Regulation of Signal Transducer and Activator of Transcription Signaling by the Tyrosine Phosphatase PTP-BL

Immunity

Volumn 26, Issue 2, 2007, Pages 163-176

  Nakahira, Masakiyo ^a   Tanaka, Takashi ^a   Robson, Bryanne E ^a   Mizgerd, Joseph P ^a   Grusby, Michael J ^a,b  

^a HARVARD SCHOOL OF PUBLIC HEALTH   (United States)

^b HARVARD MEDICAL SCHOOL   (United States)

Author keywords

CELLIMMUNO; MOLIMMUNO; SIGNALING

Indexed keywords

PHOSPHOTYROSINE; PROTEIN TYROSINE PHOSPHATASE; STAT PROTEIN; STAT4 PROTEIN; STAT6 PROTEIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; BASOPHIL; CD4+ T LYMPHOCYTE; CELL DIFFERENTIATION; CONTROLLED STUDY; CYTOKINE RELEASE; GENE ACTIVATION; HELPER CELL; MALE; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN DEPHOSPHORYLATION; PROTEIN DOMAIN; PROTEIN FAMILY; PROTEIN INTERACTION; PROTEIN PHOSPHORYLATION; RAT; TH1 CELL; TH2 CELL;

ANIMALS; BASOPHILS; CD4-POSITIVE T-LYMPHOCYTES; CELL DIFFERENTIATION; CELL LINE; ELECTROPHORETIC MOBILITY SHIFT ASSAY; HUMANS; IMMUNOBLOTTING; MICE; MICE, MUTANT STRAINS; PROTEIN-TYROSINE-PHOSPHATASE; SIGNAL TRANSDUCTION; STAT TRANSCRIPTION FACTORS; TRANSFECTION; TWO-HYBRID SYSTEM TECHNIQUES;

EID: 33847290896     PISSN: 10747613     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.immuni.2007.01.010     Document Type: Article

References (57)

