ALK5 and Smad4 are involved in TGF-β1-induced pulmonary endothelial permeability

FEBS Letters

Volumn 579, Issue 18, 2005, Pages 4031-4037

  Birukova, Anna A ^a   Adyshev, Djanibek ^a   Gorshkov, Boris ^a   Birukov, Konstantin G ^a   Verin, Alexander D ^a  

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Actin; ALK1 and 5; Permeability; Pulmonary endothelium; Smad4; TGF 1

Indexed keywords

ACTIN; ACTIVIN RECEPTOR LIKE KINASE 1; ISOENZYME; MYOSIN LIGHT CHAIN; MYOSIN PHOSPHATASE REGULATORY SUBUNIT 1; PHOSPHOTRANSFERASE; PHOSPHOTRANSFERASE INHIBITOR; PROTEIN; RECEPTOR PROTEIN; SMAD4 PROTEIN; TRANSFORMING GROWTH FACTOR BETA RECEPTOR; TRANSFORMING GROWTH FACTOR BETA RECEPTOR 1; TRANSFORMING GROWTH FACTOR BETA1; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CELL MEMBRANE PERMEABILITY; CONTROLLED STUDY; ENDOTHELIUM CELL; ENZYME ACTIVATION; LUNG ENDOTHELIUM; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; STRESS FIBER;

ACTINS; ACTIVIN RECEPTORS, TYPE I; ANIMALS; BENZAMIDES; BLOTTING, WESTERN; CATTLE; CELLS, CULTURED; CYTOSKELETON; DIOXOLES; DNA-BINDING PROTEINS; ELECTRIC IMPEDANCE; ENDOTHELIUM, VASCULAR; LUNG; MICROSCOPY, FLUORESCENCE; MYOSIN-LIGHT-CHAIN PHOSPHATASE; MYOSINS; PERMEABILITY; PHENOTYPE; PHOSPHORYLATION; RECEPTORS, TRANSFORMING GROWTH FACTOR BETA; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, SMALL INTERFERING; SIGNAL TRANSDUCTION; SMAD4 PROTEIN; TIME FACTORS; TRANS-ACTIVATORS; TRANSFORMING GROWTH FACTOR BETA; TRANSFORMING GROWTH FACTOR BETA1; TUBULIN;

EID: 21844466715     PISSN: 00145793     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.febslet.2005.06.018     Document Type: Article

References (25)

