메뉴 건너뛰기




Volumn 39, Issue 2, 2007, Pages 149-156

Inhibition of the androgen receptor by antisense oligonucleotides regulates the biological activity of androgens in SZ95 sebocytes

Author keywords

Androgens; Biological activity; Sebaceous glands; Transient transfection

Indexed keywords

2' O METHYLRIBONUCLEOTIDE DERIVATIVE; ANDROGEN RECEPTOR; ANTISENSE OLIGONUCLEOTIDE; METRIBOLONE; PHOSPHOROTHIOIC ACID DERIVATIVE; RIBONUCLEOTIDE; SMALL INTERFERING RNA; UNCLASSIFIED DRUG;

EID: 34047209460     PISSN: 00185043     EISSN: None     Source Type: Journal    
DOI: 10.1055/s-2007-961815     Document Type: Article
Times cited : (33)

References (54)
  • 2
    • 0037340162 scopus 로고    scopus 로고
    • Selective DNA recognition by the androgen receptor as a mechanism for hormone-specific regulation of gene expression
    • Verrijdt G, Haelens A, Claessens F: Selective DNA recognition by the androgen receptor as a mechanism for hormone-specific regulation of gene expression. Mol Genet Metab 2003; 78: 175-185
    • (2003) Mol Genet Metab , vol.78 , pp. 175-185
    • Verrijdt, G.1    Haelens, A.2    Claessens, F.3
  • 3
    • 0034583277 scopus 로고    scopus 로고
    • Human skin: An independent peripheral endocrine organ
    • Zouboulis CC: Human skin: an independent peripheral endocrine organ. Horm Res 2000; 54: 230-242
    • (2000) Horm Res , vol.54 , pp. 230-242
    • CC, Z.1
  • 4
    • 0041857786 scopus 로고    scopus 로고
    • The androgen receptor: Structure, mutations, and antiandrogens
    • Hirawat S, Budman DR, Kreis W: The androgen receptor: structure, mutations, and antiandrogens. Cancer Invest 2003; 21: 400-417
    • (2003) Cancer Invest , vol.21 , pp. 400-417
    • Hirawat, S.1    Budman, D.R.2    Kreis, W.3
  • 5
    • 0141676097 scopus 로고    scopus 로고
    • Endocrine mechanisms of disease: Expression and degradation of androgen receptor: mechanism and clinical implication
    • Lee DK, Chang C: Endocrine mechanisms of disease: expression and degradation of androgen receptor: mechanism and clinical implication. J Clin Endocrinol Metab 2003; 88: 4043-4054
    • (2003) J Clin Endocrinol Metab , vol.88 , pp. 4043-4054
    • Lee, D.K.1    Chang, C.2
  • 7
    • 0036731984 scopus 로고    scopus 로고
    • Adams BD, Callaghan JJ, Hendrix MJ: Androgen receptors in human synoviocytes and androgen regulation of interleukin 1beta (IL-1beta) induced IL-6 production: a link between hypoandrogenicity and rheumatoid arthritis?
    • Khalkhali-Ellis Z, Handa RJ, Price RH, Jr, Adams BD, Callaghan JJ, Hendrix MJ: Androgen receptors in human synoviocytes and androgen regulation of interleukin 1beta (IL-1beta) induced IL-6 production: a link between hypoandrogenicity and rheumatoid arthritis? J Rheumatol 2002; 29: 1843-1846
    • (2002) J Rheumatol , vol.29 , pp. 1843-1846
    • Khalkhali-Ellis, Z.1    Handa, R.J.2    RH Jr, P.3
  • 9
    • 0037566592 scopus 로고    scopus 로고
    • The CAG repeats in exon 1 of the androgen receptor gene are significantly longer in endometrial cancer patients
    • Sasaki M, Sakuragi N, Dahiya R: The CAG repeats in exon 1 of the androgen receptor gene are significantly longer in endometrial cancer patients. Biochem Biophys Res Commun 2003; 305: 1105-1108
    • (2003) Biochem Biophys Res Commun , vol.305 , pp. 1105-1108
    • Sasaki, M.1    Sakuragi, N.2    Dahiya, R.3
  • 10
    • 0036446856 scopus 로고    scopus 로고
    • Cutaneous androgen metabolism: Basic research and clinical perspectives
    • Chen W, Thiboutot D, Zouboulis ChC: Cutaneous androgen metabolism: basic research and clinical perspectives. J Invest Dermatol 2002; 119: 992-1007
    • (2002) J Invest Dermatol , vol.119 , pp. 992-1007
    • Chen, W.1    Thiboutot, D.2    ChC, Z.3
  • 11
    • 0035733383 scopus 로고    scopus 로고
