Phosphorothioate oligodeoxyribonucleotides dissociate from cationic lipids before entering the nucleus

Nucleic Acids Research

Volumn 26, Issue 8, 1998, Pages 2016-2023

  Marcusson, Eric G ^a   Bhat, Balkrishen ^a   Manoharan, Muthiah ^a   Bennett, C Frank ^a   Dean, Nicholas M ^a  

^a ISIS PHARMACEUTICALS   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTISENSE OLIGONUCLEOTIDE; FLUORESCENT DYE; LIPID; MESSENGER RNA; OLIGODEOXYRIBONUCLEOTIDE; PHOSPHOROTHIOIC ACID; PROTEIN KINASE C; RIBONUCLEASE H;

ARTICLE; CELL NUCLEUS; CELL SURFACE; CONTROLLED STUDY; CYTOPLASM; DISSOCIATION; ENZYME SUBUNIT; GENE EXPRESSION REGULATION; GENE TARGETING; HUMAN; HUMAN CELL; MESSENGER RNA SYNTHESIS; PRIORITY JOURNAL; RNA DEGRADATION;

BORON COMPOUNDS; CELL NUCLEUS; DRUG CARRIERS; FATTY ACIDS, MONOUNSATURATED; FLUORESCENT DYES; HUMANS; ISOENZYMES; KINETICS; LUNG NEOPLASMS; MOLECULAR STRUCTURE; OLIGONUCLEOTIDES, ANTISENSE; PROTEIN KINASE C; PROTEIN KINASE C-ALPHA; QUATERNARY AMMONIUM COMPOUNDS; RNA, MESSENGER; THIONUCLEOTIDES; TRANSCRIPTION, GENETIC; TUMOR CELLS, CULTURED;

EID: 0032522132     PISSN: 03051048     EISSN: None     Source Type: Journal    
DOI: 10.1093/nar/26.8.2016     Document Type: Article

References (58)

