Mechanisms of amino acid-induced insulin secretion from the glucose-responsive BRIN-BD11 pancreatic B-cell line

Journal of Endocrinology

Volumn 151, Issue 3, 1996, Pages 349-357

  McClenaghan, N H ^a   Barnett, C R ^a   O'Harte, F P M ^a   Flatt, P R ^a  

^a UNIVERSITY OF ULSTER   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

2 AMINO 2 METHYLPROPIONIC ACID; ALANINE; AMINO ACID; ARGININE; DIAZOXIDE; GLUCOSE; GLUTAMINE; GLYCINE; LEUCINE; LYSINE; PROLINE; SERINE; VERAPAMIL;

ANIMAL CELL; ARTICLE; CALCIUM TRANSPORT; DRUG EFFECT; GLYCOLYSIS; INSULIN RELEASE; NONHUMAN; NUTRIENT; PANCREAS ISLET BETA CELL; PRIORITY JOURNAL; RAT;

EID: 0029828189     PISSN: 00220795     EISSN: None     Source Type: Journal    
DOI: 10.1677/joe.0.1510349     Document Type: Article

References (42)

1. Ashcroft FM, Proks P, Smith PA, Ammala C, Bokvist K & Rorsman P 1994 Stimulus-secretion coupling in pancreatic β cells. Journal of Cellular Biochemistry 55S 54-65.
2. 2+ concentration in pancreatic B-cells. In Frontiers of Insulin Secretion and Pancreatic B-Cell Research, pp 201-211. Eds PR Flatt & S Lenzen. London: Smith-Gordon.
3. Blachier F, Mourtada A, Sener A & Malaise WJ 1989 Stimulus-secretion coupling of arginine-induced insulin release. Uptake of metabolized and nonmetabolized cationic amino acids by pancreatic islets. Endocrinology 124 134-141.
4. Briel G, Gylfe E, Hellman B & Neuhoff V 1972 Microdetermination of free amino acids in pancreatic islets isolated from obese-hyperglycemic mice. Acta Physiologica Scandinavia 84 247-253.
5. 2+ fluxes in rat pancreatic islets. Biochemical Journal 214 899-907.
6. Charles S, Tamagawa T, Nenquin M, Mathot F & Henquin JC 1981 Characterization of the insulinotropic and ionic effects of cationic amino acids. Diabetologia 21 (Suppl) 258-259.
7. + efflux from rat islets by cationic amino acids. Biochemical Journal 208 301-308.
8. Christensen HN & Handlogten ME 1981 Role of system Gly in monolayer cultures of liver cells. Biochemical and Biophysical Research Communications 98 102-107.
9. Collarini EJ & Oxender DL 1987 Mechanisms of transport of amino acids across membranes. Annual Review of Nutrition 7 75-90.
10. 2+ measurements. Biochimica et Biophysica Acta 1055 157-164.
11. Flatt PR & Bailey CJ 1981 Abnormal plasma glucose and insulin responses in heterozygous (ob/+) mice. Diabetologia 20 573-577.
12. Floyd JC, Fajans SS, Knopf RF & Conn JW 1963 Evidence that insulin release is the mechanism for experimentally induced leucine hypoglycaemia in man. Journal of Clinical Investigation 42 1714-1719.
13. Gadzar AF, Chick WL, Oie HK, Sims HL, King DL, Weir GC & Lauris V 1980 Continuous, clonal, insulin- and somatostatin-secreting cell lines established from a transplantable rat islet-cell tumor. Proceedings of the National Academy of Sciences of the USA 77 3519-3523.
14. 2+ oscillations in pancreatic β-cells exposed to leucine and arginine. Acta Physiologica Scandinavia 136 113-119.
15. Guidotti GC, Borghetti AF & Gazzola GC 1978 The regulation of amino acid transport in animal cells. Biochimica et Biophysica Acta 515 329-366.
16. Halban PA & Wollheim CB 1980 Intracellular degradation of insulin stores by pancreatic islets in vitro. An alternative pathway for homeostasis of pancreatic insulin content. Journal of Biological Chemistry 255 6003-6006.
17. Hellman B 1975 The significance of calcium for glucose stimulation of insulin release. Endocrinology 97 392-398.
18. Hellman B, Sehlin J & Täljedal I-B 1971a Transport of α-aminoisobutyric acid in mammalian pancreatic β-cells. Diabetologia 7 256-265.
19. Hellman B, Sehlin J & Täljedal I-B 1971b Uptake of alanine, arginine, and leucine by mammalian pancreatic β-cells. Endocrinology 89 1432-1439.
