Toward reformulating the diagnosis of schizophrenia

American Journal of Psychiatry

Volumn 157, Issue 7, 2000, Pages 1041-1050

  Tsuang, Ming T ^a   Stone, William S ^b   Faraone, Stephen V ^b  

^a MASSACHUSETTS MENTAL HEALTH CENTER   (United States)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

CLINICAL FEATURE; DIAGNOSTIC APPROACH ROUTE; DISEASE CLASSIFICATION; HUMAN; PRIORITY JOURNAL; PSYCHIATRIC DIAGNOSIS; PSYCHOSIS; RATING SCALE; REVIEW; SCHIZOPHRENIA;

GENETIC PREDISPOSITION TO DISEASE; HUMANS; SCHIZOPHRENIA; SCHIZOPHRENIC PSYCHOLOGY; TERMINOLOGY;

EID: 0033916024     PISSN: 0002953X     EISSN: None     Source Type: Journal    
DOI: 10.1176/appi.ajp.157.7.1041     Document Type: Review

References (78)

1. Kendler KS: Toward a scientific psychiatric nosology: strengths and limitations. Arch Gen Psychiatry 1990; 47:969-973
2. Meehl P: Diagnostic taxa as open concepts: metatheoretical and statistical questions about reliability and construct validity in the grand strategy of nosological revision, in Contemporary Directions in Psychopathology: Toward the DSM-IV. Edited by Millon T, Klerman G. New York, Guilford Press, 1986, pp 215-232
3. Andreasen NC: Understanding schizophrenia: a silent spring? (editorial). Am J Psychiatry 1998; 155:1657-1659
4. Kraepelin E: Dementia Praecox and Paraphrenia (1919). Translated by Barclay RM; edited by Robertson GM. New York, Robert E Krieger, 1971
5. Bleuler E: Dementia Praecox or the Group of Schizophrenias (1911). Translated by Zinkin J. New York, International Universities Press, 1950
6. Blashfield RK: The Classification of Psychopathology: Neo-Kraepelinian and Quantitative Approaches. New York, Plenum, 1984
7. Klerman GR: Historical background, in Psychiatry, vol 1. Edited by Michels R, Cooper AM, Guze SB, Judd LL, Klerman GL, Solnit AJ, Stunkard AJ, Wilner PJ. Philadelphia, JB Lippincott, and New York, Basic Books, 1988, section 52
8. Robins E, Guze SB: Establishment of diagnostic validity in psychiatric illness: its application to schizophrenia. Am J Psychiatry 1970; 126:983-987
9. Schneider K: Clinical Psychopathology. New York, Grune & Stratton, 1959
10. Schneider K: Klinische Psychopathologie. Stuttgart, Germany, Georg Thieme Verlag, 1980
11. Frances AJ, First MB, Widiger TA, Miele GM, Tilly SM, Davis WW, Pincus HA: An A to Z guide to DSM-IV conundrums. J Abnorm Psychol 1991; 100:407-412
12. Millon T: Classification in psychopathology: rationale, alternatives, and standards. J Abnorm Psychol 1991; 100:245-261
13. Gunderson JG, Links PS, Reich JH: Competing models of personality disorders. J Personal Disord 1991; 5:60-68
14. Bell RC, Dudgeon P, McGorry PD, Jackson HJ: The dimensionality of schizophrenia concepts in first-episode psychosis. Acta Psychiatr Scand 1998; 97:334-342
15. Crow TJ: From Kraepelin to Kretschmer leavened by Schneider. Arch Gen Psychiatry 1998; 55:502-504
16. Peralta V, Cuesta MJ, Farre C: Factor structure of symptoms in functional psychoses. Biol Psychiatry 1997; 42:806-815
17. Toomey R, Faraone SV, Simpson JC, Tsuang MT: Negative, positive, and disorganized symptom dimensions in schizophrenia, major depression, and bipolar disorder. J Nerv Ment Dis 1998; 186:470-476
18. Gottesman II: Schizophrenia Genesis: The Origin of Madness. New York, WH Freeman, 1991
19. Tsuang MT, Stone WS, Faraone SV: Schizophrenia: a review of genetic studies. Harvard Rev Psychiatry 1999; 7:185-207
20. Faraone SV, Kremen WS, Lyons MJ, Pepple JR, Seidman LJ, Tsuang MT: Diagnostic accuracy and linkage analysis: how useful are schizophrenia spectrum phenotypes? Am J Psychiatry 1995; 152:1286-1290
21. Meehl PE: Schizotaxia, schizotypy, schizophrenia. Am Psychol 1962; 17:827-838
22. Meehl PE: Schizotaxia revisited. Arch Gen Psychiatry 1989; 46: 935-944
