Global gene expression changes underlying Stachybotrys chartarum toxin-induced apoptosis in murine alveolar macrophages: Evidence of multiple signal transduction pathways

Apoptosis

Volumn 12, Issue 3, 2007, Pages 535-548

  Wang, Huiyan ^a   Yadav, Jagjit S ^a  

^a UNIVERSITY OF CINCINNATI MEDICAL CENTER   (United States)

Author keywords

Alveolar Macrophages; Apoptosis; Genotoxic stress; Microarray; Stachybotrys; Trichothecene

Indexed keywords

IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MITOGEN ACTIVATED PROTEIN KINASE; PROTEIN P53; TRANSCRIPTION FACTOR; TUMOR NECROSIS FACTOR;

ANIMAL CELL; APOPTOSIS; ARTICLE; CELL DEATH; CELL GROWTH; CELL LINE; CELL PROLIFERATION; CONTROLLED STUDY; DNA DAMAGE; GENE CONTROL; GENE EXPRESSION; GENE EXPRESSION PROFILING; GENE TARGETING; GENOTOXICITY; IMMUNE RESPONSE GENE; LUNG ALVEOLUS MACROPHAGE; MICROARRAY ANALYSIS; NONHUMAN; NUCLEOTIDE SEQUENCE; OXIDATIVE STRESS; PRIORITY JOURNAL; REAL TIME POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; STACHYBOTRYS CHARTARUM; UNINDEXED SEQUENCE; UPREGULATION;

ANIMALS; APOPTOSIS; CASPASES; CELL LINE; DNA DAMAGE; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; HUMANS; MACROPHAGES, ALVEOLAR; MICE; MITOGEN-ACTIVATED PROTEIN KINASES; MYCOTOXINS; NF-KAPPA B; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; ONCOGENES; OXIDATIVE STRESS; RECEPTORS, DEATH DOMAIN; SIGNAL TRANSDUCTION; STACHYBOTRYS; TOLL-LIKE RECEPTORS; TUMOR SUPPRESSOR PROTEIN P53;

MURINAE; STACHYBOTRYS; STACHYBOTRYS CHARTARUM;

EID: 33847291288     PISSN: 13608185     EISSN: 1573675X     Source Type: Journal    
DOI: 10.1007/s10495-006-0008-x     Document Type: Article

References (45)

