Neurofunctional correlates of vulnerability to psychosis: A systematic review and meta-analysis

Neuroscience and Biobehavioral Reviews

Volumn 31, Issue 4, 2007, Pages 465-484

  Fusar Poli, Paolo ^a,b   Perez, Jorge ^c   Broome, Matthew ^b   Borgwardt, Stefan ^b   Placentino, Anna ^c   Caverzasi, Eduardo ^a   Cortesi, Mariachiara ^d   Veggiotti, Pierangelo ^d   Politi, Peirluigi ^a   Barale, Francesco ^a   McGuire, Philip ^b  

^a UNIVERSITY OF PAVIA   (Italy)

^b KING'S COLLEGE LONDON   (United Kingdom)

^c IRCCS ISTITUTO CENTRO SAN GIOVANNI DI DIO FATEBENEFRATELLI   (Italy)

^d C MONDINO NATIONAL NEUROLOGICAL INSTITUTE   (Italy)

Author keywords

First episode; fMRI; Functional neuroimaging; High risk; MRS; PET; Psychosis; SPECT; Vulnerability

Indexed keywords

BASAL GANGLION; BRAIN FUNCTION; CEREBELLUM; CINGULATE GYRUS; COGNITION; DISEASE ASSOCIATION; EFFECT SIZE; FUNCTIONAL MAGNETIC RESONANCE IMAGING; HIGH RISK POPULATION; HIPPOCAMPUS; HUMAN; INFORMATION PROCESSING; MENTAL HEALTH; NEUROBIOLOGY; NEUROIMAGING; POSITRON EMISSION TOMOGRAPHY; PREFRONTAL CORTEX; PRIORITY JOURNAL; PSYCHOSIS; RELATIVE; REVIEW; RISK ASSESSMENT; SCHIZOPHRENIA; SINGLE PHOTON EMISSION COMPUTER TOMOGRAPHY; SYSTEMATIC REVIEW; TEMPORAL LOBE; TWINS; VULNERABLE POPULATION; WORKING MEMORY;

ADOLESCENT; ADULT; BRAIN MAPPING; COGNITION; HUMANS; MAGNETIC RESONANCE IMAGING; PREFRONTAL CORTEX; PSYCHOTIC DISORDERS; RISK ASSESSMENT; SCHIZOPHRENIA; TEMPORAL LOBE; TWIN STUDIES;

EID: 34047103295     PISSN: 01497634     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.neubiorev.2006.11.006     Document Type: Review

References (112)

