Functional Imaging as a Predictor of Schizophrenia

Biological Psychiatry

Volumn 60, Issue 5, 2006, Pages 454-462

  Whalley, Heather C ^a   Simonotto, Enrico ^a,c   Moorhead, William ^a   McIntosh, Andrew ^a   Marshall, Ian ^b   Ebmeier, Klaus P ^a   Owens, David G C ^a   Goddard, Nigel H ^a   Johnstone, Eve C ^a   Lawrie, Stephen M ^a  

^a UNIVERSITY OF EDINBURGH   (United Kingdom)

^b UNIVERSITY OF EDINBURGH   (United Kingdom)

^c Invivo Diagnostic Imaging   (United States)

Author keywords

fMRI; high risk; predictor; schizophrenia

Indexed keywords

ADULT; ARTICLE; CINGULATE GYRUS; CONTROLLED STUDY; DIAGNOSTIC ACCURACY; DIAGNOSTIC VALUE; FEMALE; FUNCTIONAL DISEASE; FUNCTIONAL MAGNETIC RESONANCE IMAGING; HIGH RISK POPULATION; HUMAN; MAJOR CLINICAL STUDY; MALE; MENTAL DISEASE; PARIETAL LOBE; PRIORITY JOURNAL; PSYCHOSIS; SCHIZOPHRENIA; TASK PERFORMANCE; TEMPORAL LOBE;

ADOLESCENT; ADULT; BRAIN MAPPING; CEREBRAL CORTEX; FEMALE; GENETIC PREDISPOSITION TO DISEASE; GYRUS CINGULI; HUMANS; IMAGE PROCESSING, COMPUTER-ASSISTED; MAGNETIC RESONANCE IMAGING; MALE; METALLOPORPHYRINS; PARIETAL LOBE; PEDIGREE; PREDICTIVE VALUE OF TESTS; REFERENCE VALUES; SCHIZOPHRENIA; TEMPORAL LOBE; VERBAL BEHAVIOR;

EID: 33745955227     PISSN: 00063223     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.biopsych.2005.11.013     Document Type: Article

References (45)

