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Volumn 2, Issue 1, 2007, Pages 24-30

Small-molecule screening: Advances in microarraying and cell-imaging technologies

Author keywords

[No Author keywords available]

Indexed keywords

CYCLIC AMP; CYCLIC AMP DEPENDENT PROTEIN KINASE; ESCHERICHIA COLI PROTEIN;

EID: 33947525308     PISSN: 15548929     EISSN: None     Source Type: Journal    
DOI: 10.1021/cb600321j     Document Type: Review
Times cited : (43)

References (72)
  • 1
    • 21144440283 scopus 로고    scopus 로고
    • Chemical genetics to chemical genomics: Small molecules offer big insights
    • Spring, D. R. (2005) Chemical genetics to chemical genomics: small molecules offer big insights, Chem. Soc. Rev. 34, 472-482.
    • (2005) Chem. Soc. Rev , vol.34 , pp. 472-482
    • Spring, D.R.1
  • 3
    • 0035415869 scopus 로고    scopus 로고
    • Chemical genetic approaches for the elucidation of signaling pathways
    • Alaimo, P. J., Shogren-Knaak, M. A., and Shokat, K. M. (2001) Chemical genetic approaches for the elucidation of signaling pathways, Curr. Opin. Chem. Biol. 5, 360-367.
    • (2001) Curr. Opin. Chem. Biol , vol.5 , pp. 360-367
    • Alaimo, P.J.1    Shogren-Knaak, M.A.2    Shokat, K.M.3
  • 4
    • 33745726644 scopus 로고    scopus 로고
    • Chemical genetics
    • Walsh, D. P., and Chang, Y.-T. (2006) Chemical genetics, Chem. Rev. 106, 2476-2530.
    • (2006) Chem. Rev , vol.106 , pp. 2476-2530
    • Walsh, D.P.1    Chang, Y.-T.2
  • 5
    • 0037416141 scopus 로고    scopus 로고
    • The small-molecule approach to biology
    • Schreiber, S. L. (2003) The small-molecule approach to biology, Chem. Eng. News 81, 51-61.
    • (2003) Chem. Eng. News , vol.81 , pp. 51-61
    • Schreiber, S.L.1
  • 6
    • 0028342763 scopus 로고
    • Methodological aspects of quantitative receptor assays
    • Smisterova, J., Ensing, K., and De Zeeuw, R. A. (1994) Methodological aspects of quantitative receptor assays, J. Pharm. Biomed. Anal. 12, 723-745.
    • (1994) J. Pharm. Biomed. Anal , vol.12 , pp. 723-745
    • Smisterova, J.1    Ensing, K.2    De Zeeuw, R.A.3
  • 7
    • 27844463050 scopus 로고    scopus 로고
    • Improving success rates for lead generation using affinity binding technologies
    • Makara, G. M., and Athanasopoulos, J. (2005) Improving success rates for lead generation using affinity binding technologies, Curr. Opin. Biotechnol. 16, 666-673.
    • (2005) Curr. Opin. Biotechnol , vol.16 , pp. 666-673
    • Makara, G.M.1    Athanasopoulos, J.2
  • 8
    • 0037463033 scopus 로고    scopus 로고
    • NMR spectroscopy techniques for screening and identifying ligand binding to protein receptors
    • Meyer, B., and Peters, T. (2003) NMR spectroscopy techniques for screening and identifying ligand binding to protein receptors, Angew. Chem. Int. Ed. 42, 864-890.
    • (2003) Angew. Chem. Int. Ed , vol.42 , pp. 864-890
    • Meyer, B.1    Peters, T.2
  • 9
    • 32444451730 scopus 로고    scopus 로고
    • Applications of mass spectroscopy in early stages of target based drug discovery
    • Deng, G., and Sanyal, G. (2006) Applications of mass spectroscopy in early stages of target based drug discovery, J. Pharm. Biomed. Anal. 40, 528-538.
    • (2006) J. Pharm. Biomed. Anal , vol.40 , pp. 528-538
    • Deng, G.1    Sanyal, G.2
  • 10
    • 13344284025 scopus 로고    scopus 로고
    • Isothermal titration calorimetry: Controlling binding forces in lead optimization
    • Freire, E. (2004) Isothermal titration calorimetry: controlling binding forces in lead optimization, Drug Discovery Today: Technol. 1, 295-299.