1. Aguirre G.K., Singh R., and D'Esposito M. Stimulus inversion and the responses of face and object-sensitive cortical areas. Neuroreport 10 (1999) 189-194
2. Andreasen N.C., Paradiso S., and O'Leary D.S. Cognitive dysmetria as an integrative theory of schizophrenia: a dysfunction in cortical-subcortical-cerebellar circuitry?. Schizophrenia Bulletin 24 (1998) 203-218
3. Barch D.M., Carter C.S., Braver T.S., Sabb F.W., MacDonald III A., Noll D.C., and Cohen J.D. Selective deficits in prefrontal cortex function in medication-naive patients with schizophrenia. Archives of General Psychiatry 58 (2001) 280-288
4. Bartha R., Williamson P.C., Drost D.J., Malla A., Carr T.J., Cortese L., Canaran G., Rylett R.J., and Neufeld R.W. Measurement of glutamate and glutamine in the medial prefrontal cortex of never-treated schizophrenic patients and healthy controls by proton magnetic resonance spectroscopy. Archives of General Psychiatry 54 (1997) 959-965
5. Bedwell J.S., and Donnelly R.S. Schizotypal personality disorder or prodromal symptoms of schizophrenia?. Schizophrenia Research 80 (2005) 263-269
6. Benes F.M. Model generation and testing to probe neural circuitry in the cingulate cortex of postmortem schizophrenic brain. Schizophrenia Bulletin 24 (1998) 219-230
7. Blackwood D.H., Glabus M.F., Dunan J., O'Carroll R.E., Muir W.J., and Ebmeier K.P. Altered cerebral perfusion measured by SPECT in relatives of patients with schizophrenia. Correlations with memory and P300. British Journal of Psychiatry 175 (1999) 357-366
8. Boksman K., Theberge J., Williamson P., Drost D.J., Malla A., Densmore M., Takhar J., Pavlosky W., Menon R.S., and Neufeld R.W. A 4.0-T fMRI study of brain connectivity during word fluency in first-episode schizophrenia. Schizophrenia Research 75 (2005) 247-263
9. Borgwardt, S.J., Riecher-Rössler, A., Dazzan, P., Chitnis, X., Aston, J., Drewe, M., Gschwandtner, U., McGuire, P., 2006. Regional grey matter abnormalities in the At Risk Mental State. Biological Psychiatry, in press.
10. Braus D.F., Ende G., Weber-Fahr W., Sartorius A., Krier A., Hubrich-Ungureanu P., Ruf M., Stuck S., and Henn F.A. Antipsychotic drug effects on motor activation measured by functional magnetic resonance imaging in schizophrenic patients. Schizophrenia Research 39 (1999) 19-29
11. Braus D.F., Ende G., Hubrich-Ungureanu P., and Henn F.A. Cortical response to motor stimulation in neuroleptic-naive first episode schizophrenics. Psychiatry Research 98 (2000) 145-154
12. Braus D.F., Weber-Fahr W., Tost H., Ruf M., and Henn F.A. Sensory information processing in neuroleptic-naive first-episode schizophrenic patients: a functional magnetic resonance imaging study. Archives of General Psychiatry 59 (2002) 696-701
13. Brewer W.J., Francey S.M., Wood S.J., Jackson H.J., Pantelis C., Phillips L.J., Yung A.R., Anderson V.A., and McGorry P.D. Memory impairments identified in people at ultra-high risk for psychosis who later develop first-episode psychosis. American Journal of Psychiatry 162 (2005) 71-78
14. Brewer W.J., Wood S.J., Phillips L.J., Francey S.M., Pantelis C., Yung A.R., Cornblatt B., and McGorry P.D. Generalized and specific cognitive performance in clinical high-risk cohorts: a review highlighting potential vulnerability markers for psychosis. Schizophrenia Bulletin 32 (2006) 538-555
15. Broome M.R., Johns L.C., and Woolley J.B. The data-gathering bias in the at-risk mental state (ARMS) for psychosis. Schizophrenia Research 70 (2004) 100-101
16. Broome, M.R., Johns, L.C., Valli, I., Woolley, J., Tabraham, P., Brett, C., Valmaggia, L.R., Peters, E., Garety, P., McGuire, P., 2006. People with an At Risk Mental State jump to conclusions. British Journal of Psychiatry, in press.