    • Coordinate regulation of epidermal differentiation and barrier homeostasis
    • Elias P, Feingold K: Coordinate regulation of epidermal differentiation and barrier homeostasis. Skin Pharmacol Appl Skin Physiol 2001; 14: 28-34
    • (2001) Skin Pharmacol Appl Skin Physiol , vol.14 , pp. 28-34
    • Elias, P.1    Feingold, K.2
  • 13
    • 0036731981 scopus 로고    scopus 로고
    • Androgen receptor-mediated inhibition of cutaneous wound healing
    • Ashcroft G, Mills S: Androgen receptor-mediated inhibition of cutaneous wound healing. J Clin Invest 2002; 110: 615-624
    • (2002) J Clin Invest , vol.110 , pp. 615-624
    • Ashcroft, G.1    Mills, S.2
  • 14
    • 10644244420 scopus 로고    scopus 로고
    • Androgen action on human skin - from basic research to clinical significance
    • Zouboulis ChC, Degitz K: Androgen action on human skin - from basic research to clinical significance. Exp Dermatol 2004; 4: 5-10
    • (2004) Exp Dermatol , vol.4 , pp. 5-10
    • Zouboulis, C.C.1    Degitz, K.2
  • 15
  • 16
    • 18044385371 scopus 로고    scopus 로고
    • Steroid hormone receptors as targets for the therapy of breast and prostate cancer - recent advances, mechanisms of resistance and new approaches
    • Hoffmann J, Sommer A: Steroid hormone receptors as targets for the therapy of breast and prostate cancer - recent advances, mechanisms of resistance and new approaches. J Steroid Biochem Mol Biol 2005; 93: 191-200
    • (2005) J Steroid Biochem Mol Biol , vol.93 , pp. 191-200
    • Hoffmann, J.1    Sommer, A.2
  • 17
    • 3042645268 scopus 로고    scopus 로고
    • Antisense approaches in prostate cancer
    • Chi KN, Gleave ME: Antisense approaches in prostate cancer. Expert Opin Biol Ther 2004; 6: 927-936
    • (2004) Expert Opin Biol Ther , vol.6 , pp. 927-936
    • Chi, K.N.1    Gleave, M.E.2
  • 19
    • 23144434218 scopus 로고    scopus 로고
    • Androgen receptor down regulation by small interference RNA induces cell growth inhibition in androgen sensitive as well as in androgen independent prostate cancer cells
    • Haag P, Bektic J, Bartsch G, Klocker H, Eder IE: Androgen receptor down regulation by small interference RNA induces cell growth inhibition in androgen sensitive as well as in androgen independent prostate cancer cells. J Steroid Biochem Mol Biol 2005; 96: 251-258
    • (2005) J Steroid Biochem Mol Biol , vol.96 , pp. 251-258
    • Haag, P.1    Bektic, J.2    Bartsch, G.3    Klocker, H.4    Eder, I.E.5
  • 20
    • 4143129940 scopus 로고    scopus 로고
    • Androgen receptor down-regulation in prostate cancer with phosphorodiamidate morpholino antisense oligomers
    • Ko YJ, Devi GR, London CA, Kayas A, Reddy MT, Iversen PL, Bubley GJ, Balk SP: Androgen receptor down-regulation in prostate cancer with phosphorodiamidate morpholino antisense oligomers. J Urol 2004; 172: 1140-1144
    • (2004) J Urol , vol.172 , pp. 1140-1144
    • Ko, Y.J.1    Devi, G.R.2    London, C.A.3    Kayas, A.4    Reddy, M.T.5    Iversen, P.L.6    Bubley, G.J.7    Balk, S.P.8
  • 21
    • 34047196935 scopus 로고    scopus 로고
    • Responsiveness to androgens and effectiveness of antisense oligonucleotides against the androgen receptor on human epidermal keratinocytes is dependent on the age of the donor and the location of cell origin
    • Fimmel S, Kurfurst R, Bonté F, Zouboulis CC: Responsiveness to androgens and effectiveness of antisense oligonucleotides against the androgen receptor on human epidermal keratinocytes is dependent on the age of the donor and the location of cell origin. Horm Metab Res 2007; 39: 157-165
    • (2007) Horm Metab Res , vol.39 , pp. 157-165
    • Fimmel, S.1    Kurfurst, R.2    Bonté, F.3    Zouboulis, C.C.4
  • 22
    • 0033397124 scopus 로고    scopus 로고