    • (2004) Drug Discovery Today: Technol , vol.1 , pp. 295-299
    • Freire, E.1
  • 11
    • 0035171181 scopus 로고    scopus 로고
    • Scanning of guanine-guanine mismatches in DNA by synthetic ligands using surface plasmon resonance
    • Nakatani, K., Sando, S., and Saito, I. (2001) Scanning of guanine-guanine mismatches in DNA by synthetic ligands using surface plasmon resonance, Nat. Biotechnol. 19, 51-55.
    • (2001) Nat. Biotechnol , vol.19 , pp. 51-55
    • Nakatani, K.1    Sando, S.2    Saito, I.3
  • 12
    • 33646040415 scopus 로고    scopus 로고
    • High throughput fluorescence polarization assay to identify small molecule inhibitors of BRCT domains of breast cancer gene 1
    • Lokesh, G. L., Rachamallu, A., Kumar, G. D. K., and Natarajan, A. (2006) High throughput fluorescence polarization assay to identify small molecule inhibitors of BRCT domains of breast cancer gene 1, Anal. Biochem. 352, 135-141.
    • (2006) Anal. Biochem , vol.352 , pp. 135-141
    • Lokesh, G.L.1    Rachamallu, A.2    Kumar, G.D.K.3    Natarajan, A.4
  • 14
    • 1442309077 scopus 로고    scopus 로고
    • Applications of bioluminescence and fluorescence resonance energy transfer to drug discovery at G protein-coupled receptors
    • Milligan, G. (2004) Applications of bioluminescence and fluorescence resonance energy transfer to drug discovery at G protein-coupled receptors, Eur. J. Pharm. Sci. 21, 397-405.
    • (2004) Eur. J. Pharm. Sci , vol.21 , pp. 397-405
    • Milligan, G.1
  • 15
    • 0000885268 scopus 로고    scopus 로고
    • Scintillation proximity assay: A versatile high-throughput screening technology
    • Cook, N. D. (1996) Scintillation proximity assay: a versatile high-throughput screening technology, Drug Discovery Today 1, 287-294.
    • (1996) Drug Discovery Today , vol.1 , pp. 287-294
    • Cook, N.D.1
  • 17
    • 27544444375 scopus 로고    scopus 로고
    • Integration of virtual screening with high-throughput flow cytometry to identify novel small molecule formylpeptide receptor antagonists
    • Edwards, B. S., Bologa, C., Young, S. M., Balakin, K. V., Prossnitz, E. R., Savchuck, N. P., Sklar, L., and Oprea, T. (2005) Integration of virtual screening with high-throughput flow cytometry to identify novel small molecule formylpeptide receptor antagonists, Mol. Pharm. 68, 1301-1310.
    • (2005) Mol. Pharm , vol.68 , pp. 1301-1310
    • Edwards, B.S.1    Bologa, C.2    Young, S.M.3    Balakin, K.V.4    Prossnitz, E.R.5    Savchuck, N.P.6    Sklar, L.7    Oprea, T.8
  • 18
    • 33745158343 scopus 로고    scopus 로고
    • Comparison between conventional indirect competitive enzyme-linked immunosorbent assay (icELISA) and simplified icELISA for small molecules
    • Zhao, J., Li, G., Yi, G.-X., Wang, B.-M., Deng, A.-X., Nan, T.-G., Li, Z.- H., and Li, Q. X. (2006) Comparison between conventional indirect competitive enzyme-linked immunosorbent assay (icELISA) and simplified icELISA for small molecules, Anal. Chim. Acta 571, 79-85.
    • (2006) Anal. Chim. Acta , vol.571 , pp. 79-85
    • Zhao, J.1    Li, G.2    Yi, G.-X.3    Wang, B.-M.4    Deng, A.-X.5    Nan, T.-G.6    Li, Z.H.7    Li, Q.X.8
  • 19
    • 0032502840 scopus 로고    scopus 로고
    • Genetic recombination as a reporter for screening steroid receptor agonists and antagonists
    • Dias, J. M., Go, N. F., Hart, C. P., and Mattheakis, L. C. (1998) Genetic recombination as a reporter for screening steroid receptor agonists and antagonists. Anal. Biochem. 258, 96-102.
