Transcriptional silencing is associated with extensive methylation of the CMV promoter following adenoviral gene delivery to muscle

Journal of Gene Medicine

Volumn 6, Issue 4, 2004, Pages 395-404

  Brooks, Alan R ^a   Harkins, Richard N ^a   Wang, Peiyin ^a   Qian, Hu Sheng ^a   Liu, Pengxuan ^a   Rubanyi, Gabor M ^a  

^a BAYER AG   (Germany)

Author keywords

Adenovirus; Gene therapy; Promoter methylation; Silencing

Indexed keywords

ADENOVIRUS VECTOR; BISULFITE; FIBROBLAST GROWTH FACTOR 4; MESSENGER RNA; VIRUS DNA;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; CYTOMEGALOVIRUS; ENHANCER REGION; GENE SILENCING; GENETIC TRANSCRIPTION; MALE; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN METHYLATION; QUANTITATIVE ANALYSIS; RAT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SEQUENCE ANALYSIS; SKELETAL MUSCLE; SOUTHERN BLOTTING; VIRAL GENE DELIVERY SYSTEM;

ANIMALS; CPG ISLANDS; CYTOMEGALOVIRUS; DNA METHYLATION; ENHANCER ELEMENTS (GENETICS); FIBROBLAST GROWTH FACTOR 4; FIBROBLAST GROWTH FACTORS; GENE EXPRESSION REGULATION; GENE SILENCING; GENE TRANSFER TECHNIQUES; GENETIC VECTORS; HUMANS; INJECTIONS, INTRAMUSCULAR; MALE; MUSCLE, SKELETAL; PROMOTER REGIONS (GENETICS); PROTO-ONCOGENE PROTEINS; RATS; RATS, SPRAGUE-DAWLEY; TRANSCRIPTION, GENETIC;

ADENOVIRIDAE; CUCUMBER MOSAIC VIRUS; CYTOMEGALOVIRUS;

EID: 13644267108     PISSN: 1099498X     EISSN: 15212254     Source Type: Journal    
DOI: 10.1002/jgm.516     Document Type: Article

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