Personality Traits of Agreeableness and Extraversion are Associated with ADH4 Variation

Biological Psychiatry

Volumn 61, Issue 5, 2007, Pages 599-608

  Luo, Xingguang ^a,b   Kranzler, Henry R ^c   Zuo, Lingjun ^a,b   Wang, Shuang ^d   Gelernter, Joel ^a,b  

^a YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b VETERANS AFFAIRS MEDICAL CENTER   (United States)

^c UNIVERSITY OF CONNECTICUT SCHOOL OF MEDICINE   (United States)

^d Columbia University ^*  (United States)

Author keywords

ADH4; MANCOVA; personality traits; substance dependence

Indexed keywords

ADULT; ALLELE; ARTICLE; CONTROLLED STUDY; EXON; EXTRAVERSION; FEMALE; GENE LOCUS; GENETIC VARIABILITY; GENOTYPE; HUMAN; MAJOR CLINICAL STUDY; MALE; MULTIVARIATE ANALYSIS OF COVARIANCE; NEUROSIS; PERSONALITY; PRIORITY JOURNAL; PROMOTER REGION; SINGLE NUCLEOTIDE POLYMORPHISM; SUBSTANCE ABUSE;

AFRICAN CONTINENTAL ANCESTRY GROUP; ALCOHOL DEHYDROGENASE; EUROPEAN CONTINENTAL ANCESTRY GROUP; EXTRAVERSION (PSYCHOLOGY); FEMALE; GENE FREQUENCY; GENOTYPE; HUMANS; LINKAGE DISEQUILIBRIUM; MALE; MULTIVARIATE ANALYSIS; PERSONALITY; PERSONALITY INVENTORY; SUBSTANCE-RELATED DISORDERS; VARIATION (GENETICS);

EID: 33847248397     PISSN: 00063223     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.biopsych.2006.05.017     Document Type: Article

References (83)

