Inverse correlation between IL-7 receptor expression and CD8 T cell exhaustion during persistent antigen stimulation

European Journal of Immunology

Volumn 35, Issue 3, 2005, Pages 738-745

  Lang, Karl S ^a   Recher, Mike ^a   Navarini, Alexander A ^a   Harris, Nicola L ^a   Löhning, Max ^a   Junt, Tobias ^a   Probst, Hans Christian ^a   Hengartner, Hans ^a   Zinkernagel, Rolf M ^a  

^a INSTITUTE OF EXPERIMENTAL IMMUNOLOGY   (Switzerland)

Author keywords

Bcl 2; Exhaustion; Lymphocytic choriomeningitis virus; Persistence; Re emergence

Indexed keywords

INTERLEUKIN 7 RECEPTOR; PROTEIN BCL 2; VIRUS ANTIGEN;

ANIMAL EXPERIMENT; ANTIGEN EXPRESSION; ARTICLE; CELL FATE; CELL SELECTION; CELL SURVIVAL; CORRELATION ANALYSIS; EXHAUSTION; FLUORESCENCE ACTIVATED CELL SORTING; HEPATITIS B; HEPATITIS B VIRUS; HEPATITIS C; HEPATITIS C VIRUS; HUMAN IMMUNODEFICIENCY VIRUS; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; IMMUNE RESPONSE; IMMUNOMODULATION; IMMUNOSTIMULATION; LYMPHOCYTIC CHORIOMENINGITIS VIRUS; MOUSE; MOUSE STRAIN; NONHUMAN; PERSISTENT VIRUS INFECTION; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN FUNCTION; PROTEIN SYNTHESIS INHIBITION; RECEPTOR DOWN REGULATION; STATISTICAL ANALYSIS; STUDENT T TEST; T LYMPHOCYTE ACTIVATION; VIRUS MENINGITIS; VIRUS STRAIN;

ANIMALS; ANTIGENS, VIRAL; APOPTOSIS; ARENAVIRIDAE INFECTIONS; CD8-POSITIVE T-LYMPHOCYTES; FLOW CYTOMETRY; LYMPHOCYTIC CHORIOMENINGITIS VIRUS; MICE; PROTO-ONCOGENE PROTEINS C-BCL-2; RECEPTORS, INTERLEUKIN-7; TIME FACTORS;

EID: 15844411342     PISSN: 00142980     EISSN: None     Source Type: Journal    
DOI: 10.1002/eji.200425828     Document Type: Article

References (30)

