Microsphere translocation and immunopotentiation in systemic tissues following intranasal administration

Vaccine

Volumn 19, Issue 32, 2001, Pages 4732-4742

  Eyles, J E ^a   Bramwell, V W ^b   Williamson, E D ^a   Alpar, H O ^b  

^a DEFENCE SCIENCE AND TECHNOLOGY LABORATORY   (United Kingdom)

^b UNIVERSITY OF LONDON   (United Kingdom)

Author keywords

Adjuvant; Aerosol; Biodegradable microparticles; Biodistribution studies; Immunological memory; Inductive site; Mucosal immunization; Vaccine; Yersinia pestis

Indexed keywords

ANTIGEN; BUFFER; CARBOXYLIC ACID DERIVATIVE; FLUORESCENT POLYSTYRENE CARBOXYLATE; FREUND ADJUVANT; IMMUNOGLOBULIN G; MICROSPHERE; SODIUM CHLORIDE; THYMIDINE; TRITIUM; UNCLASSIFIED DRUG; V ANTIGEN;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ANTIBODY PRODUCTION; ANTIGEN SPECIFICITY; ARTICLE; CELL SELECTION; CERVICAL LYMPH NODE; CONTROLLED STUDY; DNA SYNTHESIS; DRUG UPTAKE; EXPOSURE; FEMALE; FLUORESCENCE ACTIVATED CELL SORTER; HISTOLOGY; IMMUNE RESPONSE; IMMUNIZATION; IMMUNOPOTENTIATION; LYMPHATIC DRAINAGE; LYMPHOID TISSUE; MEDIASTINUM LYMPH NODE; MEMORY; MOUSE; NONHUMAN; PRIORITY JOURNAL; RESPIRATORY SYSTEM; SPLEEN; SUSPENSION; T LYMPHOCYTE; YERSINIA PESTIS;

ADJUVANTS, IMMUNOLOGIC; ADMINISTRATION, INTRANASAL; ANIMALS; ANTIBODIES, BACTERIAL; ANTIGENS, BACTERIAL; B-LYMPHOCYTES; BIOLOGICAL TRANSPORT; CYTOKINES; FEMALE; FLOW CYTOMETRY; FLUORESCEIN-5-ISOTHIOCYANATE; FLUORESCENT DYES; IMMUNIZATION; IMMUNOGLOBULIN G; LYMPHOCYTE ACTIVATION; LYMPHOCYTE COUNT; LYMPHOID TISSUE; MICE; MICE, INBRED BALB C; MICROSPHERES; ORGAN SPECIFICITY; PARTICLE SIZE; POLYESTERS; POLYSTYRENES; PORE FORMING CYTOTOXIC PROTEINS; RECOMBINANT PROTEINS; RESPIRATORY SYSTEM; SPLEEN; T-LYMPHOCYTES; TISSUE DISTRIBUTION; YERSINIA PESTIS;

EID: 0035860620     PISSN: 0264410X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0264-410X(01)00220-1     Document Type: Article

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