1. Zamecnik, P.C. and Stephenson, M.L. (1978) Proc. Natl. Acad. Sci. USA, 75, 289-294.
2. Gewirtz, A.M. (1997) Anticancer Drug Des., 12, 341-358.
3. Crooke, S.T. and Bennett, C.F. (1996) Annu. Rev. Pharmacol. Toxicol., 36, 107-129.
4. Sharma, H.W. and Narayanan, R. (1995) BioEssays, 17, 1055-1063.
5. Wagner, R.W. (1994) Nature, 372, 333-335.
6. Simons, M., Edelman, E.R., DeKeyser, J.L., Langer, R. and Rosenberg, R.D. (1992) Nature, 359, 67-70.
7. Dean, N.M. and McKay, R. (1994) Proc. Natl. Acad. Sci. USA, 91, 11762-11766.
8. Agrawal, S., Temsamani, J. and Tang, J.Y. (1991) Proc. Natl. Acad. Sci. USA, 88, 7595-7599.
9. Cossum, P.A., Sasmor, H., Dellinger, D., Truong, L., Cummins, L., Owens, S.R., Markham, P.M., Shea, J.P. and Crooke, S. (1993) J. Pharmacol. Exp. Ther., 267, 1181-1190.
10. Butler, M., Stecker, K. and Bennett, C.F. (1997) Lab. Invest., 77, 379-388.
11. Bijsterbosch, M.K., Manoharan, M., Rump, E.T., De Vrueh, R.L., van Veghel, R., Tivel, K.L., Biessen, E.A., Bennett, C.F., Cook, P.D. and van Berkel, T.J. (1997) Nucleic Acids Res., 25, 3290-3296.
12. Yakubov, L.A., Deeva, E.A., Zarytova, V.F., Ivanova, E.M., Ryte, A.S., Yurchenko, L.V. and Vlassov, V.V. (1989) Proc. Natl. Acad. Sci. USA, 86, 6454-6458.
13. Loke, S.L., Stein, C.A., Zhang, X.H., Mori, K., Nakanishi, M., Subasinghe, C., Cohen, J.S. and Neckers, L.M. (1989) Proc. Natl. Acad. Sci. USA, 86, 3474-3478.
14. Goodarzi, G., Watabe, M. and Watabe, K. (1991) Biochem. Biophys. Res. Commun., 181, 1343-1351.
15. Geselowitz, D.A. and Neckers, L.M. (1992) Antisense Res. Dev., 2, 17-25.
16. Zhao, Q., Matson, S., Herrera, C.J., Fisher, E., Yu, H. and Krieg, A.M. (1993) Antisense Res. Dev., 3, 53-66.
17. Beltinger, C., Saragovi, H.U., Smith, R.M., LeSauteur, L., Shah, N., DeDionisio, L., Christensen, L., Raible, A., Jarett, L. and Gewirtz, A.M. (1995) J. Clin. Invest., 95, 1814-1823.
18. Nakai, D., Seita, T., Terasaki, T., Iwasa, S., Shoji, Y. Mizushima, Y. and Sugiyama, Y. (1996) J. Pharmacol. Exp. Ther., 278, 1362-1372.
19. Bennett, C.F., Chiang, M.-Y., Chan, H., Shoemaker, J.E.E. and Mirabelli, C.K. (1992) Mol. Pharmacol., 41, 1023-1033.
20. Spiller, D.G. and Tidd, D.M. (1992) Anticancer Drug Des., 7, 115-129.
21. Thierry, A.R. and Dritschilo, A. (1992) Nucleic Acids Res., 20, 5691-5698.
22. Lewis, J.G., Lin, K.Y., Kothavale, A., Flanagan, W.M., Matteucci, M.D., DePrince, R.B., Mook, R.A., Jr, Hendren, R.W. and Wagner, R.W. (1996) Proc. Natl. Acad. Sci. USA, 93, 3176-3181.
23. Legendre, J.Y. and Szoka, F.C., Jr (1992) Pharmacol. Res., 9, 1235-1242.
24. Bennett, C.F. (1995) In Akhtar, S. (ed.), Delivery Strategies for Antisense Oligonucleotide Therapeutics. CRC Press, Boca Raton, FL, pp. 223-232.
25. Bongartz, J.P., Aubertin, A.M., Milhaud, P.G. and Lebleu, B. (1994) Nucleic Acids Res., 22, 4681-4688.
26. Wyman, T.B., Nicol, F., Zelphati, O., Scaria, P.V., Plank, C. and Szoka, F.C. (1997) Biochemistry, 36, 3008-3017.
27. Bielinska, A., Kukowska-Latallo, J.F., Johnson, J., Tomalia, D.A. and Baker, J.R., Jr (1996) Nucleic Acids Res., 24, 2176-2182.
28. Delong, R., Stephenson, K., Loftus, T., Fisher, M., Alahari, S., Nolting, A. and Juliano, R.L. (1997) J. Pharm. Sci., 86, 762-764.
29. Leonetti, J.P., Degols, G. and Lebleu, B. (1990) Bioconjugate Chem., 1, 149-153.