1. Pinschewer, D. D., Perez, M., Sanchez, A. B. and de la Torre, J. C., Recombinant lymphocytic choriomeningitis virus expressing vesicular stomatitis virus glycoprotein. Proc. Natl. Acad. Sci USA 2003. 100: 7895-7900.
2. Ciurea, A., Klenerman, P., Hunziker, L., Horvath, E., Odermatt, B., Ochsenbein, A. F., Hengartner, H. and Zinkernagel, R. M., Persistence of lymphocytic choriomeningitis virus at very low levels in immune mice. Proc. Natl. Acad. Sci. USA 1999. 96: 11964-11969.
3. Chisari, F. V. and Ferrari, C., Hepatitis B virus immunopathogenesis. Annu. Rev. Immunol. 1995. 13: 29-60.
4. + T-cell maturation: CD27 might provide a clue. Trends Immunol. 2002. 23: 586-591.
5. Thomsen, A. R., Johansen, J., Marker, O. and Christensen, J. P., Exhaustion of CTL memory and recrudescence of viremia in lymphocytic choriomeningitis virus-infected MHC class II-deficient mice and B cell-deficient mice. J. Immunol. 1996. 157: 3074-3080.
6. Moskophidis, D., Lechner, F., Pitcher, H. and Zinkernagel, R. M., Virus persistence in acutely infected immunocompetent mice by exhaustion of antiviral cytotoxic effector T cells. Nature 1993. 362: 758-761.
7. Appay, V., Nixon, D. F., Donahoe, S. M., Gillespie, G. M., Dong, T., King, A., Ogg, G. S., Spiegel, H. M., Conlon, C., Spina, C. A. et al., HIV-specific CD8(+) T cells produce antiviral cytokines but are impaired in cytolytic function. J. Exp. Med. 2000. 192: 63-75.
8. Gallimore, A., Glithero, A., Godkin, A., Tissot, A. C., Pluckthun, A., Elliott, T., Hengartner, H. and Zinkernagel, R., Induction and exhaustion of lymphocytic choriomeningitis virus-specific cytotoxic T lymphocytes visualized using soluble tetrameric major histocompatibility complex class I-peptide complexes. J. Exp. Med. 1998. 187: 1383-1393.
9. Toes, R. E., Offringa, R., Blom, R. J., Melief, C. J. and Kast, W. M., Peptide vaccination can lead to enhanced tumor growth through specific T-cell tolerance induction. Proc. Natl. Acad. Sci USA 1996. 93: 7855-7860.
10. + T cells is hampered by persistent systemic antigen, but full functional capacity is regained in an antigen-free environment. J. Immunol. 2004. 172: 6074-6079.
11. Kreuwel, H. T., Aung, S., Silao, C. and Sherman, L. A., Memory CD8(+) T cells undergo peripheral tolerance. Immunity 2002. 17: 73-81.
12. Schluns, K. S., Kieper, W. C., Jameson, S. C. and Lefrancois, L., Interleukin-7 mediates the homeostasis of naive and memory CD8 T cells in vivo. Nat. Immunol. 2000. 1: 426-432.
13. -/- mice. Cell 1997. 89: 1011-1019.
14. + T cell homeostasis. J. Immunol. 2003. 170: 210-217.
15. Kaech, S. M., Tan, J. T., Wherry, E. J., Konieczny, B. T., Surh, C. D. and Ahmed, R., Selective expression of the interleukin 7 receptor identifies effector CD8 T cells that give rise to long-lived memory cells. Nat. Immunol. 2003. 4: 1191-1198.
16. Schluns, K. S. and Lefrancois, L., Cytokine control of memory T-cell development and survival. Nat. Rev. Immunol. 2003. 3: 269-279.
17. Probst, H. C., Tschannen, K., Gallimore, A., Martinic, M., Basler, M., Dumrese, T., Jones, E. and van den Broek, M. F., Immunodominance of an antiviral cytotoxic T cell response is shaped by the kinetics of viral protein expression. J. Immunol. 2003. 171: 5415-5422.
18. Wherry, E. J., Blattman, J. N., Murali-Krishna, K., van der Most, R. and Ahmed, R., Viral persistence alters CD8 T-cell immunodominance and tissue distribution and results in distinct stages of functional impairment. J. Virol. 2003. 77: 4911-4927.
19. Pircher, H., Burki, K., Lang, R., Hengartner, H. and Zinkernagel, R. M., Tolerance induction in double specific T-cell receptor transgenic mice varies with antigen. Nature 1989. 342: 559-561.
20. Hernandez-Caselles, T., Martinez-Esparza, M., Sancho, D., Rubio, G. and Aparicio, P., Interleukin-7 rescues human activated T lymphocytes from apoptosis induced by glucocorticosteroids and regulates bcl-2 and CD25 expression. Hum. Immunol. 1995. 43: 181-189.
21. Amos, C. L., Woetmann, A., Nielsen, M., Geisler, C., Odum, N., Brown, B. L. and Dobson, P. R., The role of caspase 3 and BclxL in the action of interleukin 7 (IL-7): a survival factor in activated human T cells. Cytokine 1998. 10: 662-668.
22. Akashi, K., Kondo, M., von Freeden-Jeffry, U., Murray, R. and Weissman, I. L., Bcl-2 rescues T lymphopoiesis in interleukin-7 receptor-deficient mice. Cell 1997. 89: 1033-1041.
23. Lin, J. X., Migone, T. S., Tsang, M., Friedmann, M., Weatherbee, J. A., Zhou, L., Yamauchi, A., Bloom, E. T., Mietz, J., John, S. et al., The role of shared receptor motifs and common Stat proteins in the generation of cytokine pleiotropy and redundancy by IL-2, IL-4, IL-7, IL-13, and IL-15. Immunity 1995. 2: 331-339.
24. Wherry, E. J., Teichgraber, V., Becker, T. C., Masopust, D., Kaech, S. M., Antia, R., von Andrian, U. H. and Ahmed, R., Lineage relationship and protective immunity of memory CD8 T cell subsets. Nat. Immunol. 2003. 4: 225-234.
25. Aichele, P., Brduscha-Riem, K., Zinkernagel, R. M., Hengartner, H. and Pircher, H., T cell priming versus T cell tolerance induced by synthetic peptides. J. Exp. Med. 1995. 182: 261-266.
26. Liu, N., Phillips, T., Zhang, M., Wang, Y., Opferman, J. T., Shah, R. and Ashton-Rickardt, P. G., Serine protease inhibitor 2A is a protective factor for memory T cell development. Nat. Immunol. 2004. 5: 919-926.
27. Pellegrini, M., Belz, G., Bouillet, P. and Strasser, A., Shutdown of an acute T cell immune response to viral infection is mediated by the proapoptotic Bcl-2 homology 3-only protein Bim. Proc. Natl. Acad. Sci. USA 2003. 100: 14175-14180.
28. Pellegrini, M., Bouillet, P., Robati, M., Belz, G. T., Davey, G. M. and Strasser, A., Loss of Bim increases T cell production and function in interleukin 7 receptor-deficient mice. J. Exp. Med. 2004. 200: 1189-1195.
29. + T cells after acute infection. Nat. Immunol. 2004. 5: 927-933.
30. + effector T cells with high inflammatory potential and a strong bias for secretion of interleukin 10. J. Exp. Med. 2003. 197: 181-193.