HIF-1α contributes to tumour-selective killing by the sigma receptor antagonist rimcazole

Oncogene

Volumn 26, Issue 8, 2007, Pages 1137-1146

  Achison, M ^a   Boylan, M T ^a   Hupp, T R ^b   Spruce, B A ^a  

^a UNIVERSITY OF DUNDEE   (United Kingdom)

^b UNIVERSITY OF EDINBURGH   (United Kingdom)

Author keywords

HIF 1 ; Hypoxia; p53; Rimcazole

Indexed keywords

HYPOXIA INDUCIBLE FACTOR 1ALPHA; MUTANT PROTEIN; PENTAZOCINE; PROTEIN P53; RIMCAZOLE; CARBAZOLE DERIVATIVE; HIF1A PROTEIN, HUMAN; SIGMA OPIATE RECEPTOR; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; BREAST CARCINOMA; BREAST EPITHELIUM; CARCINOMA CELL; CELL DEATH; CELL KILLING; CELL STRAIN HCT116; CELL TYPE; COLORECTAL CARCINOMA; CONTROLLED STUDY; DRUG ACCUMULATION; FIBROBLAST; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN INDUCTION; RNA INTERFERENCE; WILD TYPE; DRUG ANTAGONISM; DRUG POTENTIATION; EPITHELIUM CELL; GENETICS; METABOLISM; NEOPLASM; TUMOR CELL LINE; UPREGULATION;

APOPTOSIS; CARBAZOLES; CELL LINE, TUMOR; EPITHELIAL CELLS; FIBROBLASTS; HUMANS; HYPOXIA-INDUCIBLE FACTOR 1, ALPHA SUBUNIT; NEOPLASMS; PENTAZOCINE; RECEPTORS, SIGMA; RNA INTERFERENCE; TUMOR SUPPRESSOR PROTEIN P53; UP-REGULATION;

EID: 33847177216     PISSN: 09509232     EISSN: 14765594     Source Type: Journal    
DOI: 10.1038/sj.onc.1209890     Document Type: Article

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