Signaling pathways involved in OxPAPC-induced pulmonary endothelial barrier protection

Microvascular Research

Volumn 73, Issue 3, 2007, Pages 173-181

  Birukova, Anna A ^a   Chatchavalvanich, Santipongse ^a   Oskolkova, Olga ^b   Bochkov, Valery N ^b   Birukov, Konstantin G ^a  

^a W410   (United States)

^b MEDICAL UNIVERSITY OF VIENNA   (Austria)

Author keywords

Actin; Cytoskeleton; Endothelium; FAK; Paxillin; Permeability; Phosphorylation; PKA; PKC; Rac

Indexed keywords

1 PALMITOYL 2 ARACHIDONOYLGLYCERO 3 PHOSPHOCHOLINE; 6 (4 FLUOROPHENYL) 3 [[3 (3 PYRIDYL) 1H,3H PYRROLO[1,2 C]THIAZOL 7 YL]CARBONYL] 1 INDOLECARBOXYLIC ACID DIMETHYLAMIDE; CYCLIC AMP DEPENDENT PROTEIN KINASE; CYTOTOXIN; FOCAL ADHESION KINASE; GUANOSINE TRIPHOSPHATASE; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; MITOGEN ACTIVATED PROTEIN KINASE P38; PAXILLIN; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHORYLCHOLINE; PROTEIN KINASE C; PROTEIN TYROSINE KINASE; PROTEIN TYROSINE KINASE INHIBITOR; RAC PROTEIN; RHO GUANINE NUCLEOTIDE BINDING PROTEIN; RHO KINASE; THROMBOCYTE ACTIVATING FACTOR; THROMBOCYTE ACTIVATING FACTOR ANTAGONIST; UNCLASSIFIED DRUG;

ARTICLE; CELL PROTECTION; CELL REGENERATION; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOSKELETON; ENDOTHELIUM CELL; ENZYME PHOSPHORYLATION; HUMAN; HUMAN CELL; LUNG ENDOTHELIUM; MOLECULAR BIOLOGY; OXIDATION; PRIORITY JOURNAL; PULMONARY ARTERY; SIGNAL TRANSDUCTION;

ACTINS; BACTERIAL PROTEINS; BACTERIAL TOXINS; CAPILLARY PERMEABILITY; CYCLIC AMP-DEPENDENT PROTEIN KINASES; CYTOSKELETON; ELECTRIC IMPEDANCE; ENDOTHELIAL CELLS; FOCAL ADHESION KINASE 1; HUMANS; PAXILLIN; PHOSPHATIDYLCHOLINES; PHOSPHORYLATION; PROTEIN KINASE C; PROTEIN KINASE INHIBITORS; PULMONARY ARTERY; RAC GTP-BINDING PROTEINS; SIGNAL TRANSDUCTION; SRC-FAMILY KINASES; STRESS FIBERS;

EID: 34247181078     PISSN: 00262862     EISSN: 10959319     Source Type: Journal    
DOI: 10.1016/j.mvr.2006.12.004     Document Type: Article

References (54)

