Increase in systemic blood pressure during intra-arterial PD123319 infusion: Evidence for functional expression of angiotensin type 2 receptors in normal volunteers

Blood Pressure

Volumn 13, Issue 2, 2004, Pages 110-114

  Gilles, Rozemarie ^a   Vingerhoedt, Noreen ^a   Howes, Jan ^a   Griffin, Matthew ^a   Howes, Laurence Guy ^a  

^a ST GEORGE HOSPITAL   (Australia)

Author keywords

Angiotensin receptors; Blood pressure; PD123319; Telmisartan

Indexed keywords

1 (4 DIMETHYLAMINO 3 METHYLBENZYL) 5 DIPHENYLACETYL 4,5,6,7 TETRAHYDRO 1H IMIDAZO[4,5 C]PYRIDINE 6 CARBOXYLIC ACID; ANGIOTENSIN 1 RECEPTOR; ANGIOTENSIN 1 RECEPTOR ANTAGONIST; ANGIOTENSIN 2 RECEPTOR; ANGIOTENSIN 2 RECEPTOR ANTAGONIST; ANTIHYPERTENSIVE AGENT; PLACEBO; TELMISARTAN;

ADULT; ARTICLE; BLOOD PRESSURE MEASUREMENT; BLOOD VESSEL REACTIVITY; BRACHIAL ARTERY; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DIASTOLIC BLOOD PRESSURE; DIZZINESS; DRUG INFUSION; DRUG RESPONSE; FEMALE; FOREARM BLOOD FLOW; HUMAN; HUMAN EXPERIMENT; MALE; MEAN ARTERIAL PRESSURE; NORMAL HUMAN; PRIORITY JOURNAL; RESISTANCE BLOOD VESSEL; SYSTOLIC BLOOD PRESSURE; VOLUNTEER;

ADOLESCENT; ADULT; ANGIOTENSIN II TYPE 1 RECEPTOR BLOCKERS; BENZIMIDAZOLES; BENZOATES; BLOOD FLOW VELOCITY; BLOOD PRESSURE; CROSS-OVER STUDIES; FEMALE; FOREARM; HUMANS; IMIDAZOLES; INFUSIONS, INTRA-ARTERIAL; MALE; PYRIDINES; RECEPTOR, ANGIOTENSIN, TYPE 2; VASCULAR RESISTANCE; VASOCONSTRICTOR AGENTS;

EID: 2342498644     PISSN: 08037051     EISSN: None     Source Type: Journal    
DOI: 10.1080/08037050310031017     Document Type: Article

References (8)

1. Fridman KU, Wysocki M, Friberg PR, Andersson OK. Candesartan cilexetil in hypertension: effects of 6 weeks of treatment on haemodynamics, baroreceptor sensitivity and the renin-aldosterone system. Blood Press 1999; 84: 242-7.
2. Henrion D, Kubis N, Levy BI. Physiological and pathophysiological functions of the AT2 subtype receptor of angiotensin II. Hypertension 2001; 38: 1150-7.
3. Tran D, Phoon S, Howes LG. The effects of candesartan on vascular responses to angiotensin II and norepinephrine in normal volunteers. J Renin Angiotensin-Aldo Sys 2001; 2: 199-203.
4. Phoon S, Howes LG. Forearm vasodilator response to angiotensin II in elderly women receiving candesartan: role of angiotensin type 2 receptors. J Renin Angiotensin-Aldo Sys 2002; 3: 36-9.
5. Phoon S, Howes LG. Role of angiotensin type 2 receptors in human forearm vascular responses. Clin Exp Pharmacol Physiol 2001; 28: 734-6.
6. Widdop RE, Li XC. AT2 receptor stimulation enhances the vasodilator effect of an AT1 receptor antagonist in conscious spontaneously hypertensive rats. J Hypertens 2002; 20 Suppl 4: S282 (Abstract p 1194).
7. Cao Z, Dean R, Wu L, Casley D, Cooper ME. Role of angiotensin receptor subtypes in mesenteric artery proliferation and hypertrophy. Hypertension 1999; 34: 408-414.
8. Silke B, Spiers JP, Boyd S, Graham E, McParland G, Scott ME. Evaluation of non-invasive blood pressure measurement by the Finapres method at rest and during dynamic exercise in subjects with cardiovascular insufficiency. Clin Autonom Res 1994; 4: 49-56.