A role for the actin cytoskeleton in the hormonal and growth-factor-mediated activation of protein kinase B

Biochemical Journal

Volumn 352, Issue 3, 2000, Pages 617-622

  Peyrollier, K ^a   Hajduch, E ^a   Gray, A ^a   Litherland, G J ^a   Prescott, A R ^a   Leslie, N R ^a   Hundal, H S ^a  

^a UNIVERSITY OF DUNDEE   (United Kingdom)

Author keywords

Glycogen synthase kinase 3; Insulin; Phosphatase and tensin homologue deleted on chromosome 10; Phosphoinositide 3 kinase; Platelet derived growth factor

Indexed keywords

CYTOCHALASIN D; GREEN FLUORESCENT PROTEIN; GROWTH FACTOR; HYBRID PROTEIN; INSULIN; PHOSPHATASE; PHOSPHATIDYLINOSITIDE; PLATELET DERIVED GROWTH FACTOR; PLECKSTRIN; PROTEIN KINASE B;

ACTIN FILAMENT; ANIMAL CELL; ARTICLE; CELL MEMBRANE; CHROMOSOME 10; CHROMOSOME TRANSLOCATION; CONTROLLED STUDY; CYTOSKELETON; DEPOLYMERIZATION; ENZYME ACTIVATION; ENZYME ACTIVITY; HORMONAL REGULATION; HUMAN; HUMAN CELL; NONHUMAN; NULL CELL; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; PROTEIN POLYMERIZATION; SEQUENCE HOMOLOGY;

1-PHOSPHATIDYLINOSITOL 3-KINASE; ACTINS; ADIPOCYTES; ANIMALS; BICYCLO COMPOUNDS, HETEROCYCLIC; CA(2+)-CALMODULIN DEPENDENT PROTEIN KINASE; CELL LINE; CYTOCHALASIN D; CYTOSKELETON; ENZYME ACTIVATION; GLYCOGEN SYNTHASE KINASE 3; GROWTH SUBSTANCES; HORMONES; HUMANS; INSULIN; MICE; MUSCLES; PHOSPHATIDYLINOSITOLS; PHOSPHORIC MONOESTER HYDROLASES; PHOSPHORYLATION; PLATELET-DERIVED GROWTH FACTOR; PROTEIN TRANSPORT; PROTEIN-SERINE-THREONINE KINASES; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-AKT; PTEN PHOSPHOHYDROLASE; RECOMBINANT FUSION PROTEINS; THIAZOLES; THIAZOLIDINES; TUMOR SUPPRESSOR PROTEINS;

ANIMALIA;

EID: 0034672226     PISSN: 02646021     EISSN: None     Source Type: Journal    
DOI: 10.1042/0264-6021:3520617     Document Type: Article

References (27)

1. Mechanism of activation and function of protein kinase B
2. Mechanism of activation of protein kinase B by insulin and IGF-1
3. Role of translocation in the activation and function of protein kinase B
4. Update: Signal transductior - Ptdlns(3,4,5)P-3 gets its message across
5. AH/PH domain-mediated interaction between Akt molecules and its potential role in Akt regulation
6. Characterization of a 3-phosphoinositide-dependent protein kinase which phosphorylates and activates protein kinase Bα
7. Dual role of phosphatidylinositol-3,4,5-trisphosphate in the activation of protein kinase B
8. Inhibition of glycogen synthase kinase-3 by insulin-mediated protein kinase B
9. Phosphorylation of the transcription factor forkhead family member FKHR by protein kinase B
10. Expression of a constitutively activated form of protein-kinase- B (c- Akt) in 3T3-L1 preadipose cells causes spontaneous differentiation
11. Intracellular localization of phosphatidylinositide 3-kinase and insulin receptor substrate-1 in adipocytes: Potential involvement of a membrane skeleton
12. Phosphatidylinositol 3-kinase and the actin network are not required for the stimulation of glucose-transport caused by mitochondrial uncoupling: Comparison with insulin action
13. The pleckstrin homology domains of protein kinase B and GRP1 (general receptor for phosphoinositides-1) are sensitive and selective probes for the cellular detection of phosphatidylinositol 3,4-bisphosphate and/or phosphatidylinositol 3,4,5-trisphosphate in vivo
14. Analysis of the cellular functions of PTEN using catalytic domain and C- terminal mutations: Differential effects of C-terminal deletion on signalling pathways downstream of phosphoinositide 3-kinase
15. Constitutive activation of protein kinase Bα (PKBα) by membrane targeting promotes glucose and system A amino acid transport, protein synthesis and GSK3 inactivation in L6 muscle cells
16. Evidence for the involvement of vicinal sulthydryl groups in insulin-activated hexose transport by 3T3-L1 adipocytes
17. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding
18. PDK1 acquires PDK2 activity in the presence of a synthetic peptide derived from the carboxyl terminus of PRK2
19. Identification of a pocket in the PDK1 kinase domain that interacts with PIF and the C-terminal residues of PKA
20. Leptin stimulates glucose transport and glycogen synthesis in C2C12 myotubes: Evidence for a PI3-kinase mediated effect
21. Activation of protein kinase Bβ and γ isoforms by insulin in vivo and by 3-phosphoinositide-dependent protein kinase-1 in vitro: Comparison with protein kinase Bα
22. Actin filaments participate in the relocalization of phosphatidylinositol 3-kinase to glucose transportercontaining compartments and in the stimulation of glucose uptake in 3T3-L1 adipocytes
23. Actin filaments facilitate insulin activation of the src and collagen homologous/milogen-activated protein kinase pathway leading to DNA synthesis and c-los expression
24. Role of phosphatidylinositol 3,4,5-trisphosphate in regulating the activity and localization of 3-phosphoinositide dependent protein kinase-1
25. Protein kinase B (PKB/Akt) activity is elevated in glioblastoma cells due to mutation of the tumor suppressor PTEN/MMAC
26. PTEN interactions with local adhesion kinase and suppression of the extracellular matrix-dependent phosphatidylinositol 3-kinase/Akt cell survival pathway
27. Insulin-induced actin filament remodeling colocalizes actin with phosphatidylinositol 3-kinase and GLUT4 in L6 myotubes