Association between a promoter dopamine D2 receptor gene variant and the personality trait detachment

Biological Psychiatry

Volumn 53, Issue 7, 2003, Pages 577-584

  Jönsson, Erik G ^a   Cichon, Sven ^b,c   Gustavsson, J Petter ^a   Grünhage, Frank ^b   Forslund, Kaj ^a   Mattila Evenden, Marja ^a   Rylander, Gunnar ^a   Åsberg, Marie ^a   Farde, Lars ^a   Propping, Peter ^b   Nöthen, Markus M ^b,c  

^a KAROLINSKA INSTITUTE   (Sweden)

^b UNIVERSITY OF BONN   (Germany)

^c UNIVERSITY OF ANTWERP   (Belgium)

Author keywords

Association; Dopamine; Genetics; Personality

Indexed keywords

DOPAMINE 2 RECEPTOR;

ADULT; AGED; ARTICLE; CONTROLLED STUDY; DNA POLYMORPHISM; FEMALE; GENE DELETION; GENE INSERTION; GENETIC ASSOCIATION; HUMAN; MALE; NORMAL HUMAN; PERSONALITY; PERSONALITY TEST; PRIORITY JOURNAL; PROMOTER REGION; QUESTIONNAIRE; RECEPTOR DENSITY;

EID: 12244290299     PISSN: 00063223     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-3223(02)01732-8     Document Type: Article

References (63)