1. Kuhn RC, Trimble MW, Hofer V, Lee M, Nassof RS (2005) Prevalence and airborne spore levels of Stachybotrys spp. in 200 houses with water incursions in Houston, Texas. Can J Microbiol 51:25-28
2. Shelton BG, Kirkland KH, Flanders WD, Morris GK (2002) Profiles of airborne fungi in buildings and outdoor environments in the United States. Appl Environ Microbiol 68:1743-1753
3. Meklin T, Husman T, Vepsalainen A, et al (2002) Indoor air microbes and respiratory symptoms of children in moisture damaged and reference schools. Indoor Air 12:175-183
4. Etzel RA, Montana E, Sorenson WG, et al (1998) Acute pulmonary hemorrhage in infants associated with exposure to Stachybotrys atra and other fungi. Arch Pediatr Adolesc Med 152:757-762
5. Brasel TL, Douglas DR, Wilson SC, Straus DC (2005) Detection of airborne Stachybotrys chartarum macrocyclic trichothecene mycotoxins on particulates smaller than conidia. Appl Environ Microbiol 71:114-122
6. Dorger M, Krombach F (2002) Response of alveolar macrophages to inhaled particulates. Eur Surg Res 4:47-52
7. Wang H, Yadav JS (2006) DNA damage, redox changes, and associated stress-inducible signaling events underlying the apoptosis and cytotoxicity in murine alveolar macrophage cell line MH-S by methanol-extracted Stachybotrys chartarum toxins. Toxicol Appl Pharmacol 214:297-308
8. Shifrin VI, Anderson P (1999) Trichothecene mycotoxins trigger a ribotoxic stress response that activates c-Jun N-terminal kinase and p38 mitogen-activated protein kinase and induces apoptosis. J Biol Chem 274:13985-13992
9. Yang GH, Jarvis BB, Chung YJ, Pestka JJ (2000) Apoptosis induction by the satratoxins and other trichothecene mycotoxins: relationship to ERK, p38 MAPK, and SAPK/JNK activation. Toxicol Appl Pharmacol 164:149-160
10. Yike I, Rand TG, Dearborn DG (2005) Acute inflammatory responses to Stachybotrys chartarum in the lungs of infant rats: time course and possible mechanisms. Toxicol Sci 84:408-417
11. Nagase M, Shiota T, Tsushima A, et al (2002) Molecular mechanism of satratoxin-induced apoptosis in HL-60 cells: activation of caspase-8 and caspase-9 is involved in activation of caspase-3. Immunol Lett 84:23-27
12. Jarvis BB, Sorenson WG, Hintikka EL, et al (1998) Study of toxin production by isolates of Stachybotrys chartarum and Memnoniella echinata isolated during a study of pulmonary hemosiderosis in infants. Appl Environ Microbiol 64:3620-3625
13. Rao CY, Brain JD, Burge HA (2000) Reduction of pulmonary toxicity of Stachybotrys chartarum spores by methanol extraction of mycotoxins. Appl Environ Microbiol 66:2817-2821
14. Sartor M, Schwanekamp J, Halbleib D et al (2004) Microarray results improve significantly as hybridization approaches equilibrium. Biotechniques 36:790-796.
15. Hiom K (1999) DNA repair: Rad52 - the means to an end. Curr Biol 9:446-448
16. Celeste A, Petersen S, Romanienko PJ, et al (2002) Genomic instability in mice lacking histone H2AX. Science 296:922-927
17. Weiss RS, Leder P, Vaziri C (2003) Critical role for mouse Hus1 in an S-phase DNA damage cell cycle checkpoint. Mol Cell Biol 23:791-803
18. Le May N, Dubaele S, De Santis LP, Billecocq A, Bouloy M, Egly JM (2004) TFIIH transcription factor, a target for the Rift Valley hemorrhagic fever virus. Cell 116:541-550
19. de Wind N, Dekker M, Claij N et al (1999) HNPCC-like cancer predisposition in mice through simultaneous loss of Msh3 and Msh6 mismatch-repair protein functions. Nat Genet 23:359-362
20. Zhang Y, Yuan F, Wu X, Taylor JS, Wang Z (2001) Response of human DNA polymerase iota to DNA lesions. Nucleic Acids Res 9:928-935
21. Guo C, Fischhaber PL, Luk-Paszyc MJ et al (2003) Mouse Rev1 protein interacts with multiple DNA polymerases involved in translesion DNA synthesis. EMBO J 22:6621-6630
22. Kozak KR, Prusakiewicz JJ, Marnett LJ (2004) Oxidative metabolism of endocannabinoids by COX-2. Curr Pharm Des 10:659-667