23. Faraone SV, Green AI, Seidman LJ, Tsuang MT: "Schizotaxia": clinical implications and new directions for research. Schizophr Bull (in press)
24. Faraone SV, Seidman LJ, Kremen WS, Pepple JR, Lyons MJ, Tsuang MT: Neuropsychological functioning among the non-psychotic relatives of schizophrenic patients: a diagnostic efficiency analysis. J Abnorm Psychol 1995; 104:286-304
25. Battaglia M, Torgersen S: Schizotypal disorder: at the cross-roads of genetics and nosology. Acta Psychiatr Scand 1996; 94: 303-310
26. Battaglia M, Bernardeschi L, Franchini L, Bellodi L, Smeraldi E: A family study of schizotypal disorder. Schizophr Bull 1995; 21: 33-45
27. Crow TJ: The continuum of psychosis and its genetic origins: the sixty-fifth Maudsley lecture. Br J Psychiatry 1990; 156:788-797
28. Crow TJ: The search for the psychosis gene. Br J Psychiatry 1991; 158:611-614
29. Crow TJ: Nuclear schizophrenic symptoms as a window on the relationship between thought and speech. Br J Psychiatry 1998; 173:303-309
30. Collinge J, DeLisi LE, Boccio A, Johnstone EC, Lane A, Larkin C, Leach M, Lofthouse R, Owen F, Poulter M, Shah T, Walsh C, Crow TJ: Evidence for a pseudo-autosomal locus for schizophrenia using the method of affected sibling pairs. Br J Psychiatry 1991; 158:624-629
31. Parfitt E, Asherson P, Sargeant M, Whatley S, McGuffin P, Owen M: A linkage study of the pseudoautosomal region in schizophrenia (abstract). Psychiatr Genet 1991; 2:92-93
32. DeLisi LE, Devoto M, Lofthouse R, Poulter M, Smith A, Shields G, Bass N, Chen G, Vita A, Morganti C, Ott J, Crow TJ: Search for linkage to schizophrenia on the X and Y chromosomes. Am J Med Genet Neuropsychiatr Genet 1994; 54:113-121
33. Peralta V, Cuesta MJ: Diagnostic significance of Schneider's first-rank symptoms in schizophrenia. Br J Psychiatry 1998; 174: 243-248
34. Ratakonda S, Gorman JM, Yale SA, Amador XF: Characterization of psychotic symptoms: use of the domains of psychopathology model. Arch Gen Psychiatry 1998; 55:75-81
35. Serretti A, Macciardi F, Smeraldi E: Identification of symptomologic patterns common to major psychoses: proposal for a phenotype definition. Am J Med Genet Neuropsychiatr Genet 1996; 67:393-400
36. Monti MR, Stanhellini G: Psychopathology: an edgeless razor? Compr Psychiatry 1996; 37:196-204
37. Kendler KS, Karkowski LM, Walsh D: The structure of psychosis. Arch Gen Psychiatry 1998; 55:492-499
38. Maziade M, Bissonnette L, Rouillard E, Martinez M, Turgeon M, Charron L, Pouliot V, Boutin P, Cliche D, Dion C, Fournier JP, Garneau Y, Lavalee JC, Montgrain N, Nicole L, Pires A, Ponton AM, Potvin A, Wallot H, Roy MA, Merette C: 6p24-22 region and major psychoses in the eastern Quebec population. Le Groupe IREP. Am J Med Genet Neuropsychiatr Genet 1997; 74:311-318
39. Bertelsen A, Gottesman II: Schizoaffective psychoses: genetical clues to classification. Am J Med Genet 1995; 60:7-11
40. Ginns EI, Ott J, Egeland JA, Allen CR, Fann CSJ, Pauls DL, Weissenbach J, Carulli JP, Falls KM, Keith TP, Paul SM: A genomewide search for chromosomal loci linked to bipolar affective disorder in the Old Order Amish. Nat Genet 1996; 12:431-435
41. Foroud T, Castellucio PF, Koller DL, Edenberg HJ, Goate A, Detera-Wadleigh S, Stine OC, McMahon FJ, McInnis MG, Rice J, Blehar M, Goldin LR, Badner J, Guroff J, Reich T, DePaulo JR, Gershon E, Nurnberger JL: Genomewide scan of affected relative pairs using the NIMH Genetics Initiative bipolar affective disorder pedigrees. Am J Med Genet 1998; 81:462
42. Rice JP, Goate A, Williams JT, Bierut L, Dorr D, Wu W, Shears S, Gopalakrishnan G, Edenberg HJ, Foroud T, Nurnberger J Jr, Gershon ES, Detera-Wadleigh SD, Goldin LR, Guroff JJ, McMahon FJ, Simpson S, MacKinnon D, McInnis M, Stine OC, DePaulo JR, Blehar MR, Reich T: Initial genome scan of the NIMH Genetics Initiative bipolar pedigrees: chromosomes 1, 6, 8, 10, and 12. Am J Med Genet Neuropsychiatr Genet 1997; 74:247-253