17. Bullmore E., Brammer M., Williams S.C., Curtis V., McGuire P., Morris R., Murray R., and Sharma T. Functional MR imaging of confounded hypofrontality. Human Brain Mapping 8 (1999) 86-91
18. Bunge S.A., Ochsner K.N., Desmond J.E., Glover G.H., and Gabrieli J.D. Prefrontal regions involved in keeping information in and out of mind. Brain 124 (2001) 2074-2086
19. Calhoun V.D., Adali T., Giuliani N.R., Pekar J.J., Kiehl K.A., and Pearlson G.D. Method for multimodal analysis of independent source differences in schizophrenia: combining gray matter structural and auditory oddball functional data. Human Brain Mapping 27 (2006) 47-62
20. Callicott J.H., Egan M.F., Bertolino A., Mattay V.S., Langheim F.J., Frank J.A., and Weinberger D.R. Hippocampal N-acetyl aspartate in unaffected siblings of patients with schizophrenia: a possible intermediate neurobiological phenotype. Biological Psychiatry 44 (1998) 941-950
21. Callicott J.H., Bertolino A., Mattay V.S., Langheim F.J., Duyn J., Coppola R., Goldberg T.E., and Weinberger D.R. Physiological dysfunction of the dorsolateral prefrontal cortex in schizophrenia revisited. Cerebral Cortex 10 (2000) 1078-1092
22. Callicott J.H., Egan M.F., Mattay V.S., Bertolino A., Bone A.D., Verchinksi B., and Weinberger D.R. Abnormal fMRI response of the dorsolateral prefrontal cortex in cognitively intact siblings of patients with schizophrenia. American Journal of Psychiatry 160 (2003) 709-719
23. Cannon T.D. Clinical and genetic high-risk strategies in understanding vulnerability to psychosis. Schizophrenia Research 79 (2005) 35-44
24. Chang C.J., Chen W.J., Liu S.K., Cheng J.J., Yang W.C., Chang H.J., Lane H.Y., Lin S.K., Yang T.W., and Hwu H.G. Morbidity risk of psychiatric disorders among the first degree relatives of schizophrenia patients in Taiwan. Schizophrenia Bulletin 28 (2002) 379-392
25. Cohen J. Statistical power analysis for the behavioural sciences. second ed (1988), Lawrence Erlbaum Associates, Hillsdale, NJ
26. Cohen J. A power primer. Psychology Bulletin 112 (1992) 155-159
27. Curtis V.A., Bullmore E.T., Brammer M.J., Wright I.C., Williams S.C., Morris R.G., Sharma T.S., Murray R.M., and McGuire P.K. Attenuated frontal activation during a verbal fluency task in patients with schizophrenia. American Journal of Psychiatry 155 (1998) 1056-1063
28. Davis C.E., Jeste D.V., and Eyler L.T. Review of longitudinal functional neuroimaging studies of drug treatments in patients with schizophrenia. Schizophrenia Research 78 (2005) 45-60
29. Dickey C.C., McCarley R.W., and Shenton M.E. The brain in schizotypal personality disorder: a review of structural MRI and CT findings. Harvard Review of Psychiatry 10 (2002) 1-15
30. Fox P.T., Laird A.R., and Lancaster J.L. Coordinate-based voxel-wise meta-analysis: dividends of spatial normalization. Report of a virtual workshop. Human Brain Mapping 25 (2005) 1-5
31. Frith C. The neural basis of hallucinations and delusions. Comptes Rendus des Seances de la Societe de Biologie 328 (2005) 169-175
32. Fu C.H., and McGuire P.K. Functional neuroimaging in psychiatry. Philosophical Transactions of the Royal Society of London Series B: Biological Sciences 354 (1999) 1359-1370
33. Gallinat J., and Heinz A. Combination of multimodal imaging and molecular genetic information to investigate complex psychiatric disorders. Pharmacopsychiatry 39 Suppl. 1 (2006) 76-79
34. Habel U., Klein M., Shah N.J., Toni I., Zilles K., Falkai P., and Schneider F. Genetic load on amygdala hypofunction during sadness in nonaffected brothers of schizophrenia patients. American Journal of Psychiatry 161 (2004) 1806-1813
35. Hanssen M., Bak M., Bijl R., Vollebergh W., and van Os J. The incidence and outcome of subclinical psychotic experiences in the general population. British Journal of Clinical Psychology 44 (2005) 181-191
