, Chene L, Laurendeau I, Berthon P, Cussenot O, Vidaud M. Gene expression profiling in clinically localized prostate cancer: A four-gene expression model predicts clinical behavior. Clin Cancer Res 2003;9(15):5477-5485.
46. Boire A, Covic L, Agarwal A, Jacques S, Sherifi S, Kuliopulos A. PAR1 Is a matrix metalloprotease-1 receptor that promotes invasion and tumorigenesis of breast cancer cells. Cell 2005;120(3):303-313.
47. Andrade-Gordon P, Maryanoff BE, Derian CK, Zhang HC, Addo MF, Darrow AL, Eckardt AJ, Hoekstra WJ, McComsey DF, Oksenberg D, Reynolds EE, Santulli RJ, Scarborough RM, Smith CE, White KB. Design, synthesis, and biological characterization of a peptide-mimetic antagonist for a tethered-ligand receptor. Proc Natl Acad Sci USA 1999;96(22):12257-12262.
48. Derian CK, Damiano BP, Addo MF, Darrow AL, D'Andrea MR, Nedelman M, Zhang HC, Maryanoff BE, Andrade-Gordon P. Blockade of the thrombin receptor protease-activated receptor-1 with a small-molecule antagonist prevents thrombus formation and vascular occlusion in nonhuman primates. J Pharmacol Exp Ther 2003;304(2):855-861.
49. Selnick HG, Barrow JC, Nantermet PG, Connolly TM. Non-peptidic small-molecule antagonists of the human platelet thrombin receptor PAR-1. Curr Med Chem Cardiovasc Hematol Agents 2003;1(1):47-59.