1. Birukov K.G. Oxidized lipids: the two faces of vascular inflammation. Curr. Atheroscler. Rep. 8 3 (2006) 223-231
2. Birukov K.G., Birukova A.A., et al. Shear stress-mediated cytoskeletal remodeling and cortactin translocation in pulmonary endothelial cells. Am. J. Respir. Cell Mol. Biol. 26 4 (2002) 453-464
3. Birukov K.G., Bochkov V.N., et al. Epoxycyclopentenone-containing oxidized phospholipids restore endothelial barrier function via Cdc42 and Rac. Circ. Res. 95 9 (2004) 892-901
4. Birukov K.G., Leitinger N., et al. Signal transduction pathways activated in human pulmonary endothelial cells by OxPAPC, a bioactive component of oxidized lipoproteins. Microvasc. Res. 67 1 (2004) 18-28
5. Birukova A.A., Liu F., et al. Protein kinase A attenuates endothelial cell barrier dysfunction induced by microtubule disassembly. Am. J. Physiol., Lung. Cell. Mol. Physiol. 287 1 (2004) L86-L93
6. Birukova A.A., Smurova K., et al. Role of Rho GTPases in thrombin-induced lung vascular endothelial cells barrier dysfunction. Microvasc. Res. 67 1 (2004) 64-77
7. Birukova A.A., Adyshev D., et al. ALK5 and Smad4 are involved in TGF-beta1-induced pulmonary endothelial permeability. FEBS Lett. 579 18 (2005) 4031-4037
8. Bochkov V.N., and Leitinger N. Anti-inflammatory properties of lipid oxidation products. J. Mol. Med. 81 10 (2003) 613-626
9. Bochkov V.N., Mechtcheriakova D., et al. Oxidized phospholipids stimulate tissue factor expression in human endothelial cells via activation of ERK/EGR-1 and Ca(++)/NFAT. Blood 99 1 (2002) 199-206
10. Bochkov V.N., Leitinger N., et al. Role of oxidized phospholipids in acute lung injury. Curr. Resp. Med. Rev. 2 1 (2006) 27-37
11. Chabot F., Mitchell J.A., et al. Reactive oxygen species in acute lung injury. Eur. Respir. J. 11 3 (1998) 745-757
12. Cole A.L., Subbanagounder G., et al. Oxidized phospholipid-induced endothelial cell/monocyte interaction is mediated by a cAMP-dependent R-Ras/PI3-kinase pathway. Arterioscler. Thromb. Vasc. Biol. 23 8 (2003) 1384-1390
13. Dudek S.M., and Garcia J.G. Cytoskeletal regulation of pulmonary vascular permeability. J. Appl. Physiol. 91 4 (2001) 1487-1500
14. Dudek S.M., Jacobson J.R., et al. Pulmonary endothelial cell barrier enhancement by sphingosine 1-phosphate: roles for cortactin and myosin light chain kinase. J. Biol. Chem. 279 23 (2004) 24692-24700
15. Garcia J.G., Siflinger-Birnboim A., et al. Thrombin-induced increase in albumin permeability across the endothelium. J. Cell. Physiol. 128 1 (1986) 96-104
16. Garcia J.G., Liu F., et al. Sphingosine 1-phosphate promotes endothelial cell barrier integrity by Edg-dependent cytoskeletal rearrangement. J. Clin. Invest. 108 5 (2001) 689-701
17. Gonzalez E., Kou R., et al. Rac1 modulates sphingosine 1-phosphate-mediated activation of phosphoinositide 3-kinase/Akt signaling pathways in vascular endothelial cells. J. Biol. Chem. 281 6 (2006) 3210-3216
18. Holme P.A., Solum N.O., et al. Demonstration of platelet-derived microvesicles in blood from patients with activated coagulation and fibrinolysis using a filtration technique and western blotting. Thromb. Haemost. 72 5 (1994) 666-671
19. Huang F., Subbaiah P.V., et al. Lysophosphatidylcholine increases endothelial permeability: role of PKCalpha and RhoA cross talk. Am. J. Physiol., Lung Cell. Mol. Physiol. 289 2 (2005) L176-L185
20. Huber J., Vales A., et al. Oxidized membrane vesicles and blebs from apoptotic cells contain biologically active oxidized phospholipids that induce monocyte-endothelial interactions. Arterioscler. Thromb. Vasc. Biol. 22 1 (2002) 101-107
21. Kadl A., Huber J., et al. Analysis of inflammatory gene induction by oxidized phospholipids in vivo by quantitative real-time RT-PCR in comparison with effects of LPS. Vasc. Pharmacol. 38 4 (2002) 219-227
22. Kolosova I.A., Mirzapoiazova T., et al. Signaling pathways involved in adenosine triphosphate-induced endothelial cell barrier enhancement. Circ. Res. 97 2 (2005) 115-124
23. Kouklis P., Konstantoulaki M., et al. Cdc42 regulates the restoration of endothelial barrier function. Circ. Res. 94 2 (2004) 159-166
24. Kronke G., Bochkov V.N., et al. Oxidized phospholipids induce expression of human heme oxygenase-1 involving activation of cAMP-responsive element-binding protein. J. Biol. Chem. 278 51 (2003) 51006-51014
25. Lee O.H., Lee D.J., et al. Sphingosine 1-phosphate stimulates tyrosine phosphorylation of focal adhesion kinase and chemotactic motility of endothelial cells via the G(i) protein-linked phospholipase C pathway. Biochem. Biophys. Res. Commun. 268 1 (2000) 47-53
26. Leitinger N., Tyner T.R., et al. Structurally similar oxidized phospholipids differentially regulate endothelial binding of monocytes and neutrophils. Proc. Natl. Acad. Sci. U. S. A. 96 21 (1999) 12010-12015
27. Leitinger N., Watson A.D., et al. Monocyte binding to endothelial cells induced by oxidized phospholipids present in minimally oxidized low density lipoprotein is inhibited by a platelet activating factor receptor antagonist. Adv. Exp. Med. Biol. 433 (1997) 379-382
28. 2 receptor subtype 2 as a receptor activated by OxPAPC. Circ. Res. 98 5 (2006) 642-650
