Angiotensin II type 2 receptor overexpression activates the vascular kinin system and causes vasodilation

Journal of Clinical Investigation

Volumn 104, Issue 7, 1999, Pages 925-935

  Tsutsumi, Yoshiaki ^a   Matsubara, Hiroaki ^a   Masaki, Hiroya ^a   Kurihara, Hiroki ^b   Murasawa, Satoshi ^a   Takai, Shinji ^c   Miyazaki, Mizuo ^c   Nozawa, Yoshihisa ^d   Ozono, Ryoji ^e   Nakagawa, Keigo ^e   Miwa, Takeshi ^f   Kawada, Noritaka ^f   Mori, Yasukiyo ^a   Shibasaki, Yasunobu ^a   Tanaka, Yohko ^a   Fujiyama, Soichiro ^a   Koyama, Yohko ^a   Fujiyama, Atsuko ^a   Takahashi, Hakuo ^a   Iwasaka, Toshiji ^a  

^a KANSAI MEDICAL UNIVERSITY   (Japan)

^b SUNTORY LTD   (Japan)

^c OSAKA MEDICAL COLLEGE   (Japan)

^d TAIHO PHARMACEUTICAL CO LTD   (Japan)

^e HIROSHIMA UNIVERSITY   (Japan)

^f OSAKA UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

AMILORIDE; ANGIOTENSIN; ANGIOTENSIN 2 RECEPTOR; BRADYKININ; CYCLIC GMP; ICATIBANT; KALLIKREIN; KININ; N(G) NITROARGININE METHYL ESTER; NITRIC OXIDE; PROTON; SODIUM ION;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CELL PH; CONTROLLED STUDY; ENZYME ACTIVATION; KNOCKOUT MOUSE; MOLECULAR DYNAMICS; MOUSE; NONHUMAN; PARACRINE SIGNALING; PRESSOR RESPONSE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN SYNTHESIS; PROTON SODIUM EXCHANGE; VASCULAR ENDOTHELIUM; VASCULAR SMOOTH MUSCLE; VASODILATATION;

EID: 0032698983     PISSN: 00219738     EISSN: None     Source Type: Journal    
DOI: 10.1172/JCI7886     Document Type: Article

References (56)