    • Establishment and characterization of an immortalized human sebaceous gland cell line (SZ95)
    • Zouboulis ChC, Seltmann H, Neitzel H, Orfanos CE: Establishment and characterization of an immortalized human sebaceous gland cell line (SZ95). J Invest Dermatol 1999; 113: 1011-1020
    • (1999) J Invest Dermatol , vol.113 , pp. 1011-1020
    • Zouboulis, C.C.1    Seltmann, H.2    Neitzel, H.3    Orfanos, C.E.4
  • 23
    • 0029121485 scopus 로고
    • A new deletion of the 5alpha-reductase type 2 gene in a Turkish family with 5 alpha-reductase deficiency
    • Boudon C, Lobaccaro JM, Lumbroso S, Ogur G, Ocal G, Belon C, Sultan C: A new deletion of the 5alpha-reductase type 2 gene in a Turkish family with 5 alpha-reductase deficiency. Clin Endocrinol 1995; 43: 183-188
    • (1995) Clin Endocrinol , vol.43 , pp. 183-188
    • Boudon, C.1    Lobaccaro, J.M.2    Lumbroso, S.3    Ogur, G.4    Ocal, G.5    Belon, C.6    Sultan, C.7
  • 24
    • 0034583273 scopus 로고    scopus 로고
    • Development of efficient transient transfection systems for introducing antisense oligonucleotides into human epithelial skin cells
    • Fimmel S, Saborowski A, Orfanos CE, Zouboulis ChC: Development of efficient transient transfection systems for introducing antisense oligonucleotides into human epithelial skin cells. Horm Res 2000; 54: 306-311
    • (2000) Horm Res , vol.54 , pp. 306-311
    • Fimmel, S.1    Saborowski, A.2    Orfanos, C.E.3    ChC, Z.4
  • 27
    • 0022880936 scopus 로고
    • Determination of cell number in monolayer cultures
    • Gillies RJ, Didier N, Denton M: Determination of cell number in monolayer cultures. Anal Biochem 1986; 159: 109-113
    • (1986) Anal Biochem , vol.159 , pp. 109-113
    • Gillies, R.J.1    Didier, N.2    Denton, M.3
  • 28
    • 0032126642 scopus 로고    scopus 로고
    • Quantitation of androgen receptor messenger RNA from genital skin fibroblasts by reverse transcription-competitive polymerase chain reaction
    • Nirde P, Georget V, Terouanne B, Galifer RB, Belon C, Sultan C: Quantitation of androgen receptor messenger RNA from genital skin fibroblasts by reverse transcription-competitive polymerase chain reaction. J Steroid Biochem Mol Biol 1998; 66: 35-43
    • (1998) J Steroid Biochem Mol Biol , vol.66 , pp. 35-43
    • Nirde, P.1    Georget, V.2    Terouanne, B.3    Galifer, R.B.4    Belon, C.5    Sultan, C.6
  • 29
    • 0026595896 scopus 로고
    • Androgen receptor phosphorylation, turnover, nuclear transport, and transcriptional activation. Specificity for steroids and antihormones
    • Kemppainen JA, Lane MV, Sar M, Wilson EM: Androgen receptor phosphorylation, turnover, nuclear transport, and transcriptional activation. Specificity for steroids and antihormones. J Biol Chem 1992; 267: 968-974
    • (1992) J Biol Chem , vol.267 , pp. 968-974
    • Kemppainen, J.A.1    Lane, M.V.2    Sar, M.3    Wilson, E.M.4
  • 30
    • 0035878820 scopus 로고    scopus 로고
    • Androgen blocks apoptosis of hormone- dependent prostate cancer cells
    • Kimura K, Markowski M, Bowen C, Gelmann EP: Androgen blocks apoptosis of hormone- dependent prostate cancer cells. Cancer Res 2001; 61: 5611-5618
    • (2001) Cancer Res , vol.61 , pp. 5611-5618
    • Kimura, K.1    Markowski, M.2    Bowen, C.3    Gelmann, E.P.4
  • 31
    • 0023898356 scopus 로고
    • Studies of up-regulation of androgen receptors in genital skin fibroblasts
    • Gad YZ, Berkovitz GD, Migeon CJ, Brown TR: Studies of up-regulation of androgen receptors in genital skin fibroblasts. Mol Cell Endocrinol 1988; 57: 205-213
    • (1988) Mol Cell Endocrinol , vol.57 , pp. 205-213
    • Gad, Y.Z.1    Berkovitz, G.D.2    Migeon, C.J.3    Brown, T.R.4
  • 32
    • 0042334918 scopus 로고    scopus 로고