36. Hawkins K.A., Addington J., Keefe R.S., Christensen B., Perkins D.O., Zipurksy R., Woods S.W., Miller T.J., Marquez E., Breier A., and McGlashan T.H. Neuropsychological status of subjects at high risk for a first episode of psychosis. Schizophrenia Research 67 (2004) 115-122
37. Heydebrand G., Weiser M., Rabinowitz J., Hoff A.L., DeLisi L.E., and Csernansky J.G. Correlates of cognitive deficits in first episode schizophrenia. Schizophrenia Research 68 (2004) 1-9
38. Hirvonen J., van Erp T.G., Huttunen J., Nagren K., Huttunen M., Aalto S., Lonnqvist J., Kaprio J., Cannon T.D., and Hietala J. Striatal dopamine D1 and D2 receptor balance in twins at increased genetic risk for schizophrenia. Psychiatry Research 146 (2006) 13-20
39. Honey G.D., Fletcher P.C., and Bullmore E.T. Functional brain mapping of psychopathology. Journal of Neurology, Neurosurgery and Psychiatry 72 (2002) 432-439
40. Honey G.D., Pomarol-Clotet E., Corlett P.R., Honey R.A., McKenna P.J., Bullmore E.T., and Fletcher P.C. Functional dysconnectivity in schizophrenia associated with attentional modulation of motor function. Brain 128 (2005) 2597-2611
41. Hunter J., and Schmidt F. Methods of Meta-analysis (1990), Sage Publications
42. James J.W. Frequency in relatives for an all-or-none trait. Annals of Human Genetics 35 (1971) 47-49
43. Jensen J.E., Al-Semaan Y.M., Williamson P.C., Neufeld R.W., Menon R.S., Schaeffer B., Densmore M., and Drost D.J. Region-specific changes in phospholipid metabolism in chronic, medicated schizophrenia: (31)P-MRS study at 4.0 Tesla. British Journal of Psychiatry 180 (2002) 39-44
44. Johnson J.K., Tuulio-Henriksson A., Pirkola T., Huttunen M.O., Lonnqvist J., Kaprio J., and Cannon T.D. Do schizotypal symptoms mediate the relationship between genetic risk for schizophrenia and impaired neuropsychological performance in co-twins of schizophrenic patients?. Biological Psychiatry 54 (2003) 1200-1204
45. Johnstone E.C., Ebmeier K.P., Miller P., Owens D.G., and Lawrie S.M. Predicting schizophrenia: findings from the Edinburgh High-Risk Study. British Journal of Psychiatry 186 (2005) 18-25
46. Jones H.M., Brammer M.J., O'Toole M., Taylor T., Ohlsen R.I., Brown R.G., Purvis R., Williams S., and Pilowsky L.S. Cortical effects of quetiapine in first-episode schizophrenia: a preliminary functional magnetic resonance imaging study. Biological Psychiatry 56 (2004) 938-942
47. Keshavan M.S., Montrose D.M., Pierri J.N., Dick E.L., Rosenberg D., Talagala L., and Sweeney J.A. Magnetic resonance imaging and spectroscopy in offspring at risk for schizophrenia: preliminary studies. Progress in Neuro-psychopharmacology and Biological Psychiatry 21 (1997) 1285-1295
48. Keshavan M.S., Diwadkar V.A., Spencer S.M., Harenski K.A., Luna B., and Sweeney J.A. A preliminary functional magnetic resonance imaging study in offspring of schizophrenic parents. Progress in Neuro-psychopharmacology and Biological Psychiatry 26 (2002) 1143-1149
49. Keshavan M.S., Stanley J.A., Montrose D.M., Minshew N.J., and Pettegrew J.W. Prefrontal membrane phospholipid metabolism of child and adolescent offspring at risk for schizophrenia or schizoaffective disorder: an in vivo 31P MRS study. Molecular Psychiatry 8 316-23 (2003) 251
50. Kim J.J., Mohamed S., Andreasen N.C., O'Leary D.S., Watkins G.L., Boles Ponto L.L., and Hichwa R.D. Regional neural dysfunctions in chronic schizophrenia studied with positron emission tomography. American Journal of Psychiatry 157 (2000) 542-548
51. Klemm S., Rzanny R., Riehemann S., Volz H.P., Schmidt B., Gerhard U.J., Filz C., Schonberg A., Mentzel H.J., Kaiser W.A., and Blanz B. Cerebral phosphate metabolism in first-degree relatives of patients with schizophrenia. American Journal of Psychiatry 158 (2001) 958-960
