Pyridinylimidazole p38 mitogen-activated protein kinase inhibitors block intracellular Toxoplasma gondii replication

International Journal for Parasitology

Volumn 32, Issue 8, 2002, Pages 969-977

  Wei, Shuang ^a   Marches, Florentina ^b   Daniel, Ben ^a   Sonda, Sabrina ^c   Heidenreich, Kim ^d   Curiel, Tyler ^a  

^a TULANE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b BAYLOR INSTITUTE FOR IMMUNOLOGY RESEARCH   (United States)

^c UNIVERSITY OF BASEL   (Switzerland)

^d UNIVERSITY OF COLORADO   (United States)

Author keywords

Drug therapy; Mitogen activated protein kinase; Protozoan parasite; Replication; Toxoplasma gondii

Indexed keywords

4 (4 FLUOROPHENYL) 2 (4 HYDROXYPHENYL) 5 (4 PYRIDYL)IMIDAZOLE; 4 (4 FLUOROPHENYL) 2 (4 METHYLSULFINYLPHENYL) 5 (4 PYRIDYL)IMIDAZOLE; IMIDAZOLE DERIVATIVE; MITOGEN ACTIVATED PROTEIN KINASE INHIBITOR; SB 202494; UNCLASSIFIED DRUG;

PARASITOLOGY; PROTOZOAN;

ADENOVIRUS; ARTICLE; CELL DIFFERENTIATION; CELL PROLIFERATION; CONTROLLED STUDY; DATA BASE; DRUG ACTIVITY; DRUG EFFECT; DRUG SENSITIVITY; EUKARYOTE; LEISHMANIASIS; MALARIA; NONHUMAN; PATHOGENESIS; PHYLOGENY; TOXOPLASMA GONDII; TRYPANOSOMIASIS;

ANIMALS; BUTADIENES; CELLS, CULTURED; CHOLESTEROL; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG RESISTANCE; ENZYME ACTIVATION; ENZYME INHIBITORS; FIBROBLASTS; IMIDAZOLES; INHIBITORY CONCENTRATION 50; MITOGEN-ACTIVATED PROTEIN KINASES; MUTATION; NITRILES; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PYRIDINES; TOXOPLASMA;

EUKARYOTA; PROTOZOA; TOXOPLASMA GONDII;

EID: 0036072438     PISSN: 00207519     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0020-7519(02)00061-9     Document Type: Article

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