1. American Psychiatric Association. Diagnostic and Statistical Manual of Mental Disorders. 3rd ed., revised (1987), American Psychiatric Press, Washington, DC
2. American Psychiatric Association. Diagnostic and Statistical Manual of Mental Disorders. 4th ed (1994), American Psychiatric Press, Washington, DC
3. Bau C.H., Roman T., Almeida S., and Hutz M.H. Dopamine D4 receptor gene and personality dimensions in Brazilian male alcoholics. Psychiatr Genet 9 (1999) 139-143
4. Blouin A.G., Perez E.L., and Blouin J.H. Computerized administration of the diagnostic interview schedule. Psychiatry Res 23 (1988) 335-344
5. Bouaziz H., Tong C., Yoon Y., Hood D.D., and Eisenach J.C. Intravenous opioids stimulate norepinephrine and acetylcholine release in spinal cord dorsal horn. Systematic studies in sheep and an observation in a human. Anesthesiology 84 (1996) 143-154
6. Caspi A., Begg D., Dickson N., Harrington H.L., Langley J., Moffitt T.E., et al. Personality differences predict health-risk behaviors in adulthood: Evidence from a longitudinal study. J Pers Soc Psychol 73 (1997) 1052-1063
7. Cloninger C.R. Neurogenetic adaptive mechanisms in alcoholism. Science 236 (1987) 410-416
8. Cloninger C.R., Sigvardsson S., and Bohman M. Childhood personality predicts alcohol abuse in young adults. Alcohol Clin Exp Res 12 (1988) 494-505
9. Coccaro E.F., Lee R., and McCloskey M. Norepinephrine function in personality disorder: Plasma free MHPG correlates inversely with life history of aggression. CNS Spectr 8 (2003) 731-736
10. Costa P.T., and McCrae R.R. Stability and change in personality assessment: The revised NEO Personality Inventory in the year 2000. J Pers Assess 68 (1997) 86-94
11. Costa P.T., McCrae R.R., and Dye D.A. Facet scales for agreeableness and conscientiousness: A revision of the NEO Personality Inventory. Pers Individ Dif 12 (1991) 887-898
12. Cox W.M., Lun K., and Loper R.G. Identifying pre-alcoholic personality characteristics. In: Cox W.M. (Ed). Identifying and Measuring Alcoholic Personality Characteristics (1983), Jossey-Bass, San Fransisco 5-19
13. Damberg M., Garpenstrand H., Alfredsson J., Ekblom J., Forslund K., Rylander G., et al. A polymorphic region in the human transcription factor AP-2beta gene is associated with specific personality traits. Mol Psychiatry 5 (2000) 220-224
14. Digman J.M. Personality structure: Emergence of the five-factor model. Annu Rev Psychol 41 (1990) 417-440
15. Ditlow C.C., Holmquist B., Morelock M.M., and Vallee B.L. Physical and enzymatic properties of a class II alcohol dehydrogenase isozyme of human liver: Pi-ADH. Biochemistry 23 (1984) 6363-6368
16. Du L., Bakish D., and Hrdina P.D. Gender differences in association between serotonin transporter gene polymorphism and personality traits. Psychiatr Genet 10 (2000) 159-164
17. Ebstein R.P., Segman R., Benjamin J., Osher Y., Nemanov L., and Belmaker R.H. 5-HT2C (HTR2C) serotonin receptor gene polymorphism associated with the human personality trait of reward dependence: Interaction with dopamine D4 receptor (D4DR) and dopamine D3 receptor (D3DR) polymorphisms. Am J Med Genet 74 (1997) 65-72
18. Edenberg H.J., Jerome R.E., and Li M. Polymorphism of the human alcohol dehydrogenase 4 (ADH4) promoter affects gene expression. Pharmacogenetics 9 (1999) 25-30
19. Falush D., Stephens M., and Pritchard J.K. Inference of population structure using multilocus genotype data: Linked loci and correlated allele frequencies. Genetics 164 (2003) 1567-1587
20. Feder J.N., Gnirke A., Thomas W., Tsuchihashi Z., Ruddy D.A., Basava A., et al. A novel MHC class I-like gene is mutated in patients with hereditary haemochromatosis. Nat Genet 13 (1996) 399-408
21. Finn P.R., Sharkansky E.J., Brandt K.M., and Turcotte N. The effects of familial risk, personality, and expectancies on alcohol use and abuse. J Abnorm Psychol 109 (2000) 122-133
22. Fullerton J., Cubin M., Tiwari H., Wang C., Bomhra A., Davidson S., et al. Linkage analysis of extremely discordant and concordant sibling pairs identifies quantitative-trait loci that influence variation in the human personality trait neuroticism. Am J Hum Genet 72 (2003) 879-890