52. Lencz T., Smith C.W., Auther A., Correll C.U., and Cornblatt B. Nonspecific and attenuated negative symptoms in patients at clinical high-risk for schizophrenia. Schizophrenia Research 68 (2004) 37-48
53. Lencz T., Smith C.W., McLaughlin D., Auther A., Nakayama E., Hovey L., and Cornblatt B.A. Generalized and specific neurocognitive deficits in prodromal schizophrenia. Biological Psychiatry 59 (2006) 863-871
54. MacDonald III A.W., Carter C.S., Kerns J.G., Ursu S., Barch D.M., Holmes A.J., Stenger V.A., and Cohen J.D. Specificity of prefrontal dysfunction and context processing deficits to schizophrenia in never-medicated patients with first-episode psychosis. American Journal of Psychiatry 162 (2005) 475-484
55. Manoach D.S. Prefrontal cortex dysfunction during working memory performance in schizophrenia: reconciling discrepant findings. Schizophrenia Research 60 (2003) 285-298
56. Mendrek A., Laurens K.R., Kiehl K.A., Ngan E.T., Stip E., and Liddle P.F. Changes in distributed neural circuitry function in patients with first-episode schizophrenia. British Journal of Psychiatry 185 (2004) 205-214
57. Mendrek A., Kiehl K.A., Smith A.M., Irwin D., Forster B.B., and Liddle P.F. Dysfunction of a distributed neural circuitry in schizophrenia patients during a working-memory performance. Psychological Medicine 35 (2005) 187-196
58. Miller T.J., McGlashan T.H., Rosen J.L., Somjee L., Markovich P.J., Stein K., and Woods S.W. Prospective diagnosis of the initial prodrome for schizophrenia based on the Structured Interview for Prodromal Syndromes: preliminary evidence of interrater reliability and predictive validity. American Journal of Psychiatry 159 (2002) 863-865
59. Molina V., Sanz J., Reig S., Martinez R., Sarramea F., Luque R., Benito C., Gispert J.D., Pascau J., and Desco M. Hypofrontality in men with first-episode psychosis. British Journal of Psychiatry 186 (2005) 203-208
60. Morey R.A., Inan S., Mitchell T.V., Perkins D.O., Lieberman J.A., and Belger A. Imaging frontostriatal function in ultra-high-risk, early, and chronic schizophrenia during executive processing. Archives of General Psychiatry 62 (2005) 254-262
61. Niendam T.A., Bearden C.E., Johnson J.K., McKinley M., Loewy R., O'Brien M., Nuechterlein K.H., Green M.F., and Cannon T.D. Neurocognitive performance and functional disability in the psychosis prodrome. Schizophrenia Research 84 (2006) 100-111
62. Novak B., Milcinski M., Grmek M., and Kocmur M. Early effects of treatment on regional cerebral blood flow in first episode schizophrenia patients, evaluated with 99Tc-ECD-SPECT. Neuroendocrinology Letters 26 (2005)
63. Onitsuka T., Shenton M.E., Salisbury D.F., Dickey C.C., Kasai K., Toner S.K., Frumin M., Kikinis R., Jolesz F.A., and McCarley R.W. Middle and inferior temporal gyrus gray matter volume abnormalities in chronic schizophrenia: an MRI study. American Journal of Psychiatry 161 (2004) 1603-1611
64. Pantelis C., Velakoulis D., McGorry P.D., Wood S.J., Suckling J., Phillips L.J., Yung A.R., Bullmore E.T., Brewer W., Soulsby B., Desmond P., and McGuire P.K. Neuroanatomical abnormalities before and after onset of psychosis: a cross-sectional and longitudinal MRI comparison. Lancet 361 (2003) 281-288
65. Pantelis C., Yucel M., Wood S.J., Velakoulis D., Sun D., Berger G., Stuart G.W., Yung A., Phillips L., and McGorry P.D. Structural brain imaging evidence for multiple pathological processes at different stages of brain development in schizophrenia. Schizophrenia Bulletin 31 (2005) 672-696
66. Parellada E., Catafau A.M., Bernardo M., Lomena F., Catarineu S., and Gonzalez-Monclus E. The resting and activation issue of hypofrontality: a single photon emission computed tomography study in neuroleptic-naive and neuroleptic-free schizophrenic female patients. Biological Psychiatry 44 (1998) 787-790