1. Y. Shi, and J. Massague Mechanisms of TGF-beta signaling from cell membrane to the nucleus Cell 113 2003 685 700
2. M.J. Goumans, F. Lebrin, and G. Valdimarsdottir Controlling the angiogenic switch: a balance between two distinct TGF-beta receptor signaling pathways Trends Cardiovasc. Med. 13 2003 301 307
3. S.P. Oh, T. Seki, K.A. Goss, T. Imamura, Y. Yi, P.K. Donahoe, L. Li, K. Miyazono, P. ten Dijke, and S. Kim Activin receptor-like kinase 1 modulates transforming growth factor-beta 1 signaling in the regulation of angiogenesis Proc. Natl. Acad. Sci. USA 97 2000 2626 2631
4. B.A. Roelen, M.A. van Rooijen, and C.L. Mummery Expression of ALK-1, a type 1 serine/threonine kinase receptor, coincides with sites of vasculogenesis and angiogenesis in early mouse development Dev. Dyn. 209 1997 418 430
5. M. Schiffer, G. von Gersdorff, M. Bitzer, K. Susztak, and E.P. Bottinger Smad proteins and transforming growth factor-beta signaling Kidney Int. Suppl. 77 2000 S45 S52
6. M.J. Goumans, G. Valdimarsdottir, S. Itoh, A. Rosendahl, P. Sideras, and P. ten Dijke Balancing the activation state of the endothelium via two distinct TGF-beta type I receptors EMBO J. 21 2002 1743 1753
7. E. Piek, A. Moustakas, A. Kurisaki, C.H. Heldin, and P. ten Dijke TGF-(beta) type I receptor/ALK-5 and Smad proteins mediate epithelial to mesenchymal transdifferentiation in NMuMG breast epithelial cells J. Cell Sci. 112 Pt 24 1999 4557 4568
8. V.I. Hurst, P.L. Goldberg, F.L. Minnear, R.L. Heimark, and P.A. Vincent Rearrangement of adherens junctions by transforming growth factor-beta1: role of contraction Am. J. Physiol. 276 1999 L582 L595
9. R.T. Clements, F.L. Minnear, H.A. Singer, R.S. Keller, and P.A. Vincent RhoA and Rho-kinase dependent and independent signals mediate TGF-beta-induced pulmonary endothelial cytoskeletal reorganization and permeability Am. J. Physiol. Lung Cell. Mol. Physiol. 288 2005 L294 L306
10. Birukova, A., Birukov, K., Adyshev, D., Usatyuk, P., Natarajan, V., Garcia, J.G., Verin, A. (2005) Involvement of microtubules and Rho pathway in TGF- 1-induced lung vascular barrier dysfunction. J. Cell Physiol. [Epub ahead of print].
11. M.A. Behzadian, X.L. Wang, L.J. Windsor, N. Ghaly, and R.B. Caldwell TGF-beta increases retinal endothelial cell permeability by increasing MMP-9: possible role of glial cells in endothelial barrier function Invest. Ophthalmol. Vis. Sci. 42 2001 853 859
12. A.A. Birukova, K. Smurova, K.G. Birukov, P. Usatyuk, F. Liu, K. Kaibuchi, A. Ricks-Cord, V. Natarajan, A. Alieva, and J.G. Garcia Microtubule disassembly induces cytoskeletal remodeling and lung vascular barrier dysfunction: role of Rho-dependent mechanisms J. Cell. Physiol. 201 2004 55 70
13. S.M. Elbashir, J. Harborth, W. Lendeckel, A. Yalcin, K. Weber, and T. Tuschl Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells Nature 411 2001 494 498
14. A.A. Birukova, K. Smurova, K.G. Birukov, K. Kaibuchi, J.G. Garcia, and A.D. Verin Role of Rho GTPases in thrombin-induced lung vascular endothelial cells barrier dysfunction Microvasc. Res. 67 2004 64 77
15. Birukova, A.A., Birukov, K.G., Gorshkov, B., Liu, F., Garcia, J.G., Verin, A.D. (2005) MAP kinases in lung endothelial permeability induced by microtubule disassembly. Am. J. Physiol. Lung Cell. Mol. Physiol. [Epub ahead of print].
16. A.D. Verin, A. Birukova, P. Wang, F. Liu, P. Becker, K. Birukov, and J.G. Garcia Microtubule disassembly increases endothelial cell barrier dysfunction: role of MLC phosphorylation Am. J. Physiol. Lung. Cell. Mol. Physiol. 281 2001 L565 L574
17. C. Tiruppathi, A.B. Malik, P.J. Del Vecchio, C.R. Keese, and I. Giaever Electrical method for detection of endothelial cell shape change in real time: assessment of endothelial barrier function Proc. Natl. Acad. Sci. USA 89 1992 7919 7923
18. P.L. Goldberg, D.E. MacNaughton, R.T. Clements, F.L. Minnear, and P.A. Vincent p38 MAPK activation by TGF-beta1 increases MLC phosphorylation and endothelial monolayer permeability Am. J. Physiol. Lung Cell. Mol. Physiol. 282 2002 L146 L154
19. G.J. Inman, F.J. Nicolas, J.F. Callahan, J.D. Harling, L.M. Gaster, A.D. Reith, N.J. Laping, and C.S. Hill SB-431542 is a potent and specific inhibitor of transforming growth factor-beta superfamily type I activin receptor-like kinase (ALK) receptors ALK4, ALK5, ALK7 Mol. Pharmacol. 62 2002 65 74
20. K. Kimura, M. Ito, M. Amano, K. Chihara, Y. Fukata, M. Nakafuku, B. Yamamori, J. Feng, T. Nakano, and K. Okawa Regulation of myosin phosphatase by Rho and Rho-associated kinase (Rho-kinase) Science 273 1996 245 248
21. S.M. Dudek, and J.G. Garcia Cytoskeletal regulation of pulmonary vascular permeability J. Appl. Physiol. 91 2001 1487 1500
22. T. Ota, M. Fujii, T. Sugizaki, M. Ishii, K. Miyazawa, H. Aburatani, and K. Miyazono Targets of transcriptional regulation by two distinct type I receptors for transforming growth factor-beta in human umbilical vein endothelial cells J. Cell Physiol. 193 2002 299 318
23. S. Lamouille, C. Mallet, J.J. Feige, and S. Bailly Activin receptor-like kinase 1 is implicated in the maturation phase of angiogenesis Blood 100 2002 4495 4501
24. M.J. Goumans, G. Valdimarsdottir, S. Itoh, F. Lebrin, J. Larsson, C. Mummery, S. Karlsson, and P. ten Dijke Activin receptor-like kinase (ALK)1 is an antagonistic mediator of lateral TGFbeta/ALK5 signaling Mol. Cell. 12 2003 817 828
25. F. Lebrin, M. Deckers, P. Bertolino, and P. Ten Dijke TGF-beta receptor function in the endothelium Cardiovasc. Res. 65 2005 599 608