43. Faraone SV, Matise T, Svrakic D, Pepple J, Malaspina D, Suarez B, Hampe C, Zambuto CT, Schmitt K, Meyer J, Markel P, Lee H, Harkevy Friedman J, Kaufmann CA, Cloninger CR, Tsuang MT: Genome scan of European-American schizophrenia pedigrees: results of the NIMH Genetics Initiative and Millennium Consortium. Am J Med Genet Neuropsychiatr Genet 1998; 81:290-295
44. Wildenauer D, Hallmaye RJ, Albus M: A susceptibility locus for affective and schizophrenic disorder? (abstract) Psychiatr Genet 1996; 6:152
45. Berrettini WH, Ferraro TN, Goldin LR, Weeks DE, Detera-Wadleigh S, Nurnberger JI Jr, Gershon ES: Chromosome 18 DNA markers and manic-depressive illness: evidence for a susceptibility gene. Proc Natl Acad Sci USA 1994; 91:5918-5921
46. Stine OC, Xu J, Koskela R, McMahon FJ, Gschwend M, Friddle C, Clark CD, Mclnnis MG, Simpson SG, Breschel TS, Vishio E, Riskin K, Feilotter H, Chen E, Chen S, Folstein SE, Meyers DA, Botstein D, Marr TG, DePaulo JR: Evidence for linkage of bipolar disorder to chromosome 18 with a parent-of-origin effect. Am J Hum Genet 1995; 57:1384-1394
47. Wyatt RJ: Early intervention for schizophrenia: can the course of the illness be altered? Biol Psychiatry 1995; 38:1-3
48. Knoll JL, Garver DL, Ramberg JE, Kingsbury SJ, Croissant D, McDermott B: Heterogeneity of the psychoses: is there a neurode-generative psychosis? Schizophr Bull 1998; 24:365-379
49. Andreasen NC: A unitary model of schizophrenia: Bleuler's "fragmented phrene" as schizencephaly. Arch Gen Psychiatry 1999; 56:781-787
50. Seidman LJ: The neuropsychology of schizophrenia: a neurodevelopmental and case study approach. J Neuropsychiatry 1990; 2:301-312
51. Weinberger DR: Schizophrenia as a neurodevelopmental disorder, in Schizophrenia. Edited by Hirsch SR, Weinberger DR. London, Blackwood Press, 1995, pp 293-323
52. Weinberger DR: Neurodevelopmental perspectives on schizophrenia, in Psychopharmacology: The Fourth Generation of Progress. Edited by Bloom FE, Kupfer DJ. New York, Raven Press, 1995, pp 1171-1183
53. Goldman-Rakic PS: More clues on "latent" schizophrenia point to developmental origins (editorial). Am J Psychiatry 1995; 152:1701-1703
54. Tsuang MT, Faraone SV: Genetic heterogeneity of schizophrenia. Psychiatr Neurol Japn 1995; 97:485-501
55. Bogerts B: Recent advances in the neuropathology of schizophrenia. Schizophr Bull 1993; 19:431-445
56. Shenton ME, Wible CG, McCarley RW: A review of magnetic resonance imaging studies of brain abnormalities in schizophrenia, in Brain Imaging in Clinical Psychiatry. Edited by Krishnan KRR, Doraiswamy PM. New York, Marcel Dekker, 1997, pp 297-380
57. Lipska BK, Jaskiw GE, Weinberger DR: Postpubertal emergence of hyperresponsiveness to stress and to amphetamine after neonatal excitotoxic hippocampal damage: a potential animal model of schizophrenia. Neuropsychopharmacology 1993; 9: 67-75
58. Lipska BK, Weinberger DR: Delayed effects of neonatal hippo-campal damage on haloperidol-induced catalepsy and apomorphine-induced stereotypic behaviors in the rat. Dev Brain Res 1993; 75:213-222
59. Seidman LJ: Clinical neuroscience and epidemiology in schizophrenia. Harvard Rev Psychiatry 1997; 3:338-342
60. Faraone SV, Seidman LJ, Kremen WS, Toomey R, Pepple JR, Tsuang MT: Neuropsychological functioning among the non-psychotic relatives of schizophrenic patients: a four-year follow-up study. J Abnorm Psychol 1999; 108:176-181
61. Tsuang MT, Gilbertson MW, Faraone SV: Genetic transmission of negative and positive symptoms in the biological relatives of schizophrenics, in Negative Versus Positive Schizophrenia. Edited by Marneros A, Andreasen NC, Tsuang MT. New York, Springer-Verlag, 1991, pp 265-291