    • (1998) Anal. Biochem , vol.258 , pp. 96-102
    • Dias, J.M.1    Go, N.F.2    Hart, C.P.3    Mattheakis, L.C.4
  • 20
    • 21744455897 scopus 로고    scopus 로고
    • Ion channel screening technologies today
    • Terstappen, G. C. (2005) Ion channel screening technologies today, Drug Discovery Today: Technol. 2, 133-140.
    • (2005) Drug Discovery Today: Technol , vol.2 , pp. 133-140
    • Terstappen, G.C.1
  • 23
    • 0742281392 scopus 로고    scopus 로고
    • Bioluminescence and chemiluminescence in drug screening
    • Roda, A., Guardigli, M., Pasini, P., and Mirasoli, M. (2003) Bioluminescence and chemiluminescence in drug screening, Anal. Bioanal. Chem. 377, 826-833.
    • (2003) Anal. Bioanal. Chem , vol.377 , pp. 826-833
    • Roda, A.1    Guardigli, M.2    Pasini, P.3    Mirasoli, M.4
  • 24
  • 25
    • 33644777646 scopus 로고    scopus 로고
    • Lab-on-a-chip: Microfluidics in drug discovery
    • Dittrich, P. S., and Manz, A. (2006) Lab-on-a-chip: microfluidics in drug discovery, Nat. Rev. Drug Discovery 5, 210-218.
    • (2006) Nat. Rev. Drug Discovery , vol.5 , pp. 210-218
    • Dittrich, P.S.1    Manz, A.2
  • 26
    • 33745186192 scopus 로고    scopus 로고
    • Downscaling functional bioassays by single-molecule techniques
    • Hong, F., and Root, D. D. (2006) Downscaling functional bioassays by single-molecule techniques. Drug Discovery Today 11, 640-645.
    • (2006) Drug Discovery Today , vol.11 , pp. 640-645
    • Hong, F.1    Root, D.D.2
  • 29
    • 24644510147 scopus 로고    scopus 로고
    • Fluorescence analysis in microarray technology
    • Nagl, S., Schaeferling, M., and Wolfbeis, O. S. (2005) Fluorescence analysis in microarray technology, Microchim. Acta 151, 1-21.
    • (2005) Microchim. Acta , vol.151 , pp. 1-21
    • Nagl, S.1    Schaeferling, M.2    Wolfbeis, O.S.3
  • 30
    • 33645653692 scopus 로고    scopus 로고
    • SPR imaging of photo-cross-linked small-molecule arrays on gold
    • Kanoh, N., Kyo, M., Inamori, K., Ando, A., Nakao, A., and Osada, H. (2006) SPR imaging of photo-cross-linked small-molecule arrays on gold, Anal. Chem. 78, 2226-2230.
    • (2006) Anal. Chem , vol.78 , pp. 2226-2230
    • Kanoh, N.1    Kyo, M.2    Inamori, K.3    Ando, A.4    Nakao, A.5    Osada, H.6
  • 33
    • 22244440813 scopus 로고    scopus 로고
    • Investigation of the relationship between protein-protein interaction and catalytic activity of a heme regulated phosphodiesterase from Escherichia coli (Ec DOS) by protein microarray
    • Sasakura, Y., Kanda, K, Yoshimura-Suzuki, T., Matsui, T., Fukuzono, S., and Shimizu, T. (2005) Investigation of the relationship between protein-protein interaction and catalytic activity of a heme regulated phosphodiesterase from Escherichia coli (Ec DOS) by protein microarray, Biochemistry 44, 9598-9605.
    • (2005) Biochemistry , vol.44 , pp. 9598-9605
    • Sasakura, Y.1    Kanda, K.2    Yoshimura-Suzuki, T.3    Matsui, T.4    Fukuzono, S.5    Shimizu, T.6
  • 34
    • 29244470287 scopus 로고    scopus 로고
    • Nanovolume kinase inhibition assay using a sol-gel-derived multicomponent microarray
    • Rupcich, N., Green, J. R. A., and Brennan, J. D. (2005) Nanovolume kinase inhibition assay using a sol-gel-derived multicomponent microarray, Anal. Chem. 77, 8013-8019.