1. Alexander W.S., and Hilton D.J. The role of suppressors of cytokine signaling (SOCS) proteins in regulation of the immune response. Annu. Rev. Immunol. 22 (2004) 503-529
2. Andrews R.P., Ericksen M.B., Cunningham C.M., Daines M.O., and Hershey G.K. Analysis of the life cycle of stat6. Continuous cycling of STAT6 is required for IL-4 signaling. J. Biol. Chem. 277 (2002) 36563-36569
3. Aoki N., and Matsuda T. A cytosolic protein-tyrosine phosphatase PTP1B specifically dephosphorylates and deactivates prolactin-activated STAT5a and STAT5b. J. Biol. Chem. 275 (2000) 39718-39726
4. Arora T., Liu B., He H., Kim J., Murphy T.L., Murphy K.M., Modlin R.L., and Shuai K. PIASx is a transcriptional co-repressor of signal transducer and activator of transcription 4. J. Biol. Chem. 278 (2003) 21327-21330
5. Becker S., Groner B., and Muller C.W. Three-dimensional structure of the Stat3beta homodimer bound to DNA. Nature 394 (1998) 145-151
6. Chen Y., Wen R., Yang S., Schuman J., Zhang E.E., Yi T., Feng G.S., and Wang D. Identification of Shp-2 as a Stat5A phosphatase. J. Biol. Chem. 278 (2003) 16520-16527
7. Chida D., Kume T., Mukouyama Y., Tabata S., Nomura N., Thomas M.L., Watanabe T., and Oishi M. Characterization of a protein tyrosine phosphatase (RIP) expressed at a very early stage of differentiation in both mouse erythroleukemia and embryonal carcinoma cells. FEBS Lett. 358 (1995) 233-239
8. Chughtai N., Schimchowitsch S., Lebrun J.J., and Ali S. Prolactin induces SHP-2 association with Stat5, nuclear translocation, and binding to the beta-casein gene promoter in mammary cells. J. Biol. Chem. 277 (2002) 31107-31114
9. Chung C.D., Liao J., Liu B., Rao X., Jay P., Berta P., and Shuai K. Specific inhibition of Stat3 signal transduction by PIAS3. Science 278 (1997) 1803-1805
10. Collum R.G., Brutsaert S., Lee G., and Schindler C. A Stat3-interacting protein (StIP1) regulates cytokine signal transduction. Proc. Natl. Acad. Sci. USA 97 (2000) 10120-10125
11. Cuppen E., Gerrits H., Pepers B., Wieringa B., and Hendriks W. PDZ motifs in PTP-BL and RIL bind to internal protein segments in the LIM domain protein RIL. Mol. Biol. Cell 9 (1998) 671-683
12. David M., Chen H.E., Goelz S., Larner A.C., and Neel B.G. Differential regulation of the alpha/beta interferon-stimulated Jak/Stat pathway by the SH2 domain-containing tyrosine phosphatase SHPTP1. Mol. Cell. Biol. 15 (1995) 7050-7058
13. Deng J.C., Zeng X., Newstead M., Moore T.A., Tsai W.C., Thannickal V.J., and Standiford T.J. STAT4 is a critical mediator of early innate immune responses against pulmonary Klebsiella infection. J. Immunol. 173 (2004) 4075-4083
14. Erdmann K.S. The protein tyrosine phosphatase PTP-Basophil/Basophil-like. Interacting proteins and molecular functions. Eur. J. Biochem. 270 (2003) 4789-4798
15. Erdmann K.S., Kuhlmann J., Lessmann V., Herrmann L., Eulenburg V., Muller O., and Heumann R. The Adenomatous Polyposis Coli-protein (APC) interacts with the protein tyrosine phosphatase PTP-BL via an alternatively spliced PDZ domain. Oncogene 19 (2000) 3894-3901
16. Fujimoto M., Tsutsui H., Yumikura-Futatsugi S., Ueda H., Xingshou O., Abe T., Kawase I., Nakanishi K., Kishimoto T., and Naka T. A regulatory role for suppressor of cytokine signaling-1 in T(h) polarization in vivo. Int. Immunol. 14 (2002) 1343-1350
17. Herrmann L., Dittmar T., and Erdmann K.S. The protein tyrosine phosphatase PTP-BL associates with the midbody and is involved in the regulation of cytokinesis. Mol. Biol. Cell 14 (2003) 230-240
18. Irie-Sasaki J., Sasaki T., Matsumoto W., Opavsky A., Cheng M., Welstead G., Griffiths E., Krawczyk C., Richardson C.D., Aitken K., et al. CD45 is a JAK phosphatase and negatively regulates cytokine receptor signalling. Nature 409 (2001) 349-354
19. Ivanov V.N., Lopez Bergami P., Maulit G., Sato T.A., Sassoon D., and Ronai Z. FAP-1 association with Fas (Apo-1) inhibits Fas expression on the cell surface. Mol. Cell. Biol. 23 (2003) 3623-3635