23. Gelernter J., Kranzler H., Coccaro E., Siever L., and New A. Serotonin transporter protein polymorphism and personality measures in African and European American subjects. Am J Psychiatry 155 (1998) 1332-1338
24. Gelernter J., Kranzler H., Coccaro E., Siever L., New A., and Mulgrew C. D4 dopamine-receptor (DRD4) alleles and novelty seeking in substance-dependent, personality-disorder, and control subjects. Am J Hum Genet 61 (1997) 1144-1152
25. Gleason K.A., Jensen-Campbell L.A., and Richardson D.S. Agreeableness as a predictor of aggression in adolescence. Aggress Behav 30 (2004) 43-61
26. Goldberg L.R. The structure of phenotypic personality traits. Am Psychol 48 (1993) 26-34
27. Golimbet V.E., Alfimova M.V., Manandyan K.K., Mitushina N.G., Abramova L.I., Kaleda V.G., et al. 5HTR2A gene polymorphism and personality traits in patients with major psychoses. Eur Psychiatry 17 (2002) 24-28
28. Guindalini C., Scivoletto S., Ferreira R.G., Breen G., Zilberman M., Peluso M.A., et al. Association of genetic variants in alcohol dehydrogenase 4 with alcohol dependence in Brazilian patients. Am J Psychiatry 162 (2005) 1005-1007
29. Haan C.T. Statistical Methods in Hydrology. 2nd ed (2002), Iowa State University Press, Ames, IA
30. Hasin D., Aharonovich E., Liu X., Mamman Z., Matseoane K., Carr L., et al. Alcohol and ADH2 in Israel: Ashkenazis, Sephardics, and recent Russian immigrants. Am J Psychiatry 159 (2002) 1432-1434
31. Hernandez-Avila C.A., Covault J., Gelernter J., and Kranzler H.R. Association study of personality factors and the Asn40Asp polymorphism at the μ-opioid receptor gene (OPRM1). Psychiatr Genet 14 (2004) 89-92
32. Itoh K., Hashimoto K., Kumakiri C., Shimizu E., and Iyo M. Association between brain-derived neurotrophic factor 196 G/A polymorphism and personality traits in healthy subjects. Am J Med Genet B Neuropsychiatr Genet 124 (2004) 61-63
33. Jiang R., Dong J., Wang D., and Sun F.Z. Fine-scale mapping using Hardy-Weinberg disequilibrium. Ann Hum Genet 65 (2001) 207-219
34. Jonsson E.G., Cichon S., Gustavsson J.P., Grunhage F., Forslund K., Mattila-Evenden M., et al. Association between a promoter dopamine D2 receptor gene variant and the personality trait detachment. Biol Psychiatry 53 (2003) 577-584
35. Kaufman J., Yang B.Z., Douglas-Palumberi H., Houshyar S., Lipschitz D., Krystal J.H., et al. Social supports and serotonin transporter gene moderate depression in maltreated children. Proc Natl Acad Sci U S A 101 (2004) 17316-17321
36. Koppes L.L.J., Twisk J.W.R., Snel J., Vente W.D., and Kemper H.C.G. Personality characteristics and alcohol consumption: Longitudinal analyses in men and women followed from ages 13 to 32. J Stud Alcohol 62 (2001) 494-500
37. Krueger R.F., Caspi A., and Moffitt T.E. Epidemiological personology: The unifying role of personality in population-based research on problem behaviors. J Pers 68 (2000) 967-998
38. Lang U.E., Hellweg R., and Gallinat J. BDNF serum concentrations in healthy volunteers are associated with depression-related personality traits. Neuropsychopharmacology 29 (2004) 795-798
39. Lang U.E., Hellweg R., Kalus P., Bajbouj M., Lenzen K.P., Sander T., et al. Association of a functional BDNF polymorphism and anxiety-related personality traits. Psychopharmacology 180 (2005) 95-99 (Berl)
40. Lee H.J., Lee H.S., Kim Y.K., Kim L., Lee M.S., Jung I.K., et al. D2 and D4 dopamine receptor gene polymorphisms and personality traits in a young Korean population. Am J Med Genet B Neuropsychiatr Genet 121 (2003) 44-49
41. Lesch K.P., Bengel D., Heils A., Sabol S.Z., Greenberg B.D., Petri S., et al. Association of anxiety-related traits with a polymorphism in the serotonin transporter gene regulatory region. Science 274 (1996) 1527-1531
42. Loper R.G., Kammeier M.I., and Hoffman H. MMPI characteristics of college freshman males who later became alcoholics. J Abnorm Psychol 82 (1973) 159-162
43. Luo X., Kranzler H.R., Zuo L., Lappalainen J., Yang B.Z., and Gelernter J. ADH4 gene variation is associated with alcohol and drug dependence in European Americans: Results from HWD tests and case-control association studies. Neuropsychopharmacology 31 (2006) 1085-1095