20. Hellman B, Idahl L-A, Lernmark Å, Sehlin J & Täljedal I-B 1974 The pancreatic B-cell recognition of insulin secretagogues: comparisons of glucose with glyceraldehyde isomers and dihydroxyacetone. Archives of Biochemistry and Biophysics 162 448-457.
21. Hellman B, Gylfe E, Grapengeisser E, Lund P-E & Marcström A 1992 Cytoplasmic calcium and insulin secretion. In Nutrient Regulation of Insulin Secretion, pp 213-246. Ed PR Flatt. London: Portland Press.
22. + fluxes in pancreatic B-cells. American Journal of Physiology 240 E245-E252.
23. Henquin J-C, Charles S, Henquin M, Mathot F & Tamagawa T 1982 Diazoxide and D600 inhibition of insulin release: Distinct mechanisms explain the specificity for different stimuli. Diabetes 31 776-783.
24. + permeability and membrane potential in insulin secreting cells. In Nutrient Regulation of Insulin Secretion, pp 173-192. Ed PR Flatt. London: Portland Press.
25. 2+ influx into pancreatic B cell. American Journal of Physiology 246 E38-E43.
26. + on arginine stimulation of insulin release in isolated mouse islets. Diabetologia 30 659-665.
27. +-independent transport (uniport) of amino acids and glucose in mammalian cells. Journal of Experimental Biology 196 93-108.
28. + conductance and resistance to verapamil. Archives Internationales de Physiologie et de Biochimie 90 P99.
29. 2+ influx into the pancreatic B cell. American Journal of Physiology 242 E59-E66.
30. McClenaghan N, Berts A, Dryselius S, Thorell I-M & Hellman B 1992 Non-metabolizable α-aminoisobutyric acid evokes a glucose-dependent insulin secretory response in B-cells. Diabetologia 35 (Suppl 1) A113.
31. McClenaghan NH, Barnett CR, Ah-Sing E, Abdel-Wahab YHA, O'Harte FPM, Yoon T-W, Swanston-Flatt SK & Flatt PR 1996a Characterization of a novel glucose-responsive insulin-secreting cell line, BRIN-BD11, produced by electrofusion. Diabetes 45 1132-1140.
32. McClenaghan NH, Barnett CR, O'Harte FPM, Swanston-Flatt SK, Ah-Sing E & Flatt PR 1996b Characteristics of BRIN-BG5 and BRIN-BG7, two novel glucose-responsive insulin-secreting cell lines produced by electrofusion. Journal of Endocrinology 148 409-417.
33. McGivan JD & Pastor-Anglada M 1994 Regulatory and molecular aspects of mammalian amino acid transport. Biochemical Journal 299 321-334.
34. Malaisse WJ, Plasman PO, Blachier F, Herchuelz A & Sener A 1991 Stimulus-secretion coupling of arginine-induced insulin release: significance of changes in extracellular and intracellular pH. Cell Biochemistry and Function 9 1-7.
35. Meglasson MP & Matschinsky FM 1986 Pancreatic islet glucose metabolism and regulation of insulin secretion. Diabetes and Metabolism Reviews 2 163-214.
36. Prentki M & Renold AE 1983 Neutral amino acid transport in isolated rat pancreatic islets. Journal of Biological Chemistry 258 14239-14244.
37. Rasschaert J, Flatt PR, Barnett CR, McClenaghan NH & Malaisse WJ 1996 D-Glucose metabolism in BRIN-BD11 islet cells. Biochemical and Molecular Medicine 57 97-105.
38. Sener A & Malaisse WJ 1980 Stimulation of insulin release by L-glutamine. Molecular and Cellular Biochemistry 33 157-159.
39. 2+], code for glucose-induced insulin release in mouse pancreatic islets of Langerhans. In Frontiers of Insulin Secretion and Pancreatic B-Cell Research, pp 229-235. Ed PR Flatt & S Lenzen. London: Smith-Gordon.
40. 2+ oscillations into a sustained increase parallels potentiation of insulin release. Biochimica et Biophysica Acta 1137 243-247.
41. 1 in the fetal rat β-cell. Diabetes 44 118-124.
42. Yada T 1994 Action mechanisms of amino acids in pancreatic B-cells. In Frontiers of Insulin Secretion and Pancreatic B-Cell Research, pp 129-135. Eds PR Flatt & S Lenzen. London: Smith-Gordon.