67. Perlstein W.M., Carter C.S., Noll D.C., and Cohen J.D. Relation of prefrontal cortex dysfunction to working memory and symptoms in schizophrenia. American Journal of Psychiatry 158 (2001) 1105-1113
68. Petrides M., and Pandya D.N. Dorsolateral prefrontal cortex: comparative cytoarchitectonic analysis in the human and the macaque brain and corticocortical connection patterns. European Journal of Neuroscience 11 (1999) 1011-1036
69. Raemaekers M., Ramsey N.F., Vink M., van den Heuvel M.P., and Kahn R.S. Brain activation during antisaccades in unaffected relatives of schizophrenic patients. Biological Psychiatry 59 (2006) 530-535
70. Rajah M.N., and D'Esposito M. Region-specific changes in prefrontal function with age: a review of PET and fMRI studies on working and episodic memory. Brain 128 (2005) 1964-1983
71. Ramsey N.F., Koning H.A., Welles P., Cahn W., van der Linden J.A., and Kahn R.S. Excessive recruitment of neural systems subserving logical reasoning in schizophrenia. Brain 125 (2002) 1793-1807
72. Rasser P.E., Johnston P., Lagopoulos J., Ward P.B., Schall U., Thienel R., Bender S., Toga A.W., and Thompson P.M. Functional MRI BOLD response to Tower of London performance of first-episode schizophrenia patients using cortical pattern matching. Neuroimage 26 (2005) 941-951
73. Riehemann S., Volz H.P., Stutzer P., Smesny S., Gaser C., and Sauer H. Hypofrontality in neuroleptic-naive schizophrenic patients during the Wisconsin Card Sorting Test-a fMRI study. European Archives of Psychiatry and Clinical Neuroscience 251 (2001) 66-71
74. Riley E.M., McGovern D., Mockler D., Doku V.C., OCeallaigh S., Fannon D.G., Tennakoon L., Santamaria M., Soni W., Morris R.G., and Sharma T. Neuropsychological functioning in first-episode psychosis-evidence of specific deficits. Schizophrenia Research 43 (2000) 47-55
75. Rzanny R., Klemm S., Reichenbach J.R., Pfleiderer S.O., Schmidt B., Volz H.P., Blanz B., and Kaiser W.A. 31P-MR spectroscopy in children and adolescents with a familial risk of schizophrenia. European Radiology 13 (2003) 763-770
76. Salisbury D.F., Shenton M.E., Griggs C.B., Bonner-Jackson A., and McCarley R.W. Mismatch negativity in chronic schizophrenia and first-episode schizophrenia. Archives of General Psychiatry 59 (2002) 686-694
77. Schaufelberger M., Senhorini M.C., Barreiros M.A., Amaro Jr. E., Menezesk P.R., Scazufca M., Castro C.C., Ayres A.M., Murray R.M., McGuire P.K., and Busatto G.F. Frontal and anterior cingulate activation during overt verbal fluency in patients with first episode psychosis. Revista Brasileira de Psiquiatrica 27 (2005) 228-232
78. Seidman L.J., Faraone S.V., Goldstein J.M., Goodman J.M., Kremen W.S., Toomey R., Tourville J., Kennedy D., Makris N., Caviness V.S., and Tsuang M.T. Thalamic and amygdala-hippocampal volume reductions in first-degree relatives of patients with schizophrenia: an MRI-based morphometric analysis. Biological Psychiatry 46 (1999) 941-954
79. Seidman L.J., Faraone S.V., Goldstein J.M., Kremen W.S., Horton N.J., Makris N., Toomey R., Kennedy D., Caviness V.S., and Tsuang M.T. Left hippocampal volume as a vulnerability indicator for schizophrenia: a magnetic resonance imaging morphometric study of nonpsychotic first-degree relatives. Archives of General Psychiatry 59 (2002) 839-849
80. Seidman L.J., Thermenos H.W., Poldrack R., Peace N., Koch J., Faraone S.V., and Tsuang M.T. Altered brain activation in frontal cortex in adolescents and young adults at genetic risk for schizophrenia: an fMRI study of working memory. Schizophrenia Research 85 (2006) 58-72
