Do schizotypal symptoms mediate the relationship between genetic risk for schizophrenia and impaired neuropsychological performance in co-twins of schizophrenic patients?

Biological Psychiatry

Volumn 54, Issue 11, 2003, Pages 1200-1204

  Johnson, Jennifer K ^a   Tuulio Henriksson, Annamari ^b   Pirkola, Tiia ^b   Huttunen, Matti O ^b   Lönnqvist, Jouko ^b   Kaprio, Jaakko ^b,c   Cannon, Tyrone D ^b  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b NATIONAL PUBLIC HEALTH INSTITUTE   (Finland)

^c UNIVERSITY OF HELSINKI   (Finland)

Author keywords

Genetic; Neuropsychological performance; Schizophrenia; Schizotypy; Twin

Indexed keywords

ADULT; APTITUDE TEST; ARTICLE; COGNITION; COGNITIVE DEFECT; CONTROLLED STUDY; FAMILY HISTORY; FEMALE; GENETIC RISK; HEREDITY; HUMAN; INTERVIEW; MAJOR CLINICAL STUDY; MALE; NEUROPSYCHOLOGICAL TEST; PRIORITY JOURNAL; SCHIZOPHRENIA; SCHIZOTYPAL PERSONALITY DISORDER; TASK PERFORMANCE; TWINS; WORKING MEMORY;

EID: 0345293139     PISSN: 00063223     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-3223(03)00637-1     Document Type: Article

References (24)

1. Diagnostic and Statistical Manual of Mental Disorder. 4th ed :1994;American Psychiatric Association, Washington, DC.
2. Benton A, Hamsher K (1976): Multilingual Aphasia Examination. Iowa City: University of Iowa.
3. Cannon T.D., Huttunen M.O., Lonnqvist J., Tuulio-Henriksson A., Pirkola T., Glahn D., et al. The inheritance of neuropsychological dysfunction in twins discordant for schizophrenia. Am J Hum Genet. 67:2000;369-382.
4. Cannon T.D., Kaprio J., Lonnqvist J., Huttunen M., Koskenvuo M. The genetic epidemiology of schizophrenia in a Finnish twin cohort. A population-based modeling study. Arch Gen Psychiatry. 55:1998;67-74.
5. Delis D., Kramer J., Kaplan E., Ober B. California Verbal Learning Test, Research Edition. 1998;The Psychological Corporation, Cleveland, OH.
6. Egan M.F., Goldberg T.E., Gscheidle T., Weirich M., Rawlings R., Hyde T.M., et al. Relative risk for cognitive impairments in siblings of patients with schizophrenia. Biol Psychiatry. 50:2001;98-107.
7. Faraone S.V., Seidman L.J., Kremen W.S., Pepple J.R. Neuropsychological functioning among the nonpsychotic relatives of schizophrenic patients A diagnostic efficiency analysis . J Abnorm Psychol. 104:1995;286-304.
8. Faraone S.V., Seidman L.J., Kremen W.S., Toomey R., Pepple J.R., Tsuang M.T. Neuropsychologic functioning among the nonpsychotic relatives of schizophrenic patients The effect of genetic loading . Biol Psychiatry. 48:2000;120-126.
9. Gasperoni T.L., Ekelund J., Huttunen M.O., Palmer C.G.S., Tuulio-Henriksson A., Lonnqvist J., et al. Genetic linkage and association between chromosome 1Q and working memory function in schizophrenia. Am J Med Genet. 116B:2003;8-16.
10. Heaton R., Cfhelune G., Talley J., Kay G., Curtiss G. Wisconsin Card Sorting Test Manual Revised and Expanded . 2003;Psychological Assessment Resources, Odessa, FL.
11. Hovatta I., Varilo T., Suvisaari J., Terwilliger J.D., Ollikainen V., Arajarvi R., et al. A genomewide screen for schizophrenia genes in an isolated Finnish subpopulation, suggesting multiple susceptibility loci. Am J Hum Genet. 65:1999;1114-1124.
12. Kremen W.S., Seidman L.S., Pepple J.R., Lyons M.J. Neuropsychological risk indicators for schizophrenia A review of family studies . Schizophr Bull. 20:1994;103-119.
13. Millar J.K., Wilson-Annan J.C., Anderson S., Christie S., Taylor M.S., Semple C.A., et al. Disruption of two novel genes by a translocation co-segregating with schizophrenia. Hum Mol Genet. 9:2000;1415-1423.
14. Rauhala U. The quantitative strength of the social strate of Finnish society. Sosiaalinen-Aikakauskirja. 63:1970;347-362.
15. Reitan R., Wolfson D. The Halstead-Reitan Neuropsychological Test Battery Theory and Clinical Interpretation . 1970;Neuropsychology Press, Tucson, AZ.
16. Silverman J.M., Siever L.J., Horvath T.B., Coccaro E.F., Klar H., Davidson M., et al. Schizophrenia-related and affective personality disorder traits in relatives of probands with schizophrenia and personality disorders. Am J Psychiatry. 150:1993;435-442.
17. Spitzer R.L., Williams J.B.W. Structured Clinical Interview for DSM-III-R Personality Disorders. 1993;Biometrics Research Department, New York State Psychiatric Institute, New York. [SCID-II, 2-1-86].
18. Spitzer R.L., Williams J.B.W., Gibbon M., First M.B. Instructional Manual for the Structured Clinical Interview for DSM-III-R. 1989;Biometrics Research Department, New York State Psychiatric Institute, New York.
19. Torgersen S. Relationship of schizotypal personality disorder to schizophrenia Genetics . Schizophr Bull. 11:1985;554-563.
20. Trestman R.L., Keefe R.S.E., Mitropoulou V., Harvey P.D., deVegvar M.L., Lees-Roitman S., et al. Cognitive function and biological correlates of cognitive performance in schizotypal personality disorder. Psychiatry Res. 59:1995;127-136.
21. Wechsler D. Wechsler Adult Intelligence Scale-Revised (WAIS-R) Manual. 1995;The Psychological Corporation, San Antonio, TX.
22. Wechsler D. Wechsler Memory Scale-Revised (WMS-R) Manual. 1995;The Psychological Corporation, San Antonio, TX.
23. Wechsler D. WAIS-R Käsikirja. 1995;Psykologien Kustannus, Helsinki. [WAIS-R manual, in Finnish].
24. Wechsler D. WMS-R Käsikirja. 1995;Psykologien Kustannus, Helsinki. [WMS-R manual, in Finnish].