44. Luo X., Kranzler H.R., Zuo L., Wang S., Blumberg H.P., and Gelernter J. CHRM2 gene predisposes to alcohol dependence, drug dependence, and affective disorders: Results from an extended case-control structured association study. Hum Mol Genet 14 (2005) 2421-2434
45. Luo X., Kranzler H.R., Zuo L., Wang S., Schork N.J., and Gelernter J. Diplotype trend regression analysis of the ADH gene cluster and ALDH2 gene: Multiple significant associations for alcohol dependence. Am J Hum Genet 78 (2006) 973-987
46. Luo X., Kranzler H.R., Zuo L., Yang B.Z., Lappalainen J., and Gelernter J. ADH4 gene variation is associated with alcohol and drug dependence in European Americans: Results from family-controlled and population-structured association studies. Pharmacogenet Genomics 15 (2005) 755-768
47. Marchini J., Donnelly P., and Cardon L.R. Genome-wide strategies for detecting multiple loci that influence complex diseases. Nat Genet 37 (2005) 413-417
48. Mardh G., Dingley A.L., Auld D.S., and Vallee B.L. Human class II (pi) alcohol dehydrogenase has a redox-specific function in norepinephrine metabolism. Proc Natl Acad Sci U S A 83 (1986) 8908-8912
49. McCrae R.R., and Costa P.T. Personality trait structure as a human universal. Am Psychol 52 (1997) 509-516
50. Melke J., Landen M., Baghei F., Rosmond R., Holm G., Bjorntorp P., et al. Serotonin transporter gene polymorphisms are associated with anxiety-related personality traits in women. Am J Med Genet 105 (2001) 458-463
51. Muramatsu T., Wang Z.C., Fang Y.R., Hu K.B., Yan H., Yamada K., et al. Alcohol and aldehyde dehydrogenase genotypes and drinking behavior of Chinese living in Shanghai. Hum Genet 96 (1995) 151-154
52. Niu T., Qin Z.D., Xu X., and Liu J.S. Bayesian haplotype inference for multiple linked single-nucleotide polymorphisms. Am J Hum Genet 70 (2002) 157-169
53. Otter C., and Martin C. Personality and addictive behaviours. In: Bonner A., and Waterhouse J. (Eds). Addictive Behaviour: Molecules to Mankind Perspectives on the Nature of Addiction (1996), St Martins Press, New York 87-117
54. Ponce G., Jimenez-Arriero M.A., Rubio G., Hoenicka J., Ampuero I., Ramos J.A., et al. The A1 allele of the DRD2 gene (TaqI A polymorphisms) is associated with antisocial personality in a sample of alcohol-dependent patients. Eur Psychiatry 18 (2003) 356-360
55. Pritchard J.K., Stephens M., and Donnelly P. Inference of population structure using multilocus genotype data. Genetics 155 (2000) 945-959
56. Retz W., Retz-Junginger P., Supprian T., Thome J., and Rosler M. Association of serotonin transporter promoter gene polymorphism with violence: Relation with personality disorders, impulsivity, and childhood ADHD psychopathology. Behav Sci Law 22 (2004) 415-425
57. Rosmond R., Rankinen T., Chagnon M., Perusse L., Chagnon Y.C., Bouchard C., et al. Polymorphism in exon 6 of the dopamine D(2) receptor gene (DRD2) is associated with elevated blood pressure and personality disorders in men. J Hum Hypertens 15 (2001) 553-558
58. Rujescu D., Giegling I., Gietl A., Hartmann A.M., and Moller H.J. A functional single nucleotide polymorphism (V158M) in the COMT gene is associated with aggressive personality traits. Biol Psychiatry 54 (2003) 34-39
59. Sander T., Gscheidel N., Wendel B., Samochowiec J., Smolka M., Rommelspacher H., et al. Human mu-opioid receptor variation and alcohol dependence. Alcohol Clin Exp Res 22 (1998) 2108-2110
60. Sander T., Harms H., Dufeu P., Kuhn S., Hoehe M., Lesch K.P., et al. Serotonin transporter gene variants in alcohol-dependent subjects with dissocial personality disorder. Biol Psychiatry 43 (1998) 908-912
61. Schuckit M.A. Genetic and clinical implications of alcoholism and affective disorder. Am J Psychiatry 143 (1986) 140-147
62. Sen S., Nesse R.M., Stoltenberg S.F., Li S., Gleiberman L., Chakravarti A., et al. A BDNF coding variant is associated with the NEO personality inventory domain neuroticism, a risk factor for depression. Neuropsychopharmacology 28 (2003) 397-401
63. Sher K.J., and Trull T.J. Personality and disinhibitory psychopathology: Alcoholism and antisocial personality disorder. J Abnorm Psychol 103 (1994) 92-102