    • (2005) Anal. Chem , vol.77 , pp. 8013-8019
    • Rupcich, N.1    Green, J.R.A.2    Brennan, J.D.3
  • 36
    • 11244299467 scopus 로고    scopus 로고
    • Light-directed radial combinatorial chemistry: Orthogonal safety-catch protecting groups for the synthesis of small molecule microarrays
    • Shaginian, A., Patel, M., Li, M.-H., Flickinger, S. T., Kim, C., Cerrina, F., and Belshaw, P. J. (2004) Light-directed radial combinatorial chemistry: orthogonal safety-catch protecting groups for the synthesis of small molecule microarrays, J. Am. Chem. Soc. 126, 16704-16705.
    • (2004) J. Am. Chem. Soc , vol.126 , pp. 16704-16705
    • Shaginian, A.1    Patel, M.2    Li, M.-H.3    Flickinger, S.T.4    Kim, C.5    Cerrina, F.6    Belshaw, P.J.7
  • 37
    • 0034674919 scopus 로고    scopus 로고
    • Small molecule microarrays: Covalent attachment and screening of alcohol-containing small molecules on glass slides
    • Hergenrother, P. J., Depew, K. M., and Schreiber, S. L. (2000) Small molecule microarrays: covalent attachment and screening of alcohol-containing small molecules on glass slides, J. Am. Chem. Soc. 122, 7849-7850.
    • (2000) J. Am. Chem. Soc , vol.122 , pp. 7849-7850
    • Hergenrother, P.J.1    Depew, K.M.2    Schreiber, S.L.3
  • 39
    • 0033199751 scopus 로고    scopus 로고
    • Printing small molecules as microarrays and detecting protein-small molecule interactions en masse
    • MacBeath, G., Koehler, A. N., and Schreiber, S. L. (1999) Printing small molecules as microarrays and detecting protein-small molecule interactions en masse, J. Am. Chem. Soc. 121, 7967-7968.
    • (1999) J. Am. Chem. Soc , vol.121 , pp. 7967-7968
    • MacBeath, G.1    Koehler, A.N.2    Schreiber, S.L.3
  • 40
    • 0036232915 scopus 로고    scopus 로고
    • Carbohydrate arrays for the evaluation of protein binding and enzymatic modification
    • Houseman, B. T., and Mrksich, M. (2002) Carbohydrate arrays for the evaluation of protein binding and enzymatic modification, Chem. Biol. 9, 443-454.
    • (2002) Chem. Biol , vol.9 , pp. 443-454
    • Houseman, B.T.1    Mrksich, M.2
  • 41
    • 0344667656 scopus 로고    scopus 로고
    • Immobilization of natural products on glass slides by using a photoaffinity reaction and the detection of protein-small-molecule interactions
    • Kanoh, N., Kumashiro, S., Simizu, S., Kondoh, Y., Hatakeyama, S., Tashiro, H., and Osada, H. (2003) Immobilization of natural products on glass slides by using a photoaffinity reaction and the detection of protein-small-molecule interactions, Angew. Chem. Int. Ed. 42, 5584-5587.
    • (2003) Angew. Chem. Int. Ed , vol.42 , pp. 5584-5587
    • Kanoh, N.1    Kumashiro, S.2    Simizu, S.3    Kondoh, Y.4    Hatakeyama, S.5    Tashiro, H.6    Osada, H.7
  • 43
    • 0037061492 scopus 로고    scopus 로고
    • Dissecting glucose signalling with diversity oriented synthesis and small-molecule microarrays
    • Kuruvilla, F.G., Shamii, A.F., Stemson, S.M., Hergenrother, P.J., and Schreiber, S. L. (2002) Dissecting glucose signalling with diversity oriented synthesis and small-molecule microarrays, Nature 416, 653-657.
    • (2002) Nature , vol.416 , pp. 653-657
    • Kuruvilla, F.G.1    Shamii, A.F.2    Stemson, S.M.3    Hergenrother, P.J.4    Schreiber, S.L.5
  • 44
    • 0038682103 scopus 로고    scopus 로고
    • Expanding the functional group compatibility of small-molecule microarrays: Discovery of novel calmodulin ligands
    • Bames-Seeman, D., Park, S. B., Koehler, A. N., and Schreiber, S. L. (2003) Expanding the functional group compatibility of small-molecule microarrays: discovery of novel calmodulin ligands, Angew. Chem. Int. Ed.. 42, 2376-2379.
