Sch 207278: A novel farnesyl protein transferase inhibitor from an unidentified fungus

Bioorganic and Medicinal Chemistry Letters

Volumn 7, Issue 19, 1997, Pages 2547-2550

  Chu, Min ^a   Mierzwa, Ronald ^a   Barrabee, Ellen ^a   King, Arthur ^a   Hallade, Marc ^a   Terracciano, Joseph ^a   Patel, Mahesh G ^a   Patton, Robert ^a   Bishop, W Robert ^a   Puar, Mohindar S ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ENZYME INHIBITOR; PROTEIN FARNESYLTRANSFERASE; SCH 207278; UNCLASSIFIED DRUG;

ARTICLE; DRUG IDENTIFICATION; DRUG ISOLATION; DRUG STRUCTURE; FERMENTATION; FUNGUS; NONHUMAN; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; NUCLEAR OVERHAUSER EFFECT;

EID: 0030819085     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-894X(97)10012-9     Document Type: Article

References (15)

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12. The fungus was supplied by Dr. B. Katz from MYCOsearch.
13. The purity of 1 was analyzed by normal phase HPLC under conditions as follows: YMC PVA-Sil column, 4.6 × 150 mm, S-5, 120 Å, 40% EtOAc in hexane, isocratic, 1 mL/min, UV detection at 260 nm, 95% purity by area integration normalization.
14. 3, 100 MHz) δ 20.4 (q), 20.5 (q), 20.9 (q), 88.2 (d), 125.7 (s), 126.6 (d), 127.5 (d), 127.7 (s), 127.8 (d), 131.3 (d), 132.5 (d), 139.6 (s), 143.3 (s), 146.9 (s), 149.8 (s), 150.8 (s), 167.9 (s), 168.5 (s), 168.8 (s), 188.1 (s), 189.5 (d).
15. Bishop, W. R.; Bond, R.; Petrin, J.; Wang, L.; Patton, R.; Doll, R.; Njoroge, G.; Catino, J.; Schwartz, J.; Carr, D,; James, L.; Kirschmeier, P. J. Biol. Chem. 1995, 270, 30611.