20. Jones M.R., Simms B.T., Lupa M.M., Kogan M.S., and Mizgerd J.P. Lung NF-kB activation and neutrophil recruitment require IL-1 and TNF receptor signaling during pneumococcal pneumonia. J. Immunol. 175 (2005) 7530-7535
21. Kamata T., Yamashita M., Kimura M., Murata K., Inami M., Shimizu C., Sugaya K., Wang C.R., Taniguchi M., and Nakayama T. src homology 2 domain-containing tyrosine phosphatase SHP-1 controls the development of allergic airway inflammation. J. Clin. Invest. 111 (2003) 109-119
22. Kaplan M.H., Sun Y.L., Hoey T., and Grusby M.J. Impaired IL-12 responses and enhanced development of Th2 cells in Stat4-deficient mice. Nature 382 (1996) 174-177
23. Kaplan M.H., Schindler U., Smiley S.T., and Grusby M.J. Stat6 is required for mediating responses to IL-4 and for development of Th2 cells. Immunity 4 (1996) 313-319
24. Karaghiosoff M., Neubauer H., Lassnig C., Kovarik P., Schindler H., Pircher H., McCoy B., Bogdan C., Decker T., Brem G., et al. Partial impairment of cytokine responses in Tyk2-deficient mice. Immunity 13 (2000) 549-560
25. Klingmuller U., Lorenz U., Cantley L.C., Neel B.G., and Lodish H.F. Specific recruitment of SH-PTP1 to the erythropoietin receptor causes inactivation of JAK2 and termination of proliferative signals. Cell 80 (1995) 729-738
26. Liu B., Liao J., Rao X., Kushner S.A., Chung C.D., Chang D.D., and Shuai K. Inhibition of Stat1-mediated gene activation by PIAS1. Proc. Natl. Acad. Sci. USA 95 (1998) 10626-10631
27. Liu B., Mink S., Wong K.A., Stein N., Getman C., Dempsey P.W., Wu H., and Shuai K. PIAS1 selectively inhibits interferon-inducible genes and is important in innate immunity. Nat. Immunol. 5 (2004) 891-898
28. Lorber B., Hendriks W.J., Van der Zee C.E., Berry M., and Logan A. Effects of LAR and PTP-BL phosphatase deficiency on adult mouse retinal cells activated by lens injury. Eur. J. Neurosci. 21 (2005) 2375-2383
29. Meyer T., Marg A., Lemke P., Wiesner B., and Vinkemeier U. DNA binding controls inactivation and nuclear accumulation of the transcription factor Stat1. Genes Dev. 17 (2003) 1992-2005
30. Murphy K.M., and Reiner S.L. The lineage decisions of helper T cells. Nat. Rev. Immunol. 2 (2002) 933-944
31. Myers M.P., Andersen J.N., Cheng A., Tremblay M.L., Horvath C.M., Parisien J.P., Salmeen A., Barford D., and Tonks N.K. TYK2 and JAK2 are substrates of protein-tyrosine phosphatase 1B. J. Biol. Chem. 276 (2001) 47771-47774
32. Nakahira M., Tomura M., Iwasaki M., Ahn H.J., Bian Y., Hamaoka T., Ohta T., Kurimoto M., and Fujiwara H. An absolute requirement for STAT4 and a role for IFN-gamma as an amplifying factor in IL-12 induction of the functional IL-18 receptor complex. J. Immunol. 167 (2001) 1306-1312
33. Nakai Y., Irie S., and Sato T.A. Identification of IkappaBalpha as a substrate of Fas-associated phosphatase-1. Eur. J. Biochem. 267 (2000) 7170-7175
34. Nguyen K.B., Watford W.T., Salomon R., Hofmann S.R., Pien G.C., Morinobu A., Gadina M., O'Shea J.J., and Biron C.A. Critical role for STAT4 activation by type 1 interferons in the interferon-gamma response to viral infection. Science 297 (2002) 2063-2066
35. O'Shea J.J., Gadina M., and Schreiber R.D. Cytokine signaling in 2002: new surprises in the Jak/Stat pathway. Cell 109 Suppl (2002) S121-S131
36. Palmer A., Zimmer M., Erdmann K.S., Eulenburg V., Porthin A., Heumann R., Deutsch U., and Klein R. EphrinB phosphorylation and reverse signaling: regulation by Src kinases and PTP-BL phosphatase. Mol. Cell 9 (2002) 725-737
37. Rogers R.S., Horvath C.M., and Matunis M.J. SUMO modification of STAT1 and its role in PIAS-mediated inhibition of gene activation. J. Biol. Chem. 278 (2003) 30091-30097
38. Ruan S., Young E., Luce M.J., Reiser J., Kolls J.K., and Shellito J.E. Conditional expression of interferon-gamma to enhance host responses to pulmonary bacterial infection. Pulm. Pharmacol. Ther. 19 (2006) 251-257