64. Sher K.J., Trull T.J., Bartholow B.D., and Vieth A. Personality and alcoholism: Issues, methods, and etiological processes. In: Leonard K.E., and Blane H.T. (Eds). Psychological Theories of Drinking and Alcoholism (1999), Guilford Press, New York 54-105
65. Sher K.J., Walitzer K.S., Wood P.K., and Brent E.E. Characteristics of children of alcoholics: Putative risk factors, substance use and abuse, and psychopathology. J Abnorm Psychol 100 (1991) 427-448
66. Shi M.M., Myrand S.P., Bleavins M.R., and de la Iglesia F.A. High throughput genotyping for the detection of a single nucleotide polymorphism in NAD(P)H quinone oxidoreductase (DT diaphorase) using TaqMan probes. Mol Pathol 52 (1999) 295-299
67. Slutske W.S., Heath A.C., Dinwiddie S.H., Madden P.A.F., Bucholz K.K., Dunne M.P., et al. Common genetic risk factors for conduct disorder and alcohol dependence. J Abnorm Psychol 107 (1998) 363-374
68. Slutske W.S., Heath A.C., Madden P.A., Bucholz K.K., Statham D.J., and Martin N.G. Personality and the genetic risk for alcohol dependence. J Abnorm Psychol 111 (2002) 124-133
69. Sofuoglu M., Nelson D., Babb D.A., and Hatsukami D.K. Intravenous cocaine increases plasma epinephrine and norepinephrine in humans. Pharmacol Biochem Behav 68 (2001) 455-459
70. Spitzer R.L., Williams J.B.W., Gibbon M., and First M.B. The structured clinical interview for DSM-III-R (SCID), I: History, rationale, and description. Arch Gen Psychiatry 49 (1992) 624-629
71. Stein M.B., Schork M.J., and Gelernter J. A polymorphism of the β1-adrenergic receptor is associated with shyness and low extraversion. Biol Psychiatry 56 (2004) 217-224
72. Stephens M., and Donnelly P. A comparison of Bayesian methods for haplotype reconstruction from population genotype data. Am J Hum Genet 73 (2003) 1162-1169
73. Stephens M., Smith N.J., and Donnelly P. A new statistical method for haplotype reconstruction from population data. Am J Hum Genet 68 (2001) 978-989
74. Tabachnick B.G., and Fidell L.S. Using Multivariate Statistics. 3rd ed (1996), Harper Collins College Publishers, New York
75. Thomasson H.R., Crabb D.W., Edenberg H.J., Li T.K., Hwu H.G., Chen C.C., et al. Low frequency of the ADH2*2 allele among Atayal natives of Taiwan with alcohol use disorders. Alcohol Clin Exp Res 18 (1994) 640-643
76. Thome J., Weijers H.G., Wiesbeck G.A., Sian J., Nara K., Boning J., et al. Dopamine D3 receptor gene polymorphism and alcohol dependence: Relation to personality rating. Psychiatr Genet 9 (1999) 17-21
77. Tsai S.J., Hong C.J., Yu Y.W., and Chen T.J. Association study of catechol-O-methyltransferase gene and dopamine D4 receptor gene polymorphisms and personality traits in healthy young Chinese females. Neuropsychobiology 50 (2004) 153-156
78. Verheul R., van den Brink W., and Ball S. Substance abuse and personality disorders. In: Kranzler H.R., and Tinsley J.A. (Eds). Dual Diagnosis and Treatment: Substance Abuse and Comorbid Psychiatric Disorders. 2nd ed (2004), Marcel Dekker, New York 261-316
79. Wand G.S., McCaul M., Yang X., Reynolds J., Gotjen D., Lee S., et al. The muopioid receptor gene polymorphism (A118G) alters HPA axis activation induced by opioid receptor blockade. Neuropsychopharmacology 26 (2002) 106-114
80. Westberg L., Melke J., Landen M., Nilsson S., Baghaei F., Rosmond R., et al. Association between a dinucleotide repeat polymorphism of the estrogen receptor alpha gene and personality traits in women. Mol Psychiatry 8 (2003) 118-122
81. Wiesbeck G.A., Weijers H.G., Wodarz N., Keller H.K., Michel T.M., Herrmann M.J., et al. Serotonin transporter gene polymorphism and personality traits in primary alcohol dependence. World J Biol Psychiatry 5 (2004) 45-48
82. Zhang H., Luo X., Kranzler H.R., Lappalainen J., Yang B.Z., Krupitsky E., et al. Association between two mu-opioid receptor gene (OPRM1) haplotype blocks and drug or alcohol dependence. Hum Mol Genet 15 (2006) 807-819
83. Zucker R.A., and Lisansky Gomberg E.S. Etiology of alcoholism reconsidered: The case for a biopsychosocial process. Am Psychol 41 (1986) 783-793