Chromosome mapping of the human genes encoding the MAP kinase kinase MEK1 (MAP2K1) to 15q21 and MEK2 (MAP2K2) to 7q32

Cytogenetics and Cell Genetics

Volumn 88, Issue 3-4, 2000, Pages 249-252

  Meloche, Sylvain ^a   Gopalbhai, K ^a   Beatty, B G ^b   Scherer, S W ^b   Pellerin, J ^a  

^a CENTRE HOSPITALIER DE L UNIVERSITÉ DE MONTRÉAL   (Canada)

^b HOSPITAL FOR SICK CHILDREN   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

DNA; MITOGEN ACTIVATED PROTEIN KINASE KINASE;

ARTICLE; CHROMOSOME 15Q; CHROMOSOME 7Q; CHROMOSOME 8P; DNA SEQUENCE; FLUORESCENCE IN SITU HYBRIDIZATION; GENE MAPPING; HUMAN; HUMAN CELL; HYBRID CELL; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PSEUDOGENE; YEAST ARTIFICIAL CHROMOSOME;

EID: 0034121499     PISSN: 03010171     EISSN: None     Source Type: Journal    
DOI: 10.1159/000015530     Document Type: Article

References (25)

1. Achille A, Biasi MO, Zamboni G, Bogina G, Magalini AR, Pederzoli P, Perucho M, Scarpa A: Chromosome 7q allelic losses in pancreatic carcinoma. Cancer Res 56:3808-38013 (1996).
2. Alberola-Ila J, Forbush KA, Seger R, Krebs EG, Perlmutter RM: Selective requirement for MAP kinase activation in thymocyte differentiation. Nature 373:620-623 (1995).
3. Boultwood J, Fidler C: Chromosomal deletions in myelodysplasia. Leuk Lymphoma 17:71-78 (1995).
4. Brott BK, Alessandrini A, Largaespada DA, Copeland NG, Jenkins NA, Crews CM, Erikson RL: MEK2 is a kinase related to MEK1 and is differentially expressed in murine tissues. Cell Growth Differ 4:921-929 (1993).
5. Crews CM, Alessandrini A, Erikson RL: The primary structure of MEK, a protein kinase that phosphorylates the ERK gene product. Science 258:478-480 (1992).
6. Grigorenko EL, Wood FB, Meyer MS, Hart LA, Speed WC, Shuster A, Pauls DL: Susceptibility loci for distinct components of developmental dyslexia on chromosomes 6 and 15. Am J hum Genet 60:27-39 (1997).
7. Heng HHQ, Tsui LC: Modes of DAPI banding and simultaneous in situ hybridization. Chromosoma 102:325-332 (1993).
8. Ioannou PA, Amemiya CT, Garnes J, Kroisel PM, Shizuya H, Chen C, Batzer MA, de Jong PJ: A new bacteriophage P1-derived vector for the propagation of large human DNA fragments. Nature Genet 6:84-89 (1994).
9. Johansson B, Mertens F, Mitelman F: Cytogenetic deletion maps of hematologic neoplasms: circumstantial evidence for tumor suppressor loci. Genes Chrom Cancer 8:205-218 (1993).
10. Lichter P, Tang CJC, Call K, Hermanson G, Evans GA, Housman D, Ward DC: High-resolution mapping of human chromosome 11 by in situ hybridization with cosmid clones. Science 247:64-69 (1990).
11. Lin AW, Barradas M, Stone JC, van Aelst L, Serrano M, Lowe SW: Premature senescence involving p53 and p16 is activated in response to constitutive MEK/MAPK mitogenic signaling. Genes Dev 12:3008-3019 (1998).
12. Lind L, Sandstrom H, Wahlin A, Eriksson M, Nilsson-Sojka B, Sikstrom C, Holmgren G: Localization of the gene for congenital dyserythropoietic anemia type III, CDAN3, to chromosome 15q21→q25. Hum Mol Genet 4:109-112 (1995).
13. Meloche S, Beatty BG, Pellerin J: Primary structure, expression and chromosomal locus of a human homolog of rat ERK3. Oncogene 13:1575-1579 (1996).
14. Mishmar D, Rahat A, Scherer SW, Nyakatura G, Hinzmann B, Kohwi Y, Mandel-Gutfroind Y, Lee JR, Drescher B, Sas DE, Margalit H, Platzer M, Weiss A, Tsui LC, Rosenthal A, Kerem B: Molecular characterization of a common fragile site (FRA7H) on human chromosome 7 by the cloning of a simian virus 40 integration site. Proc natl Acad Sci. USA 95:8141-8146 (1998).
15. Offit K, Louie DC, Parsa NZ, Noy A, Chaganti RS: Del (7)(q32) is associated with a subset of small lymphocytic lymphoma with plasmacytoid features. Blood 86:2365-2370 (1995).
16. Ogata T, Oshimura M, Namba M, Fujii M, Oishi M, Ayusawa D: Genetic complementation of the immortal phenotype in group D cell lines by introduction of chromosome 7. Jpn J Cancer Res 86:35-40 (1995).
17. Osella P, Carlson A, Wyandt H, Milunsky A: Cytogenetic studies of eight squamous cell carcinomas of the head and neck. Deletion of 7q, a possible primary chromosomal event. Cancer Genet Cytogenet 59:73-78 (1992).
18. mapk are required for fibroblast proliferation. Proc natl Acad Sci, USA 90:8319-8323 (1993).
19. Pastural E, Barrat FJ, Dufourcq-Lagelouse R, Certain S, Sanal O, Jabado N, Seger R, Griscelli C, Fischer A, de Saint Basile G: Griscelli disease maps to chromosome 15q21 and is associated with mutations in the Myosin-Va gene. Nature Genet 16:289 (1997).
20. Rampoldi L, Zimbello R, Bortoluzzi S, Tiso N, Valle G, Lanfranchi G, Danieli GA: Chromosomal localization of four MAPK signaling cascade genes: MEK1, MEK3, MEK4 and MEKK5. Cytogenet Cell Genet 78:301-303 (1997).
21. Scherer SW, Tompkins BJ, Tsui LC: A human chromosome 7-specific genomic DNA library in yeast artificial chromosomes. Mammal Genome 5:179-181 (1992).
22. Seger R, Seger D, Lozeman FJ, Ahn NG, Graves LM, Campbell JS, Ericsson L, Harrylock M, Jensen AM, Krebs EG: Human T-cell mitogen-activated protein kinase kinases are related to yeast signal transduction kinases. J biol Chem 267:25628-25631 (1992).
23. Tahara H, Smith AP, Gas RD, Cryns VL, Arnold A: Genomic localization of novel candidate tumor suppressor gene loci in human parathyroid adenomas. Cancer Res 56:599-605 (1996).
24. Whalen AM, Galasinski SC, Shapiro PS, Stines Nahreini T, Ahn NG: Megakaryocytic differentiation induced by constitutive activation of mitogen-activated protein kinase kinase. Mol Cell Biol 17:1947-1958 (1997).
25. Widmann C, Gibson S, Jarpe MB, Johnson GL: Mitogen-activated protein kinase: conservation of a three-kinase module from yeast to human. Physiol Rev 79:143-180 (1999).