1. Becker J.T., MacAndrew D.K., and Fiez J.A. A comment on the functional localization of the phonological storage subsystem of working memory. Brain Cogn 41 (1999) 27-38
2. Blackwood D.H.R., Glabus M.F., Dunan J., O'Carroll R.E., Muir W.J., and Ebmeier K.P. Altered cerebral perfusion measured by SPECT in relatives of patients with schizophrenia. Correlations with memory and P300. Br J Psychiatry 175 (1999) 357-366
3. Bloom P.A., and Fischler I. Completion norms for 329 sentence contexts. Mem Cognit 8 (1980) 631-642
4. Bullmore E., Horwitz B., Honey G., Brammer M., Williams S.C., and Sharma T. How good is good enough in path analysis of fMRI data?. Neuroimage 11 (2000) 289-301
5. Burgess P., and Shallice T. The Hayling and Brixton Tests (1997), Thames Valley Test Company Limited, Bury St. Edmunds, UK
6. Callicott J.H., Egan M.F., Mattay V.S., Bertolino A., Bone A.D., Verchinksi B., et al. Abnormal fMRI response of the dorsolateral prefrontal cortex in cognitively intact siblings of patients with schizophrenia. Am J Psychiatry 160 (2003) 709-719
7. Chapman J. The early symptoms of schizophrenia. Br J Psychiatry 112 (1966) 225-251
8. Collette F., Van der Linden M., Delfiore G., Degueldre C., Luxen A., and Salmon E. The functional anatomy of inhibition processes investigated with the Hayling task. Neuroimage 14 (2001) 258-267
9. Craddock N., and Owen M.J. Modern molecular genetic approaches to psychiatric disease. Br Med Bull 52 (1996) 434-452
10. Culham J.C., and Kanwisher N.G. Neuroimaging of cognitive functions in human parietal cortex. Curr Opin Neurobiol 11 (2001) 157-163
11. Curtis V.A., Bullmore E.T., Brammer M.J., Wright I.C., Williams S.C., Morris R.G., et al. Attenutated frontal activation during a verbal fluency task in patients with schizophrenia. Am J Psychiatry 155 (1998) 1056-1063
12. Erlenmeyer-Kimling L., Rock D., Roberts S.A., Janal M., Kestenbaum C., Cornblatt B., et al. Attention, memory, and motor skills as childhood predictors of schizophrenia-related psychoses. The New York High-Risk Project. Am J Psychiatry 157 (2000) 1416-1422
13. Fletcher P.C. Functional neuroimaging of schizophrenia. From a genetic predisposition to the emergence of symptoms. Brain 127 (2004) 457-459
14. Fletcher P.C., McKenna P.J., Frith C.D., Grasby P.M., Friston K.J., and Dolan R.J. Brain activations in schizophrenia during a graded memory task studied with functional neuroimaging. Arch Gen Psychiatry 55 (1998) 1001-1008
15. Franck N., O'Leary D.S., Flaum M., Hichwa R.D., and Andreasen N.C. Cerebral blood flow changes associated with Schneiderian first-rank symptoms in schizophrenia. J Neuropsychiatry Clin Neurosci 14 (2002) 277-282
16. Frith C.D., Friston K.J., Herold S., Silbersweig D., Fletcher P., Cahill C., et al. Regional brain activity in chronic schizophrenic patients during the performance of a verbal fluency task. Br J Psychiatry 167 (1995) 343-349
17. Hambrecht M., Lammertink M., Klosterkotter J., Matuschek E., and Pukrop R. Subjective and objective neuropsychological abnormalities in a psychosis prodrome clinic. Br J Psychiatry Suppl 43 (2002) s30-s37
18. Hodges A., Byrne M., Grant E., and Johnstone E. People at risk of schizophrenia. Sample characteristics of the first 100 cases in the Edinburgh high-risk study. Br J Psychiatry 174 (1999) 547-553
19. Johnstone E.C., Abukmeil S.S., Byrne M., Clafferty R., Grant E., Hodges A., et al. Edinburgh high risk study-findings after four years. Demographic, attainment and psychopathological issues. Schizophr Res 46 (2000) 1-15
20. Johnstone E.C., Cooling N.J., Frith C.D., Crow T.J., and Owens D.G. Phenomenology of organic and functional psychoses and the overlap between them. Br J Psychiatry 153 (1988) 770-776
21. Johnstone E.C., Ebmeier K.P., Miller P., Owens D.G.C., and Lawrie S.M. Predicting schizophrenia-findings from the Edinburgh High Risk Study. Br J Psychiatry 186 (2005) 18-25
22. Johnstone E.C., Lawrie S.M., and Cosway R. What does the Edinburgh High-Risk Study tell us about schizophrenia. Am J Med Genet 114 (2002) 906-912
23. Keshavan M.S., Diwadkar V.A., Spencer S.M., Harenski K.A., Luna B., and Sweeney J.A. A preliminary functional magnetic resonance imaging study in offspring of schizophrenic parents. Prog Neuropsychopharmacol Biol Psychiatry 26 (2002) 1143-1149
