PPARα siRNA-treated expression profiles uncover the causal sufficiency network for compound-induced liver hypertrophy

PLoS Computational Biology

Volumn 3, Issue 3, 2007, Pages 0389-0401

  Dai, Xudong ^a   De Souza, Angus T ^a   Dai, Hongyue ^a   Lewis, David L ^b   Lee, Chang Kyu ^a   Spencer, Andy G ^b   Herweijer, Hans ^b   Hagstrom, Jim E ^b   Linsley, Peter S ^a   Bassett, Douglas E ^a   Ulrich, Roger G ^a   He, Yudong D ^a  

^a ROSETTA INPHARMATICS   (United States)

^b Mirus Bio Corporation   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOLOGY; GENE EXPRESSION; PATHOLOGY; RNA;

CELLULAR FUNCTION; EFFECTIVE TOOL; EXPRESSION PROFILE; LIVER HYPERTROPHY; MECHANISM-BASED; PHENOTYPIC RESPONSE; PHENOTYPIC SCREENING; RNA INTERFERENCE; SMALL INTERFERING RNA; TOXICOGENOMICS;

TOXICITY;

PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR; SMALL INTERFERING RNA; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR ALPHA; PROTEOME;

ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; GENE IDENTIFICATION; GENETIC TRANSCRIPTION; LIVER HYPERTROPHY; MOLECULAR MECHANICS; MOUSE; NONHUMAN; PHENOTYPE; RAT; RNA INTERFERENCE; ANIMAL; BIOLOGICAL MODEL; CHEMICALLY INDUCED DISORDER; COMPUTER SIMULATION; DRUG EFFECT; GENE EXPRESSION PROFILING; GENE SILENCING; GENETICS; HYPERTROPHY; LIVER; METABOLISM; METHODOLOGY; PATHOLOGY; SIGNAL TRANSDUCTION;

ANIMALIA; RODENTIA;

ANIMALS; COMPUTER SIMULATION; GENE EXPRESSION PROFILING; GENE SILENCING; HYPERTROPHY; LIVER; MICE; MODELS, BIOLOGICAL; PPAR ALPHA; PROTEOME; RNA, SMALL INTERFERING; SIGNAL TRANSDUCTION;

EID: 34047207830     PISSN: 1553734X     EISSN: 15537358     Source Type: Journal    
DOI: 10.1371/journal.pcbi.0030030     Document Type: Article

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