    • (2003) Angew. Chem. Int. Ed , vol.42 , pp. 2376-2379
    • Bames-Seeman, D.1    Park, S.B.2    Koehler, A.N.3    Schreiber, S.L.4
  • 46
  • 47
    • 30444453443 scopus 로고    scopus 로고
    • Activity-based fingerprinting of proteases
    • Srinivasan, R., Huang, X., Ng, S. L., and Yao, S. Q. (2006) Activity-based fingerprinting of proteases, ChemBioChem 7, 32-36.
    • (2006) ChemBioChem , vol.7 , pp. 32-36
    • Srinivasan, R.1    Huang, X.2    Ng, S.L.3    Yao, S.Q.4
  • 48
    • 0041806643 scopus 로고    scopus 로고
    • Printing chemical libraries on microarrays for fluid phase nanoliter reactions
    • Gosalia, D. N., and Diamond, S. L. (2003) Printing chemical libraries on microarrays for fluid phase nanoliter reactions, Proc. Natl. Acad. Sci. U.S.A 100, 8721-8726.
    • (2003) Proc. Natl. Acad. Sci. U.S.A , vol.100 , pp. 8721-8726
    • Gosalia, D.N.1    Diamond, S.L.2
  • 49
    • 1842786781 scopus 로고    scopus 로고
    • The evolution of microarrayed compound screening
    • Hoever, M., and Zbinden, P. (2004) The evolution of microarrayed compound screening, Drug Discovery Today 9, 358-365.
    • (2004) Drug Discovery Today , vol.9 , pp. 358-365
    • Hoever, M.1    Zbinden, P.2
  • 53
    • 9244230048 scopus 로고    scopus 로고
    • Microarrays of small molecules embedded in biodegradable polymers for use in mammalian cell-based screens
    • Bailey, S. N., Sabatini, D. M., and Stockwell, B. R. (2004) Microarrays of small molecules embedded in biodegradable polymers for use in mammalian cell-based screens, Proc. Natl. Acad. Sci. U.S.A. 101, 16144-16149.
    • (2004) Proc. Natl. Acad. Sci. U.S.A , vol.101 , pp. 16144-16149
    • Bailey, S.N.1    Sabatini, D.M.2    Stockwell, B.R.3
  • 55
    • 12344250982 scopus 로고    scopus 로고
    • Small-molecule screening and profiling by using automated microscopy
    • Mitchison, T. J. (2005) Small-molecule screening and profiling by using automated microscopy, ChemBioChem 6, 33-39.
    • (2005) ChemBioChem , vol.6 , pp. 33-39
    • Mitchison, T.J.1
  • 56
    • 15744382282 scopus 로고    scopus 로고
    • Screening for cell migration inhibitors via automated microscopy reveals a Rho-kinase inhibitor
    • Yarrow, J. C., Totsukawa, G., Charras, G. T., and Mitchison, T. J. (2005) Screening for cell migration inhibitors via automated microscopy reveals a Rho-kinase inhibitor, Chem. Biol. 12, 385-395.
    • (2005) Chem. Biol , vol.12 , pp. 385-395
    • Yarrow, J.C.1    Totsukawa, G.2    Charras, G.T.3    Mitchison, T.J.4
  • 57
    • 13444261101 scopus 로고    scopus 로고
    • Selective chemical labelling of proteins in living cells
    • Miller, L. W., and Comish, V. W. (2005) Selective chemical labelling of proteins in living cells, Curr. Opin. Chem. Biol. 9, 56-61.
    • (2005) Curr. Opin. Chem. Biol , vol.9 , pp. 56-61
    • Miller, L.W.1    Comish, V.W.2
  • 58
    • 0348087040 scopus 로고    scopus 로고
    • Longterm multiple color imaging of live cells using quantum dot bioconjugates
    • Jaiswal, J. K., Mattoussi, H., Mauro, J. M., and Simon, S. M. (2003) Longterm multiple color imaging of live cells using quantum dot bioconjugates, Nat. Biotechnol. 21, 47-51.
    • (2003) Nat. Biotechnol , vol.21 , pp. 47-51
    • Jaiswal, J.K.1    Mattoussi, H.2    Mauro, J.M.3    Simon, S.M.4
  • 59
    • 21644460729 scopus 로고    scopus 로고
    • Green fluorescent proteins in receptor research: An emerging tool for drug discovery
    • Arun, K. H. S., Kaul, C. L., and Ramarao, P. (2005) Green fluorescent proteins in receptor research: an emerging tool for drug discovery, J. Pharm. Toxicol. Methods 51, 1-23.