1. Baker, K.M., Booz, G.W., and Dostal, D.E. 1992. Cardiac actions of angiotensin II: role of an intracardiac renin-angiotensin system. Annu. Rev. Physiol. 54:227-241.
2. Inagami, T., and Kitami, Y. 1994. Angiotensin II receptor: molecular cloning, functions and regulation. Hypertens. Res. 17:87-97.
3. Matsubara, H., and Inada, M. 1998. Molecular insights into angiotensin II type 1 and type 2 receptors: expression, signaling and physiological function and clinical application of its antagonists. Endocr. J. 45:137-150.
4. Matsubara, H. 1998. Pathophysiological roles of angiotensin II type2 receptor in cardiovascular and renal diseases. Circ. Res. 83:1182-1191.
5. Shibasaki, Y., et al. 1999. Differential kinetics of circulating angiotensin IV and II after treatment with angiotensin II type I receptor antagonist and their plasma levels in patients with chronic renal failure. Clin. Nephrol. 51:83-91.
6. Vinswanathan, M., Tsutsumi, K., Correa, F.M.A., and Saavedra, J.M. 1991. Changes in expression of angiotensin receptor subtypes in the rat aorta during development. Biochem. Biophys. Res. Commun. 179:1361-1367.
7. Song, Y., et al. 1995. Mapping of angiotensin II receptor subtypes in peripheral tissues of spontaneous hypertensive rats by in vitro autoradiography. Clin. Exp. Pharmacol. Physiol. 22(Suppl. 1):S17-S19.
8. Nora, E.H., Munzenmaier, D.H., Hansen-Smith, F.M., Lombard, J.H., and Greene, A.S. 1998. Localization of the ANG II type2 receptor in the microcirculation of skeletal muscle, Am. J. Physiol. 275:H1395-H1403.
9. Ichiki, T., et al. 1995. Effects on blood pressure and exploratory behavior of mice lacking angiotensin II type-2 receptor. Nature. 377:748-750.
10. Hein, L., Barsh, G.S., Pratt, R.E., Dzau, V.J., and Koblika, B.K. 1995. Behavioural and cardiovascular effects of disrupting the angiotensin II type-2 receptor gene in mice. Nature. 377:744-747.
11. Pitt, B., et al. 1997. Randomised trial of losartan versus captoril in patients over 65 with heart failure. Lancet. 349:747-752.
12. Wiemer, G., et al. 1993. The functional role of angiotensin II-subtype 2-receptors in endothelial cells and isolated ischemic rat hearts. Pharm. Pharmacol. Lett. 3:24-27.
13. Boulanger, C.M., Caputo, L., and Levy, B.I. 1995. Endothelial AT1-mediated release of nitric oxide decreases angiotensin II contractions in rat carotid artery. Hypertension. 26:752-757.
14. Seyedi, N., Xu, X.B., Najiletti, A., and Hintze, T.H. 1995. Coronary kinin generation mediates nitric oxide release after angiotensin receptor stimulation. Hypertension. 26:164-170.
15. Munzenmaier, D.H., and Greene, A.S. 1994. Stimulation of soluble guanylate cyclase activity by angiotensin II is mediated by a non-AT1 receptor mechanism in rat aorta. FASEB J. 8:A367.(Abstr.)
16. Liu, Y.H., et al. 1997. Effects of angiotensin-converting enzyme inhibitors and angiotensin II type 1 receptor antagonists in rat with heart failure. Role of kinins and angiotensin II type 2 receptors. J. Clin. Invest. 99:1926-1935.
17. Bartunek, J., Weinberg, E.O., Tajima, M., Rohrbach, S., and Lorell, B.H. 1999. Angiotensin II type 2 receptor blockade amplifies the early signals of cardiac growth response to angiotensin II in hypertrophied hearts. Circulation. 99:22-25.
18. Gohlke, P., Pees, C., and Unger, T. 1998. AT2 receptor stimulation increases aortic cyclic GMP in SHRSP by a kinin-dependent mechanism. Hypertension. 31:349-355.
19. Lo, M., Liu, K.L., Lantelme, P., and Sassard, J. 1995. Subtype 2 of angiotensin II receptors controls pressure-natriuresis in rats. J. Clin. Invest. 95:1394-1397.
20. Madrid, M.I., Garcia-Salom, M., Torenel, J., de Gasparo, M., and Fenoy, F.J. 1997. Effect of interactions between nitric oxide and angiotensin II on pressure diuresis and natriuresis. Am. J. Physiol. 273:R1676-R1682.
21. Siragy, H.M., and Carey, R.M. 1996, The subtype-2 (AT2) angiotensin receptor regulates renal cyclic guanosine 3′,5′-monophosphate and AT1 receptor-mediated prostaglandin E2 production in conscious rats. J. Clin. Invest. 97:1978-1982.
22. Siragy, H.M., and Carey, R.M. 1997. The subtype 2 (AT2) angiotensin receptor mediates renal production of nitric oxide in conscious rats. J. Clin. Invest. 100:264-269.
23. Kawada, N., et al. 1999. The role of intron 1 in smooth muscle-actin transcriptional regulation in activated mesangial cells in vivo. Kidey Int. 55:2338-2348.
24. Masaki, H., et al. 1998. Cardiac-specific overexpression of angiotensin AT2 receptor causes attenuated response to ATI receptor-mediated pressor and chronotropic effects. J. Clin. Invest. 101:527-535.
25. Kijima, K., Matsubara, H., Komuro, I., Yazaki, Y., and Inada, M. 1996. Mechanical stretch induces enhanced expression of angiotensin II receptors in neonatal rat cardiac myocytes. Circ. Res. 79:887-897.
26. Tsutsumi, Y., et al. 1998. Angiotensin II type 2 receptor is up-egulated in human heart with interstitial fibrosis and cardiac fibroblasts are the major cell type for its expression. Circ. Res 83:1035-1046.