24. Kircher T.T., Bulimore E.T., Brammer M.J., Williams S.C., Broome M.R., Murray R.M., et al. Differential activation of temporal cortex during sentence completion in schizophrenic patients with and without formal thought disorder. Schizophr Res 50 (2001) 27-40
25. Klosterkotter J., Hellmich M., Steinmeyer E.M., and Schultze-Lutter F. Diagnosing schizopohrenia in the initial prodromal phase. Arch Gen Psychiatry 58 (2001) 158-164
26. Klosterkotter J., Schultze-Lutter F., Gross G., Huber G., and Steinmeyer E.M. Early self-experienced neuropsychological deficits and subsequent schizophrenic diseases. An 8-year average follow-up prospective study. Acta Psychiatr Scand 95 (1997) 396-404
27. Lawrie S.M., and Abukmeil S.S. Brain abnormality in schizophrenia. A systematic and quantitative review of volumetric magnetic resonance imaging studies. Br J Psychiatry 172 (1998) 110-120
28. Lawrie S.M., Buechel C., Whalley H.C., Frith C.D., Friston K.J., and Johnstone E.C. Reduced frontotemporal functional connectivity in schizophrenia associated with auditory hallucinations. Biol Psychiatry 51 (2002) 1008-1011
29. Lewis D.A. Distributed disturbances in brain structure and function in schizophrenia. Am J Psychiatry 157 (2000) 1-2
30. Metz C.E. Basic principles of ROC analysis. Semin Nucl Med 8 (1978) 283-298
31. Nathaniel-James D.A., Fletcher P., and Frith C.D. The functional anatomy of verbal initiation and suppression using the Hayling Test. Neuropsychologia 35 (1997) 559-566
32. Nathaniel-James D.A., and Frith C.D. The role of the dorsolateral prefrontal cortex. Evidence from the effects of contextual constraint in a sentence completion task. Neuroimage 16 (2002) 1094-1102
33. O'Driscoll G.A., Benkelfat C., Florencio P.S., Wolff A.L., Joober R., Lal S., et al. Neural correlates of eye tracking deficits in first-degree relatives of schizophrenic patients. A positron emission tomography study. Arch Gen Psychiatry 56 (1999) 1127-1134
34. Owens D.G.C., Miller P., Lawrie S.M., and Johnstone E.C. Pathogenesis of schizophrenia. A psychopathological perspective. Br J Psychiatry 186 (2005) 386-393
35. Petersen S.E., Fox P.T., Snyder A.Z., and Raichle M.E. Activation of extrastriate and frontal cortical areas by visual words and word-like stimuli. Science 249 (1990) 1041-1044
36. Shenton M.E., Dickey C.C., Frumin M., and McCarley R.W. A review of MRI findings in schizophrenia. Schizophr Res 49 (2001) 1-52
37. Sommer I.E., Ramsey N.F., Mandl R.C., van Oel C.J., and Kahn R.S. Language activation in monozygotic twins discordant for schizophrenia. Br J Psychiatry 184 (2004) 128-135
38. Spence S.A., Brooks D.J., Hirsch S.R., Liddle P.F., Meehan J., and Grasby P.M. A PET study of voluntary movement in schizophrenic patients experiencing passivity phenomena (delusions of alien control). Brain 120 (1997) 1997-2011
39. Spence S.A., Liddle P.F., Stefan M.D., Hellewell J.S., Sharma T., Friston K.J., et al. Functional anatomy of verbal fluency in people with schizophrenia and those at genetic risk. Focal dysfunction and distributed disconnectivity reappraised. Br J Psychiatry 176 (2000) 52-60
40. Thermenos H.W., Seidman L.J., Breiter H., Goldstein J.M., Goodman J.M., Poldrack R., et al. Functional magnetic resonance imaging during auditory verbal working memory in nonpsychotic relatives of persons with schizophrenia. A pilot study. Biol Psychiatry 55 (2004) 490-500
41. Ward N.S., Brown M.M., Thompson A.J., and Frackowiak R.S.J. Neural correlates of outcome after stroke. A cross-sectional fMRI study. Brain 126 (2003) 1430-1448
42. Whalley H.C., Simonotto E., Flett S., Marshall I., Ebmeier K.P., Owens D.G.C., et al. fMRI correlates of state and trait effects in subjects at genetically enhanced risk of schizophrenia. Brain 127 (2004) 478-490
43. Wing J.K., Cooper J.E., and Sartorius N. The Description and Classification of Psychiatric Symptoms. An Instruction Manual for the PSE and Catego Systems (1974), Cambridge University Press, Cambridge, UK
44. World Health Organisation. ICD-10: The ICD-10 Classification of Mental and Behavioural Disorders: Diagnostic Criteria for Research (1993), World Health Organisation, Geneva
45. Zweig M.H., and Campbell G. Receiver-operating characteristic (ROC) plots. A fundamental evaluation tool in clinical medicine. Clin Chem 39 (1993) 561-577