62. Kendler KS, Neale MC, Walsh D: Evaluating the spectrum concept of schizophrenia in the Roscommon Family Study. Am J Psychiatry 1995; 152:749-754
63. Woods BT: Is schizophrenia a progressive neurodevelopmental disorder? toward a unitary pathogenetic mechanism. Am J Psychiatry 1998; 155:1661-1670
64. Nopoulos P, Torres I, Flaum M, Andreasen NC, Ehrhardt JC, Yuh WTC: Brain morphology in first-episode schizophrenia. Am J Psychiatry 1995; 152:1721-1723
65. Cannon TD, Mednick SA, Parnas J, Schulsinger F, Praestholm J, Vestergaard A: Developmental brain abnormalities in the offspring of schizophrenic mothers, I: contributions of genetic and perinatal factors. Arch Gen Psychiatry 1993; 50:551-564
66. Cannon TD, Mednick SA, Parnas J, Schulsinger F, Praestholm J, Vestergaard A: Developmental brain abnormalities in the offspring of schizophrenic mothers, II: structural brain characteristics of schizophrenia and schizotypal personality disorder. Arch Gen Psychiatry 1994; 51:955-962
67. Arolt V, Lencer R, Achim N, Muller-Myhsok B, Purmann S, Schurmann M, Leutelt J, Pinnow M, Schwinger E: Eye tracking dysfunction is a putative phenotypic susceptibility marker of schizophrenia and maps to a locus on chromosome 6p in families with multiple occurrence of the disease. Am J Med Genet Neuropsychiatr Genet 1996; 67:560-563
68. Freedman R, Coon H, Myles-Worsley M, Orr-Urtreger A, Olincy A, Davis A, Polmeropoulos M, Holik J, Hopkins J, Hoff M, Rosenthal J, Waldo MC, Reimherr F, Wender P, Yaw J, Young DA, Breese C, Adams CR, Patterson D, Adler LE, Kruglyak L, Leonard S, Byerley W: Linkage of a neurophysiological deficit in schizophrenia to a chromosome 15 locus Proc Natl Acad Sci USA 1997;94:587-592
69. Catts SV, McConaghy N, Ward PB, Fox AM, Hadzi-Pavlovic D: Allusive thinking in parents of schizophrenics: meta-analysis. J Nerv Ment Dis 1993; 181:298-302
70. Erlenmeyer-Kimling L, Cornblatt B, Friedman D, Marcuse Y, Rutschmann J, Simmens S, Devi F: Neurological, electrophysiological, and attentional deviations in children at risk for schizophrenia, in Schizophrenia as a Brain Disease. Edited by Henn FA, Nasrallah HA. New York, Oxford University Press, 1982, pp 61-98
71. Friedman D, Squires-Wheeler E: Event-related potentials (ERPs) as indicators of risk for schizophrenia. Schizophr Bull 1994; 20: 63-74
72. Seidman LJ, Faraone SV, Goldstein JM, Goodman JM, Kremen WS, Toomey R, Tourville J, Kennedy D, Makris N, Caviness VS, Tsuang MT: Thalamic and amygdala-hippocampal volume reductions in first degree relatives of patients with schizophrenia: an MRI-based morphometric analysis. Biol Psychiatry 1999; 46:941-954
73. Kremen WS, Seidman LJ, Pepple JR, Lyons MJ, Tsuang MT, Faraone SV: Neuropsychological risk indicators for schizophrenia: a review of family studies. Schizophr Bull 1994; 20:103-119
74. Tsuang MT, Stone WS, Seidman LJ, Faraone SV, Zimmet S, Wojcik J, Kelleher J, Green Al: Treatment of nonpsychotic relatives of patients with schizophrenia: four case studies. Biol Psychiatry 1999;41:1412-1418
75. Andreasen NC: Scale for the Assessment of Negative Symptoms (SANS). Iowa City, University of Iowa, 1983
76. Rossi A, Mancini F, Stratta P, Mattei P, Gismondi R, Pozzi F, Casacchia M: Risperidone, negative symptoms and cognitive deficit in schizophrenia: an open study. Acta Psychiatr Scand 1997; 95:40-43
77. Green MF, Marshall BD Jr. Wirshing WC, Ames D, Marder SR, McGurk S, Kern RS, Mintz J: Does risperidone improve verbal working memory in treatment-resistant schizophrenia? Am J Psychiatry 1997; 154:799-804
78. Faraone SV, Tsuang D, Tsuang MT: Psychiatric Genetics: A Guide for Mental Health Professionals. New York, Guilford, 1999