Isolation of Xenopus HIF-prolyl 4-hydroxylase and rescue of a small-eye phenotype caused by Siah2 over-expression

Biochemical and Biophysical Research Communications

Volumn 355, Issue 2, 2007, Pages 419-425

  Imaoka, Susumu ^a   Muraguchi, Taichi ^a   Kinoshita, Tsutomu ^a  

^a KWANSEI GAKUIN UNIVERSITY   (Japan)

Author keywords

HIF 1 ; Prolyl hydroxylase domain protein; Siah2; Xenopus laevis

Indexed keywords

BETA ACTIN; COMPLEMENTARY DNA; HYPOXIA INDUCIBLE FACTOR 1ALPHA; NUCLEAR PROTEIN; PROCOLLAGEN PROLINE 2 OXOGLUTARATE 4 DIOXYGENASE; SIAH2 PROTEIN; UNCLASSIFIED DRUG;

ARTICLE; DNA SYNTHESIS; EGG; EMBRYO; EMBRYO DEVELOPMENT; EYE DEVELOPMENT; GENE OVEREXPRESSION; HUMAN; MOLECULAR CLONING; NONHUMAN; NUCLEOTIDE SEQUENCE; PHENOTYPE; PHOTORECEPTOR CELL; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN EXPRESSION; WESTERN BLOTTING; XENOPUS;

AMINO ACID SEQUENCE; ANIMALS; BASE SEQUENCE; CATALYTIC DOMAIN; DNA PRIMERS; EMBRYONIC DEVELOPMENT; EYE ABNORMALITIES; EYE PROTEINS; HUMANS; HYPOXIA-INDUCIBLE FACTOR 1; MOLECULAR SEQUENCE DATA; PROCOLLAGEN-PROLINE DIOXYGENASE; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SEQUENCE HOMOLOGY, AMINO ACID; XENOPUS LAEVIS; XENOPUS PROTEINS;

XENOPUS LAEVIS;

EID: 33847095500     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2007.01.166     Document Type: Article

References (24)