1. 2 receptor gene is associated with schizophrenia. Hum Mol Genet. 6:1997;577-582.
2. Bacanu S., Devlin B., Roeder K. The power of genomic control. Am J Hum Genet. 66:2000;1933-1944.
3. 4 dopamine receptor gene and measures of novelty seeking. Nat Genet. 12:1996;81-84.
4. Benjamini Y., Hochberg Y. Controlling the false discovery rate A practical and powerful approach to multiple testing . J R Statist Soc Bull. 57:1995;289-300.
5. Bergman H., Bergman I., Engelbrektsson K., Holm L., Johannesson K., Lindberg S. Psykologhandbok vid Magnus Huss kliniken [Handbook for psychologists at the Magnus Huss Clinic]. 1982;Magnus Huss-kliniken, Karolinska Sjukhuset, Stockholm.
6. 2 receptor (DRD2), and dopamine transporter (DAT1) genes with schizoid/avoidant behaviors. Mol Psychiatry. 2:1997;239-246.
7. Breen G., Brown J., Maude S., Fox H., Collier D., Li T., et al. -141 C del/ins polymorphism of the dopamine receptor 2 gene is associated with schizophrenia in a British population. Am J Med Genet. 88:1999;407-410.
8. Breier A., Kestler L., Adler C., Elman I., Wiesenfeld N., Malhotra A., et al. Dopamine D2 receptor density and personal detachment in healthy subjects. Am J Psychiatry. 155:1998;1440-1442.
9. Burt SA, McGue M, Iacono W, Comings D, MacMurray J (2002): An examination of the association between DRD4 and DRD2 polymorphisms and personality traits. Personality and Individual Differences33:849-859.
10. Carlsson A. Antipsychotic drugs, neurotransmitters, and schizophrenia. Am J Psychiatry. 135:1978;164-173.
11. Cloninger C.R. A unified biosocial theory of personality and its role in the development of anxiety states. Psychiatr Dev. 4:1986;167-226.
12. Cloninger C.R. A systematic method for clinical description and classification of personality variants. A proposal. Arch Gen Psychiatry. 44:1987;573-588.
13. Cloninger C.R. A unified biosocial theory of personality and its role in the development of anxiety states A reply to commentaries . Psychiatr Dev. 6:1988;83-120.
14. Cloninger C.R., Przybeck T.R., Svrakic D.M., Wetzel R.D. The Temperament and Character Inventory (TCI) A Guide to its Development and Use . 1994;Center for Psychobiology of Personality, St Louis.
15. Cohen J. Statistical Power Analysis For The Behavioral Sciences. 2nd ed:1988;Lawrence Erlbaum Associates, Hillsdale, NJ.
16. Costa P.T., McCrae R.R. Revised NEO Personality Inventory (NEO PI-R) and NEO Five Inventory (NEO-FFI) Professional Manual. 1992;Psychological Assessment Resources, Odessa, Fla.
17. Costa P.T. Jr, McCrae R.R. Four ways five factors are basic. Personality and Individual Differences. 13:1992;653-665.
18. 1 polymorphism and alcoholism in a Mexican population. Arch Med Res. 26:1995;421-426.
19. Curtin F., Walker J.P., Badan M., Schulz P. The relations between scores on analogous scales from four personality questionnaires in 50 normal men. Personality and Individual Differences. 19:1995;705-711.
20. Devlin B., Roeder K. Genomic control for association studies. Biometrics. 55:1999;997-1004.
21. 4 receptor (D4DR) exon III polymorphism associated with the human personality trait of novelty seeking. Nat Genet. 12:1996;78-80.
22. Erdfelder E., Faul F., Buchner A. GPower A general power analysis program . Behav Res Methods Instruments Comput. 28:1996;1-11.
23. 2 dopamine receptors and personality traits. Nature. 385:1997;590.
24. 11C] raclopride in man . Synapse. 20:1995;200-208.
25. 2 receptor promoter region with bipolar or unipolar disorders. Am J Med Genet. 81:1998;385-387.
26. 2 receptor genes with personality in healthy individuals. Psychiatr Genet. 10:2000;131-137.
27. 2-receptor gene polymorphisms in Scandinavian chronic alcoholics. Eur Arch Psychiatry Clin Neurosci. 244:1994;26-32.
28. Gelernter J., Kranzler H., Cubells J.F., Ichinose H., Nagatsu T. DRD2 allele frequencies and linkage disequilibria, including the -141C ins/del promoter polymorphism, in European-American, African-American, and Japanese subjects. Genomics. 51:1998;21-26.
29. Gustavsson J.P. Stability and Validity of Self-Reported Personality Traits. Contributions to the Evaluation of the Karolinska Scales of Personality. 1997;Karolinska Institutet, Stockholm.
30. Gustavsson J.P., Bergman H., Edman G., Ekselius L., von Knorring L., Linder J. Swedish universities Scales of Personality (SSP) Construction, internal consistency and normative data . Acta Psychiatr Scand. 102:2000;217-225.
31. Gustavsson JP, Jönsson EG, Linder J, Weinryb RM (2002): The HP5 inventory: Definition and assessment of five health-relevant personality traits from a five-factor model perspective. Pers Individ Diff [In press].