30. Boussif, O., Lezoualc'h, F. Zanta, M.A., Mergny, M.D., Scherman, D., Demeneix, B. and Behr, J.P. (1995) Proc. Natl. Acad. Sci. USA, 92, 7297-7301.
31. Krieg, A.M., Tonkinson, J., Matson, S., Zhao, Q., Saxon, M., Zhang, L.M., Bhanja, U., Yakubov, L. and Stein, C.A. (1993) Proc. Natl. Acad. Sci. USA, 90, 1048-1052.
32. Alahari, S.K., Dean, N.M., Fisher, M.H., Delong, R., Manoharan, M., Tivel, K.L. and Juliano, R.L. (1996) Mol. Pharmacol., 50, 808-819.
33. Citro, G., Perrotti, D., Cucco, C., O'Agnano, I., Sacchi, A., Zupi, G. and Calabretta, B. (1992) Proc. Natl. Acad. Sci. USA, 89, 7031-7035.
34. Wu, G.Y. and Wu, C.H. (1992) J. Biol. Chem., 267, 12436-12439.
35. Watson, P.H., Pon, R.T. and Shiu, R.P. (1992) Exp. Cell Res., 202, 391-397.
36. Bergan, R., Connell, Y., Fahmy, B. and Neckers, L. (1993) Nucleic Acids Res., 21, 3567-3573.
37. Zelphati, O. and Szoka, F.C., Jr (1996) Pharmacol. Res., 13, 1367-1372.
38. Zelphati, O. and Szoka, F.C., Jr (1996) Proc. Natl. Acad. Sci. USA, 93, 11493-11498.
39. Szoka, F.C., Xu, Y.H. and Zelphati, O. (1997) Advanced Drug Delivery Rev., 24, 291.
40. Dean, N.M., McKay, R., Condon, T.P. and Bennett, C.F. (1994) J. Biol. Chem., 269, 16416-16424.
41. Monia, B.P., Johnston, J.F., Ecker, D.J., Zounes, M.A., Lima, W.F. and Freier, S.M. (1992) J. Biol. Chem., 267, 19954-19962.
42. Chiang, M.Y., Chan, H., Zounes, M.A., Freier, S.M., Lima, W.F. and Bennett, C.F. (1991) J. Biol. Chem., 266, 18162-18171.
43. Dean, N.M., McKay, R., Miraglia, L., Howard, R., Cooper, S., Gidding, J., Nicklin, P., Meister, L., Zeil, R., Geiger, T., Muller, M. and Fabbro, D. (1996) Cancer Res., 56, 3499-3507.
44. Yazaki, T., Ahmad, S., Chahlavi, A., Zylber-Katz, E., Dean, N.M., Rabkin, S.D., Martuza, R.L. and Glazer, R.I. (1996) Mol. Pharmacol., 50, 236-242.
45. Illinger, D. and Kuhry, J.G. (1994) J. Cell Biol, 125, 783-794.
46. Hartmann, G., Krug, A., Eigler. A., Moeller, J., Murphy, J., Albrecht, R. and Endres, S. (1996) Antisense Nucleic Acid Drug Dev., 6, 291-299.
47. Thierry, A.R., Rahman, A. and Dritschilo, A. (1993) Biochem. Biophys. Res. Commun., 190, 952-960.
48. Guy-Caffey, J.K., Bodepudi, V., Bishop, J.S., Jayaraman, K. and Chaudhary, N. (1995) J. Biol. Chem., 270, 31391-31396.
49. Stewart, A.J., Pichon, C. Meunier, L., Midoux, R. Monsigny, M. and Roche, A.C. (1996) Mol. Pharmacol., 50, 1487-1494.
50. Hughes, J.A., Aronsohn, A.I., Avrutskaya, A.V. and Juliano, R.L. (1996) Pharmacol. Res., 13, 404-410.
51. Wang, S., Lee, R.J., Cauchon, G., Gorenstein, D.G. and Low, P.S. (1995) Proc. Natl. Acad. Sci. USA, 92, 3318-3322.
52. Takle, G.B., Thierry, A.R., Flynn, S.M., Peng, B., White, L., Devonish, W., Galbraith, R.A., Goldberg, A.R. and George, S.T. (1997) Antisense Nucleic Acid Drug Dev., 7, 177-185.
53. Walker, I., Irwin, W.J. and Akhtar, S. (1995) Pharmacol. Res., 12, 1548-1553.
54. Ma, D.D. and Wei, A.Q. (1996) Leukemia Res., 20, 925-930.
55. Zabner, J., Fasbender, A.J., Moninger, T., Poellinger, K.A. and Welsh, M.J. (1995) J. Biol. Chem., 270, 18997-19007.
56. Chin, D.J., Green, G.A., Zon, G., Szoka, F.C., Jr and Straubinger, R.M. (1990) New Biologist, 2, 1091-1100.
57. Leonetti, J.P., Mechti, N., Degols, G., Gagnor, C. and Lebleu, B. (1991) Proc. Natl. Acad. Sci. USA, 88, 2702-2706.
58. Kanaya, S. and Ikehara, M. (1995) Subcell. Biochem., 24, 377-422.