    • Expression of peroxisome proliferator-activated receptor and CCAAT/enhancer binding protein transcription factors in cultured human sebocytes
    • Chen W, Yang CC, Sheu HM, Seltmann H, Zouboulis ChC: Expression of peroxisome proliferator-activated receptor and CCAAT/enhancer binding protein transcription factors in cultured human sebocytes. J Invest Dermatol 2003; 121: 441-447
    • (2003) J Invest Dermatol , vol.121 , pp. 441-447
    • Chen, W.1    Yang, C.C.2    Sheu, H.M.3    Seltmann, H.4    ChC, Z.5
  • 33
    • 0032522132 scopus 로고    scopus 로고
    • Phosphorothioate oligodeoxyribonucleotides dissociate from cationic lipids before entering the nucleus
    • Marcusson EG, Bhat B, Manoharan M, Bennett CF, Dean NM: Phosphorothioate oligodeoxyribonucleotides dissociate from cationic lipids before entering the nucleus. Nucleic Acid Res 1998; 26: 2016-2023
    • (1998) Nucleic Acid Res , vol.26 , pp. 2016-2023
    • Marcusson, E.G.1    Bhat, B.2    Manoharan, M.3    Bennett, C.F.4    Dean, N.M.5
  • 34
    • 24144463114 scopus 로고    scopus 로고
    • Progress in the delivery of therapeutic oligonucleotides: Organ/cellular distribution and targeted delivery of oligonucleotides in vivo
    • Wang L, Prakash RK, Stein CA, Koehn RK, Ruffne DE: Progress in the delivery of therapeutic oligonucleotides: organ/cellular distribution and targeted delivery of oligonucleotides in vivo. Antisense Nucleic Acid Drug Dev 2003; 13: 169-189
    • (2003) Antisense Nucleic Acid Drug Dev , vol.13 , pp. 169-189
    • Wang, L.1    Prakash, R.K.2    Stein, C.A.3    Koehn, R.K.4    Ruffne, D.E.5
  • 37
    • 0029619816 scopus 로고
    • Kinetic characteristics of Escherichia coli RNase H1: Cleavage of various antisense oligonucleotide- RNA duplexes
    • Crooke ST, Lemonidis KM, Neilson L, Griffey R, Lesnik EA, Monia BP: Kinetic characteristics of Escherichia coli RNase H1: cleavage of various antisense oligonucleotide- RNA duplexes. Biochem J 1995; 312: 599-608
    • (1995) Biochem J , vol.312 , pp. 599-608
    • Crooke, S.T.1    Lemonidis, K.M.2    Neilson, L.3    Griffey, R.4    Lesnik, E.A.5    Monia, B.P.6
  • 38
    • 0036567147 scopus 로고    scopus 로고
    • Design of antisense oligonucleotides stabilized by locked nucleic acids
    • Kurreck J, Wyszko E, Gillen C, Erdmann VA: Design of antisense oligonucleotides stabilized by locked nucleic acids. Nucleic Acids Res 2002; 30: 1911-1918
    • (2002) Nucleic Acids Res , vol.30 , pp. 1911-1918
    • Kurreck, J.1    Wyszko, E.2    Gillen, C.3    Erdmann, V.A.4
  • 39
    • 0031010177 scopus 로고    scopus 로고
    • 2′-O-(2-Methoxy)ethyl-modified anti-intercellular adhesion molecule 1 (ICAM-1) oligonucleotides selectively increase the ICAM-1 mRNA level and inhibit formation of the ICAM-1 translation initiation complex in human umbilical vein endothelial cells
    • Baker BF, Lot SS, Condon TP, Cheng S, Flournoy F, Lesnik EA, Sasmor H, Bennett CF: 2′-O-(2-Methoxy)ethyl-modified anti-intercellular adhesion molecule 1 (ICAM-1) oligonucleotides selectively increase the ICAM-1 mRNA level and inhibit formation of the ICAM-1 translation initiation complex in human umbilical vein endothelial cells. J Biol Chem 1997; 272: 1994-2000
    • (1997) J Biol Chem , vol.272 , pp. 1994-2000
    • Baker, B.F.1    Lot, S.S.2    Condon, T.P.3    Cheng, S.4    Flournoy, F.5    Lesnik, E.A.6    Sasmor, H.7    Bennett, C.F.8
  • 41
    • 0035862164 scopus 로고    scopus 로고
    • Effect of 2′-O-methyl antisense ORNs on expression of thymidylate synthase in human colon cancer RKO cells
    • Schmitz JC, Yu D, Agrawal S, Chu E: Effect of 2′-O-methyl antisense ORNs on expression of thymidylate synthase in human colon cancer RKO cells. Nucleic Acids Res 2001; 29: 415-422
    • (2001) Nucleic Acids Res , vol.29 , pp. 415-422
