The anti-rheumatic gold salt aurothiomalate suppresses interleukin-1 β-induced hyaluronan accumulation by blocking HAS1 transcription and by acting as a COX-2 transcriptional repressor

Journal of Biological Chemistry

Volumn 282, Issue 4, 2007, Pages 2250-2258

  Stuhlmeier, Karl M ^a  

^a LUDWIG BOLTZMANN INSTITUTE FOR LUNG VASCULAR RESEARCH   (Austria)

Author keywords

[No Author keywords available]

Indexed keywords

HYALURONAN; HYALURONAN ACCUMULATION; TRANSCRIPTIONAL REPRESSOR;

DISEASES; DRUG PRODUCTS; ENZYME ACTIVITY; GENES; GOLD COMPOUNDS; PATIENT TREATMENT;

TRANSCRIPTION;

ANTIRHEUMATIC AGENT; AUROTHIOMALATE; CYCLOOXYGENASE 2; CYCLOOXYGENASE 2 TRANSCRIPTION REPRESSOR; DNA; GOLD SALT; HYALURONIC ACID; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 1BETA; REGULATOR PROTEIN; REPRESSOR PROTEIN; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR HAS1; UNCLASSIFIED DRUG; GLUCURONOSYLTRANSFERASE; HYALURONAN SYNTHASE; MEMBRANE PROTEIN; PTGS2 PROTEIN, HUMAN;

ANTIINFLAMMATORY ACTIVITY; ARTICLE; BINDING SITE; BIOACCUMULATION; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG EFFECT; DRUG MECHANISM; ENZYME ACTIVATION; ENZYME INHIBITION; FIBROBLAST; GENE FUNCTION; HUMAN; HUMAN CELL; PHARMACOLOGICAL BLOCKING; PRIORITY JOURNAL; PROTEIN INTERACTION; RHEUMATOID ARTHRITIS; SYNOVIOCYTE; TRANSCRIPTION REGULATION; BIOSYNTHESIS; CELL LINE; CYTOLOGY; DOWN REGULATION; DRUG ANTAGONISM; GENE EXPRESSION REGULATION; GENETIC TRANSCRIPTION; GENETICS; METABOLISM; RHEUMATIC DISEASE; SYNOVIUM;

ANTIRHEUMATIC AGENTS; CELL LINE; CYCLOOXYGENASE 2; DOWN-REGULATION; FIBROBLASTS; GENE EXPRESSION REGULATION, ENZYMOLOGIC; GLUCURONOSYLTRANSFERASE; GOLD SODIUM THIOMALATE; HUMANS; HYALURONIC ACID; INTERLEUKIN-1BETA; MEMBRANE PROTEINS; NF-KAPPA B; RHEUMATIC DISEASES; SYNOVIAL MEMBRANE; TRANSCRIPTION, GENETIC;

EID: 34047260409     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M605011200     Document Type: Article

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