Search for protein farnesyltransferase inhibitors of microbial origin: Our strategy and results as well as the results obtained by other groups

Journal of Antibiotics

Volumn 60, Issue 1, 2007, Pages 1-12

  Iwasaki, Shigeo ^b   Omura, Satoshi ^a  

^a KITASATO UNIVERSITY   (Japan)

^b KITASATO INSTITUTE   (Japan)

Author keywords

Andrastins; Gliotoxin; Inhibitor of protein farnesyltransferase; Kurasoins; Microbial metabolites; Pepticinnamins; Screening and assay system

Indexed keywords

1 O METHYLTHYSANONE; 10' DESMETHOXYSTREPTONIGERIN; ACETYLGLIOTOXIN; ACTINOPLANIC ACID; ANDRASTIN A; ANDRASTIN B; ANDRASTIN C; CHAETOMERIC ACID A; CHAETOMERIC ACID B; CITOREOHYBRIDONE; FUSIDIENOL; GENTAMICIN; GLIOTOXIN; KURASOIN A; KURASOIN B; PENICILLIC ACID; PEPTICINNAMIN A; PEPTICINNAMIN B; PEPTICINNAMIN C; PEPTICINNAMIN D; PEPTICINNAMIN E; PEPTICINNAMIN F; PROTEIN FARNESYLTRANSFERASE; PROTEIN FARNESYLTRANSFERASE INHIBITOR; SCLEROTIORIN; SPICULISPORIC ACID; THYSANONE; UNCLASSIFIED DRUG; UNINDEXED DRUG; ZARAGOZIC ACID A; ZARAGOZIC ACID C; ANDROSTANE DERIVATIVE; ENZYME INHIBITOR; OLIGOPEPTIDE; P21(RAS) FARNESYL PROTEIN TRANSFERASE; P21(RAS) FARNESYL-PROTEIN TRANSFERASE; PHENOL DERIVATIVE; TRANSFERASE;

AMINO ACID SEQUENCE; DRUG INHIBITION; DRUG SCREENING; DRUG STRUCTURE; PRIORITY JOURNAL; REVIEW; BACTERIUM; DRUG ANTAGONISM; FUNGUS; METABOLISM;

ALKYL AND ARYL TRANSFERASES; ANDROSTADIENES; BACTERIA; DRUG EVALUATION, PRECLINICAL; ENZYME INHIBITORS; FUNGI; GLIOTOXIN; OLIGOPEPTIDES; PHENOLS;

EID: 34247251454     PISSN: 00218820     EISSN: None     Source Type: Journal    
DOI: 10.1038/ja.2007.1     Document Type: Review

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