Substrate conformation modulates aggrecanase (ADAMTS-4) affinity and sequence specificity: Suggestion of a common topological specificity for functionally diverse proteases

Journal of Biological Chemistry

Volumn 282, Issue 1, 2007, Pages 142-150

  Lauer Fields, Janelle L ^a   Minond, Dmitriy ^a   Sritharan, Thilaka ^a   Kashiwagi, Masahide ^b   Nagase, Hideaki ^b   Fields, Gregg B ^a  

^a FLORIDA ATLANTIC UNIVERSITY   (United States)

^b IMPERIAL COLLEGE LONDON   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

FUNCTIONALLY DIVERSE PROTEASES; HELICAL PEPTIDES; SINGLE-STRANDED POLY(PRO) II HELICAL PEPTIDES;

AMINO ACIDS; ENZYME INHIBITION; FUNCTIONAL GROUPS; HYDROLYSIS;

PROTEINS;

AGGRECANASE; AGGRECANASE 1; COLLAGENASE 3; INTERSTITIAL COLLAGENASE; PEPTIDE; THERMOLYSIN USING TRIPLE HELICAL PEPTIDE; TRYPSIN; UNCLASSIFIED DRUG; ADAM PROTEIN; AGGRECANASE-1; PROCOLLAGEN N PROTEINASE;

ARTICLE; BINDING AFFINITY; ENZYME ANALYSIS; ENZYME CONFORMATION; ENZYME STRUCTURE; ENZYME SUBSTRATE; HYDROLYSIS; PRIORITY JOURNAL; PROTEIN MOTIF; SEQUENCE ANALYSIS; AMINO ACID SEQUENCE; CHEMISTRY; CIRCULAR DICHROISM; ENZYME SPECIFICITY; ESCHERICHIA COLI; HUMAN; KINETICS; METABOLISM; MOLECULAR GENETICS; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN SECONDARY STRUCTURE;

ADAM PROTEINS; AMINO ACID SEQUENCE; CIRCULAR DICHROISM; ESCHERICHIA COLI; HUMANS; KINETICS; MATRIX METALLOPROTEINASE 1; MATRIX METALLOPROTEINASE 13; MOLECULAR SEQUENCE DATA; PEPTIDES; PROCOLLAGEN N-ENDOPEPTIDASE; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN STRUCTURE, SECONDARY; SUBSTRATE SPECIFICITY;

EID: 33846979113     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M605236200     Document Type: Article

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