A polymorphic region in the human transcription factor AP-2β gene is associated with specific personality traits

Molecular Psychiatry

Volumn 5, Issue 2, 2000, Pages 220-224

  Damberg, M ^a   Garpenstrand, H ^a   Alfredsson, J ^a   Ekblom, J ^a   Forslund, K ^b   Rylander, G ^b   Oreland, L ^a,c  

^a UPPSALA UNIVERSITY   (Sweden)

^b KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

^c UPPSALA UNIVERSITY   (Sweden)

Author keywords

5 HT; Anxiety; Dopamine; Gene expression; Karolinska Scales of Personality (KSP); Personality

Indexed keywords

TRANSCRIPTION FACTOR AP 2;

AGGRESSION; ANXIETY NEUROSIS; ARTICLE; FEMALE; GENETIC POLYMORPHISM; GENOTYPE; HUMAN; MALE; NORMAL HUMAN; PERSONALITY DISORDER; PRIORITY JOURNAL;

EID: 0034055665     PISSN: 13594184     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.mp.4000691     Document Type: Article

References (27)

1. 1 Mitchell PJ, Timmons PM, Herbert JM, Rigby PW, Tjian R. Transcription factor AP-2 is expressed in neural crest lineages during mouse embryogenesis. Genes & Dev 1991; 5: 105-119.
2. 2 Moser M, Rüschoff J, Buettner R. Comparative analysis of AP-2α and AP-2β gene expression during murine embryogenesis. Dev Dyn 1997; 208: 115-124.
3. 3 Moser M, Pscherer A, Roth C, Becker J, Mücher G, Zerres K et al. Enhanced apoptotic cell death of renal epithelial cells in mice lacking transcription factor AP-2β. Genes & Dev 1997; 11: 1938-1948.
4. 4 Williams T, Admon A, Luscher B, Tjian R. Cloning and expression of AP-2, a cell-type-specific transcription factor that activates inducible enhancer elements. Genes & Dev 1988; 2: 1557-1509.
5. 5 Moser M, Pscherer A, Imhof A, Bauer R, Kerscher M, Amselgruber W et al. Cloning and characterisation of a second AP-2 transcription activator gene, AP-2β. Development 1995; 121: 2779-2788.
6. 6 Oulad-Abdelghani M, Bouillet P, Chazaud C, Dollé P, Chambon P. AP-2.2: a novel AP-2 related transcription factor induced by retinoic acid during differentiation of P19 embryonal carcinoma cells. Exp Cell Res 1996; 224: 338-347.
7. 7 Chazaud C, Oulad-Abdelghani M, Bouillet P, Décimo D, Chambon P, Dollé P. AP-2.2, a novel gene related to AP-2, is expressed in the forebrain, limbs and face during mouse embryogenesis. Mech Dev 1996; 54: 83-94.
8. 8 Williams T, Tjian R. Analysis of the DNA-binding and activation properties of the human transcription factor AP-2. Genes & Dev 1991; 5: 670-682.
9. 9 Williams T, Tjian R. Characterization of a dimerization motif in AP-2 and its function in heterologous DNA binding proteins. Science 1991; 251: 1067-1071.
10. 10 Bosher JM, Totty NF, Hsuan JI, Williams T, Hurst HC. A family of AP-2 proteins regulates c-erbB-2 expression in mammary carcinoma. Oncogene 1996; 13: 1701-1707.
11. 11 Roesler WJ, Vandenbark GR, Hanson RW. Cyclic AMP and the induction of eukaryotic gene transcription. J Biol Chem 1988; 263: 9063-9066.
12. 12 Kobayashi K, Kurosawa Y, Fujita K, Nagatsu T. Dopamine β-hydroxylase gene: two mRNA types having different 3′-terminal regions are produced through alternative polyadenylation. Nucleic Acids Res 1989; 17: 1089-1102.
13. 13 Greco D, Zellmer E, Zhang Z, Lewis E. Transcription factor AP-2 regulates expression of the dopamine β-hydroxylase gene. J Neurochem 1995; 65: 510-516.
14. 14 McMahon M, Sabban E. Regulation of expression of dopamine β-hydroxylase in PC12 cells by glucocorticoids and cyclic AMP analogues. J Neurochem 1992; 59: 2040-2047.
15. 15 Healy DP, O'Rourke DA. Regulation of dopamine-1A (DIA) receptor gene transcription. Clin Exp Hypertens 1997; 19: 1-13.
16. 16 Hahn SL, Hahn M, Kang UJ, Joh TH. Structure of the rat aromatic L-amino acid decarboxylase gene: evidence for an alternative promoter usage. J Neurochem 1993; 60: 1058-1064.
17. 17 Bradely CC, Blakely RD. Alternative splicing of the human serotonin transporter gene. J Neurochem 1997; 69: 1356-1367.
18. 18 Du YL, Wilcox BD, Teitler M, Jeffrey JJ. Isolation and characterization of the rat 5-hydroxitryptamine type 2 receptor promoter: constitutive and inducible activity in myometrial smooth muscle cells. Mol Pharmacol 1994; 45: 1125-1131.
19. 19 Quirin-Stricker C, Mauvais C, Schmitt M. Transcriptional activation of human choline acetyltransferase by AP2- and NGF-induced factors. Mol Brain Res 1997; 49: 165-174.
20. 20 Baskin F, Li Y-P, Hersh LB, Davis RM, Rosenberg RN. An AP-2 binding sequence within exon 1 of human and porcine choline acetyltransferase genes enhances transcription in neural cells. Neuroscience 1997; 76: 821-827.
21. 21 Stallings MC, Hewitt J-K, Cloninger CR, Heath AC, Eaves LJ. Genetic and environmental structure of the tridimensional personality questionnaire: three or four temperament dimensions. J Person Social Psychol 1996; 70: 127-140.
22. 22 Watson D, Clark LA. Negative affectivity: the disposition to experience aversive emotional states. Psychol Bull 1984; 96: 465-490.
23. 23 Helleday J, Edman G, Rietzen EM, Siwers B. Personality characteristics and platelet MAO activity in women with congenital adrenal hyperplasia (CAH). Psychoneuroendocrinology 1993; 18: 343-354.
24. 24 Hartmann J, Kunig G, Riederer P. Involvement of transmitter systems in neuropsychiatric diseases. Acta Neurol Scand Suppl 1993; 146: 18-21.
25. 25 Perneger TV. What's wrong with Bonferroni adjustments. BMJ 1998; 316: 1236-1238.
26. 26 Schalling D, sberg M, Edman G, Oreland L. Markers for vulnerability to psychopathology: temperament traits associated with platelet MAO activity. Acta Psychiatr Scand 1978; 76: 172-182.
27. 27 Bassam BJ, Caetano-Anollés G, Gresshof PM. Fast and sensitive silver staining of DNA in polyacrylamide gels. Anal Chem 1991; 196: 80-83.