32. Gustavsson J.P., Nöthen M.M., Jönsson E.G., Neidt H., Forslund K., Rylander G., et al. No association between serotonin transporter gene polymorphisms and personality traits. Am J Med Genet. 88:1999;430-436.
33. Himei A., Koh J., Sakai J., Inada Y., Akabame K., Yoneda H. The influence on the schizophrenic symptoms by the DRD2Ser/Cys311 and -141C ins/del polymorphisms. Psychiatry Clin Neurosci. 56:2002;97-102.
34. 2 receptor gene polymorphisms and schizophrenia. Am J Med Genet. 105:2001;176-178.
35. 2 receptor gene and schizophrenia in Japanese subjects Replication and evaluation for antipsychotic-related features . Int J Neuropsychopharmacol. 2:1999;181-186.
36. Johnson D.L., Wiebe J.S., Gold S.M., Andreasen N.C., Hichwa R.D., Watkins G.L., et al. Cerebral blood flow and personality A positron emission tomography study . Am J Psychiatry. 156:1999;252-257.
37. 4 receptor gene variants and novelty seeking. Mol Psychiatry. 7:2002;18-20.
38. 2 receptor gene and their relationships to striatal dopamine receptor density of healthy volunteers. Mol Psychiatry. 4:1999;290-296.
39. 4 receptor gene polymorphisms. Am J Psychiatry. 154:1997;697-699.
40. 4 receptor gene and personality traits. Psychol Med. 28:1998;985-989.
41. 2 receptor gene and schizophrenia. Schizophr Res. 40:1999;31-36.
42. 2 receptor and personality traits. Psychiatry Res. 105:2001;123-127.
43. 2 receptor density and personality Preliminary evidence from the NEO personality inventory-revised . Neuropsychiatry Neuropsychol Behav Neurol. 13:2000;48-52.
44. Li T., Arranz M., Aitchison K.J., Bryant C., Liu X., Kerwin R.W., et al. Case-control, haplotype relative risk and transmission disequilibrium analysis of a dopamine D2 receptor functional promoter polymorphism in schizophrenia. Schizophr Res. 32:1998;87-92.
45. Loehlin J.C. Genes and Environment in Personality Development. 1992;SAGE Publications, Newbury Park.
46. 4 receptor gene (DRD4) is associated with novelty seeking (NS) and substance abuse The saga continues . Mol Psychiatry. 6:2001;497-499.
47. 4 dopamine receptor polymorphisms and personality. Am J Med Genet. 81:1998;257-267.
48. 11C]NMSP. Psychiatry Res. 61:1995;67-83.
49. 2 and 5-HT2 receptor occupancy induced by risperidone in poor metabolizers of debrisoquin and risperidone. Psychopharmacology. 119:1995;345-348.
50. 2 dopamine receptor occupancy in the living human brain. A PET study with risperidone. Psychopharmacology. 110:1993;265-272.
51. Ohara K., Nagai M., Tani K., Nakamura Y., Ino A., Ohara K. Functional polymorphism of -141C ins/del in the dopamine D2 receptor gene promoter and schizophrenia. Psychiatry Res. 81:1998;117-123.
52. 4 receptor gene Novelty or nonsense? Neuropsychopharmacology. 21:1999;3-16.
53. 4 receptor gene polymorphism and personality traits in healthy volunteers. Eur Arch Psychiatry Clin Neurosci. 250:2000;203-206.
54. Pohjalainen T., Någren K., Syvälahti E.K., Hietala J. The dopamine D-2 receptor 5′-flanking variant, C-141 ins/del, is not associated with reduced dopamine D-2 receptor density in vivo. Pharmacogenetics. 9:1999;505-509.
55. Pritchard J.K., Stephens M., Rosenberg N.A., Donnelly P. Association mapping in structured populations. Am J Hum Genet. 67:2000;170-181.
56. Rosmond R., Rankinen T., Chagnon M., Perusse L., Chagnon Y.C., Bouchard C., et al. Polymorphism in exon 6 of the dopamine D(2) receptor gene (DRD2) is associated with elevated blood pressure and personality disorders in men. J Hum Hypertens. 15:2001;553-588.
57. Schalling D., Åsberg M., Edman G., Oreland L. Markers for vulnerability to psychopathology Temperament traits associated with platelet MAO activity . Acta Psychiatr Scand. 76:1987;172-182.
58. Sham P.C., Curtis D. Monte Carlo tests for associations between disease and alleles at highly polymorphic loci. Ann Hum Genet. 59:1995;97-105.
59. Spitzer RL, Williams JB, Gibbon M (1986): Structured Clinical Interview for DSM-III-R - Non Patient Version (SCID-NP). New York: Biometrics Research Department, New York State Psychiatric Institute 1986.
60. 2 receptor gene Lack of association with schizophrenia and bipolar affective disorder. Short communication . J Neural Transm. 105:1998;101-109.
61. Sugiura M., Kawashima R., Nakagawa M., Okada K., Sato T., Goto R., et al. Correlation between human personality and neural activity in cerebral cortex. Neuroimage. 11:2000;541-546.
62. 2 receptors in the insular cortex and the personality trait of novelty seeking. Neuroimage. 13:2001;891-895.
63. 2 receptor promoter polymorphism No association with schizophrenia . Psychiatry Res. 85:1999;215-219.