29. Liu F., Schaphorst K.L., et al. Hepatocyte growth factor enhances endothelial cell barrier function and cortical cytoskeletal rearrangement: potential role of glycogen synthase kinase-3beta. FASEB J. 16 9 (2002) 950-962
30. Lum H., and Malik A.B. Mechanisms of increased endothelial permeability. Can. J. Physiol. Pharmacol. 74 7 (1996) 787-800
31. Mallat Z., Benamer Z., et al. Elevated levels of shed membrane microparticles with procoagulant potential in the peripheral circulating blood of patients with acute coronary syndromes. Circulation 101 8 (2000) 841-843
32. Marathe G.K., Davies S.S., et al. Inflammatory platelet-activating factor-like phospholipids in oxidized low density lipoproteins are fragmented alkyl phosphatidylcholines. J. Biol. Chem. 274 40 (1999) 28395-28404
33. Marathe G.K., Prescott S.M., et al. Oxidized LDL contains inflammatory PAF-like phospholipids. Trends Cardiovasc. Med. 11 3-4 (2001) 139-142
34. Mehta D., Tiruppathi C., et al. Modulatory role of focal adhesion kinase in regulating human pulmonary arterial endothelial barrier function. J. Physiol. 539 Pt 3 (2002) 779-789
35. 2+ mediates rac activation and adherens junction assembly in endothelial cells. J. Biol. Chem. 280 17 (2005) 17320-17328
36. Moy A.B., Bodmer J.E., Blackwell K., Shasby S.S., and Shasby D.M. cAMP protects endothelial barrier function independent of inhibiting MLC20-dependent tension development. Am. J. Physiol. 274 18 (1998) L1024-L1029
37. Moy A.B., Blackwell K., et al. Differential effects of histamine and thrombin on endothelial barrier function through actin-myosin tension. Am. J. Physiol., Heart Circ. Physiol. 282 1 (2002) H21-H29
38. Petrache I., Verin A.D., et al. Differential effect of MLC kinase in TNF-alpha-induced endothelial cell apoptosis and barrier dysfunction. Am. J. Physiol., Lung Cell. Mol. Physiol. 280 6 (2001) L1168-L1178
39. Rhee S.G., Chang T.S., et al. Cellular regulation by hydrogen peroxide. J. Am. Soc. Nephrol. 14. 8 Suppl 3 (2003) S211-S215
40. Servitja J.M., Marinissen M.J., et al. Rac1 function is required for Src-induced transformation. Evidence of a role for Tiam1 and Vav2 in Rac activation by Src. J. Biol. Chem. 278 36 (2003) 34339-34346
41. Shikata Y., Birukov K.G., et al. Involvement of site-specific FAK phosphorylation in sphingosine-1 phosphate- and thrombin-induced focal adhesion remodeling: role of Src and GIT. FASEB J. 17 15 (2003) 2240-2249
42. Shikata Y., Rios A., et al. Differential effects of shear stress and cyclic stretch on focal adhesion remodeling, site-specific FAK phosphorylation, and small GTPases in human lung endothelial cells. Exp. Cell Res. 304 1 (2005) 40-49
43. Singleton P.A., Dudek S.M., et al. Regulation of sphingosine 1-phosphate-induced endothelial cytoskeletal rearrangement and barrier enhancement by S1P1 receptor, PI3 kinase, Tiam1/Rac1, and alpha-actinin. FASEB J. 19 12 (2005) 1646-1656
44. Subbanagounder G., Leitinger N., et al. Evidence that phospholipid oxidation products and/or platelet-activating factor play an important role in early atherogenesis: in vitro and in vivo inhibition by WEB 2086. Circ. Res. 85 4 (1999) 311-318
45. Subbanagounder G., Watson N., et al. Bioactive products of phospholipid oxidation: isolation, identification, measurement and activities. Free Radical Biol. Med. 28 12 (2000) 1751-1761
46. Tiruppathi C., Malik A.B., et al. Electrical method for detection of endothelial cell shape change in real time: assessment of endothelial barrier function. Proc. Natl. Acad. Sci. U. S. A. 89 17 (1992) 7919-7923
47. van Nieuw Amerongen G.P., Draijer G.P., et al. Transient and prolonged increase in endothelial permeability induced by histamine and thrombin: role of protein kinases, calcium, and RhoA. Circ. Res. 83 11 (1998) 1115-1123
48. van Nieuw Amerongen G.P., Natarajan K., et al. GIT1 mediates thrombin signaling in endothelial cells: role in turnover of RhoA-type focal adhesions. Circ. Res. 94 8 (2004) 1041-1049
49. Vouret-Craviari V., Bourcier C., et al. Distinct signals via Rho GTPases and Src drive shape changes by thrombin and sphingosine-1-phosphate in endothelial cells. J. Cell Sci. 115 Pt 12 (2002) 2475-2484
50. Watson A.D., Leitinger N., et al. Structural identification by mass spectrometry of oxidized phospholipids in minimally oxidized low density lipoprotein that induce monocyte/endothelial interactions and evidence for their presence in vivo. J. Biol. Chem. 272 21 (1997) 13597-13607
51. Wood L.G., Gibson P.G., et al. Biomarkers of lipid peroxidation, airway inflammation and asthma. Eur. Respir. J. 21 1 (2003) 177-186
52. Yeh M., Gharavi N.M., et al. Oxidized phospholipids increase interleukin 8 (IL-8) synthesis by activation of the c-src/signal transducers and activators of transcription (STAT)3 pathway. J. Biol. Chem. 279 29 (2004) 30175-30181
53. Zhang Q., Magnusson M.K., et al. Lysophosphatidic acid and microtubule-destabilizing agents stimulate fibronectin matrix assembly through Rho-dependent actin stress fiber formation and cell contraction. Mol. Biol. Cell 8 8 (1997) 1415-1425
54. Zheng Y. Dbl family guanine nucleotide exchange factors. Trends Biochem. Sci. 26 12 (2001) 724-732