No vasoactive role of the angiotensin II type 2 receptor in normotensive Wistar rats

Journal of Hypertension

Volumn 17, Issue 12 SUPPL., 1999, Pages 1879-1884

  Schuijt, Martin P ^b   De Vries, René ^b   Saxena, Pramod R ^b   Danser, A H Jan ^a  

^a ERASMUS UNIVERSITY ROTTERDAM   (Netherlands)

^b NONE

Author keywords

Angiotensin; Angiotensin receptors; Irbesartan; PD123319

Indexed keywords

1 (4 DIMETHYLAMINO 3 METHYLBENZYL) 5 DIPHENYLACETYL 4,5,6,7 TETRAHYDRO 1H IMIDAZO[4,5 C]PYRIDINE 6 CARBOXYLIC ACID; ANGIOTENSIN; ANGIOTENSIN 2 RECEPTOR; ANGIOTENSIN ANTAGONIST; IRBESARTAN; RADIOACTIVE MICROSPHERE; VASOACTIVE AGENT;

ANIMAL EXPERIMENT; CONFERENCE PAPER; CONTROLLED STUDY; HEART OUTPUT; HEART RATE; KIDNEY BLOOD FLOW; MALE; MEAN ARTERIAL PRESSURE; MUSCLE BLOOD FLOW; NONHUMAN; ORGAN BLOOD FLOW; PRIORITY JOURNAL; RAT; VASOCONSTRICTION; VASODILATATION;

EID: 0033507895     PISSN: 02636352     EISSN: None     Source Type: Journal    
DOI: 10.1097/00004872-199917121-00016     Document Type: Conference Paper

References (42)