1. Semenza G.L. HIF-1: mediator of physiological and pathophysiological responses to hypoxia. J. Appl. Physiol. 88 (2000) 1474-1480
2. Chen E.Y., Fujinaga M., and Giaccia A.J. Hypoxic microenvironment within an embryo induces apoptosis and is essential for proper morphological development. Teratology 60 (1999) 215-225
3. Wang G.L., and Semenza G.L. Purification and characterization of hypoxia-inducible factor 1. J. Biol. Chem. 270 (1995) 1230-1237
4. Wang G.L., Jiang B.H., Rue E.A., and Semenza G.L. Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension. Proc. Natl. Acad. Sci. USA 92 (1995) 5510-5514
5. 2 sensing. Science 292 (2001) 464-468
6. 2-regulated prolyl hydroxylation. Science 292 (2001) 468-472
7. Maxwell P.H., Wiesener M.S., Chang G.W., Clifford S.C., Vaux E.C., Cockman M.E., Wykoff C.C., Pugh C.W., Maher E.R., and Ratcliffe P.J. The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis. Nature 399 (1999) 271-275
8. Epstein A.C., Gleadle J.M., McNeill L.A., Hewitson K.S., O'Rourke J., Mole D.R., Mukherji M., Metzen E., Wilson M.I., Dhanda A., Tian Y.M., Masson N., Hamilton D.L., Jaakkola P., Barstead R., Hodgkin J., Maxwell P.H., Pugh C.W., Schofield C.J., and Ratcliffe P.J. C. elegans EGL-9 and mammalian homologs define a family of dioxygenases that regulate HIF by prolyl hydroxylation. Cell 107 (2001) 43-54
9. Bruick R.K., and McKnight S.L. A conserved family of prolyl-4-hydroxylases that modify HIF. Science 294 (2001) 1337-1340
10. Appelhoff R.J., Tian Y.M., Raval R.R., Turley H., Harris A.L., Pugh C.W., Ratcliffe P.J., and Gleadle J.M. Differential function of the prolyl hydroxylases PHD1, PHD2, and PHD3 in the regulation of hypoxia-inducible factor. J. Biol. Chem. 279 (2004) 38458-38465
11. Metzen E., Berchner-Pfannschmidt U., Stengel P., Marxsen J.H., Stolze I., Klinger M., Huang W.Q., Wotzlaw C., Hellwig-Burgel T., Jelkmann W., Acker H., and Fandrey J. Intracellular localisation of human HIF-1 alpha hydroxylases: implications for oxygen sensing. J. Cell Sci. 116 (2003) 1319-1326
12. Carthew R.W., and Rubin G.M. Seven in absentia, a gene required for specification of R7 cell fate in the Drosophila eye. Cell 63 (1990) 561-577
13. Bogdan S., Senkel S., Esser F., Ryffel G.U., Pogge E., and Strandmann v. Misexpression of Xsiah-2 induces a small eye phenotype in Xenopus. Mech. Dev. 103 (2001) 61-69
14. Nakayama K., Frew I.J., Hagensen M., Skals M., Habelhah H., Bhoumik A., Kadoya T., Erdjument-Bromage H., Tempst P., Frappell P.B., Bowtell D.D., and Ronai Z. Siah2 regulates stability of prolyl-hydroxylases, controls HIF1alpha abundance, and modulates physiological responses to hypoxia. Cell 117 (2004) 941-952
15. Kiyota T., Jono H., Kuriyama S., Hasegawa K., Miyatani S., and Kinoshita T. X-Serrate-1 is involved in primary neurogenesis in Xenopus laevis in a complementary manner with X-Delta-1. Dev. Genes Evol. 211 (2001) 367-376
16. J. Gerhart, M. Kirschner (Ed.), Normal Table of Xenopus laevis (Daudin), Garland Publishing, New York and London, 1994.
17. Osada M., Imaoka S., Sugimoto T., Hiroi T., and Funae Y. NADPH-cytochrome P-450 reductase in the plasma membrane modulates the activation of hypoxia-inducible factor 1. J. Biol. Chem. 277 (2002) 23367-23373
18. Choi K.O., Lee T., Lee N., Kim J.H., Yang E.G., Yoon J.M., Kim J.H., Lee T.G., and Park H. Inhibition of the catalytic activity of hypoxia-inducible factor-1α-prolyl-hydroxylase 2 by a MYND-type zinc finger. Mol. Pharmacol. 68 (2005) 1803-1809
19. McDonough M.A., Li V., Flashman E., Chowdhury R., Mohr C., Lienard B.M., Zondlo J., Oldham N.J., Clifton I.J., Lewis J., McNeill L.A., Kurzeja R.J., Hewitson K.S., Yang E., Jordan S., Syed R.S., and Schofield C.J. Cellular oxygen sensing: Crystal structure of hypoxia-inducible factor prolyl hydroxylase (PHD2). Proc. Natl. Acad. Sci. USA 103 (2006) 9814-9819
20. Sipe C.W., Gruber E.J., and Saha M.S. Short upstream region drives dynamic expression of hypoxia-inducible factor 1alpha during Xenopus development. Dev. Dyn. 230 (2004) 229-238
21. Berra E., Benizri E., Ginouves A., Volmat V., Roux D., and Pouyssegur J. HIF prolyl-hydroxylase 2 is the key oxygen sensor setting low steady-state levels of HIF-1α in normoxia. EMBO J. 22 (2003) 4082-4090
22. Stiehl D.P., Wirthner R., Koditz J., Spielmann P., Camenisch G., and Wenger R.H. Increased prolyl 4-hydroxylase domain proteins compensate for decreased oxygen levels. Evidence for an autoregulatory oxygen-sensing system. J. Biol. Chem. 281 (2006) 23482-23491
23. Khurana A., Nakayama K., Williams S., Davis R.J., Mustelin T., and Ronai Z. Regulation of the ring finger E3 ligase Siah2 by p38 MAPK. J. Biol. Chem. 281 (2006) 35316-35326
24. Nakayama K., Gazdoiu S., Abraham R., Pan Z.Q., and Ronai Z. Hypoxia-induced assembly of prolyl hydroxylase PHD3 into complexes: implications for its activity and susceptibility for degradation by the E3 ligase Siah2. Biochem. J. 401 (2007) 217-226