    • (2005) J. Pharm. Toxicol. Methods , vol.51 , pp. 1-23
    • Arun, K.H.S.1    Kaul, C.L.2    Ramarao, P.3
  • 60
    • 27944475132 scopus 로고    scopus 로고
    • Fluorescent proteins as a toolkit for in vivo imaging
    • Chudakov, D. M., Lukyanov, S., and Lukyanov, K. A. (2005) Fluorescent proteins as a toolkit for in vivo imaging, Trends Biotechnol. 23, 605-613.
    • (2005) Trends Biotechnol , vol.23 , pp. 605-613
    • Chudakov, D.M.1    Lukyanov, S.2    Lukyanov, K.A.3
  • 61
    • 0032814850 scopus 로고    scopus 로고
    • Imaging systems in assay screening
    • Ramm, P. (1999) Imaging systems in assay screening, Drug Discovery Today 4, 401-410.
    • (1999) Drug Discovery Today , vol.4 , pp. 401-410
    • Ramm, P.1
  • 62
    • 7044235459 scopus 로고    scopus 로고
    • Intracellular trafficking pathways and drug delivery: Fluorescence imaging of living and fixed cells
    • Watson, P., Jones, A. T., and Stephens, D. J. (2005) Intracellular trafficking pathways and drug delivery: fluorescence imaging of living and fixed cells, Adv. Drug Delivery Rev. 57, 43-61.
    • (2005) Adv. Drug Delivery Rev , vol.57 , pp. 43-61
    • Watson, P.1    Jones, A.T.2    Stephens, D.J.3
  • 63
    • 7044253241 scopus 로고    scopus 로고
    • Advanced microscopy solutions for monitoring the kinetics and dynamics of drug-DNA targeting in living cells
    • Errington, R. J., Ameer-beg, S. M., Vojnovic, B., Patterson, L. H., Zloh, M., and Smith, P. J. (2005) Advanced microscopy solutions for monitoring the kinetics and dynamics of drug-DNA targeting in living cells, Adv. Drug Delivery Rev. 57, 153-167.
    • (2005) Adv. Drug Delivery Rev , vol.57 , pp. 153-167
    • Errington, R.J.1    Ameer-beg, S.M.2    Vojnovic, B.3    Patterson, L.H.4    Zloh, M.5    Smith, P.J.6
  • 64
    • 33749343202 scopus 로고    scopus 로고
    • Raman imaging microscopy - a potential cost-effective tool for drug development
    • Ling, J. (2005) Raman imaging microscopy - a potential cost-effective tool for drug development, Am. Pharm. Rev. 8, 44-49.
    • (2005) Am. Pharm. Rev , vol.8 , pp. 44-49
    • Ling, J.1
  • 66
    • 12344288635 scopus 로고    scopus 로고
    • Parallel chemical genetic and genome-wide RNAi screens identity cytokinesis inhibitors and targets
    • Eggert, U. S., Kiger, A. A., Richter, C., Perlman, Z. E., Perrimon, N., Mitchison, T. J., and Field, C. M. (2004) Parallel chemical genetic and genome-wide RNAi screens identity cytokinesis inhibitors and targets, PLoS Blot 2, 2135-2143.
    • (2004) PLoS Blot , vol.2 , pp. 2135-2143
    • Eggert, U.S.1    Kiger, A.A.2    Richter, C.3    Perlman, Z.E.4    Perrimon, N.5    Mitchison, T.J.6    Field, C.M.7
  • 70
    • 0037138650 scopus 로고    scopus 로고
    • Diversity-oriented synthesis of biaryl-containing medium rings using a one bead/one stock solution platform
    • Spring, D. R., Knishnan, S., Blackwell, H. E., and Schreiber, S. L. (2002) Diversity-oriented synthesis of biaryl-containing medium rings using a one bead/one stock solution platform. J. Am. Chem. Soc. 124, 1354-1363.
    • (2002) J. Am. Chem. Soc , vol.124 , pp. 1354-1363
    • Spring, D.R.1    Knishnan, S.2    Blackwell, H.E.3    Schreiber, S.L.4


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