23. Junn E, Han SH, Im JY, et al (2000) Vitamin D3 up-regulated protein 1 mediates oxidative stress via suppressing the thioredoxin function. J Immunol 164:6287-6295
24. Hoornaert I, Marynen P, Goris J, Sciot R, Baens M (2003) MAPK phosphatase DUSP16/MKP-7, a candidate tumor suppressor for chromosome region 12p12-13, reduces BCR-ABL-induced transformation. Oncogene 22:7728-7736
25. Tanoue T, Moriguchi T, Nishida E (1999) Molecular cloning and characterization of a novel dual specificity phosphatase, MKP-5. J Biol Chem 274:19949-19956
26. 2. J Biol Chem 271:26981-26988
27. Ohkusu-Tsukada K, Tominaga N, Udono H, Yui K (2004) Regulation of the maintenance of peripheral T-cell anergy by TAB1-mediated p38 alpha activation. Mol Cell Biol 24:6957-6966
28. Meloche S, Gopalbhai K, Beatty BG, Scherer SW, Pellerin J (2000) Chromosome mapping of the human genes encoding the MAP kinase kinase MEK1 (MAP2K1) to 15q21 and MEK2 (MAP2K2) to 7q32. Cytogenet Cell Genet 88:249-252
29. Dickinson RJ, Williams DJ, Slack DN, Williamson J, Seternes OM, Keyse SM (2002) Characterization of a murine gene encoding a developmentally regulated cytoplasmic dual-specificity mitogen-activated protein kinase phosphatase. Biochem J 364:145-55
30. Chang NS (2000) The non-ankyrin C terminus of Ikappa B alpha physically interacts with p53 in vivo and dissociates in response to apoptotic stress, hypoxia, DNA damage, and transforming growth factor-beta 1-mediated growth suppression. J Biol Chem 277:10323-10331
31. Boyd MT, Vlatkovic N, Haines DS (2000) A novel cellular protein (MTBP) binds to MDM2 and induces a G1 arrest that is suppressed by MDM2. J Biol Chem 275:31883-31890
32. Shikama N, Lee CW, France S, et al (1999) A novel cofactor for p300 that regulates the p53 response. Mol Cell 4:365-376
33. Sheikh MS, Hollander MC, Fornance AJ Jr (2000) Role of Gadd45 in apoptosis. Biochem Pharmacol 59:43-45
34. Imai Y, Kimura T, Murakami A, Yajima N, Sakamaki K, Yonehara S (1999) The CED-4-homologous protein FLASH is involved in Fas-mediated activation of caspase-8 during apoptosis. Nature 398:777-785
35. Afford, SC, Ahmed-Choudhury CJ, Randhawa S et al (20001) CD40 activation-induced, Fas-dependent apoptosis and NFkappaB/AP-1 signaling in human intrahepatic biliary epithelial cells. FASEB J 15:2345-2354
36. Prasad KV, Ao Z, Yoon Y et al (1997) CD27, a member of the tumor necrosis factor receptor family, induces apoptosis and binds to Siva, a proapoptotic protein. Proc Natl Acad Sci USA 94:6346-6351
37. Wagner KW, Engels IH, Deveraux QL (2004) Caspase-2 can function upstream of bid cleavage in the TRAIL apoptosis pathway. J Biol Chem 279:35047-35052
38. Gross A, McDonnell JM, Korsmeyer SJ (1999) BCL-2 family members and the mitochondria in apoptosis. Genes Dev 13:1899-1911
39. Villunger A, Michalak EM, Coultas L, et al (2003) p53- and drug-induced apoptotic responses mediated by BH3-only proteins puma and noxa. Science 302:1036-1038
40. Marani M, Tenev T, Hancock D, Downward J, Lemoine NR (2002) Identification of novel isoforms of the BH3 domain protein Bim which directly activate Bax to trigger apoptosis. Mol Cell Biol 22:3577-3589
41. Pahl HL (1999) Activators and target genes of Rel/NF-kappaB transcription factors. Oncogene 18:6853-6866
42. Zampetaki A, Mitsialis SA, Pfeilschifter J, Kourembanas S (2004) Hypoxia induces macrophage inflammatory protein-2 (MIP-2) gene expression in murine macrophages via NF-kappaB: the prominent role of p42/ p44 and PI3 kinase pathways. FASEB J 18:1090-1092
43. Carpentier I, Beyaert R (1999) TRAF1 is a TNF inducible regulator of NF-kappaB activation. FEBS Lett 460:246-250
44. Tao W, Pennica D, Xu L, Kalejta RF, Levine AJ (2001) Wrch-1, a novel member of the Rho gene family that is regulated by Wnt-1. Genes Dev 15:1796-1807
45. Schuster N, Krieglstein K (2002) Mechanisms of TGF-beta-mediated apoptosis. Cell Tissue Res 307:1-14