81. Selemon L.D., Mrzljak J., Kleinman J.E., Herman M.M., and Goldman-Rakic P.S. Regional specificity in the neuropathologic substrates of schizophrenia: a morphometric analysis of Broca's area 44 and area 9. Archives of General Psychiatry 60 (2003) 69-77
82. Siever L.J., and Davis K.L. The pathophysiology of schizophrenia disorders: perspectives from the spectrum. American Journal of Psychiatry 161 (2004) 398-413
83. Siever L.J., Koenigsberg H.W., Harvey P., Mitropoulou V., Laruelle M., Abi-Dargham A., Goodman M., and Buchsbaum M. Cognitive and brain function in schizotypal personality disorder. Schizophrenia Research 54 (2002) 157-167
84. Snitz B.E., Macdonald III A., Cohen J.D., Cho R.Y., Becker T., and Carter C.S. Lateral and medial hypofrontality in first-episode schizophrenia: functional activity in a medication-naive state and effects of short-term atypical antipsychotic treatment. American Journal of Psychiatry 162 (2005) 2322-2329
85. Sommer I., Ramsey N.F., Mandl R., Van Oel C., and Kahn R. Language activation in monozygotic twins discordant for schizophrenia. British Journal of Psychiatry 184 (2004) 128-135
86. Spence S.A., Liddle P.F., Stefan M.D., Hellewell J.S., Sharma T., Friston K.J., Hirsch S.R., Frith C.D., Murray R.M., Deakin J.F., and Grasby P.M. Functional anatomy of verbal fluency in people with schizophrenia and those at genetic risk. Focal dysfunction and distributed disconnectivity reappraised. British Journal of Psychiatry 176 (2000) 52-60
87. Staal W.G., Hulshoff Pol H.E., Schnack H., van der Schot A.C., and Kahn R.S. Partial volume decrease of the thalamus in relatives of patients with schizophrenia. American Journal of Psychiatry 155 (1998) 1784-1786
88. Steen R.G., Hamer R.M., and Lieberman J.A. Measurement of brain metabolites by 1H magnetic resonance spectroscopy in patients with schizophrenia: a systematic review and meta-analysis. Neuropsychopharmacology 30 (2005) 1949-1962
89. Stephan K.E., Magnotta V.A., White T., Arndt S., Flaum M., O'Leary D.S., and Andreasen N.C. Effects of olanzapine on cerebellar functional connectivity in schizophrenia measured by fMRI during a simple motor task. Psychological Medicine 31 (2001) 1065-1078
90. Talairach J., and Tournoux P. A Co-planar Stereotactic Atlas of the Human Brain (1988), Thieme Medical Publishers
91. Tan H.Y., Choo W.C., Fones C.S., and Chee M.W. fMRI study of maintenance and manipulation processes within working memory in first-episode schizophrenia. American Journal of Psychiatry 162 (2005) 1849-1858
92. Thermenos H.W., Seidman L.J., Breiter H., Goldstein J.M., Goodman J.M., Poldrack R., Faraone S.V., and Tsuang M.T. Functional magnetic resonance imaging during auditory verbal working memory in nonpsychotic relatives of persons with schizophrenia: a pilot study. Biological Psychiatry 55 (2004) 490-500
93. Tibbo P., Hanstock C., Valiakalayil A., and Allen P. 3-T proton MRS investigation of glutamate and glutamine in adolescents at high genetic risk for schizophrenia. American Journal of Psychiatry 161 (2004) 1116-1118
94. Tsuang M.T., Stone W.S., and Faraone S.V. Toward reformulating the diagnosis of schizophrenia. American Journal of Psychiatry 157 (2000) 1041-1050
95. Tsuang M.T., Stone W.S., and Faraone S.V. Understanding predisposition to schizophrenia: toward intervention and prevention. Canadian Journal of Psychiatry 47 (2002) 518-526
96. Van Erp T.G., Saleh P.A., Rosso I.M., Huttunen M., Lonnqvist J., Pirkola T., Salonen O., Valanne L., Poutanen V.P., Standertskjold-Nordenstam C.G., and Cannon T.D. Contributions of genetic risk and fetal hypoxia to hippocampal volume in patients with schizophrenia or schizoaffective disorder, their unaffected siblings, and healthy unrelated volunteers. American Journal of Psychiatry 159 (2002) 1514-1520
