Specific block of androgen receptor activity by antisense oligonucleotides

Prostate Cancer and Prostatic Diseases

Volumn 6, Issue 1, 2003, Pages 27-33

  Hamy, Francois ^a,b   Brondani, V ^a   Spoerri, R ^a   Rigo, S ^a   Stamm, C ^a   Klimkait, T ^b  

^a NOVARTIS PHARMA AG   (Switzerland)

^b UNIVERSITY OF BASEL   (Switzerland)

Author keywords

Androgen receptor; Antisense; Gene regulation; LNCaP; Probasin; Prostate cancer; Prostate specific antigen

Indexed keywords

ANDROGEN RECEPTOR; ANTISENSE OLIGONUCLEOTIDE; MESSENGER RNA; PROBASIN; PROSTATE SPECIFIC ANTIGEN; SOMATOMEDIN C;

3' UNTRANSLATED REGION; 5' UNTRANSLATED REGION; ARTICLE; CANCER CELL CULTURE; CONTROLLED STUDY; DRUG MECHANISM; DRUG SCREENING; DRUG SELECTIVITY; DRUG SYNTHESIS; DRUG TARGETING; GENE EXPRESSION REGULATION; GROWTH REGULATION; HORMONE ACTION; HUMAN; HUMAN CELL; HYPOTHESIS; IN VIVO STUDY; MALE; MOLECULAR DYNAMICS; NUCLEOTIDE SEQUENCE; POINT MUTATION; PRIORITY JOURNAL; PROSTATE ADENOCARCINOMA; SEQUENCE ANALYSIS; TRANSACTIVATION; TRANSCRIPTION REGULATION;

ANDROGEN-BINDING PROTEIN; ANIMALS; BASE SEQUENCE; DNA PRIMERS; GENE EXPRESSION; HUMANS; INSULIN-LIKE GROWTH FACTOR I; MALE; MOLECULAR SEQUENCE DATA; OLIGONUCLEOTIDES, ANTISENSE; PLASMIDS; POLYMERASE CHAIN REACTION; PROMOTER REGIONS (GENETICS); PROSTATE-SPECIFIC ANTIGEN; PROSTATIC NEOPLASMS; RATS; RECEPTORS, ANDROGEN; TRANS-ACTIVATION (GENETICS); TRANSFECTION; TUMOR CELLS, CULTURED;

EID: 0037252094     PISSN: 13657852     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.pcan.4500603     Document Type: Article

References (20)

1. Trapman J, Brinkmann AO. The androgen receptor in prostate cancer. Path Res Pract 1996; 192: 752-760.
2. Yeung F et al. Regions of prostate-specific antigen (PSA) promoter confer androgen-independent expression of PSA in prostate cancer cell line. J Biol Chem 2000; 275: 40846-40855.
3. Visakorpi T et al. In vivo amplification of the androgen receptor gene and progression of human prostate cancer. Nature Genet 1995; 9: 401-404.
4. Gottlieb B et al. Update of the androgen receptor gene mutation database. Hum Mutat 1999; 14: 103-114.
5. Suzuki H et al. Androgen receptor gene mutations in human prostate cancer. Steroid Biochem Mol Biol 1993; 46: 759-765.
6. Nessler-Menardi C et al. Expression of androgen receptor coregulatory proteins in prostate cancer ans stromal-cell culture models. Prostate 2000; 45: 124-131.
7. Culig Z et al. Androgen receptor activation in prostatic tumor cell lines by insulin-like growth factor-I, Keratinocyte growth factor and epidermal growth factor. Eur Urol 1995; 27: 45-47.
8. Horoszewicz JS et al. LNCaP model of human prostatic carcinoma. Cancer Res 1983; 43: 1809-1818.
9. Dodd JG, Sheppard PC, Matusik RJ. Characterization and cloning of rat dorsal prostate mRNAs. Androgen regulation of two closely related abundant mRNAs. J Biol Chem 1983; 258: 177-180.
10. Matusik RJ et al. Regulation of prostatic genes: role of androgens and zinc in gene expression. Biochem Cell Biol 1986; 64: 601-607.
11. Sweetland R, Sheppard PC, Dodd JG, Matusik RJ. Post-castration rebound of an androgen regulated prostatic gene. Mol Cell, Biochem 1988; 84: 3-15.
12. Rennie PS et al. Characterization of two cis-acting DNA elements involved in the androgen regulation of the probasin gene. Mol Endocrinol 1993; 7: 23-26.
13. Laudet V. Evolution of the nuclear receptor superfamily: early diversification from an ancestral orphan receptor. J Mol Endocrinol 1997; 19: 207-226.
14. Stamey TA et al. Prostate-specific antigen as a serum marker for adenocarcinoma of the prostate. N Engl J Med 1987; 317: 909-916.
15. Riegman PHJ et al. The promoter of the prostate-specific antigen gene contains an androgen-responsive element. Mol Endocrinol 1991; 5: 1921-1930.
16. Helene C, Toulme JJ. Specific gene regulation of gene expression by antisense, sense and antigene nucleic acids. Biochim Biophys Acta 1990; 1049: 99-125.
17. Wyatt JR et al. Combinatorially selected guanosine-quartet structure is a potent inhibitor of human immunodeficiency virus envelope-mediated cell fusion. Proc Natl Acad Sci USA 1994; 91: 1356-1360.
18. Weiler J, Hoheisel JD. Combining the preparation of oligonucleotide arrays and synthesis of high-quality primers. Anal Biochem 1996; 243: 218-227.
19. Eder IE et al. Inhibition of LNCaP prostate cancer cells by means of androgen receptor antisense oligonucleotides. Cancer Gene Ther 2000; 7: 997-1007.
20. Eder IE et al. Inhibition of LNCaP prostate tumor growth in-vivo by an antisense oligonucleotide directed against the human androgen receptor. Cancer Gene Ther 2002; 9: 117-125.