Andrastins A∼C, new protein farnesyltransferase inhibitors, produced by Penicillium sp. FO-3929

Tetrahedron Letters

Volumn 37, Issue 8, 1996, Pages 1265-1268

  Shiomi, Kazuro ^a   Uchida, Ryuji ^a   Inokoshi, Junji ^b   Tanaka, Haruo ^b   Iwai, Yuzuru ^a   Omura, Satoshi ^a  

^a KITASATO INSTITUTE   (Japan)

^b KITASATO UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

PENICILLIUM SP.;

ANDRASTIN A; ANDRASTIN B; ANDRASTIN C; ENZYME INHIBITOR; PROTEIN FARNESYLTRANSFERASE; TRANSFERASE INHIBITOR; UNCLASSIFIED DRUG;

ARTICLE; DRUG ISOLATION; DRUG STRUCTURE; MASS SPECTROMETRY; NUCLEAR MAGNETIC RESONANCE; PENICILLIUM;

EID: 0030022282     PISSN: 00404039     EISSN: None     Source Type: Journal    
DOI: 10.1016/0040-4039(95)02412-3     Document Type: Article

References (10)

1. Tamanoi, F. Trends Biochem. Sci. 1993, 18, 349-353.
2. Van Der Pyl, D.; Inokoshi, J.; Shiomi, K.; Yang, H.; Takeshima, H.; Ōmura, S. J. Antibiotics 1992, 45, 1802-1805.
3. Ōmura, S.; D. Van Der Pyl, D.; Inokoshi, J.; Takahashi, Y.; Takeshima, H. J. Antibiotics 1993, 46, 222-228.
4. Shiomi, K.; Yang, H.; Inokoshi, J.; D. Van Der Pyl, D.; Nakagawa, A.; Takeshima, H.; Ōmura, S. J. Antibiotics 1993, 46, 229-234.
5. Uchida, R.; Inokoshi, J.; Shiomi, K.; Masuma, R; Kawakubo, T.; Tanaka, H.; Iwai, Y.; Yamamura, S.; Ōmura, S. J. Antibiotics, in preparation.
6. 4 (4:1) for 3) to give white powders of 1 (1.48 g), 2 (330 mg), and 3 (36.6 mg).
7. 13C NMR (67.8 MHz) δ 201.7, 188.0, 172.5, 172.0, 136.4, 126.1, 114.4, 79.6, 68.8, 58.1, 54.4, 52.0, 50.3, 43.4, 38.1, 37.7, 34.4, 34.0, 28.2, 23.5, 22.0, 21.1, 19.8, 18.8, 18.1, 17.3, 16.1, 6.3.
8. Shiomi, K.; Inokoshi, J.; Uchida, R.; Sunazuka, T.; Tanaka, H.; Iwai, Y.; Takayanagi, H.; Ōmura, S. J. Antibiotics, in preparation.
9. Kosemura, S.; Miyata, H.; Matsunaga, K.; Yamamura, S. Tetrahedron Lett. 1992, 33, 3883-3886.
10. Kosemura, S.; Miyata, H.; Yamamura, S.; Albone, K.; Simpson, T. J. J. Chem. Soc. Perkin Trans. 1 1994, 135-139.