97. Van Erp T.G., Saleh P.A., Huttunen M., Lonnqvist J., Kaprio J., Salonen O., Valanne L., Poutanen V.P., Standertskjold-Nordenstam C.G., and Cannon T.D. Hippocampal volumes in schizophrenic twins. Archives of General Psychiatry 61 (2004) 346-353
98. Velakoulis D., Wood S.J., Wong M.T., McGorry P.D., Yung A., Phillips L., Smith D., Brewer W., Proffitt T., Desmond P., and Pantelis C. Hippocampal and amygdala volumes according to psychosis stage and diagnosis: a magnetic resonance imaging study of chronic schizophrenia, first-episode psychosis, and ultra-high-risk individuals. Archives of General Psychiatry 63 (2006) 139-149
99. Vita A., De Peri L., Silenzi C., and Dieci M. Brain morphology in first-episode schizophrenia: A meta-analysis of quantitative magnetic resonance imaging studies. Schizophrenia Research 82 (2006) 75-88
100. Volz H., Gaser C., and Sauer H. Supporting evidence for the model of cognitive dysmetria in schizophrenia-a structural magnetic resonance imaging study using deformation-based morphometry. Schizophrenia Research 46 (2000) 45-56
101. Ward P.B. Structural brain imaging and the prevention of schizophrenia: can we identify neuroanatomical markers for young people at risk for the development of schizophrenia?. Australian and New Zealand Journal of Psychiatry 34 Suppl. (2000) S127-S130
102. Weinbergerm D.R., Egan M.F., Bertolino A., Callicott J.H., Mattay V.S., Lipska B.K., Berman K.F., and Goldberg T.E. Prefrontal neurons and the genetics of schizophrenia. Biological Psychiatry 50 (2001) 825-844
103. Whalley H.C., Simonotto E., Flett S., Marshall I., Ebmeier K.P., Owens D.G., Goddard N.H., Johnstone E.C., and Lawrie S.M. fMRI correlates of state and trait effects in subjects at genetically enhanced risk of schizophrenia. Brain 127 (2004) 478-490
104. Whalley H.C., Simonotto E., Marshall I., Owens D.G., Goddard N.H., Johnstone E.C., and Lawrie S.M. Functional disconnectivity in subjects at high genetic risk of schizophrenia. Brain 128 (2005) 2097-2108
105. Whalley, H.C., Simonotto, E., Moorhead, W., McIntosh, A., Marshall, I., Ebmeier, K.P., Owens, D.G., Goddard, N.H., Johnstone, E.C., Lawrie, S.M., 2006. Functional imaging as a predictor of schizophrenia. Biological Psychiatry.
106. Whyte M.C., Brett C., Harrison L.K., Byrne M., Miller P., Lawrie S.M., and Johnstone E.C. Neuropsychological performance over time in people at high risk of developing schizophrenia and controls. Biological Psychiatry 59 (2006) 730-739
107. Wood S.J., Berger G., Velakoulis D., Phillips L.J., McGorry P.D., Yung A.R., Desmond P., and Pantelis C. Proton magnetic resonance spectroscopy in first episode psychosis and ultra high-risk individuals. Schizophrenia Bulletin 29 (2003) 831-843
108. Yucel M., Stuart G.W., Maruff P., Wood S.J., Savage G.R., Smith D.J., Crowe S.F., Copolov D.L., Velakoulis D., and Pantelis C. Paracingulate morphologic differences in males with established schizophrenia: a magnetic resonance imaging morphometric study. Biological Psychiatry 52 (2002) 15-23
109. Yung A.R., and McGorry P.D. The prodromal phase of first-episode psychosis: past and current conceptualizations. Schizophrenia Bulletin 22 (1996) 353-370
110. Yung A.R., Phillips L.J., McGorry P.D., McFarlane C.A., Francey S., Harrigan S., Patton G.C., and Jackson H.J. Prediction of psychosis. A step towards indicated prevention of schizophrenia. British Journal of Psychiatry 172 Suppl. (1998) 14-20
111. Yung A.R., Phillips L.J., Yuen H.P., Francey S.M., McFarlane C.A., Hallgren M., and McGorry P.D. Psychosis prediction: 12-month follow up of a high-risk ("prodromal") group. Schizophrenia Research 60 (2003) 21-32
112. Yung A.R., Phillips L.J., Yuen H.P., and McGorry P.D. Risk factors for psychosis in an ultra high-risk group: psychopathology and clinical features. Schizophrenia Research 67 (2004) 131-142