27. Takai, S., et al. 1998. 12-hydroxy-eicosatetraenoic acid directly potentiates angiotensin II-induced vascular contraction. Eur. J. Phamacol. 358:161-164.
28. Sugaya, T., et al. 1995. Angiotensin II type 1a receptor-deficient mice with hypotension and hyperreninemia. J. Biol. Chem. 270:18719-18722.
29. Carretera, O.S., Oza, N.B., Pionska, A., Ocholik, T., and Scicli, A.G. 1976. Measurement of urinary kallikrein activity by kinin radioimmunoassay. Biochem. Pharmacol. 25:2265-2270.
30. Nolly, H., Scicli, A.G., Scicli, G., and Carretero, O.S. 1985. Characterization of a kininogenase from rat vascular tissue resembling tissue kallikrein. Circ. Res. 56:816-821.
31. Shimamoto, K., et al. 1982. An improved method for the determination of human blood kinin levels by sensitive kinin radioimmunoassay. Endocrinol. Jpn. 29:487-494.
32. Oza, N.B., Schwartz, J.H., Goud, H.D., and Levinsky, N.G. 1990. Rat aortic smooth muscle cells in culture express kallikrein, kininogen and bradykinin activity. J. Clin. Invest. 85:597-600.
33. Ishikawa, S., Okada, K., and Saito, T. 1992. pH dependence of the action of arginine vasopressin in renal collecting tubule. Am. J. Physiol. 31:F784-F792.
34. + exchange in cultured vascular smooth muscle cells. J. Biol. Chem. 262:5057-5064.
35. 2+/calmodulin-dependent transactivation of epidermal growth factor receptor. Circ. Res. 82:1338-1348.
36. Ozono, R., et al. 1997. Expression of the subtype 2 angiotensin (AT2) receptor protein in rat kidney. Hypertension. 30:1238-1246.
37. Mukoyama, M., et al. 1993. Expression cloning of type 2 angiotensin II receptor reveals a unique class of seven-transmembrane receptors. J. Biol. Chem. 268:24539-24542.
38. Ichiki, T., et al. 1995. Effects on blood pressure and exploratory behavior of mice lacking angiotensin II type-2 receptor. Nature 377:748-750.
39. Nolly, H., Carretero, O.A., and Scicli, A.G. 1993. Kallikrein release by vascular tissue. 1993. Am. J. Physiol. 265:H1209-H1214.
40. Moshi, M.J., Zeitlin, I.J., Wainwrighr, C.L., and Parratt, J.R. 1992. Acid optimum kininogenases in canine myocardium and aorta. Cardiovasc. Res. 26:367-370.
41. Chao, J., et al. 1990. Tissue kallikrein-binding protein is a serpin. I. Purification, characterization, and distribution in normotensive and spontaneously hypertensive rats. J. Biol. Chem. 265:16394-16401.
42. Scheuer, D.A., and Perrone, M.H. 1993. Angiotensin type2 receptors mediate the depressor phase of biphasic pressure response to angiotensin II. Am. J. Physiol. 264:R917-R923.
43. Munzenmaier, D.H., and Greene, A.S. 1996. Opposing actions of angiotensin II on microvascular growth and arterial blood pressure. Hypertension. 27:760-765.
44. Akishita, M., et al. 1999. Expression of the AT2 receptor developmentally programs extracellular signal-regulated kinase activity and influences fetal vascular growth. J. Clin. Invest. 103:63-71.
45. Okamoto, H., Yayama, K., Shibata, H., Nagaoka, M., and Takano, M. 1998. Kininogen expression by rat vascular smooth muscle cells: stimulation by lipopolysaccharide and angiotensin II. Biochim. Biophys. Acta. 1404:329-337.
46. Stoll, M., et al. 1995. The angiotensin AT2-receptor mediates inhibition of cell proliferation in coronary endothelial cells. J. Clin. Invest. 95:651-657.
47. Pueyo, M.E., N'Diane, N., and Michel, J.B. 1996. Angiotensin II-elicited signal transduction via AT1 receptor in endothelial cells. Br. J. Pharmacol. 118:79-84.
48. Tallant, E.A., Lu, X., Weiss, R.B., Chappel, M.C., and Ferrario, C.M. 1997. Bovine aortic endothelial cells contain an angiotensin (1-7) receptor. Hypertension. 29:388-393.
49. Mineo, C., Schimizu, H., Takada, K.I., Imanaka, Z., and Takano, T. 1994. Angiotensin II binding activity in cultured porcine arterial endothelial cells. Biochem. Pharmacol. 48:1993-1995.
50. Matsubara, H., et al. 1998. Cellular localization of angiotensin type 1 and type 2 receptor mRNAs in human renal cortex using in situ hybridization. Nephron. 80:25-34.
51. Lauar, N., and Bhoola, K. 1986. Release of tissue kallikrein from the isolated perfused kidney. Adv. Exp. Med. Biol. 198:347-354.
52. MacDonald, R.J., Southard-Smith, E.M., and Kroon, E. 1996. Disparate tissue-specific expression of members of the tissue kallikrein multigene family of the rat. J. Biol. Chem. 271:13684-13690.
53. Berk, B.C., and Corson, M.A. 1997. Angiotensin II signal transduction in vascular smooth muscle: role of tyrosine kinases. Circ. Res. 80:607-616.
54. + exchanger kinase. Circ. Res. 81:268-273.
55. Yang, B.C., et al. 1998. Increased angiotensin II type1 receptor expression in hypercholesterolemic atherosclerosis in rabbits. Arterioscler. Thromb. Vasc. Biol. 18:1433-1439.
56. Nakajima, M., et al. 1995. The angiotensin II type 2 (AT2) antagonizes the growth effects of the AT1 receptor: gain-of-function study using gene transfer. Proc. Natl. Acad. Sci. USA. 82:10663-10667.