    • Schmitz, J.C.1    Yu, D.2    Agrawal, S.3    Chu, E.4
  • 43
    • 0037064019 scopus 로고    scopus 로고
    • Regulation of lipoprotein lipase by protein kinase C alpha in 3T3-F442A adipocytes
    • Ranganathan G, Song W, Dean N, Monia B, Barger SW, Kern PA: Regulation of lipoprotein lipase by protein kinase C alpha in 3T3-F442A adipocytes. J Biol Chem 2002; 277: 38669-38675
    • (2002) J Biol Chem , vol.277 , pp. 38669-38675
    • Ranganathan, G.1    Song, W.2    Dean, N.3    Monia, B.4    Barger, S.W.5    Kern, P.A.6
  • 44
    • 0142217034 scopus 로고    scopus 로고
    • The androgen receptor transactivation domain: The interplay between protein conformation and protein-protein interactions
    • Reid J, Betney R, Watt K, McEwan IJ: The androgen receptor transactivation domain: the interplay between protein conformation and protein-protein interactions. Biochem Soc Trans 2003; 31: 1042-1046
    • (2003) Biochem Soc Trans , vol.31 , pp. 1042-1046
    • Reid, J.1    Betney, R.2    Watt, K.3    McEwan, I.J.4
  • 45
    • 0025037581 scopus 로고
    • Testosterone at high concentrations interacts with the human androgen receptor similarly to dihydrotestosterone
    • Grino PB, Griffin JE, Wilson JD: Testosterone at high concentrations interacts with the human androgen receptor similarly to dihydrotestosterone. Endocrinology 1990; 126: 1165-1172
    • (1990) Endocrinology , vol.126 , pp. 1165-1172
    • Grino, P.B.1    Griffin, J.E.2    Wilson, J.D.3
  • 46
    • 0035016799 scopus 로고    scopus 로고
    • Sebocytes are the key regulators of androgen homeostasis in human skin
    • Fritsch M, Orfanos CE, Zouboulis ChC: Sebocytes are the key regulators of androgen homeostasis in human skin. J Invest Dermatol 2001; 116: 793-800
    • (2001) J Invest Dermatol , vol.116 , pp. 793-800
    • Fritsch, M.1    Orfanos, C.E.2    ChC, Z.3
  • 50
    • 0033305556 scopus 로고    scopus 로고
    • Differential posttranscriptional regulation of androgen receptor gene expression by androgen in prostate and breast cancer cells
    • Yeap BB, Krueger RG, Leedman PJ: Differential posttranscriptional regulation of androgen receptor gene expression by androgen in prostate and breast cancer cells. Endocrinology 1999; 40: 3282-3291
    • (1999) Endocrinology , vol.40 , pp. 3282-3291
    • Yeap, B.B.1    Krueger, R.G.2    Leedman, P.J.3
  • 51
  • 52
    • 0027214174 scopus 로고
    • Transcriptional and posttranscriptional regulation of human androgen receptor expression by androgen
    • Wolf DA, Herzinger T, Hermeking H, Blaschke D, Horz W: Transcriptional and posttranscriptional regulation of human androgen receptor expression by androgen. Mol Endocrinol 1993; 7: 924-936
    • (1993) Mol Endocrinol , vol.7 , pp. 924-936
    • Wolf, D.A.1    Herzinger, T.2    Hermeking, H.3    Blaschke, D.4    Horz, W.5
  • 53
    • 0035704028 scopus 로고    scopus 로고
    • Does antisense make sense in Dermatology?
    • van Erp PE, Wingens M: Does antisense make sense in Dermatology? Acta Derm Venereol 2001; 81: 385-391
    • (2001) Acta Derm Venereol , vol.81 , pp. 385-391
    • van Erp, P.E.1    Wingens, M.2
  • 54
    • 0038061619 scopus 로고    scopus 로고
    • Liposomes increase skin penetration of entrapped and non-entrapped hydrophilic substances into human skin: A skin penetration and confocal laser scanning microscopy study
    • Verma DD, Verma S, Blume G, Fahr A: Liposomes increase skin penetration of entrapped and non-entrapped hydrophilic substances into human skin: a skin penetration and confocal laser scanning microscopy study. Eur J Pharm Biopharm 2003; 55: 271-277
    • (2003) Eur J Pharm Biopharm , vol.55 , pp. 271-277
    • Verma, D.D.1    Verma, S.2    Blume, G.3    Fahr, A.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.