39. Sato T., Irie S., Kitada S., and Reed J.C. FAP-1: a protein tyrosine phosphatase that associates with Fas. Science 268 (1995) 411-415
40. Shimoda K., van Deursen J., Sangster M.Y., Sarawar S.R., Carson R.T., Tripp R.A., Chu C., Quelle F.W., Nosaka T., Vignali D.A., et al. Lack of IL-4-induced Th2 response and IgE class switching in mice with disrupted Stat6 gene. Nature 380 (1996) 630-633
41. Shimoda K., Kato K., Aoki K., Matsuda T., Miyamoto A., Shibamori M., Yamashita M., Numata A., Takase K., Kobayashi S., et al. Tyk2 plays a restricted role in IFN alpha signaling, although it is required for IL-12-mediated T cell function. Immunity 13 (2000) 561-571
42. Shuai K. Modulation of STAT signaling by STAT-interacting proteins. Oncogene 19 (2000) 2638-2644
43. Shuai K., and Liu B. Regulation of JAK-STAT signalling in the immune system. Nat. Rev. Immunol. 3 (2003) 900-911
44. Shuai K., Liao J., and Song M.M. Enhancement of antiproliferative activity of gamma interferon by the specific inhibition of tyrosine dephosphorylation of Stat1. Mol. Cell. Biol. 16 (1996) 4932-4941
45. Simoncic P.D., Lee-Loy A., Barber D.L., Tremblay M.L., and McGlade C.J. The T cell protein tyrosine phosphatase is a negative regulator of janus family kinases 1 and 3. Curr. Biol. 12 (2002) 446-453
46. Sugimoto N., Nakahira M., Ahn H.J., Micallef M., Hamaoka T., Kurimoto M., and Fujiwara H. Differential requirements for JAK2 and TYK2 in T cell proliferation and IFN-gamma production induced by IL-12 alone or together with IL-18. Eur. J. Immunol. 33 (2003) 243-251
47. Takeda K., Tanaka T., Shi W., Matsumoto M., Minami M., Kashiwamura S., Nakanishi K., Yoshida N., Kishimoto T., and Akira S. Essential role of Stat6 in IL-4 signalling. Nature 380 (1996) 627-630
48. Tanaka T., Soriano M.A., and Grusby M.J. SLIM is a nuclear ubiquitin E3 ligase that negatively regulates STAT signaling. Immunity 22 (2005) 729-736
49. ten Hoeve J., de Jesus Ibarra-Sanchez M., Fu Y., Zhu W., Tremblay M., David M., and Shuai K. Identification of a nuclear Stat1 protein tyrosine phosphatase. Mol. Cell. Biol. 22 (2002) 5662-5668
50. Thierfelder W.E., van Deursen J.M., Yamamoto K., Tripp R.A., Sarawar S.R., Carson R.T., Sangster M.Y., Vignali D.A., Doherty P.C., Grosveld G.C., and Ihle J.N. Requirement for Stat4 in interleukin-12-mediated responses of natural killer and T cells. Nature 382 (1996) 171-174
51. Ungureanu D., Vanhatupa S., Kotaja N., Yang J., Aittomaki S., Janne O.A., Palvimo J.J., and Silvennoinen O. PIAS proteins promote SUMO-1 conjugation to STAT1. Blood 102 (2003) 3311-3313
52. Wansink D.G., Peters W., Schaafsma I., Sutmuller R.P., Oerlemans F., Adema G.J., Wieringa B., van der Zee C.E., and Hendriks W. Mild impairment of motor nerve repair in mice lacking PTP-BL tyrosine phosphatase activity. Physiol. Genomics 19 (2004) 50-60
53. Wu T.R., Hong Y.K., Wang X.D., Ling M.Y., Dragoi A.M., Chung A.S., Campbell A.G., Han Z.Y., Feng G.S., and Chin Y.E. SHP-2 is a dual-specificity phosphatase involved in Stat1 dephosphorylation at both tyrosine and serine residues in nuclei. J. Biol. Chem. 277 (2002) 47572-47580
54. Wurster A.L., Tanaka T., and Grusby M.J. The biology of Stat4 and Stat6. Oncogene 19 (2000) 2577-2584
55. Yamamoto K., Quelle F.W., Thierfelder W.E., Kreider B.L., Gilbert D.J., Jenkins N.A., Copeland N.G., Silvennoinen O., and Ihle J.N. Stat4, a novel gamma interferon activation site-binding protein expressed in early myeloid differentiation. Mol. Cell. Biol. 14 (1994) 4342-4349
56. You M., Yu D.H., and Feng G.S. Shp-2 tyrosine phosphatase functions as a negative regulator of the interferon-stimulated Jak/STAT pathway. Mol. Cell. Biol. 19 (1999) 2416-2424
57. Zhang X., Wrzeszczynska M.H., Horvath C.M., and Darnell J.E.J. Interacting regions in Stat3 and c-Jun that participate in cooperative transcriptional activation. Mol. Cell. Biol. 19 (1999) 7138-7146