1. de Gasparo M, Husain A, Alexander W, Catt KJ, Chiu AT, Drew M, et al. Proposed update of angiotensin receptor nomenclature. Hypertension 1995; 25:924-927.
2. 2 receptors in the developing rat fetus. J Clin Invest 1991; 88:921-933.
3. 2 angiotensin II receptor subtypes in the rat brain during development. Proc Natl Acad Sci USA 1991; 88:11440-11444.
4. Tsutsumi K, Stromberg C, Viswanathan M, Saavedra JM. Angiotensin-II receptor subtypes in fetal tissue of the rat: autoradiography, guanine nucleotide sensitivity, and association with phosphoinositide hydrolysis. Endocrinology 1991; 129:1075-1082.
5. 2 receptor antagonist. Eur J Pharmacol 1995; 275:277-282.
6. Sechi LA, Griffin CA, Grady EF, Kalinyak JE, Schambelan M. Characterization of angiotensin II receptor subtypes in rat heart. Circ Res 1992; 71:1482-1489.
7. 2) receptor protein in rat heart. Hypertension 1998; 32:78-83.
8. 1-receptor subtype in failing human ventricular myocardium. Circulation 1997; 95:1193-1200.
9. Grone HJ, Simon M, Fuchs E. Autoradiographic characterization of angiotensin receptor subtypes in fetal and adult human kidney. Am J Physiol 1992; 262:F326-F331.
10. 2 receptor stimulation increases aortic cyclic GMP in SHRSP by a kinin-dependent mechanism. Hypertension 1998; 31:349-355.
11. 2-receptor mediates inhibition of cell proliferation in coronary endothelial cells. J Clin Invest 1995; 95:651-657.
12. Yamada T, Horiuchi M, Dzau VJ. Angiotensin II type 2 receptor mediates programmed cell death. Proc Natl Acad Sci USA 1996; 93:156-160.
13. van Kesteren CAM, van Heugten HAA, Lamers JMJ, Saxena PR, Schalekamp MADH, Danser AHJ. Angiotensin II-mediated growth and antigrowth effects in cultured neonatal rat cardiac myocytes and fibroblasts. J Mol Cell Cardiol 1997; 29:2147-2157.
14. Ichiki T, Labosky PA, Shiota C, Okuyama S, Imagawa Y, Fogo A, et al. Effects on blood pressure and exploratory behaviour of mice lacking angiotensin II type-2 receptor. Nature 1995; 377:748-750.
15. Hein L, Barsh GS, Pratt RE, Dzau VJ, Kobilka BK. Behavioural and cardio-vascular effects of disrupting the angiotensin II type-2 receptor in mice. Nature 1995; 377:744-747.
16. Arima S, Endo Y, Yaoita H, Omata K, Ogawa S, Tsunoda K, et al. Possible role of P-450 metabolite of arachidonic acid in vasodilator mechanism of angiotensin II type 2 receptor in the isolated microperfused rabbit afferent arteriole. J Clin Invest 1997; 100:2816-2823.
17. Endo Y, Arima S, Yaoita H, Omata K, Tsunoda K, Takeuchi K, et al. Function of angiotensin II type 2 receptor in the postglomerular efferent arteriole. Kidney Int 1997; 52 (suppl 63):S205-S207.
18. 1 receptors in the rat. Am J Physiol 1998; 274:E115-E123.
19. 2 angiotensin receptor antagonists in angiotensin II-infused rats. Hypertension 1998; 31:487-492.
20. Munzenmaier DH, Greene AS. Opposing actions of angiotensin II on microvascular growth and arterial blood pressure. Hypertension 1996; 27:760-765.
21. Scheuer DA, Perrone MH. Angiotensin type 2 receptors mediate depressor phase of biphasic pressure response to angiotensin. Am J Physiol 1993; 264:R917-R923.
22. 2 receptors in angiotensin II-stimulated contraction of small mesenteric arteries in young SHR. Hypertension 1999; 33:366-372.
23. 1-receptor antagonist, EXP 3174. Br J Pharmacol 1992; 107:873-880.
24. Widdop RE, Gardiner SM, Kemp PA, Bennett T. Central administration of PD 123319 or EXP-3174 inhibits effects of angiotensin II. Am J Physiol 1993;264:H117-H125.
25. 2 receptor ligands CGP 42112B and PD 123319 in the sodium-depleted rat. Eur J Pharmacol 1993; 249:85-93.
26. de Vries P, de Visser PA, Heiligers JPC, Villalon CM, Saxena PR. Changes in systemic and regional haemodynamics during 5-HT7 receptor-mediated depressor responses in rats. Naunyn Schmiedebergs Arch Pharmacol 1999; 359:331-338.
27. McDevitt DG, Nies AS. Simultaneous measurement of cardiac output and its distribution with microspheres in the rat. Cardiovasc Res 1976; 10:494-498.
28. Trippodo NC, Panchal BC, Fox M. Repression of angiotensin II and potentiation of bradykinin contribute to the synergistic effects of dual metalloprotease inhibition in heart failure. J Pharmacol Exp Ther 1995; 272:619-627.
29. Saxena PR, Schamhardt HC, Forsyth RP, Hoeve J. Computer programs for the radioactive microsphere technique. Determination of regional blood flows and other haemodynamic variables in different experimental circumstances. Comput Programs Biomed 1980; 12:63-84.
30. Ohkubo N, Matsubara H, Nozawa Y, Mori Y, Murasawa S, Kijima K, et al. Angiotensin type 2 receptors are reexpressed by cardiac fibroblasts from failing myopathic hamster hearts and inhibit cell growth and fibrillar collagen metabolism. Circulation 1997; 96:3954-3962.
31. Matsubara H. Pathophysiological role of angiotensin II type 2 receptor in cardiovascular and renal diseases. Circ Res 1998; 83:1182-1191.
32. 2 receptors in the rat skin during experimental wound healing. Peptides 1992; 13:783-786.
33. 1 receptor-mediated prostaglandin E2 production in conscious rats. J Clin Invest 1996; 97:1978-1982.
34. Brink M, Erne P, de Gasparo M, Rogg H, Schmid A, Stulz P, et al. Localization of the angiotensin II receptor subtypes in the human atrium. J Mol Cell Cardiol 1996; 28:1789-1799.
35. 2 receptors in the normal and failing human heart. J Pharmacol Exp Ther 1998; 284:323-336.
36. 2) angiotensin receptor mediates renal production of nitric oxide in conscious rats. J Clin Invest 1997; 100:264-269.
37. Christophe B, Libon R, Cazaubon C, Nisato D, Manning A, Chatelain P. Effects of irbesartan (SR47436/BMS-186295) on angiotensin II-induced pressor responses in the pithed rat: potential mechanisms of action. Eur J Pharmacol 1995; 281:161-171.
38. Ohlstein EH, Brooks DP, Feuerstein GZ, Ruffolo RR Jr. Inhibition of sympathetic outflow by the angiotensin II receptor antagonist, eprosartan, but not by losartan, valsartan or irbesartan: relationship to differences in prejunctional angiotensin II receptor blockade. Pharmacology 1997; 55:244-251.
39. Johnston CI, Naitoh M, Burrell LM. Rationale and pharmacology of angiotensin II receptor antagonists: current status and future issues. J Hypertens 1997; 15 (suppl):S3-6.
40. Ferrario CM, Chappell MC, Tallant EA, Brosnihan KB, Diz Dl. Counter-regulatory actions of angiotensin-(1-7). Hypertension 1997; 30:535-541.
41. van Kats JP, Sassen LMA, Danser AHJ, Polak MPJ, Soei LK, Derkx FHM, et al. Assessment of the role of the renin-angiotensin system in cardiac contractility utilizing the renin inhibitor remikiren. Br J Pharmacol 1996; 117:891-901.
42. 1 receptor-mediated pressor and chronotropic effects. J Clin Invest 1998; 101:527-535.